Elspar combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 6 Male 1/6/2006 Physician Australia
Primary
Concomitant
Coronary Artery Stenosis Hospitalization 1/31/2006 Male 194 lb 2/8/2006 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/28/2006 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 4/4/1973 4 Male 1/20/2006 Physician United States
Primary
Concomitant
Tremor Required Intervention 3/14/2006 67 Male 159 lb 3/17/2006 United States
Primary
Secondary
Sepsis Other Serious 15 Male 3/17/2006 United States
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 2/20/2006 Male 134 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 10 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/5/2006 Physician United States
Primary
Concomitant
Pulmonary Infarction Other Serious 12/10/2005 Male 178 lb 5/9/2006 United States
Primary
Secondary
Vith Nerve Paralysis Hospitalization 69 Female 5/19/2006 Physician United States
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 10 Female 6/3/2006 Physician Canada
Primary
Secondary
Metastasis Other Serious 3 Male 7/25/2006 Physician Turkey
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 13 Female 7/25/2006 Physician Turkey
Primary
Secondary
Primitive Neuroectodermal Tumour Death 10 Male 7/25/2006 Physician Turkey
Primary
Secondary
Insulin-like Growth Factor Decreased Other Serious 15 Male 122 lb 7/28/2006 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Staphylococcal Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Enterobacter Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Bacterial Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Treatment Related Secondary Malignancy Other Serious 3 Male 8/3/2006 Consumer United States
Primary
Secondary
Pulmonary Mycosis Required Intervention 8 Female 7/25/2006 Consumer Israel
Primary
Secondary
Concomitant
Blood Growth Hormone Decreased Other Serious 12 Female 8/4/2006 Other Health Professional United States
Primary
Secondary
Epiphyseal Disorder Other Serious 15 Male 8/4/2006 Other Health Professional United States
Primary
Secondary
Sinus Disorder Required Intervention 8 Female 7/25/2006 Israel
Primary
Secondary
Concomitant
Growth Hormone Deficiency Other Serious 12 Female 8/7/2006 United States
Primary
Secondary
Growth Hormone Deficiency Other Serious 15 Male 8/7/2006 United States
Primary
Secondary
Vith Nerve Paralysis Hospitalization 69 Female 8/23/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Required Intervention 16 Male 9/1/2006 Other Health Professional Spain
Primary
Concomitant
Urinary Incontinence Required Intervention 1/1/1997 16 Male 9/20/2006 Other Health Professional Spain
Primary
Concomitant
Weight Decreased Other Serious 51 Male 9/21/2006 France
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 9/29/2006 83 10/10/2006 Physician United States
Primary
Secondary
Fungal Infection Death 10/2/2006 Physician United States
Primary
Concomitant
Mucormycosis Death 10/2/2006 Physician United States
Primary
Concomitant
Neurotoxicity Other Serious 7/4/2003 17 Female 10/7/2006 United States
Primary
Concomitant
Neurotoxicity Other Serious 20 Male 10/7/2006 United States
Primary
Concomitant
Toxic Skin Eruption Other Serious 43 Male 1/9/2007 Other Health Professional Spain
Primary
Concomitant
Depression Hospitalization 6/24/2005 Male 157 lb 3/7/2007 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 9/2/2005 Female 170 lb 4/3/2007 Other Health Professional United States
Primary
Secondary
Hemiplegia Other Serious 3/29/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious 3/29/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Monoplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Monoplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Monoplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Hemiplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Mental Status Changes Other Serious 3/29/2007 Consumer France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Musculoskeletal Disorder Other Serious 3/29/2007 Consumer France
Primary
Secondary
Spinal Cord Disorder Other Serious 3/29/2007 Consumer France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 Consumer France
Primary
Secondary
Neuropathy Peripheral Other Serious 3/29/2007 Other Health Professional France
Primary
Secondary
Paresis Other Serious 3/29/2007 Other Health Professional France
Primary
Secondary
Neuropathy Peripheral Other Serious 3/29/2007 Consumer France
Primary
Secondary
Paralysis Flaccid Other Serious 3/29/2007 Consumer France
Primary
Secondary
Encephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Hemiplegia Other Serious 3/29/2007 Consumer France
Primary
Secondary
Hemiplegia Other Serious 3/29/2007 Consumer France
Primary
Secondary
Sensory Disturbance Other Serious 3/29/2007 Consumer France
Primary
Secondary
Spinal Disorder Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Spinal Disorder Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Spinal Disorder Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Neuropathy Peripheral Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Paraplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Spinal Disorder Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Sensory Disturbance Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Neuropathy Peripheral Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Superior Sagittal Sinus Thrombosis Other Serious 25 Male 4/19/2007 Japan
Primary
Concomitant
Pyrexia Other Serious 3/7/2007 38 Female 189 lb 5/8/2007 Pharmacist United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/7/2007 38 Female 189 lb 5/8/2007 Pharmacist United States
Primary
Secondary
Concomitant
Superior Sagittal Sinus Thrombosis Other Serious 25 Male 151 lb 5/9/2007 Japan
Primary
Secondary
Concomitant
Tremor Other Serious 58 Male 6/11/2007 Physician Japan
Primary
Concomitant
Septic Shock Death Male 6/12/2007
Primary
Secondary
Thrombocytopenic Purpura Other Serious 10 Female 6/15/2007 Consumer Canada
Primary
Secondary
Respiratory Rate Increased Hospitalization 7/13/2007 Female 146 lb 7/17/2007 United States
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 1/20/2006 24 Female 8/3/2007 Consumer United States
Primary
Secondary
Pneumonia Hospitalization Female 170 lb 8/1/2007 Other Health Professional United States
Primary
Secondary
Pneumonia Hospitalization Female 170 lb 8/1/2007 Other Health Professional United States
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 France
Primary
Secondary
Neuropathy Peripheral Other Serious 9/19/2007 France
Primary
Secondary
Encephalopathy Other Serious 9/19/2007 France
Primary
Secondary
Neurotoxicity Other Serious 9/19/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 France
Primary
Secondary
Encephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious NotSpecified 9/19/2007 Other Health Professional France
Primary
Secondary
Neurotoxicity Other Serious NotSpecified 9/19/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious NotSpecified 9/19/2007 Other Health Professional France
Primary
Secondary
Neurotoxicity Other Serious NotSpecified 9/19/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Monoplegia Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Encephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Leukoencephalopathy Other Serious 9/19/2007 Other Health Professional France
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 4 Female 10/10/2007
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 13 Male 10/10/2007
Primary
Secondary
Concomitant
Vomiting Death 3/1/2004 4 Female 11/20/2007
Primary
Secondary
Concomitant
Glioblastoma Multiforme Other Serious 6 Male 11/20/2007
Primary
Secondary
Hemiparesis Other Serious 10 Male 11/20/2007
Primary
Secondary
Concomitant
Staphylococcal Sepsis 12/5/2007 Male 44 lb 12/6/2007 United States
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 17 Male 12/18/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 12/24/2007 39 Male 176 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 1/12/2008 Female 161 lb 1/14/2008 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 1/12/2008 Female 161 lb 1/16/2008 United States
Primary
Secondary
Plasmapheresis Other Serious 10 Male 1/17/2008 Italy
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 1/10/2008 20 Male 234 lb 1/25/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/25/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Hospitalization 1/12/2008 Female 161 lb 1/24/2008 United States
Primary
Secondary
Wrong Technique In Drug Usage Process Hospitalization 1/12/2008 Female 161 lb 1/17/2008 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 1/10/2008 20 Male 234 lb 1/30/2008 Physician United States
Primary
Secondary
Ulcer Hospitalization 1/12/2008 Female 161 lb 1/28/2008 United States
Primary
Secondary
Mass Hospitalization 2/4/2008 Physician Hong Kong
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 2/12/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2 Female 2/7/2008 Physician Canada
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 2/5/2008 3 Male 29 lb 2/26/2008 Other Health Professional Canada
Primary
Concomitant
Transaminases Increased Other Serious 5 Female 3/10/2008
Primary
Secondary
Concomitant
Vomiting Other Serious 29 Female 4/1/2008 Other Health Professional Turkey
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 15 Male 93 lb 4/17/2008 Other Health Professional Belgium
Primary
Concomitant
Interacting
Protein Total Decreased Other Serious Male 176 lb 4/21/2008 Pharmacist Australia
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 5/6/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 10 Female 5/7/2008
Primary
Secondary
Concomitant
Panniculitis Other Serious 29 Female 5/27/2008 Turkey
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 4/20/2008 28 Female 6/3/2008 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 30 Male 6/5/2008
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 4/20/2008 Female 6/9/2008 Other Health Professional France
Primary
Secondary
Concomitant
Stomatitis Hospitalization 4 Female 6/2/2008 United States
Primary
Secondary

Drug Data