Efavirenz combined with Isoniazid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sleep Disorder Other Serious 42 Male 104 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2003 29 Female 90 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Drug Level Increased Other Serious 40 Female 3/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 4/6/2006 53 Male 102 lb 5/17/2006 United States
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 4/6/2006 53 Male 102 lb 5/18/2006 United States
Primary
Secondary
Concomitant
Vena Cava Thrombosis Hospitalization 2/23/2006 Male 107 lb 6/22/2006 France
Primary
Concomitant
Pyrexia Other Serious 52 Male 6/23/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 5/4/2006 36 Male 7/3/2006 Consumer South Africa
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/28/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 30 Male 8/30/2006 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/31/2006 Male 8/31/2006 Other Health Professional United States
Primary
Secondary
Renal Failure Hospitalization 7/26/2006 Male 9/25/2006 Consumer United States
Primary
Secondary
Weight Decreased Other Serious 9 Female 10/6/2006
Primary
Secondary
Concomitant
Lymph Node Tuberculosis Other Serious 12 Male 10/6/2006 India
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/31/2006 Male 11/9/2006 Other Health Professional United States
Primary
Secondary
Drug Level Increased Other Serious 40 Female 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 7/31/2006 Male 11/13/2006 Other Health Professional United States
Primary
Secondary
Renal Failure Hospitalization 7/31/2006 Male 11/13/2006 Other Health Professional United States
Primary
Secondary
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/17/2006 Other Health Professional France
Primary
Secondary
Concomitant
Sputum Culture Positive Life Threatening 10/26/2006 31 Male 132 lb 11/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2006 31 Male 132 lb 12/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/31/2006 Male 12/21/2006 Other Health Professional United States
Primary
Secondary
Renal Failure Hospitalization 7/26/2006 Male 12/21/2006 Consumer United States
Primary
Secondary
Jaundice Other Serious 11/16/2006 27 Male 2/1/2007 Physician Viet Nam
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious 1/9/2007 24 Female 90 lb 2/9/2007 Pharmacist United Kingdom
Primary
Concomitant
Jaundice Other Serious 11/16/2006 27 Male 2/15/2007 Physician Viet Nam
Primary
Secondary
Vomiting Hospitalization 31 Female 3/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Uveitis Other Serious 40 Male 6/22/2007 India
Primary
Secondary
Tuberculoma Of Central Nervous System Other Serious 54 Male 6/26/2007 Taiwan, Province Of China
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 7/9/2007 United States
Primary
Secondary
Concomitant
Uveitis Other Serious 40 Male 7/28/2007 Physician India
Primary
Secondary
Uveitis Other Serious 40 Male 8/2/2007
Primary
Secondary
Uveitis Other Serious 40 Male 8/1/2007 Other Health Professional India
Primary
Secondary
Uveitis Other Serious 40 Male 8/3/2007 Physician India
Primary
Secondary
Concomitant
Encephalitis Hospitalization 4/1/2004 43 Male 8/17/2007 United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 8/22/2007 United States
Primary
Secondary
Concomitant
Speech Disorder Other Serious 4/1/2004 43 Male 9/4/2007 Other Health Professional United States
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 9/18/2007 United States
Primary
Secondary
Concomitant
Vitritis Hospitalization 2/1/2007 Male 163 lb 9/25/2007 Physician United Kingdom
Primary
Concomitant
Immune Reconstitution Syndrome Hospitalization 2/23/2006 Male 112 lb 10/31/2007 France
Primary
Concomitant
Renal Failure Hospitalization 7/31/2006 Male 11/26/2007 Other Health Professional United States
Primary
Secondary
Pulmonary Tuberculosis Hospitalization 6/9/2007 27 Female 60 lb 11/26/2007 United States
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 11/16/2007 34 Female 117 lb 12/20/2007 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 54 Male 12/28/2007 Brazil
Primary
Secondary
Concomitant
Vomiting Other Serious 27 Male 12/28/2007 Brazil
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 11/16/2007 34 Female 117 lb 1/25/2008 United States
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/27/2007 40 Male 1/28/2008 Pharmacist Japan
Primary
Concomitant
Vomiting Death 12/6/2007 48 Female 1/11/2008 Other Health Professional United States
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious 1/7/2007 24 Female 90 lb 2/1/2008 Pharmacist United Kingdom
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/27/2007 Male 2/19/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/4/2008 7 Male 3/21/2008 Physician Uganda
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/4/2008 7 Male 4/2/2008 Physician Uganda
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/4/2008 7 Male 4/7/2008 Physician Uganda
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/27/2006 28 Male 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pancytopenia Other Serious 9/18/2006 52 Female 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pruritus Other Serious 10/4/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 4/27/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 3/23/2007 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 7/12/2006 4/10/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 3/22/2006 25 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 4/7/2006 25 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 10/27/2006 28 Female 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 12/5/2006 29 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/26/2006 24 Female 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Jaundice Other Serious 5/31/2006 27 Male 4/11/2008 Physician Viet Nam
Primary
Secondary
Vomiting Other Serious 9/12/2006 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 8/25/2006 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 2/22/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 2/5/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/11/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 10/4/2007 4/11/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 30 Male 4/14/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Hepatitis Other Serious 1/15/2007 25 Male 4/14/2008 Physician Viet Nam
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/4/2008 7 Male 4/30/2008 Physician Uganda
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/8/2007 38 Male 4/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tuberculoid Leprosy Other Serious 37 Male 5/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tuberculoid Leprosy Other Serious 37 Male 5/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 28 Female 5/14/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 28 Female 5/21/2008 United Kingdom
Primary
Secondary
Tuberculosis Hospitalization 5/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 19 Female 5/28/2008 Other Health Professional Romania
Primary
Secondary
Concomitant
Death Death 5/15/2008 44 Male 5/28/2008 Physician Peru
Primary
Concomitant
Sinus Tachycardia Other Serious 19 Female 5/30/2008 Other Health Professional Romania
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 6/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatotoxicity Life Threatening 6/17/2008 37 Male 7/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 28 Female 7/29/2008 United Kingdom
Primary
Secondary
Rash Pruritic Other Serious 37 Female 9/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Immune Reconstitution Syndrome Other Serious 37 Female 9/22/2008 United Kingdom
Primary
Secondary
Concomitant
Jaundice Hospitalization 10/10/2008 Male 78 lb 10/28/2008 India
Primary
Secondary
Jaundice Hospitalization 10/10/2008 Male 78 lb 11/4/2008 India
Primary
Secondary
Renal Failure Acute Hospitalization 5/23/2008 Male 12/23/2008 Physician France
Primary
Secondary
Concomitant
Interacting
Pulmonary Tuberculosis Other Serious 43 Male 12/29/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 2/2/2009 United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/30/2008 47 Female 121 lb 2/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 1/13/2009 47 Female 131 lb 2/10/2009 Physician United States
Primary
Secondary
Concomitant
Anaemia Other Serious 4/1/2008 41 Male 3/3/2009 Consumer Malaysia
Primary
Concomitant
Vomiting Hospitalization 33 Male 3/3/2009 Consumer India
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 2/16/2009 34 Female 140 lb 3/6/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Gain Poor Other Serious 2 Male 4/16/2009 South Africa
Primary
Secondary
Dyspnoea Death 4/8/2009 49 Male 5/12/2009 Physician India
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 5/19/2009 32 Female 90 lb 6/1/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/29/2009 47 Male 123 lb 6/5/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 27 Male 6/12/2009 Physician Canada
Primary
Secondary
Concomitant
Vomiting Death 5/23/2009 43 Male 119 lb 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Death 6/20/2009 40 Male 98 lb 7/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 27 Male 6/12/2009 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 6/29/2009 46 Male 112 lb 7/22/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 6/29/2009 46 Male 112 lb 8/14/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 7/2/2009 25 Male 133 lb 8/10/2009 Physician United States
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 6/16/2009 34 Female 8/18/2009 Botswana
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Death 54 Male 8/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 8/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Hepatotoxicity Life Threatening 8/28/2009 29 Female 108 lb 9/8/2009 Consumer United States
Primary
Secondary
Concomitant
Coma Hepatic Life Threatening 8/31/2009 29 Female 108 lb 9/9/2009 Consumer United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 11 Female 9/11/2009 Consumer South Africa
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 8/28/2009 29 Female 108 lb 9/14/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Death 9/1/2009 29 Female 9/16/2009 Physician United States
Primary
Secondary
Concomitant
Delirium Hospitalization 11 Female 9/30/2009 Other Health Professional South Africa
Primary
Secondary
Vomiting Life Threatening 3/4/2008 Male 47 lb 10/9/2009 Physician Uganda
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/16/2009 Consumer United States
Primary
Secondary
Concomitant
Meningitis Tuberculous Other Serious 11 Female 10/9/2009 South Africa
Primary
Secondary
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/26/2009 Consumer United States
Primary
Secondary
Concomitant
Gastroenteritis Death 9/7/2009 42 Male 110 lb 10/26/2009 United States
Primary
Secondary
Concomitant
Status Epilepticus Death 10/15/2009 42 Male 99 lb 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 42 Male 11/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 11/17/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/12/2006 32 Male 11/30/2009 Physician Viet Nam
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 12/5/2006 29 Male 11/30/2009 Physician Viet Nam
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/29/2009 Physician United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 7/8/2009 48 Female 115 lb 1/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/24/2009 Male 140 lb 1/15/2010 Mexico
Primary
Secondary
Concomitant
Meningitis Tuberculous Death 12/22/2009 43 Male 123 lb 1/11/2010 Physician United States
Primary
Secondary
Concomitant
Death Death 12/22/2009 43 Male 123 lb 2/3/2010 United States
Primary
Concomitant
Hyponatraemia Death 6/25/2009 39 Male 93 lb 2/3/2010 United States
Primary
Secondary
Concomitant
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 2/19/2010 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 12/28/2009 Male 140 lb 2/19/2010 Mexico
Primary
Secondary
Concomitant
Cell Death Other Serious 4/1/2010 26 Female 143 lb 4/23/2010 Cote D'ivoire
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 47 Male 6/17/2010 Colombia
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 47 Male 7/13/2010 Other Health Professional Colombia
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 7/16/2010 United States
Primary
Secondary
Concomitant
Plasmodium Falciparum Infection Other Serious 3/30/2010 39 Female 143 lb 7/27/2010 France
Primary
Concomitant

Drug Data