Doxorubicin Hcl combined with Melphalan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombosis Death 7/5/2009 Female 8/17/2009 Pharmacist United Kingdom
Primary
Concomitant
Sepsis Other Serious Unknown 12/14/2009 Germany
Primary
Secondary
Agranulocytosis Hospitalization 7/7/2009 Male 1/26/2010 Physician United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 5/1/2008 Male 172 lb 2/4/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Death 2/18/2010 Physician Italy
Primary
Secondary
Concomitant
Septic Shock Death 2/18/2010 Physician Italy
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Death 3/11/2010 Italy
Primary
Secondary
Thrombocytopenia Death Unknown 3/11/2010 Physician Italy
Primary
Secondary
Thrombocytopenia Death 3/11/2010 Italy
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 Male 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 Female 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 57 Female 3/26/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Septic Shock Life Threatening 3/16/2007 57 Male 3/26/2010 Physician Italy
Primary
Secondary
Concomitant
Septic Shock Death 6/26/2007 76 Male 3/26/2010 Physician Italy
Primary
Secondary
Concomitant
Tremor Other Serious 4/7/2010 Italy
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 48 Male 4/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tremor Other Serious 4/14/2010 Italy
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 48 Male 4/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 75 Female 4/16/2010 Physician United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 65 Male 5/5/2010
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 48 Male 5/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Varices Oesophageal Other Serious 7/1/2002 59 Female 142 lb 5/12/2010 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 75 Female 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Death Unknown 5/10/2010 France
Primary
Secondary
Pneumonia Bacterial Death 5/10/2010 France
Primary
Secondary
Pancreatitis Death 5/10/2010 France
Primary
Secondary
Cerebral Haemorrhage Death 5/10/2010 Italy
Primary
Secondary
Tongue Disorder Other Serious 53 Female 5/25/2010 Other Health Professional Brazil
Primary
Secondary
Pneumonia Death 11/4/2007 46 Male 6/23/2010 Physician Italy
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/23/2010 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/25/2010 Physician United States
Primary
Secondary
No Therapeutic Response Disability 64 Male 8/24/2010 United Kingdom
Primary
Concomitant
Wound Drainage Other Serious 5/1/2000 75 Female 9/24/2010 United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2010 50 Male 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Cerebrovascular Accident Other Serious 1/1/2010 65 Female 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Transient Ischaemic Attack Other Serious 1/1/2010 63 Male 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Transient Ischaemic Attack Other Serious 1/1/2010 59 Male 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Cerebrovascular Accident Other Serious 65 Female 9/24/2010 Netherlands
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 50 Male 9/24/2010 Netherlands
Primary
Secondary
Transient Ischaemic Attack Other Serious 63 Male 9/24/2010 Netherlands
Primary
Secondary
Arterial Thrombosis Other Serious 63 Male 9/24/2010 Netherlands
Primary
Secondary
Myocardial Infarction Other Serious 59 Male 9/24/2010 Netherlands
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 9/30/2010 United States
Primary
Secondary
Concomitant
Liver Injury Other Serious 59 Female 10/4/2010 Consumer Japan
Primary
Secondary
Concomitant
Varices Oesophageal Other Serious 7/1/2002 59 Female 142 lb 10/20/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/14/1999 48 Male 10/29/2010 United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 31 Female 11/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Failure Acute Other Serious 1/1/2009 63 Female 3/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Diabetic Ketoacidosis Other Serious 70 Female 5/11/2011 Other Health Professional Japan
Primary
Secondary
Deep Vein Thrombosis Hospitalization 9/29/2010 65 Male 165 lb 5/11/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 64 Female 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 66 Male 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Syncope Hospitalization 5/3/2011 70 Female 5/20/2011 Physician United States
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 4/8/2011 51 Female 132 lb 5/20/2011 Consumer United Kingdom
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Hospitalization 7/1/2010 75 Male 159 lb 5/20/2011 Other Health Professional United States
Primary
Concomitant
Back Pain Other Serious 10/1/2010 68 Female 5/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Lividity Hospitalization 70 Female 6/2/2011 Other Health Professional Japan
Primary
Secondary
Pyrexia Hospitalization 68 Female 6/6/2011 Other Health Professional Spain
Primary
Secondary
Respiratory Tract Infection Other Serious Male 6/6/2011 Other Health Professional Spain
Primary
Secondary
Lymphoma Death Male 6/9/2011 Physician United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 1/1/1991 16 Female 6/14/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Erythema Multiforme Hospitalization 70 Female 6/14/2011 Other Health Professional Japan
Primary
Secondary
Anaemia Other Serious 4/1/2008 54 Male 6/15/2011 Other Health Professional Spain
Primary
Secondary
Pyrexia Hospitalization 68 Female 6/15/2011 Physician Spain
Primary
Secondary
Type 1 Diabetes Mellitus Hospitalization 1/1/2010 70 Female 6/21/2011 Other Health Professional Japan
Primary
Secondary
Herpes Zoster Male 6/23/2011 Physician United Kingdom
Primary
Secondary
Acute Graft Versus Host Disease Death 5 6/23/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Neoplasm Malignant Death 5 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Acute Graft Versus Host Disease Death 3 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Dermatitis Contact Other Serious 7/1/2002 59 Female 142 lb 6/29/2011 Lawyer United States
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 6/29/2011 Other Health Professional China
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 68 Male 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 68 Male 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Disease Recurrence Other Serious 66 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 70 Female 6/30/2011 Other Health Professional Japan
Primary
Secondary
Intervertebral Disc Degeneration Other Serious 3/14/1999 48 Male 7/7/2011 Lawyer United States
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 70 Female 6/27/2011 Other Health Professional Japan
Primary
Secondary
Toxicity To Various Agents Death 7/18/2011 Physician Denmark
Primary
Secondary
Toxicity To Various Agents Death 7/18/2011 Physician Denmark
Primary
Secondary
Pharyngitis Other Serious 7/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hodgkin's Disease Recurrent Other Serious Male 7/20/2011 Other Health Professional Italy
Primary
Secondary
Myelodysplastic Syndrome Other Serious 1/1/2006 Female 8/3/2011 Other Health Professional United States
Primary
Secondary
Disease Progression Hospitalization 2/10/2009 57 Female 4/16/2011 Other Health Professional Japan
Primary
Concomitant
Death Death 8/19/2011 Consumer United Kingdom
Primary
Secondary
Diabetic Ketoacidosis Hospitalization 9/29/2006 Female 243 lb 8/17/2011 Other Health Professional Japan
Primary
Secondary
Pancytopenia Other Serious 72 Female 9/7/2011 Other Health Professional United States
Primary
Secondary
Parainfluenzae Virus Infection Death 72 Female 8/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Death 9/9/2011 Other Health Professional France
Primary
Secondary
Concomitant
Epistaxis Death 6/16/2009 67 Female 9/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 7/3/2008 52 Male 148 lb 10/5/2011 Other Health Professional United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 7/3/2008 52 Male 148 lb 10/18/2011 Other Health Professional United States
Primary
Secondary
Acute Graft Versus Host Disease Other Serious 34 Female 10/19/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 10/24/2010 19 Male 97 lb 10/21/2011 Physician Japan
Primary
Concomitant
Neoplasm Other Serious 11/17/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/17/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/16/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/16/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/16/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/16/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/17/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Neoplasm Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Haematological Malignancy Other Serious 11/16/2011 Physician United States
Primary
Secondary
Skin Lesion Other Serious 55 Male 11/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Blast Cell Crisis Other Serious 55 Male 11/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 11 Male 11/28/2011 Other Health Professional Greece
Primary
Secondary
Urinary Incontinence Other Serious 1/1/2003 77 Female 11/28/2011 United States
Primary
Secondary
Concomitant
Nausea Death 4/11/2008 72 Male 11/29/2011 Physician Japan
Primary
Concomitant
Cytogenetic Abnormality Other Serious 12/1/2011 Greece
Primary
Secondary
Disease Progression Other Serious Male 12/1/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 11 Male 12/6/2011 Physician Greece
Primary
Secondary
Myelodysplastic Syndrome Other Serious 11 Male 12/12/2011 Physician Greece
Primary
Secondary
Quality Of Life Decreased Other Serious 12/16/2011 Physician Germany
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 1/31/2011 62 Female 12/19/2011 Consumer France
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 11 Male 12/27/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 1/5/2012 Other Health Professional Spain
Primary
Secondary
Epstein-barr Virus Infection Other Serious 37 Female 1/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/11/2012 Japan
Primary
Secondary
C-reactive Protein Increased Death 4/14/2008 73 Male 1/11/2012 Physician Japan
Primary
Concomitant
Neoplasm Progression Other Serious 9/1/2007 64 Male 1/6/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Disorder Hospitalization 1/14/2012 2 Female 35 lb 1/18/2012 Physician United States
Primary
Secondary
Pancytopenia Other Serious Male 2/9/2012 Physician Greece
Primary
Secondary
General Physical Health Deterioration Other Serious 59 Male 2/10/2012 Physician Japan
Primary
Secondary
Nervous System Disorder Death 4/21/2011 16 Male 95 lb 2/17/2012 Physician Japan
Primary
Secondary
Concomitant
Hodgkin's Disease Recurrent Other Serious 68 Male 3/1/2012 Other Health Professional Greece
Primary
Secondary
Febrile Neutropenia Other Serious Male 3/5/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious Male 3/5/2012 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 3/5/2012 Germany
Primary
Concomitant
Epilepsy Other Serious 1/1/2003 77 Female 3/6/2012 Physician United States
Primary
Secondary
Concomitant
Nervous System Disorder Death 4/21/2011 16 Male 95 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Acute Lymphocytic Leukaemia Recurrent Death 10/24/2010 19 Male 97 lb 3/16/2012 Physician Japan
Primary
Concomitant
Drug Ineffective Other Serious 11/10/2010 55 Male 3/29/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Electrolyte Imbalance Death 4/2/2012 Physician United States
Primary
Secondary
Death Other Serious 4/24/2012 Other Health Professional Denmark
Primary
Secondary
Death Other Serious 4/27/2012 Physician Denmark
Primary
Secondary
Hepatitis B Other Serious 4/30/2012 Physician Italy
Primary
Secondary
Autoimmune Hepatitis Other Serious 56 Female 5/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 56 Female 5/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatitis B Death 5/16/2012 Physician Italy
Primary
Secondary
Drug Ineffective Death 46 Female 6/5/2012 Other Health Professional United States
Primary
Concomitant
Death Other Serious 6/8/2012 Other Health Professional United States
Primary
Secondary

Drug Data