Diphenhydramine Hcl combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/14/2006 11 Female 60 lb 1/4/2007 Physician Canada
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 10/14/2006 11 Female 60 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 2/5/2008 3 Male 29 lb 2/26/2008 Other Health Professional Canada
Primary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/19/2008 Lawyer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/23/2008 Lawyer United States
Primary
Secondary
Concomitant
Infusion Related Reaction Life Threatening 6/14/2008 14 Female 110 lb 6/25/2008 Physician Indonesia
Primary
Concomitant
Infusion Related Reaction Hospitalization 3/5/2008 29 Female 6/30/2008 Consumer United States
Primary
Concomitant
Dysphagia 7/23/2008 Female 9/4/2008 Pharmacist United States
Primary
Concomitant
Ventricular Dysfunction Hospitalization 9/28/2008 Male 200 lb 10/6/2008 Consumer United States
Primary
Secondary
Concomitant
Inflammation Hospitalization 11/1/2008 Male 90 lb 11/18/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 9 Female 2/23/2009
Primary
Secondary
Rheumatoid Arthritis Hospitalization 27 Female 5/21/2009 Consumer United Kingdom
Primary
Concomitant
Renal Impairment Life Threatening 15 Female 6/4/2009
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 27 Female 6/5/2009 Consumer United Kingdom
Primary
Concomitant
Skin Disorder Hospitalization 3/11/2009 Female 136 lb 8/11/2009 Other Health Professional Canada
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2009 Female 213 lb 10/12/2009 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2009 Female 213 lb 10/13/2009 Consumer United States
Primary
Concomitant
Pneumonia Bacterial Death 55 Female 12/2/2009 Consumer United Kingdom
Primary
Secondary
Wrong Technique In Drug Usage Process Other Serious 1/1/2009 Female 230 lb 12/18/2009 Consumer United States
Primary
Concomitant
Scar Other Serious Female 4/2/2010 Other Health Professional Canada
Primary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 10/3/2003 46 Female 128 lb 8/31/2010 United States
Primary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/8/2010 Physician United States
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/24/2010 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 9/16/2009 22 Male 169 lb 9/28/2010 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 8/7/2010 13 Male 130 lb 10/18/2010 United States
Primary
Secondary
Concomitant
Stent Placement Hospitalization 65 Female 10/27/2010 Consumer United States
Primary
Concomitant
Tongue Biting 71 Male 10/13/2010 Consumer United States
Primary
Concomitant
Lower Respiratory Tract Infection Fungal Death 1/9/2011 28 Female 249 lb 3/31/2011 Physician United States
Primary
Secondary
Concomitant
Hypercalcaemia Hospitalization 10/3/2003 46 Female 128 lb 4/5/2011 United States
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Pericardial Effusion Life Threatening 10/10/2009 12 Male 92 lb 7/5/2011 Physician Japan
Primary
Concomitant
Ankle Fracture Hospitalization 10/3/2003 46 Female 128 lb 7/20/2011 Physician United States
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/5/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 8/8/2011 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/7/2011 60 Female 233 lb 8/22/2011 Physician United States
Primary
Secondary
Concomitant
Hepatic Failure Hospitalization 6/16/2011 23 Male 307 lb 8/18/2011 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 7/25/2011 67 Male 182 lb 8/28/2011 Physician United States
Primary
Concomitant
Colitis Other Serious 7/25/2011 67 Male 182 lb 8/30/2011 Physician United States
Primary
Concomitant
Failure To Thrive Other Serious 7/25/2011 67 Male 182 lb 9/2/2011 Physician United States
Primary
Concomitant
Vomiting Hospitalization 6/7/2011 60 Female 233 lb 9/2/2011 Physician United States
Primary
Secondary
Concomitant
Throat Irritation Hospitalization 8/4/2011 10 Female 75 lb 8/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Decreased Appetite Death 2/1/2011 74 Female 9/20/2011 Consumer Japan
Primary
Secondary
Concomitant
Myocardial Fibrosis Disability 1/1/2000 11 Male 77 lb 9/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria Hospitalization 6/7/2011 -1 Female 233 lb 9/27/2011 Physician United States
Primary
Concomitant
Ileal Perforation Hospitalization 10/7/2011 4 Female 36 lb 10/10/2011 Physician United States
Primary
Secondary
Concomitant
Rash Other Serious 6/7/2011 60 Female 233 lb 10/20/2011 Physician United States
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 9/6/2011 42 Female 150 lb 10/28/2011 Brazil
Primary
Concomitant
Neutropenia Other Serious 41 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 26 Male 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 54 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 51 Male 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 22 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 49 Female 11/3/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Gastrointestinal Necrosis Hospitalization 10/7/2011 4 Female 36 lb 11/4/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 53 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 69 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 36 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 18 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenic Sepsis Other Serious 26 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Death 41 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 54 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 22 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 49 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Other Serious 36 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Death 51 Male 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Neutropenia Other Serious 33 Female 11/15/2011 Other Health Professional Malaysia
Primary
Secondary
Concomitant
Enteritis Infectious Hospitalization 8/7/2011 62 Female 180 lb 11/28/2011 Canada
Primary
Concomitant
Bone Lesion Death Female 12/1/2011 Lawyer United States
Primary
Secondary
Concomitant
Death Death 12/1/2011 81 Male 182 lb 12/16/2011 Other Health Professional Canada
Primary
Concomitant
Crohn's Disease Hospitalization 11/25/2011 11 Female 81 lb 12/16/2011 Physician United States
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 11/1/2011 54 Male 165 lb 12/27/2011 Canada
Primary
Concomitant
Tachycardia Hospitalization Female 140 lb 1/3/2012 Canada
Primary
Concomitant
Completed Suicide Death 57 Female 1/4/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 57 Female 1/6/2012 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2010 57 Female 1/3/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 57 Female 1/10/2012 Physician United States
Primary
Secondary
Sinus Tachycardia Other Serious Female 160 lb 1/4/2012 Lawyer United States
Primary
Concomitant
Completed Suicide Death 1/1/2010 57 Female 1/9/2012 Physician United States
Primary
Secondary
Abdominal Abscess Hospitalization 11/25/2011 11 Female 81 lb 1/18/2012 Physician United States
Primary
Secondary
Concomitant
Nasopharyngitis Hospitalization 1/6/2012 73 Female 168 lb 1/18/2012 Canada
Primary
Concomitant
Abdominal Abscess Hospitalization 11/25/2011 11 Female 81 lb 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Incorrect Dose Administered Death 1/1/2010 57 Female 1/10/2012 Physician United States
Primary
Secondary
Respiratory Arrest Death 57 Female 1/12/2012 Physician United States
Primary
Secondary
Bone Lesion Other Serious Female 1/27/2012 Lawyer United States
Primary
Secondary
Concomitant
Skin Papilloma Hospitalization Female 1/31/2012 Physician United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 15 Male 1/27/2012 Consumer United States
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 2/10/2012 19 Male 185 lb 2/23/2012 Consumer Canada
Primary
Concomitant
Completed Suicide Death 57 Female 3/2/2012 Other Health Professional United States
Primary
Secondary
Hypoaesthesia Other Serious 12/18/2011 55 Male 176 lb 3/2/2012 Consumer Canada
Primary
Concomitant
Depression Other Serious 3/5/2012 54 Female 125 lb 3/5/2012 Consumer Canada
Primary
Concomitant
Infusion Related Reaction Other Serious 2/16/2012 45 Female 130 lb 3/12/2012 Canada
Primary
Concomitant
Transaminases Increased Other Serious 3/14/2012 United States
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 81 3/14/2012 United States
Primary
Secondary
Concomitant
Infusion Related Reaction Other Serious 2/16/2012 45 Female 130 lb 3/16/2012 Canada
Primary
Concomitant
Multiple Myeloma Other Serious 1/1/2012 57 Female 145 lb 3/20/2012 Canada
Primary
Concomitant
Infusion Related Reaction Other Serious 2/16/2012 45 Female 130 lb 3/27/2012 Other Health Professional Canada
Primary
Concomitant
Nausea Other Serious 1/1/2010 34 Female 170 lb 3/28/2012 Consumer Canada
Primary
Concomitant
Hyperglycaemia Hospitalization 3/21/2012 20 Female 186 lb 3/23/2012 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 5/13/2008 1 Female 19 lb 3/28/2012 Physician Croatia (Local Name: Hrvatska)
Primary
Concomitant
Completed Suicide Death 57 Female 4/3/2012 Other Health Professional United States
Primary
Secondary
Type 2 Diabetes Mellitus Other Serious 1/1/2010 55 Male 200 lb 4/4/2012 Consumer Canada
Primary
Concomitant
Hypoaesthesia Other Serious 16 Female 106 lb 4/2/2012 Pharmacist Canada
Primary
Concomitant
Multiple Myeloma Other Serious 1/1/2012 57 Female 145 lb 4/16/2012 Canada
Primary
Concomitant
Wrist Fracture Hospitalization 8/16/2011 87 Female 117 lb 4/20/2012 Consumer Canada
Primary
Concomitant
Upper Limb Fracture Other Serious 1/1/2011 50 Female 165 lb 4/23/2012 Consumer Canada
Primary
Concomitant
Flushing Other Serious 1/1/2011 48 Female 185 lb 4/24/2012 Consumer Canada
Primary
Concomitant
Coagulation Time Prolonged Other Serious 4/18/2012 70 Male 280 lb 4/26/2012 Consumer United States
Primary
Concomitant
Completed Suicide Death 57 Female 4/27/2012 Other Health Professional United States
Primary
Secondary
Spinal Fracture Other Serious 2/27/2012 61 Female 150 lb 5/1/2012 Consumer Canada
Primary
Concomitant
Osteomyelitis Other Serious 2/24/2012 11 Female 116 lb 5/2/2012 Physician United States
Primary
Concomitant
Spinal Fracture Other Serious 2/27/2012 61 Female 150 lb 5/2/2012 Physician Canada
Primary
Concomitant
Muscle Atrophy Other Serious 4 Male 35 lb 5/1/2012 Pharmacist Canada
Primary
Concomitant
Cartilage Atrophy Hospitalization 11/1/2011 67 Male 173 lb 5/11/2012 Consumer Canada
Primary
Concomitant
Cartilage Atrophy Hospitalization 11/1/2011 67 Male 173 lb 5/18/2012 Canada
Primary
Concomitant
Hypertension Death 2/24/2012 11 Female 116 lb 5/22/2012 Other Health Professional United States
Primary
Concomitant
Lumbar Radiculopathy Hospitalization 8/10/2010 51 Female 5/23/2012 Physician United States
Primary
Secondary
Concomitant
Drug Effect Decreased Other Serious 12/12/2011 70 Female 187 lb 5/25/2012 Consumer Canada
Primary
Concomitant
Diabetes Mellitus Other Serious 5/18/2012 50 Female 155 lb 5/25/2012 Consumer Canada
Primary
Concomitant
Diabetes Mellitus Other Serious 5/18/2012 50 Female 155 lb 5/28/2012 Canada
Primary
Concomitant
Myocardial Infarction Hospitalization 12/1/2011 77 Female 220 lb 6/4/2012 Consumer Canada
Primary
Concomitant
Febrile Neutropenia Other Serious 3/18/2012 45 Female 6/11/2012 Physician United States
Primary
Secondary
Concomitant
Malaise Other Serious 55 Female 197 lb 5/16/2012 Pharmacist United States
Primary
Concomitant
Eye Disorder Other Serious Female 6/12/2012 Consumer Canada
Primary
Concomitant
Arthralgia Hospitalization 12/1/2011 77 Female 220 lb 6/21/2012 Canada
Primary
Concomitant
Eye Disorder Other Serious Female 7/2/2012 Consumer Canada
Primary
Concomitant
Muscular Weakness Hospitalization 10/29/2010 34 Male 349 lb 7/13/2012 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/18/2011 55 Male 165 lb 7/17/2012 Physician Canada
Primary
Concomitant
Pulmonary Embolism Other Serious 12/25/2011 57 Female 269 lb 7/24/2012 Physician Canada
Primary
Concomitant
Pleural Effusion Other Serious 3/29/2012 70 Female 194 lb 8/1/2012 Physician United States
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 10/29/2010 34 Male 349 lb 8/3/2012 Other Health Professional United States
Primary
Concomitant
Arthropathy Other Serious 5/1/2007 41 Female 8/20/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Bladder Haemorrhage Hospitalization 8/2011 Female 140 lb 12/13/2012 Physician Ca
Primary
Concomitant
Wound Other Serious 2/27/2012 61 Female 150 lb 9/7/2012 Physician Ca
Primary
Concomitant
Nasopharyngitis Other Serious 6/7/2012 68 Male 150 lb 1/16/2013 Consumer Ca
Primary
Concomitant
Rash Hospitalization 6/16/2012 35 Female 110 lb 3/25/2013 Other Health Professional Ca
Primary
Concomitant
Laryngeal Oedema Other Serious 11/7/2012 55 Female 149 lb 11/22/2012 Other Health Professional Ca
Primary
Concomitant
Weight Decreased Other Serious 3/2012 Female 125 lb 2/25/2013 Consumer Ca
Primary
Concomitant
Renal Disorder Other Serious 2012 Female 11/29/2012 Physician Ca
Primary
Concomitant
Pruritus Generalised Other Serious 12/19/2012 60 Female 146 lb 3/18/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Death Death Female 150 lb 1/28/2013 Consumer Ca
Primary
Concomitant
Death Death Female 2/11/2013 Other Health Professional Ca
Primary
Concomitant
Pruritus Other Serious Female 219 lb 2/27/2013 Other Health Professional Ca
Primary
Concomitant
Rib Fracture Hospitalization 10/2012 Male 170 lb 3/1/2013 Other Health Professional Ca
Primary
Concomitant
Dementia Other Serious Male 1/25/2013 Physician Ca
Primary
Concomitant

Drug Data