Doxycycline combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Infection Other Serious 6/26/2004 Male 121 lb 2/3/2006 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/26/2004 Male 121 lb 2/17/2006 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Death 1/1/2005 Female 3/29/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 8/1/2005 70 Female 122 lb 1/13/2006 Physician United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 2/13/2006 Male 203 lb 5/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 1/1/2006 59 Female 205 lb 4/20/2006 United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 2/13/2006 Male 203 lb 9/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Infection Other Serious 6/26/2004 Male 121 lb 9/18/2006 Physician United Kingdom
Primary
Concomitant
Sepsis Other Serious Female 9/26/2006 Physician United States
Primary
Concomitant
Drug Hypersensitivity Other Serious 9/23/2003 Female 190 lb 12/27/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection 12/11/2006 70 Female 4/19/2007 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 10/11/2007 54 Female 11/14/2007
Primary
Secondary
Concomitant
Alopecia 8/1/2007 Female 170 lb 12/14/2007 Physician United States
Primary
Concomitant
Constipation Hospitalization 2/8/2008 66 Female 168 lb 5/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Constipation Hospitalization 2/8/2008 66 Female 167 lb 4/25/2008 United States
Primary
Secondary
Concomitant
Constipation Hospitalization 2/8/2008 66 Female 167 lb 5/7/2008 United States
Primary
Secondary
Concomitant
Swollen Tongue 12/1/2007 Male 180 lb 6/12/2008 United States
Primary
Concomitant
Malaise 5/1/2004 141 lb 6/13/2008 Consumer United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 103 lb 6/18/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 6/27/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 9/11/2008 Consumer United States
Primary
Secondary
Concomitant
Goitre Hospitalization 2/15/2008 Female 256 lb 9/12/2008 United States
Primary
Concomitant
Swollen Tongue 12/1/2007 Male 180 lb 9/12/2008 United States
Primary
Concomitant
Tremor 5/1/2008 Female 210 lb 9/12/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 7/15/2008 Female 110 lb 9/12/2008 Consumer United States
Primary
Concomitant
Superinfection Hospitalization 69 Male 9/17/2008
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/17/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 10/23/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/29/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/5/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 11/18/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/1/2008 76 Female 231 lb 11/21/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/24/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/3/2008 Consumer United States
Primary
Secondary
Concomitant
Tremor 5/1/2008 Female 210 lb 12/12/2008 Consumer United States
Primary
Concomitant
Weight Increased 8/1/2008 Female 12/12/2008 Other Health Professional United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/29/2008 Consumer United States
Primary
Secondary
Concomitant
Photosensitivity Reaction 6/27/2008 42 Female 229 lb 12/31/2008 Other Health Professional United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 7/29/2008 61 Male 12/31/2008 Consumer United States
Primary
Concomitant
Dyspepsia Hospitalization 10/27/2008 68 Female 2/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Life Threatening 9/1/2008 Male 3/4/2009 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal Life Threatening 9/1/2008 Male 3/11/2009 Pharmacist United States
Primary
Concomitant
Injection Site Pruritus 12/1/2008 Female 174 lb 3/14/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 49 Male 5/11/2009 Other Health Professional Denmark
Primary
Secondary
Vomiting Hospitalization 49 Male 5/18/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/10/2009 Female 271 lb 5/29/2009 Physician United States
Primary
Secondary
Concomitant
Supraventricular Tachycardia Female 127 lb 6/11/2009 United States
Primary
Concomitant
Injection Site Irritation 2/6/2009 Female 196 lb 6/12/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Wrist Fracture Other Serious 6/1/2009 Female 134 lb 9/3/2009 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis 7/15/2008 Female 110 lb 9/12/2009 Consumer United States
Primary
Concomitant
Sleep Disorder 7/18/2005 54 Female 236 lb 9/23/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Aortic Aneurysm Hospitalization 2/8/2009 Male 206 lb 10/21/2009 Physician United States
Primary
Secondary
Concomitant
Constipation Hospitalization 2/8/2008 Female 167 lb 11/12/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Constipation Hospitalization 2/8/2008 Female 167 lb 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Required Intervention 49 Male 11/20/2009 Other Health Professional Denmark
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/1/2007 Female 1/21/2010 Other Health Professional United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2007 Female 2/5/2010 Other Health Professional United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2007 Female 2/18/2010 Other Health Professional United States
Primary
Concomitant
Rash Macular Hospitalization 2/15/2010 Female 203 lb 3/2/2010 Czech Republic
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 Female 3/12/2010 Other Health Professional United States
Primary
Concomitant
Stress Fracture Hospitalization 1/1/2009 70 Female 4/6/2010 Physician United States
Primary
Secondary
Concomitant
Neutrophilia Other Serious 38 4/5/2010 Physician Switzerland
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 42 Female 4/9/2010 Other Health Professional United States
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2009 70 Female 4/12/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Hospitalization 1/1/2009 70 Female 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Hepatic Lesion Hospitalization 2/8/2008 66 Female 168 lb 4/5/2010 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 53 Female 4/15/2010 United States
Primary
Concomitant
Hypophosphataemia Hospitalization 3/30/2010 56 Female 218 lb 4/28/2010 Physician Sweden
Primary
Secondary
Concomitant
Eye Discharge 1/12/2010 44 Female 5/6/2010 Consumer United States
Primary
Concomitant
Tooth Disorder Other Serious 1/1/2009 70 Female 152 lb 5/13/2010 Physician United States
Primary
Secondary
Concomitant
Amnesia Hospitalization 3/30/2010 56 Female 218 lb 5/14/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Amnesia Hospitalization 3/30/2010 56 Female 218 lb 5/25/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/1/2002 42 Female 146 lb 5/28/2010 United States
Primary
Concomitant
Amnesia Hospitalization 3/30/2010 56 Female 218 lb 5/27/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/30/2010 57 Female 218 lb 6/1/2010 Physician United States
Primary
Secondary
Concomitant
Amnesia Hospitalization 3/30/2010 56 Female 218 lb 6/14/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/30/2010 57 Female 218 lb 6/30/2010 Physician United States
Primary
Secondary
Concomitant
Amnesia Hospitalization 3/30/2010 56 Female 218 lb 7/7/2010 Sweden
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/30/2010 57 Female 218 lb 7/21/2010 Physician United States
Primary
Secondary
Concomitant
Rash Macular Hospitalization 2/15/2010 60 Female 203 lb 7/14/2010 Czech Republic
Primary
Concomitant
Neutrophilia Other Serious 38 Female 8/4/2010 Physician Switzerland
Primary
Concomitant
Wernicke-korsakoff Syndrome Other Serious 62 Female 8/5/2010
Primary
Secondary
Wernicke-korsakoff Syndrome Hospitalization 62 Female 8/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wernicke-korsakoff Syndrome Hospitalization 62 Female 8/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypoxia Other Serious 38 Female 8/13/2010 Physician Switzerland
Primary
Concomitant
Vomiting Required Intervention 62 Female 8/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Macular 5/18/2010 40 Female 8/29/2010 Consumer United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 42 Female 146 lb 9/8/2010 United States
Primary
Concomitant
Deep Vein Thrombosis Disability 63 Male 265 lb 9/8/2010 Other Health Professional Switzerland
Primary
Concomitant
Vomiting Hospitalization 4/1/2010 50 Female 9/9/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2010 50 Female 9/13/2010 Consumer United States
Primary
Secondary
Concomitant
Wernicke-korsakoff Syndrome Required Intervention 62 Female 10/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nephropathy Toxic Hospitalization 11/9/2010 27 Male 245 lb 11/10/2010 Pharmacist United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 42 Female 146 lb 11/30/2010 United States
Primary
Concomitant
Tenosynovitis Other Serious 1/1/2009 12/14/2010 Physician United States
Primary
Secondary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Intervertebral Disc Degeneration Female 146 lb 11/6/2010 Consumer United States
Primary
Concomitant
Cholesterosis Other Serious 5/20/2008 25 Female 1/17/2011 Lawyer United States
Primary
Concomitant
Influenza 6/1/2009 62 1/28/2011 United States
Primary
Secondary
Concomitant
Ovarian Cancer Other Serious 1/1/2010 36 Female 150 lb 1/29/2011 Consumer United States
Primary
Concomitant
Dyspnoea 8/18/2010 60 Female 1/30/2011 Consumer United States
Primary
Concomitant
Pulmonary Sarcoidosis Other Serious 11/12/2010 Male 220 lb 1/28/2011 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 5/20/2008 25 Female 178 lb 3/10/2011 Consumer United States
Primary
Concomitant
Myopericarditis Hospitalization 4/26/2010 45 Male 154 lb 3/21/2011 Consumer United Kingdom
Primary
Concomitant
Death Death 4/30/2008 50 Female 103 lb 5/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Lymphopenia Death 4/30/2008 50 Female 103 lb 6/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Clostridial Infection Hospitalization 8/1/2009 63 Male 6/8/2011 Physician United States
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization Female 209 lb 6/30/2011 Consumer United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 6/7/2011 Male 7/1/2011 Consumer United States
Primary
Concomitant
Depression Hospitalization 8/1/2009 63 Male 164 lb 7/13/2011 Physician United States
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization Female 209 lb 7/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Wegener's Granulomatosis Hospitalization Female 209 lb 7/7/2011 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Decreased Other Serious 77 Female 152 lb 7/25/2011 Consumer United States
Primary
Secondary
Concomitant
Wegener's Granulomatosis Hospitalization Female 7/14/2011 Other Health Professional United Kingdom
Primary
Concomitant
Osteoarthritis Other Serious 4/1/2011 53 Female 108 lb 8/10/2011 Other Health Professional New Zealand
Primary
Concomitant
Osteoarthritis Other Serious 4/1/2011 53 Female 108 lb 8/11/2011 Other Health Professional New Zealand
Primary
Concomitant
Wegener's Granulomatosis Hospitalization Female 176 lb 8/26/2011 Physician United Kingdom
Primary
Concomitant
Pulmonary Granuloma Hospitalization 6/1/2009 Female 209 lb 9/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Herpes Zoster Hospitalization 5/11/2010 70 Female 150 lb 9/8/2011 Physician Czech Republic
Primary
Concomitant
Wegener's Granulomatosis Hospitalization 22 Female 176 lb 9/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Wegener's Granulomatosis Hospitalization 22 Female 9/9/2011 United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 22 Female 176 lb 9/19/2011 Physician United Kingdom
Primary
Concomitant
Condition Aggravated Hospitalization 22 Female 9/20/2011 United Kingdom
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 6/1/2009 22 Female 176 lb 10/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Condition Aggravated Hospitalization Female 176 lb 10/14/2011 Physician United Kingdom
Primary
Concomitant
Haemorrhoids Other Serious 10/31/2007 35 Female 116 lb 10/19/2011 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 12/20/2010 63 10/28/2011 Consumer United States
Primary
Concomitant
Pain Other Serious 8/10/2009 29 Female 151 lb 11/11/2011 Other Health Professional United States
Primary
Concomitant
Psychological Trauma Other Serious 8/10/2009 29 Female 151 lb 11/11/2011 Other Health Professional United States
Primary
Concomitant
Injection Site Swelling 10/13/2010 31 Male 170 lb 11/17/2011 Consumer United States
Primary
Concomitant
Pain In Extremity Hospitalization 5/20/2008 27 Female 207 lb 11/30/2011 Other Health Professional United States
Primary
Concomitant
Impetigo 11/11/2011 59 Female 12/12/2011 Physician United States
Primary
Secondary
Concomitant
Hypercapnia Life Threatening 6/16/2008 71 Male 230 lb 12/5/2011 Lawyer United States
Primary
Concomitant
Convulsion 7/8/2011 40 Female 130 lb 10/5/2011 United States
Primary
Concomitant
Drug Interaction Hospitalization 11/3/2011 40 Female 12/20/2011 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 11/3/2011 40 Female 12/21/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Toxicity To Various Agents Hospitalization 11/3/2011 40 Female 12/28/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Bacteraemia Other Serious 6/21/2007 50 Female 103 lb 1/11/2012 United States
Primary
Secondary
Concomitant
Injection Site Nodule 6/1/2011 40 Female 170 lb 1/28/2012 Consumer United States
Primary
Concomitant
Tunnel Vision 4/22/2011 19 Female 1/28/2012 Other Health Professional United States
Primary
Concomitant
Cold Sweat 7/1/2011 59 Female 1/28/2012 Consumer United States
Primary
Concomitant

Drug Data