Erlotinib Hydrochloride combined with Sorafenib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Urine Output Decreased Other Serious 8/27/2009 69 Female 9/18/2009 Consumer Germany
Primary
Secondary
Concomitant
Varices Oesophageal Other Serious 8/30/2009 55 Male 11/6/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/2/2009 79 Male 11/13/2009 Other Health Professional Singapore
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/16/2009 55 Male 12/11/2009 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Death Death 11/20/2009 47 Female 12/11/2009 Other Health Professional China
Primary
Secondary
Pain In Extremity Hospitalization 12/11/2009 58 Male 1/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/23/2010 61 Male 2/12/2010 Physician Singapore
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/30/2009 55 Male 2/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 2/15/2010 56 Female 131 lb 3/9/2010 Physician United States
Primary
Secondary
Oral Candidiasis Other Serious 12/12/2009 82 Male 3/30/2010 United Kingdom
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Hospitalization 2/5/2010 62 Male 4/6/2010 Other Health Professional France
Primary
Secondary
Hypoxia Hospitalization 4/11/2009 80 Female 139 lb 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Ulcer Hospitalization 3/23/2010 44 Male 4/27/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Yellow Skin Hospitalization 4/2/2010 45 Male 4/30/2010 Other Health Professional China
Primary
Secondary
Concomitant
Somnolence Hospitalization 3/2/2010 56 Male 5/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatic Carcinoma Metastatic Hospitalization 5/16/2010 59 Female 112 lb 5/18/2010 Other Health Professional United States
Primary
Secondary
Thrombocytopenia Other Serious 10/31/2009 69 Male 5/21/2010 Physician France
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 5/8/2010 69 Male 5/21/2010 Physician Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/16/2010 59 Female 112 lb 5/18/2010 Other Health Professional United States
Primary
Secondary
Hepatic Cirrhosis Hospitalization 5/8/2010 69 Male 5/25/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 10/31/2009 69 Male 6/1/2010 Other Health Professional France
Primary
Secondary
Concomitant
Pancreatic Carcinoma Death 5/23/2010 59 Female 111 lb 6/10/2010 Other Health Professional United States
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 5/16/2010 41 Male 6/16/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Ulcer Hospitalization 3/22/2010 44 Male 6/28/2010 Physician Germany
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 4/28/2010 64 Male 7/7/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Ulcer Hospitalization 3/22/2010 44 Male 7/6/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 6/28/2009 41 Male 7/15/2010 Other Health Professional China
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 12/11/2009 58 Male 7/15/2010 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Uveitis Other Serious 8/2/2010 77 Male 159 lb 8/16/2010 Physician Israel
Primary
Secondary
Concomitant
Anaemia Hospitalization 7/19/2010 60 Male 8/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Enterocolitis Infectious Hospitalization 7/2/2010 68 Male 8/17/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 8/6/2010 43 Male 9/3/2010 Physician Spain
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 8/6/2010 43 Male 9/13/2010 Physician Spain
Primary
Secondary
Concomitant
Hypoglycaemia Hospitalization 6/23/2010 72 Male 143 lb 9/14/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 8/23/2010 69 Male 9/7/2010 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Rash Other Serious 12/12/2009 82 Male 9/15/2010
Primary
Secondary
Concomitant
Vasculitis Other Serious 7/15/2010 64 Male 159 lb 9/23/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 8/10/2010 58 Female 181 lb 9/29/2010 Other Health Professional United States
Primary
Secondary
Encephalopathy Hospitalization 5/8/2010 69 Male 9/29/2010 Physician Canada
Primary
Secondary
Concomitant
Rash Other Serious 7/8/2010 64 Male 159 lb 10/7/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 7/29/2010 43 Male 10/25/2010 Physician Spain
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 6/30/2010 58 Male 10/21/2010 France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 6/7/2010 57 Female 165 lb 11/2/2010 Physician United States
Primary
Secondary
Concomitant
Uveitis Other Serious 8/2/2010 77 Male 159 lb 11/10/2010 Physician Israel
Primary
Secondary
Concomitant
Haemothorax Hospitalization 11/10/2010 69 Male 11/23/2010 Physician Germany
Primary
Secondary
Concomitant
Vertigo Hospitalization 10/25/2010 Male 11/24/2010 Physician Germany
Primary
Secondary
Renal Failure Life Threatening 9/15/2010 75 Male 117 lb 11/24/2010 Physician France
Primary
Secondary
Concomitant
Ulcer Hospitalization 3/22/2010 44 Male 150 lb 12/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Uveitis Other Serious 8/1/2010 77 Male 2/9/2011 Other Health Professional Israel
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 6/30/2010 58 Male 2/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 3/25/2011 68 Female 132 lb 4/20/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Nausea Hospitalization 4/11/2011 56 Female 142 lb 4/29/2011 Other Health Professional United States
Primary
Secondary
Blood Lactate Dehydrogenase Increased Hospitalization 4/11/2011 56 Female 142 lb 4/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 3/25/2011 68 Female 132 lb 5/4/2011 Physician United States
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Death Male 5/18/2011 Physician United States
Primary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 10/18/2010 55 Male 139 lb 5/11/2011 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 1/15/2011 61 Male 136 lb 5/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Disease Progression Hospitalization 10/18/2010 55 Male 139 lb 5/12/2011 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Anaemia Hospitalization 7/19/2010 60 Male 209 lb 5/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Death 1/15/2010 73 Male 146 lb 5/26/2011 Physician Germany
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Death 1/15/2010 73 Male 146 lb 6/3/2011 Physician Germany
Primary
Secondary
Concomitant
Ascites Hospitalization 4/18/2011 56 Female 117 lb 6/7/2011 Physician United States
Primary
Secondary
Death Death Female 117 lb 6/8/2011 Other Health Professional United States
Primary
Secondary
Abdominal Pain Death 5/7/2011 76 Male 214 lb 6/15/2011 Physician United States
Primary
Secondary
Syncope Other Serious 1/15/2010 73 Male 146 lb 6/29/2011 Physician Germany
Primary
Secondary
Concomitant
Varices Oesophageal Hospitalization 6/15/2011 63 Male 139 lb 6/29/2011 Physician Peru
Primary
Secondary
Concomitant
Haemorrhoidal Haemorrhage Hospitalization 6/15/2011 63 Male 139 lb 7/6/2011 Physician Peru
Primary
Secondary
Concomitant
Leukopenia Hospitalization 6/15/2011 63 Male 139 lb 7/21/2011 Physician Peru
Primary
Secondary
Concomitant
Overdose Other Serious 4/19/2010 67 Female 157 lb 7/27/2011 Other Health Professional Brazil
Primary
Secondary
Tongue Haemorrhage Other Serious 4/6/2010 58 Male 205 lb 7/29/2011 Other Health Professional Brazil
Primary
Secondary
Skin Lesion Other Serious 3/31/2010 36 Male 8/4/2011 Other Health Professional Brazil
Primary
Secondary
Hyperamylasaemia Other Serious 8/8/2011 Other Health Professional Italy
Primary
Secondary
Haemorrhage Other Serious 8/9/2011 Other Health Professional Italy
Primary
Secondary
Anaemia Other Serious 8/9/2011 Other Health Professional Italy
Primary
Secondary
Cardiac Disorder Other Serious 8/8/2011 Other Health Professional Italy
Primary
Secondary
Overdose Other Serious 4/14/2010 58 Male 157 lb 8/8/2011 Other Health Professional Brazil
Primary
Secondary
Hyperlipasaemia Other Serious 8/8/2011 Other Health Professional Italy
Primary
Secondary
Overdose Other Serious 4/19/2010 67 Female 157 lb 8/11/2011 Other Health Professional Brazil
Primary
Secondary
Hepatic Neoplasm Malignant Other Serious Male 8/18/2011 Physician United States
Primary
Concomitant
Abdominal Distension Hospitalization 5/17/2011 73 Male 198 lb 8/26/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Presyncope Hospitalization 6/13/2011 53 Male 154 lb 9/2/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 5/17/2011 73 Male 198 lb 9/2/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Death 8/31/2011 61 Male 170 lb 9/8/2011 Other Health Professional Brazil
Primary
Secondary
Concomitant
Blood Pressure Increased Other Serious 4/6/2010 58 Male 205 lb 9/9/2011 Other Health Professional Brazil
Primary
Secondary
Chest Pain Death 11/12/2010 45 Male 115 lb 9/16/2011 Physician New Zealand
Primary
Secondary
Concomitant
Ascites Hospitalization 8/31/2011 61 Male 170 lb 9/19/2011 Other Health Professional Brazil
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 1/15/2010 73 Male 146 lb 9/20/2011 Physician Germany
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Death 1/15/2010 73 Male 146 lb 9/26/2011 Physician Germany
Primary
Secondary
Concomitant
Confusional State Hospitalization 9/14/2011 64 Female 163 lb 9/28/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Off Label Use Hospitalization 9/14/2011 64 Female 163 lb 10/6/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Other Serious 1/15/2010 73 Male 146 lb 10/11/2011 Physician Germany
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 6/1/2011 53 Male 154 lb 10/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/4/2010 29 Male 174 lb 10/20/2011 Other Health Professional United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 1/15/2010 73 Male 146 lb 10/28/2011 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/4/2010 29 Male 174 lb 11/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Depression Hospitalization 6/1/2011 53 Male 154 lb 11/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 11/11/2011 72 Male 265 lb 11/11/2011 Consumer United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11/11/2011 72 Male 265 lb 11/11/2011 United States
Primary
Secondary
Concomitant
Pulmonary Embolism Death 2/4/2010 29 Male 174 lb 11/23/2011 Physician United States
Primary
Secondary
Concomitant
Off Label Use Death 11/11/2011 Male 265 lb 11/28/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Arrest Hospitalization 11/11/2011 72 Male 225 lb 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/31/2011 55 Female 110 lb 12/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hypokalaemia Hospitalization 10/5/2011 63 Male 134 lb 12/20/2011 Other Health Professional Peru
Primary
Secondary
Hyponatraemia Hospitalization 10/5/2011 63 Male 134 lb 12/24/2011 Other Health Professional Peru
Primary
Secondary
Contusion Other Serious 10/5/2011 63 Male 134 lb 12/29/2011 Other Health Professional Peru
Primary
Secondary
Fall Hospitalization 10/5/2011 63 Male 134 lb 2/7/2012 Other Health Professional Peru
Primary
Secondary
Off Label Use Other Serious Female 146 lb 2/9/2012 Other Health Professional United States
Primary
Secondary
Traumatic Intracranial Haemorrhage Hospitalization 2/1/2012 66 Male 126 lb 2/13/2012 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 1/6/2012 70 Male 123 lb 2/14/2012 Physician Brazil
Primary
Secondary
Concomitant
Disease Progression Death 2/17/2011 70 Male 2/14/2012 Physician Peru
Primary
Secondary
Concomitant
Ecchymosis Hospitalization 2/1/2012 66 Male 126 lb 2/15/2012 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Off Label Use Hospitalization 2/10/2012 70 Male 132 lb 2/16/2012 Physician Brazil
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2011 63 Male 134 lb 2/16/2012 Physician Peru
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2011 63 Male 134 lb 2/17/2012 Physician Peru
Primary
Secondary
Concomitant
Off Label Use Hospitalization 9/18/2010 68 Male 132 lb 2/20/2012 Physician Brazil
Primary
Secondary
Concomitant
Anaemia Other Serious 10/11/2011 69 Male 123 lb 2/21/2012 Physician Brazil
Primary
Secondary
Concomitant
Off Label Use Death 2/17/2011 69 Male 170 lb 2/21/2012 Physician Peru
Primary
Secondary
Concomitant
Off Label Use Other Serious 12/23/2010 54 Female 146 lb 2/23/2012 Other Health Professional United States
Primary
Secondary
Platelet Count Decreased Other Serious 12/16/2010 54 Female 146 lb 3/1/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Gastritis Erosive Hospitalization 2/6/2012 66 Male 190 lb 3/2/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 5/5/2011 64 Male 190 lb 3/2/2012 Physician Germany
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 10/11/2011 69 Male 123 lb 3/5/2012 Physician Brazil
Primary
Secondary
Concomitant
Metastases To Abdominal Cavity Hospitalization 2/6/2012 66 Male 190 lb 3/9/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Cataract Disability 3/5/2012 77 Male 174 lb 3/19/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 2/6/2012 65 Male 190 lb 3/28/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Epistaxis Hospitalization 5/5/2011 64 Male 190 lb 3/28/2012 Physician Germany
Primary
Secondary
Concomitant
Dyspnoea Other Serious 5/5/2011 64 Male 190 lb 4/9/2012 Physician Germany
Primary
Secondary
Concomitant
Hepatic Cirrhosis Hospitalization 10/13/2011 63 Male 134 lb 4/24/2012 Physician Peru
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 5/5/2011 64 Male 190 lb 4/24/2012 Physician Germany
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 5/5/2011 64 Male 190 lb 5/9/2012 Physician Germany
Primary
Secondary
Concomitant
Off Label Use Hospitalization 4/30/2012 65 Male 181 lb 5/18/2012 Other Health Professional Chile
Primary
Secondary
Concomitant
Haemorrhagic Anaemia Other Serious 5/5/2011 64 Male 203 lb 5/31/2012 Physician Germany
Primary
Secondary
Concomitant
Metastases To Abdominal Cavity Hospitalization 2/6/2012 65 Male 185 lb 6/1/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 4/30/2012 65 Male 181 lb 6/4/2012 Other Health Professional Chile
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 2/1/2012 66 Male 126 lb 6/4/2012 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Renal Failure Death 11/1/2009 48 Male 115 lb 6/9/2012 Physician China
Primary
Secondary
Diarrhoea Hospitalization 4/7/2010 62 Male 141 lb 6/9/2012 Physician Brazil
Primary
Secondary
Concomitant
Dehydration Other Serious 7/1/2010 68 Female 123 lb 6/9/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Bilirubin Conjugated Increased Death 2/17/2011 69 Male 170 lb 6/22/2012 Physician Peru
Primary
Secondary
Concomitant
Hypokalaemia Hospitalization 10/5/2011 63 Male 134 lb 6/22/2012 Other Health Professional Peru
Primary
Secondary
Off Label Use Death 10/13/2011 63 Male 134 lb 6/22/2012 Physician Peru
Primary
Secondary
Concomitant
Anaemia Hospitalization 6/15/2011 63 Male 139 lb 6/22/2012 Physician Peru
Primary
Secondary
Concomitant
Anaemia Other Serious 10/11/2011 69 Male 123 lb 6/22/2012 Physician Brazil
Primary
Secondary
Concomitant
Off Label Use Other Serious 4/14/2010 58 Male 157 lb 6/22/2012 Other Health Professional Brazil
Primary
Secondary
Off Label Use Other Serious 3/31/2010 36 Male 6/22/2012 Other Health Professional Brazil
Primary
Secondary
Presyncope Hospitalization 6/1/2011 53 Male 154 lb 6/22/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Metastases To Abdominal Cavity Other Serious 2/6/2012 65 Male 185 lb 6/22/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Constipation Hospitalization 2/1/2012 66 Male 126 lb 6/22/2012 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 5/5/2011 64 Male 203 lb 6/22/2012 Physician Germany
Primary
Secondary
Concomitant
Off Label Use Hospitalization Female 176 lb 7/30/2012 Other Health Professional Australia
Primary
Secondary
Concomitant

Drug Data