Efavirenz combined with Rifampicin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Other Serious 30 Male 1/4/2006 Physician Poland
Primary
Secondary
Concomitant
Sleep Disorder Other Serious 42 Male 104 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2003 29 Female 90 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Drug Level Increased Other Serious 40 Female 3/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metabolic Acidosis Other Serious 3/27/2006 29 Female 99 lb 4/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 3/27/2006 29 Female 98 lb 4/26/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 6/23/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 5/4/2006 36 Male 7/3/2006 Consumer South Africa
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/28/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 30 Male 8/30/2006 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 8/30/2006 9/12/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 9 Female 10/6/2006
Primary
Secondary
Concomitant
Lymph Node Tuberculosis Other Serious 12 Male 10/6/2006 India
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Drug Level Increased Other Serious 40 Female 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tuberculosis Other Serious 30 Female 11/3/2006 France
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/17/2006 Other Health Professional France
Primary
Secondary
Concomitant
Sputum Culture Positive Life Threatening 10/26/2006 31 Male 132 lb 11/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2006 31 Male 132 lb 12/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Jaundice Other Serious 11/16/2006 27 Male 2/1/2007 Physician Viet Nam
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious 1/9/2007 24 Female 90 lb 2/9/2007 Pharmacist United Kingdom
Primary
Concomitant
Jaundice Other Serious 11/16/2006 27 Male 2/15/2007 Physician Viet Nam
Primary
Secondary
Vomiting Hospitalization 31 Female 3/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 8/30/2006 40 Male 3/15/2007 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 8/30/2006 40 Male 4/10/2007 Physician United States
Primary
Secondary
Concomitant
Tuberculoma Of Central Nervous System Other Serious 54 Male 6/26/2007 Taiwan, Province Of China
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 7/9/2007 United States
Primary
Secondary
Concomitant
Uveitis Other Serious 40 Male 7/28/2007 Physician India
Primary
Secondary
Uveitis Other Serious 40 Male 8/1/2007 Other Health Professional India
Primary
Secondary
Uveitis Other Serious 40 Male 8/3/2007 Physician India
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 8/22/2007 United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 9/18/2007 United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 11/26/2007 United States
Primary
Secondary
Concomitant
Syncope Hospitalization 7/29/2006 Female 12/13/2007 Physician Japan
Primary
Concomitant
Hyperbilirubinaemia Hospitalization 11/16/2007 34 Female 117 lb 12/20/2007 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 54 Male 12/28/2007 Brazil
Primary
Secondary
Concomitant
Vomiting Other Serious 27 Male 12/28/2007 Brazil
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 11/16/2007 34 Female 117 lb 1/25/2008 United States
Primary
Secondary
Concomitant
Vomiting Death 12/6/2007 48 Female 1/11/2008 Other Health Professional United States
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious 1/7/2007 24 Female 90 lb 2/1/2008 Pharmacist United Kingdom
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/27/2007 Male 2/19/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Syncope Hospitalization 7/27/2006 Female 2/21/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 9/28/2006 33 Male 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/27/2006 28 Male 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pancytopenia Other Serious 9/18/2006 52 Female 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pruritus Other Serious 10/4/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 4/27/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 3/23/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 7/12/2006 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 3/22/2006 25 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 4/7/2006 25 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 10/27/2006 28 Female 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 12/5/2006 29 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/26/2006 24 Female 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Jaundice Other Serious 5/31/2006 27 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Vomiting Other Serious 9/12/2006 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 8/25/2006 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 2/22/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 2/5/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 4/27/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/11/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 10/4/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 30 Male 4/14/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 1/15/2007 25 Male 4/14/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Tuberculoid Leprosy Other Serious 37 Male 5/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 28 Female 5/14/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 28 Female 5/21/2008 United Kingdom
Primary
Secondary
Tuberculosis Hospitalization 5/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 5/15/2008 44 Male 5/28/2008 Physician Peru
Primary
Concomitant
Tuberculosis Hospitalization 6/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 28 Female 7/29/2008 United Kingdom
Primary
Secondary
Drug Level Decreased Other Serious 8/13/2008 South Africa
Primary
Secondary
Rash Pruritic Other Serious 37 Female 9/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Immune Reconstitution Syndrome Other Serious 37 Female 9/22/2008 United Kingdom
Primary
Secondary
Concomitant
Jaundice Hospitalization 10/10/2008 Male 78 lb 10/28/2008 India
Primary
Secondary
Hepatotoxicity Other Serious 11/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Jaundice Hospitalization 10/10/2008 Male 78 lb 11/4/2008 India
Primary
Secondary
Renal Failure Acute Hospitalization 5/23/2008 Male 12/23/2008 Physician France
Primary
Secondary
Concomitant
Interacting
Pulmonary Tuberculosis Other Serious 43 Male 12/29/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/30/2008 47 Female 121 lb 2/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Anaemia Other Serious 4/1/2008 41 Male 3/3/2009 Consumer Malaysia
Primary
Concomitant
Vomiting Hospitalization 33 Male 3/3/2009 Consumer India
Primary
Secondary
Concomitant
Weight Gain Poor Other Serious 2 Male 4/16/2009 South Africa
Primary
Secondary
Dyspnoea Death 4/8/2009 49 Male 5/12/2009 Physician India
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 5/19/2009 32 Female 90 lb 6/1/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 27 Male 6/12/2009 Physician Canada
Primary
Secondary
Concomitant
Weight Decreased Death 6/20/2009 40 Male 98 lb 7/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 27 Male 6/12/2009 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 6/29/2009 46 Male 112 lb 7/22/2009 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 7/2/2009 25 Male 133 lb 8/10/2009 Physician United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 44 Male 8/19/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 44 Male 8/24/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 1/7/2009 84 Female 8/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Life Threatening 8/28/2009 29 Female 108 lb 9/8/2009 Consumer United States
Primary
Secondary
Concomitant
Coma Hepatic Life Threatening 8/31/2009 29 Female 108 lb 9/9/2009 Consumer United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 11 Female 9/11/2009 Consumer South Africa
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 8/28/2009 29 Female 108 lb 9/14/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Death 9/1/2009 29 Female 9/16/2009 Physician United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 44 Male 9/29/2009
Primary
Secondary
Delirium Hospitalization 11 Female 9/30/2009 Other Health Professional South Africa
Primary
Secondary
Meningitis Tuberculous Other Serious 11 Female 10/9/2009 South Africa
Primary
Secondary
Skin Lesion Other Serious 44 Male 10/21/2009 Consumer Spain
Primary
Secondary
Concomitant
Gastroenteritis Death 9/7/2009 42 Male 110 lb 10/26/2009 United States
Primary
Secondary
Concomitant
Status Epilepticus Death 10/15/2009 42 Male 99 lb 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Skin Lesion Other Serious 44 Male 11/5/2009 Consumer Spain
Primary
Secondary
Concomitant
Pneumonia Other Serious 42 Male 11/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Tuberculosis Life Threatening 1/7/2009 34 Female 11/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 9/28/2006 33 Male 11/30/2009 Physician Viet Nam
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/12/2006 32 Male 11/30/2009 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 12/5/2006 29 Male 11/30/2009 Physician Viet Nam
Primary
Secondary
Concomitant
Meningitis Tuberculous Death 12/22/2009 43 Male 123 lb 1/11/2010 Physician United States
Primary
Secondary
Concomitant
Death Death 12/22/2009 43 Male 123 lb 2/3/2010 United States
Primary
Concomitant
Hyponatraemia Death 6/25/2009 39 Male 93 lb 2/3/2010 United States
Primary
Secondary
Concomitant
Tuberculosis Life Threatening 1/7/2009 34 Female 5/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 47 Male 6/17/2010 Colombia
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 47 Male 7/13/2010 Other Health Professional Colombia
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 7/21/2010 21 Male 106 lb 8/5/2010 Brazil
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 7/21/2010 21 Male 106 lb 8/16/2010 Brazil
Primary
Secondary
Concomitant
Virologic Failure Other Serious 12/1/2009 70 Male 10/8/2010 Consumer United States
Primary
Secondary
Concomitant
Interacting
Tuberculosis Hospitalization 3 Male 11/12/2010 South Africa
Primary
Secondary
Concomitant
Hemiparesis Hospitalization 28 Male 6/16/2011 Consumer India
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 6/8/2011 Male 6/22/2011 Physician Kenya
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 6/8/2011 Male 6/28/2011 Physician Kenya
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 6/8/2011 Male 7/5/2011 Physician Kenya
Primary
Secondary
Concomitant
Hiv Associated Nephropathy Other Serious 13 Male 8/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 6/8/2011 Male 8/22/2011 Physician Kenya
Primary
Secondary
Concomitant
Dizziness Other Serious 44 Male 9/6/2011 Physician Romania
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 6/8/2011 Male 9/22/2011 Physician Kenya
Primary
Secondary
Concomitant
Bradycardia Death 2/25/2012 37 Male 4/5/2012 Physician India
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 37 Female 4/17/2012 Consumer United Kingdom
Primary
Secondary
Condition Aggravated Other Serious 35 Male 4/23/2012 Other Health Professional India
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Disability 1/1/2012 59 Female 5/6/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Dehydration Other Serious 3/26/2012 44 Female 110 lb 5/8/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatitis Hospitalization 3/26/2012 44 Female 110 lb 5/16/2012 Consumer United States
Primary
Secondary
Concomitant
Cardiac Hypertrophy Hospitalization 34 Male 5/29/2012 Physician South Africa
Primary
Secondary
Concomitant
Hepatitis Other Serious 3/26/2012 44 Female 110 lb 7/2/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiogenic Shock Hospitalization 34 Male 7/25/2012 Physician South Africa
Primary
Secondary
Concomitant
Cardiogenic Shock Hospitalization 34 Male 7/25/2012 Physician South Africa
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 34 Male 8/3/2012 Other Health Professional South Africa
Primary
Secondary
Concomitant
Tuberculosis 59 Female 9/17/2012 Other Health Professional Za
Primary
Secondary
Tuberculosis Other Serious 59 Female 9/7/2012 Other Health Professional Za
Primary
Secondary
Interacting
Drug Reaction With Eosinophilia And Systemic Symptoms Other Serious 59 Female 9/19/2012 Other Health Professional Za
Primary
Secondary
Upper Motor Neurone Lesion Hospitalization 10 Female 11/9/2012 Other Health Professional Za
Primary
Secondary
Concomitant
Skin Hyperpigmentation Hospitalization 39 Male 11/20/2012 Other Health Professional Za
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 34 Male 12/10/2012 Physician Za
Primary
Secondary
Concomitant
Pneumonia Aspiration Death 5/15/2009 38 Male 12/21/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Vomiting Death 6 Male 3/1/2013 Other Health Professional Za
Primary
Secondary
Concomitant
Jaundice Other Serious 58 Female 5/22/2013 Other Health Professional Za
Primary
Concomitant

Drug Data