Diphenhydramine combined with Morphine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Haemorrhage Death 10/7/2004 50 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 11/23/2004 1/6/2006 Physician United States
Primary
Concomitant
Pruritus 11/7/2005 85 Male 141 lb 11/9/2005 United States
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 12/16/2005 36 Male 272 lb 2/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 12/16/2005 36 Male 272 lb 2/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Respiratory Depression Other Serious 7/12/2006 Female 120 lb 8/14/2006 Pharmacist United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Required Intervention 7/21/2006 6 Female 47 lb 8/22/2006 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 7/11/2006 71 Male 8/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 11/2/2007 15 Female 208 lb 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Meningitis Enterococcal Hospitalization 11/10/2007 1 Female 11/16/2007 Physician United States
Primary
Concomitant
Mouth Ulceration Other Serious 1/16/2009 Male 243 lb 4/1/2009 United States
Primary
Concomitant
Microangiopathic Haemolytic Anaemia Death 2/24/2009 44 6/4/2009 Physician Taiwan, Province Of China
Primary
Concomitant
Xanthochromia Hospitalization 18 Female 10/16/2009 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 6/27/2009 Male 145 lb 10/28/2009 United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 7 Male 57 lb 10/28/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Spinal Fracture Other Serious 1/1/2009 Male 142 lb 11/2/2009 Physician United States
Primary
Secondary
Concomitant
Personality Change Required Intervention 12/23/2008 Female 90 lb 8/29/2009 Pharmacist United States
Primary
Concomitant
Product Quality Issue Other Serious 9/27/2009 52 Male 201 lb 10/7/2009 United States
Primary
Concomitant
Transfusion Other Serious 1/1/2004 Male 11/5/2009 Physician United States
Primary
Concomitant
Intentional Drug Misuse Death Male 115 lb 11/6/2009 Consumer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 1/1/2008 50 Female 1/14/2010 Physician United States
Primary
Secondary
Blood Bilirubin Increased 10/21/2009 77 Male 161 lb 1/13/2010 Other Health Professional United States
Primary
Concomitant
Drug Toxicity Death 70 Female 1/22/2010 Physician United States
Primary
Secondary
Incorrect Dose Administered Death 50 Female 1/19/2010 United States
Primary
Secondary
Drug Toxicity Death 50 Female 1/27/2010 United States
Primary
Secondary
Sepsis Other Serious 11/1/2009 55 Male 2/19/2010 Consumer United States
Primary
Secondary
Concomitant
Death Death 50 Female 2/22/2010 United States
Primary
Secondary
Cardio-respiratory Arrest Death 50 Female 2/23/2010 Physician United States
Primary
Secondary
Death Death 70 Female 2/23/2010 Physician United States
Primary
Secondary
Skin Exfoliation Disability 57 Female 2/24/2010 Consumer United States
Primary
Concomitant
Multiple Drug Overdose Death 5/31/1994 Male 179 lb 2/25/2010 Other Health Professional United States
Primary
Secondary
Drug Toxicity Death Female 238 lb 3/1/2010 Consumer United States
Primary
Secondary
Drug Toxicity Death Male 228 lb 3/1/2010 Consumer United States
Primary
Secondary
Restlessness Other Serious 28 Female 269 lb 3/1/2010
Primary
Secondary
Concomitant
Drug Toxicity Death Female 128 lb 3/1/2010 Physician United States
Primary
Secondary
Concomitant
Electrocardiogram Qrs Complex Prolonged Death 1/1/2010 81 Male 128 lb 5/11/2010 Pharmacist United States
Primary
Concomitant
Wheezing Hospitalization 11/20/2003 61 Female 140 lb 5/18/2010 Lawyer United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5/13/2010 31 Female 176 lb 6/16/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5/13/2010 31 Female 6/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 6/9/2010 58 Female 101 lb 6/14/2010 Pharmacist United States
Primary
Concomitant
Vaginal Lesion Hospitalization 4/14/2010 3 Female 43 lb 6/17/2010 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/4/2010 3 Female 43 lb 6/21/2010 United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/5/2008 55 Male 150 lb 6/29/2010 Lawyer United States
Primary
Concomitant
Somnolence Other Serious 6/1/2010 69 Female 100 lb 6/30/2010 Physician United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2007 69 Female 148 lb 7/1/2010 Lawyer United States
Primary
Secondary
Concomitant
Pneumonia Life Threatening 11/22/2009 14 Male 165 lb 7/2/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/1/2004 55 Female 180 lb 7/8/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 1/1/2008 42 Female 7/8/2010 Lawyer United States
Primary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 7/8/2010 United States
Primary
Secondary
Concomitant
Septic Shock Life Threatening 9/29/2009 15 Male 240 lb 7/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence Other Serious 6/1/2010 69 Female 100 lb 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/1/2004 55 Female 180 lb 7/14/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization 4/30/2010 31 Female 7/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 4/30/2010 31 Female 176 lb 7/21/2010 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Hospitalization 4/30/2010 31 Female 7/21/2010 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 9/19/2009 17 Male 198 lb 7/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Vomiting Death 1/1/2008 50 Female 7/21/2010 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 10/19/1999 64 Female 7/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Nausea Other Serious 11/1/2007 62 Female 207 lb 7/23/2010 Lawyer United States
Primary
Concomitant
Ventricular Fibrillation Life Threatening 12/4/2007 69 Female 326 lb 7/19/2010 Lawyer United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 34 Female 129 lb 7/26/2010 Other Health Professional Canada
Primary
Concomitant
Venoocclusive Disease Other Serious 4/30/2010 31 Female 7/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Transfusion Other Serious 1/1/2004 77 Male 7/28/2010 Other Health Professional United States
Primary
Concomitant
Pneumonia Life Threatening 11/22/2009 14 Male 165 lb 8/3/2010 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 11/5/2009 65 Female 194 lb 8/5/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 9/19/2009 17 Male 198 lb 8/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Pneumonia Life Threatening 11/22/2009 14 Male 165 lb 8/11/2010 Physician United States
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 8/2/2010 86 Female 133 lb 8/16/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 2/1/2004 55 Female 180 lb 8/20/2010 United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 9/29/2010 United States
Primary
Secondary
Concomitant
Cardiomyopathy Other Serious 9/22/2010 25 Female 120 lb 10/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vena Cava Thrombosis Other Serious 9/17/2002 43 Female 204 lb 10/5/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/19/1999 64 Female 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vena Cava Thrombosis Other Serious 9/17/2002 43 Female 204 lb 10/8/2010 United States
Primary
Secondary
Concomitant
Cardiomyopathy Other Serious 9/22/2010 25 Female 119 lb 10/13/2010 Physician United States
Primary
Secondary
Concomitant
Swelling Other Serious 10/18/2007 40 Female 227 lb 10/15/2010 Other Health Professional United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2007 66 Female 238 lb 10/15/2010 Lawyer United States
Primary
Secondary
Concomitant
Transfusion Other Serious 1/1/2004 77 Male 11/12/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2007 36 Female 12/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Haemorrhage Other Serious 12/1/2007 57 Female 12/2/2010 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 7/1/2007 1 Male 18 lb 12/2/2010 Lawyer United States
Primary
Concomitant
Thrombosis Other Serious 4/18/2010 18 Female 223 lb 12/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vena Cava Thrombosis Other Serious 9/17/2002 43 Female 204 lb 12/31/2010 United States
Primary
Secondary
Concomitant
Drug Abuse Death 27 Male 1/10/2011 Physician United States
Primary
Secondary
Drug Abuse Death 1/1/2009 27 Male 1/7/2011 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 27 Male 1/11/2011 Other Health Professional United States
Primary
Secondary
Bronchitis Other Serious 9/17/2002 43 Female 204 lb 1/11/2011 Lawyer United States
Primary
Secondary
Concomitant
Gastritis Hospitalization 9/17/2002 43 Female 204 lb 1/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Metabolic Syndrome Hospitalization 6/1/2006 47 Female 1/26/2011 Physician United States
Primary
Concomitant
Multi-organ Failure Death 7/1/2007 1 Male 18 lb 1/27/2011 Physician United States
Primary
Concomitant
Proteinuria Hospitalization 11/22/2010 13 Female 98 lb 1/20/2011 Physician United States
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 4/18/2010 18 Female 223 lb 2/1/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Abuse Death 27 Male 2/7/2011 Other Health Professional United States
Primary
Secondary
Drug Abuse Death 27 Male 2/7/2011 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 51 Female 2/7/2011 Other Health Professional United States
Primary
Secondary
Poisoning Death 1/1/2009 27 Male 1/27/2011 Physician United States
Primary
Secondary
Lethargy Death 10/18/2007 40 Female 227 lb 2/15/2011 Lawyer United States
Primary
Concomitant
Completed Suicide Death 1/1/2009 55 Female 2/4/2011 Physician United States
Primary
Secondary
Concomitant
Drug Abuse Death 1/1/2009 27 Male 2/4/2011 Physician United States
Primary
Secondary
Proteinuria Hospitalization 11/22/2010 13 Female 98 lb 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Hospitalization 7/12/1999 63 Female 2/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/22/2010 13 Female 98 lb 2/15/2011 Physician United States
Primary
Secondary
Concomitant
Drug Abuse Death 27 Male 3/1/2011 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 51 Female 3/4/2011 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death Female 3/4/2011 Physician United States
Primary
Secondary
Completed Suicide Death 51 Female 3/8/2011 Consumer United States
Primary
Secondary
Akathisia Other Serious 1/1/1984 32 Female 115 lb 2/28/2011 Lawyer United States
Primary
Concomitant
Nausea Hospitalization 7/12/1999 63 Female 3/15/2011 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 9/17/2002 43 Female 204 lb 3/16/2011 Physician United States
Primary
Secondary
Concomitant
Rash Erythematous 1/31/2008 52 Male 159 lb 3/25/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Death 3/2/2011 66 Male 254 lb 4/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 2/7/2011 14 Female 98 lb 4/5/2011 Physician United States
Primary
Secondary
Concomitant
Syncope Death 8/18/2010 33 Female 229 lb 4/20/2011 Pharmacist United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Female 172 lb 5/6/2011 Consumer United Kingdom
Primary
Concomitant
Jaundice Cholestatic Death 3/19/2011 70 Female 94 lb 5/12/2011 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Rash Maculo-papular Hospitalization 11/17/2011 59 Male 174 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Serotonin Syndrome Death 1/1/2011 75 Female 226 lb 3/22/2012 Pharmacist United States
Primary
Secondary
Concomitant
Interacting
Serotonin Syndrome Death 1/1/2011 75 Female 226 lb 3/27/2012 Pharmacist United States
Primary
Concomitant
Interacting
Drug Interaction Death 1/1/2011 75 Female 226 lb 4/24/2012 Pharmacist United States
Primary
Concomitant
Interacting
Febrile Neutropenia Other Serious 9/19/2011 67 Female 144 lb 4/25/2012 Physician United States
Primary
Secondary
Concomitant
Hyperthermia Malignant Death 1/1/2011 75 Female 235 lb 4/25/2012 Physician United States
Primary
Concomitant
Interacting
Serotonin Syndrome Death 1/1/2011 75 Female 235 lb 5/3/2012 Consumer United States
Primary
Concomitant
Interacting
Oedema Peripheral Hospitalization 3/6/2012 57 Female 222 lb 5/6/2012 Pharmacist United States
Primary
Concomitant
Serotonin Syndrome Death 1/1/2011 75 Female 226 lb 5/10/2012 Pharmacist United States
Primary
Concomitant
Interacting
Urinary Tract Infection Staphylococcal Hospitalization 1/19/2011 67 Male 207 lb 10/25/2012 Physician Us
Primary
Concomitant
Abdominal Abscess Hospitalization 11/25/2011 12 Female 81 lb 8/31/2012 Physician Us
Primary
Secondary
Concomitant
Neutropenia Hospitalization 4/23/2012 4 Female 11/12/2012 Physician Us
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 4/23/2012 4 Female 11/19/2012 Physician Us
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 12/21/2011 70 Female 198 lb 10/11/2012 Physician Us
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/21/2011 70 Female 194 lb 10/3/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Colitis Ulcerative Hospitalization 4/1/2012 17 Male 136 lb 9/19/2012 Other Health Professional Us
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 12/16/2011 60 Male 1/7/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Disability 12/16/2011 60 Male 239 lb 1/9/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Tremor Other Serious 10 Female 77 lb 10/6/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Wound Infection Hospitalization 4/9/2012 47 Female 181 lb 10/30/2012 Physician Us
Primary
Secondary
Concomitant
Surgery Death 11/5/2012 Other Health Professional De
Primary
Secondary
Sepsis Hospitalization 8/6/2012 13 Female 2/15/2013 Physician Us
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 10/25/2012 34 Male 10/25/2012 Other Health Professional Us
Primary
Concomitant
Accidental Poisoning Death 34 Male 10/22/2012 Other Health Professional Us
Primary
Secondary
Mucosal Inflammation Hospitalization 8/19/2012 4 Female 11/8/2012 Physician Us
Primary
Secondary
Concomitant
Sepsis Death 8/6/2012 12 Female 10/18/2013 Physician Us
Primary
Secondary
Concomitant
Vascular Neoplasm Life Threatening 8/6/2012 12 Female Other Health Professional Us
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 34 Male 11/28/2012 Other Health Professional Us
Primary
Secondary
Pruritus Death 11/10/2012 78 Female 1/4/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Ventricular Hypertrophy Other Serious 11/16/2012 12 Male 80 lb 1/4/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 8/2012 Female 313 lb 1/15/2013 Physician Us
Primary
Concomitant
Toxicity To Various Agents Death 34 Male 12/11/2012 Other Health Professional Us
Primary
Secondary
White Blood Cell Count Decreased Disability 12/16/2011 60 Male 238 lb 1/9/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/16/2011 60 Male 238 lb 1/10/2013 Physician Gb
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/21/2002 68 Female 1/28/2013 Consumer Us
Primary
Secondary
Concomitant

Drug Data