Doxorubicin Hydrochloride combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 3/28/2006 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/3/2004 30 Female 99 lb 4/11/2006 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 2/4/2006 40 Female 209 lb 4/13/2006 Physician France
Primary
Secondary
Concomitant
Pneumonia Death 2/13/2004 63 Male 4/14/2006 Physician Japan
Primary
Secondary
Concomitant
Hepatitis Toxic Hospitalization 2/24/2006 31 Male 5/8/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 5/8/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/7/2006 40 Female 209 lb 5/15/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/12/2005 65 Male 6/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Hepatitis Toxic Hospitalization 2/24/2006 31 Male 6/27/2006 Physician France
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 7/2/2006 Male 109 lb 7/10/2006 United States
Primary
Secondary
Urosepsis Hospitalization 6/27/2006 Female 176 lb 7/13/2006 United States
Primary
Secondary
Tuberculosis Hospitalization 6/28/2006 Male 30 lb 7/19/2006 United States
Primary
Secondary
Mucosal Inflammation Hospitalization 7/31/2006 Male 168 lb 8/1/2006 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 8/23/2006 Male 53 lb 8/24/2006 United States
Primary
Secondary
Leukoencephalopathy Other Serious 56 Male 9/11/2006 United States
Primary
Secondary
Septic Shock Life Threatening 8/29/2006 50 Male 9/18/2006 Physician Israel
Primary
Concomitant
Febrile Neutropenia Life Threatening 7/1/2006 51 Male 132 lb 10/16/2006 Physician France
Primary
Concomitant
Pain Hospitalization 9/21/2006 Male 168 lb 10/11/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 10/20/2006 United States
Primary
Secondary
Sepsis Hospitalization Female 87 lb 11/9/2006 United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 56 Male 11/22/2006 Consumer United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 11/22/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 11/16/2006 Male 136 lb 11/17/2006 United States
Primary
Secondary
Venoocclusive Liver Disease Hospitalization 11/23/2006 Female 40 lb 11/27/2006 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 11/23/2006 Female 40 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Vulval Disorder Hospitalization 11/27/2006 Female 188 lb 12/6/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10/18/2006 Female 87 lb 12/13/2006 United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 47 Female 12/4/2006 Other Health Professional United States
Primary
Secondary
Vomiting Hospitalization 12/10/2006 Female 100 lb 12/13/2006 United States
Primary
Secondary
Vaginal Ulceration Hospitalization 11/27/2006 Female 188 lb 12/12/2006 United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/3/2006 Female 147 lb 12/15/2006 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 12/14/2006 Female 140 lb 12/18/2006 United States
Primary
Secondary
Vomiting Hospitalization 11/23/2006 Female 40 lb 12/18/2006 United States
Primary
Secondary
Vomiting Hospitalization 12/10/2006 Female 100 lb 1/12/2007 United States
Primary
Secondary
Red Blood Cell Count Decreased Hospitalization 12/27/2006 Female 136 lb 1/10/2007 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 12/14/2006 Female 140 lb 1/18/2007 United States
Primary
Secondary
Osteoporosis Other Serious 11/1/1998 43 Male 2/9/2007 Other Health Professional United Kingdom
Primary
Secondary
Aspartate Aminotransferase Increased Hospitalization 8/31/2006 Female 105 lb 2/16/2007 United States
Primary
Secondary
Concomitant
Osteoporosis Other Serious 11/1/1998 43 Male 2/23/2007 United Kingdom
Primary
Secondary
Vomiting Hospitalization 1/29/2007 6 Female 45 lb 2/20/2007 Physician United States
Primary
Secondary
Sinusitis Fungal Hospitalization 2/22/2007 Male 227 lb United States
Primary
Secondary
Osteoporosis Other Serious 11/1/1998 43 Male 3/1/2007 United Kingdom
Primary
Secondary
Headache Life Threatening 12/20/2006 49 Male 3/6/2007 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Life Threatening 1/29/2007 6 Female 45 lb 3/2/2007 Physician United States
Primary
Secondary
Peripheral Motor Neuropathy Required Intervention 1/4/2006 5 Female 35 lb 3/1/2007 Physician United States
Primary
Secondary
Concomitant
Spinal Compression Fracture Other Serious 11/1/1998 43 Male 3/16/2007 United Kingdom
Primary
Secondary
Concomitant
Spinal Compression Fracture Other Serious 11/1/1998 43 Male 3/20/2007 United Kingdom
Primary
Secondary
Concomitant
Vulval Ulceration Hospitalization 11/27/2006 Female 188 lb 3/20/2007 United States
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Pharyngolaryngeal Pain Male 3/28/2007 Other Health Professional United States
Primary
Concomitant
Neutrophil Count Decreased 7/24/2006 21 Male 3/28/2007 Pharmacist United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Vomiting Life Threatening 1/30/2007 6 Female 45 lb 4/4/2007 Physician United States
Primary
Secondary
Concomitant
Spinal Fracture Other Serious 4/1/1998 43 Male 4/18/2007 United Kingdom
Primary
Secondary
Spinal Fracture Other Serious 4/1/1998 43 Male 5/3/2007 United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 4/27/2007 Male 194 lb 5/8/2007 United States
Primary
Secondary
Metastasis Hospitalization 1/1/2002 40 Female 8/3/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Mucoepidermoid Carcinoma Other Serious 17 Male 8/9/2007 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 8 Male 8/9/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 6/1/2005 66 Male 8/15/2007 Consumer United States
Primary
Secondary
Concomitant
Spinal Anaesthesia Hospitalization 1/1/2002 40 Female 8/31/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Septic Shock Hospitalization 7/8/2007 Female 99 lb 9/14/2007 United States
Primary
Secondary
Tumour Lysis Syndrome Hospitalization 9/18/2007 Male 492 lb 10/2/2007 United States
Primary
Secondary
Vision Blurred Hospitalization 9 Male 10/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Ureaplasma Infection Other Serious 28 Male 10/15/2007 Switzerland
Primary
Secondary
Concomitant
Wound Secretion Hospitalization 9/27/2007 Male 467 lb 10/8/2007 United States
Primary
Secondary
Spinal Fracture Other Serious 11/1/1998 43 Male 10/26/2007 United Kingdom
Primary
Secondary
Concomitant
Respiratory Arrest Hospitalization 9/17/2007 Male 34 lb 10/29/2007 United States
Primary
Secondary
Infective Spondylitis Hospitalization 8/1/2007 70 Male 11/19/2007 Other Health Professional Japan
Primary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 11/13/2007 United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/9/2007 Male 175 lb 11/19/2007 United States
Primary
Secondary
Tongue Biting Hospitalization 11/9/2007 Male 203 lb 11/20/2007 United States
Primary
Secondary
Swelling Face Hospitalization 10/31/2007 Male 291 lb 11/20/2007 United States
Primary
Secondary
Staring Hospitalization 11/13/2007 Female 104 lb 11/28/2007 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/29/2007 Female 173 lb 11/30/2007 United States
Primary
Secondary
Septic Shock Hospitalization 10/21/2007 Male 84 lb 11/27/2007 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/29/2007 Male 291 lb 12/4/2007 United States
Primary
Secondary
Staphylococcal Sepsis 12/5/2007 Male 44 lb 12/6/2007 United States
Primary
Secondary
Concomitant
Osteoporosis Other Serious 11/1/1998 43 Male 12/14/2007 United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 12/5/2007 Male 46 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Osteoporosis Other Serious 11/1/1998 43 Male 12/20/2007 United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 12/12/2007 Male 139 lb 12/13/2007 United States
Primary
Secondary
Spondylitis Hospitalization 8/1/2007 70 Male 12/21/2007 Other Health Professional Japan
Primary
Concomitant
Supraventricular Extrasystoles Hospitalization 12/12/2007 Male 139 lb 12/19/2007 United States
Primary
Secondary
Vomiting Hospitalization 12/19/2007 Male 62 lb 12/28/2007 United States
Primary
Secondary
Pseudomonas Infection Hospitalization 12/12/2007 Female 166 lb 1/2/2008 United States
Primary
Secondary
Hemiparesis Hospitalization 2/13/2008 Female 42 lb 2/13/2008 United States
Primary
Secondary
Shock Hospitalization 10/21/2007 Male 84 lb 2/20/2008 United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 7/8/2007 Female 99 lb 2/25/2008 United States
Primary
Secondary
Cerebrovascular Accident Hospitalization 2/13/2008 Female 42 lb 2/26/2008 United States
Primary
Secondary
Osteoporosis Other Serious 11/1/1998 43 Male 3/5/2008 United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Hospitalization 3/17/2008 Female 31 lb 3/21/2008 United States
Primary
Secondary
Thrombocytopenia 1/1/2006 31 Male 3/28/2008 Physician United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 4/4/2008 Male 61 lb 4/18/2008 United States
Primary
Secondary
Hypocalcaemia Hospitalization 3/4/2008 Male 183 lb 5/8/2008 United States
Primary
Secondary
Neutropenia Hospitalization 3/4/2008 Female 6/3/2008 Other Health Professional France
Primary
Concomitant
Stomatitis Hospitalization 5/1/2008 Male 54 lb 6/11/2008 United States
Primary
Secondary
Wheezing Other Serious 1/1/2001 58 Male 6/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 4/14/2008 Female 73 lb 6/18/2008 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 3/17/2008 Female 31 lb 7/17/2008 United States
Primary
Secondary
Thrombocytopenia Hospitalization 7/10/2008 Female 257 lb 7/28/2008 United States
Primary
Secondary
Vasculitis Hospitalization 1/13/2006 59 Female 8/5/2008 France
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Other Serious 11/1/1998 43 Male 8/6/2008 United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 7/6/2008 Female 134 lb 7/29/2008 United States
Primary
Secondary
Renal Impairment Hospitalization 8/29/2008 Female 139 lb 9/3/2008 United States
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 1/1/2007 20 Male 10/24/2008 Physician Japan
Primary
Secondary
Gamma-glutamyltransferase Increased 10/20/2008 Male 104 lb 10/22/2008 United States
Primary
Secondary
Stomatitis Hospitalization 10/18/2008 Male 159 lb 10/20/2008 United States
Primary
Secondary
Neoplasm Malignant Death 4/9/2008 Male 11/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Neoplasm Malignant Death 4/9/2008 Male 11/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Rhabdomyosarcoma Other Serious 14 Female 12/2/2008 Japan
Primary
Secondary
Vomiting Hospitalization 12/20/2008 Male 146 lb 12/29/2008 United States
Primary
Secondary
Shock Hospitalization 12/26/2008 Female 236 lb 12/29/2008 United States
Primary
Secondary
Rhabdomyosarcoma Other Serious 14 Female 1/13/2009 Japan
Primary
Secondary
Stomatitis Hospitalization 11/24/2008 Male 36 lb 1/13/2009 United States
Primary
Secondary
Sepsis Hospitalization 12/26/2008 Female 236 lb 1/15/2009 United States
Primary
Secondary
Renal Failure Acute Hospitalization 1/18/2009 Male 172 lb 1/22/2009 United States
Primary
Secondary
Vomiting Hospitalization 1/26/2009 25 Female 159 lb 2/5/2009 Pharmacist Canada
Primary
Secondary
Concomitant
Vomiting Life Threatening 5/1/2007 72 Male 2/24/2009 Physician Japan
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 1/14/2009 Male 260 lb 2/18/2009 United States
Primary
Secondary
Pericarditis Hospitalization 73 Female 4/28/2009 Physician France
Primary
Concomitant
Osteonecrosis Other Serious 9/1/2007 63 Male 5/15/2009 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Hospitalization 5/1/2009 67 Male 5/22/2009 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 8/1/2006 63 Male 5/28/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Life Threatening 1/1/2009 74 Male 6/8/2009 Other Health Professional France
Primary
Secondary
Concomitant
Vasculitic Rash Hospitalization 5/1/2009 67 Male 169 lb 6/9/2009 Physician United Kingdom
Primary
Concomitant
Leukopenia Death 67 Female 6/23/2009 Other Health Professional Germany
Primary
Secondary
Sepsis Other Serious 6/12/2009 70 Female 6/25/2009 Physician France
Primary
Secondary
Large Intestine Perforation Death 7/9/2009 Physician Sweden
Primary
Secondary
Concomitant
Hepatic Necrosis Death 7/9/2009 Physician Sweden
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 9/1/2007 63 Male 8/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/23/2009 Female 119 lb 10/30/2009 United States
Primary
Secondary
Urine Output Decreased Hospitalization 3/11/2010 Male 137 lb 3/12/2010 United States
Primary
Secondary
Scedosporium Infection Hospitalization 6/11/2010 32 Male 233 lb 6/17/2010 United States
Primary
Secondary
Thrombocytopenia Hospitalization 2/17/2010 12 Male 106 lb 6/29/2010 United States
Primary
Secondary
Blood Glucose Increased 6/20/2010 3 Male 34 lb 6/29/2010 United States
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 6/24/2010 28 Female 135 lb 7/1/2010 United States
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 6/10/2010 26 Female 125 lb 6/30/2010 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 6/2/2010 13 Female 132 lb 6/29/2010 Canada
Primary
Secondary
Concomitant
Scedosporium Infection Hospitalization 7/4/2010 32 Male 233 lb 7/9/2010 United States
Primary
Secondary
Red Blood Cell Count Decreased Other Serious 10/25/2007 62 Male 186 lb 7/20/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 2/17/2010 12 Male 106 lb 7/16/2010 United States
Primary
Secondary
Neutrophil Count Increased Other Serious 5/23/2010 55 Female 108 lb 7/27/2010 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 6/11/2010 21 Male 126 lb 7/27/2010 United States
Primary
Secondary
Vomiting Hospitalization 7/30/2010 21 Male 126 lb United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 7/31/2010 44 Female 250 lb 8/6/2010 United States
Primary
Secondary
Blood Glucose Increased 8/5/2010 15 Male 148 lb 8/10/2010 United States
Primary
Secondary
Respiratory Distress Hospitalization 8/7/2010 9 Male 82 lb 8/11/2010 United States
Primary
Secondary
Red Blood Cell Count Decreased Other Serious 10/25/2007 62 Male 186 lb 9/7/2010 Physician Japan
Primary
Secondary
Concomitant

Drug Data