Diltiazem combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Other Serious 1/1/2005 Male 1/17/2006 United States
Primary
Secondary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/2005 Male 1/30/2006 United States
Primary
Secondary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Pulmonary Oedema Other Serious 71 Female 2/14/2006 Netherlands
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 3/14/2004 42 Female 105 lb 2/22/2006 Physician Japan
Primary
Secondary
Concomitant
Odynophagia Hospitalization 1/15/2006 71 Male 3/10/2006 Physician Japan
Primary
Secondary
Atrial Fibrillation Hospitalization 4/24/2005 77 Male 214 lb 3/15/2006 Other Health Professional Canada
Primary
Concomitant
Angioneurotic Oedema Hospitalization 1/15/2006 71 Male 3/17/2006 Physician Japan
Primary
Secondary
White Blood Cell Count Increased Hospitalization 1/15/2006 71 Male 4/3/2006 Physician Japan
Primary
Secondary
Syncope Required Intervention 12/1/2005 77 Female 12/2/2005 Pharmacist United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/21/2005 68 Male 154 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Effect Decreased 10/1/2005 63 Male 240 lb 4/3/2006 Consumer United States
Primary
Concomitant
Hypoaesthesia Hospitalization 4/24/2005 77 Male 192 lb 6/7/2006 Physician Canada
Primary
Concomitant
Urine Abnormality Hospitalization 72 Female 7/20/2006 Spain
Primary
Secondary
Concomitant
Neuromuscular Block Prolonged Other Serious 78 Female 152 lb 7/28/2006 Physician Canada
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/4/2006 73 Female 8/23/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Angina Pectoris Other Serious 71 Male 8/25/2006 United Kingdom
Primary
Concomitant
Nervous System Disorder Other Serious 6/14/2006 Female 108 lb 9/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Multiple Drug Overdose Intentional Death 82 NotSpecified 11/14/2006 Physician United States
Primary
Secondary
Skin Reaction Other Serious 10/6/2006 62 Female 198 lb 11/27/2006 United Kingdom
Primary
Secondary
Concomitant
Completed Suicide Death 82 12/18/2006 United States
Primary
Secondary
Asthma Other Serious 1/21/2007 42 Male 1/31/2007 Consumer United Kingdom
Primary
Concomitant
Asthma Other Serious 1/21/2007 42 Male 2/2/2007 Consumer United Kingdom
Primary
Concomitant
Vomiting Required Intervention 73 Female 2/12/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 63 Female 3/5/2007 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 63 Female 3/20/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/21/2007 42 Male 4/9/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Death 1/1/2007 77 Female 4/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Cytomegaloviral Hospitalization 12/19/2006 Male 4/17/2007 Physician United Kingdom
Primary
Concomitant
Melaena Hospitalization 11/7/2006 79 Female 4/9/2007 Physician France
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 12/19/2006 Male 4/27/2007 Physician United Kingdom
Primary
Concomitant
Swelling Face Disability 2/12/2002 Male 4/20/2007 United Kingdom
Primary
Concomitant
Diverticulum Intestinal Haemorrhagic Hospitalization 2/28/2006 80 Male 12/13/2006 Physician United States
Primary
Concomitant
Pneumonia Cytomegaloviral Hospitalization 12/19/2006 Male 5/30/2007 Physician United Kingdom
Primary
Concomitant
Wound Dehiscence Hospitalization 6/4/2007 Male 170 lb 6/7/2007 United States
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Life Threatening 12/19/2006 Male 6/19/2007 Physician United Kingdom
Primary
Concomitant
Urine Flow Decreased Other Serious 5/1/2006 59 Female 4/26/2007 United States
Primary
Concomitant
Cerebellar Ataxia Other Serious 6/14/2006 Female 108 lb 7/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/21/2007 42 Male 7/27/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 7/20/2007 Male 8/2/2007 Consumer United Kingdom
Primary
Concomitant
Drug Interaction Death 77 Female 8/16/2007 Sweden
Primary
Concomitant
Interacting
Vomiting Hospitalization 6/7/2007 73 Female 9/26/2007 Physician Netherlands
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 10/5/2007 Physician United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/1/2004 22 Male 10/9/2007 Other Health Professional Poland
Primary
Secondary
Blood Glucose Fluctuation Other Serious 8/28/2007 60 Male 220 lb 10/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Extrasystoles Life Threatening 7/18/2007 47 Female 126 lb 10/26/2007 Physician United States
Primary
Secondary
Concomitant
Nausea Life Threatening 7/18/2007 47 Female 11/6/2007 United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/7/2007 82 Male 11/19/2007 Physician United States
Primary
Secondary
Drug Ineffective Other Serious 78 Male 11/22/2007 Japan
Primary
Secondary
Drug Ineffective Other Serious 54 Male 12/17/2007 Australia
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 12/1/2007 Female 2/6/2008 Physician United States
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 2/6/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 9/1/2007 Female 157 lb 2/15/2008 Brazil
Primary
Concomitant
Tinnitus Hospitalization 7/1/2007 Female 2/15/2008 United Kingdom
Primary
Concomitant
Wound Other Serious 9/1/2007 Female 157 lb 2/25/2008 Brazil
Primary
Concomitant
Pneumonia Cytomegaloviral Life Threatening 12/19/2006 Male 4/14/2008 Physician United Kingdom
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 4/3/2008 71 Male 176 lb 5/9/2008 Consumer United Kingdom
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 6/17/2008 Pharmacist China
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 6/23/2008 Pharmacist China
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 5/7/2008 Female 9/11/2008 Other Health Professional Portugal
Primary
Secondary
Concomitant
Ventricular Hypokinesia Hospitalization 5/7/2008 Female 9/24/2008 Other Health Professional Portugal
Primary
Secondary
Concomitant
Lethargy Other Serious 4/18/2005 Male 10/17/2008 Physician United States
Primary
Concomitant
Lethargy Other Serious 4/18/2005 Male 10/24/2008 Consumer United States
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 12/4/2008 Pharmacist China
Primary
Concomitant
Coronary Artery Disease Hospitalization 7/29/2008 Male 183 lb 12/15/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 12/17/2008 Pharmacist China
Primary
Concomitant
Syncope Hospitalization 11/1/2008 75 Female 12/17/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 7/1/2008 62 Female 180 lb 12/17/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 12/23/2008 Physician Spain
Primary
Concomitant
Product Quality Issue Other Serious 2/28/2008 83 Female 12/19/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 1/1/2008 79 Female 12/22/2008 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 10/25/2008 75 Female 118 lb 12/29/2008 Physician United Kingdom
Primary
Concomitant
Product Quality Issue Other Serious 1/1/2003 79 Female 180 lb 12/23/2008 Consumer United States
Primary
Secondary
Concomitant
Product Quality Issue Hospitalization 4/1/2008 82 Male 125 lb 12/30/2008 Consumer United States
Primary
Concomitant
Rash Erythematous Hospitalization 11/27/2008 70 Male 194 lb 1/9/2009 Consumer United States
Primary
Concomitant
Pain Hospitalization 11/1/2008 74 Female 1/14/2009 Consumer United Kingdom
Primary
Secondary
Somnolence Other Serious 11/1/2008 Female 1/19/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 1/28/2009 Physician Spain
Primary
Concomitant
Vertigo Hospitalization 11/1/2008 55 Female 112 lb 1/23/2009 Consumer United States
Primary
Concomitant
Product Quality Issue Other Serious 10/25/2008 75 Female 118 lb 2/25/2009 Physician United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 3/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 3/20/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 10/13/2008 44 Male 3/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 56 Female 3/20/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 3/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 3/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Other Serious 11/1/2008 Female 5/4/2009 Consumer United States
Primary
Concomitant
Transmission Of An Infectious Agent Via A Medicinal Product Hospitalization 1/1/2005 87 Female 5/27/2009 United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2005 87 Female 6/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Hospitalization 87 Female 6/8/2009
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 87 Female 6/10/2009 United Kingdom
Primary
Concomitant
Chest Pain Hospitalization 5/12/2009 47 Male 280 lb 6/15/2009 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/1/2005 87 Female 6/15/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 7/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2008 81 Female 7/8/2009 Physician Spain
Primary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 7/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 67 Female 7/13/2009
Primary
Concomitant
Vision Blurred Other Serious 5/1/2002 47 Female 255 lb 7/23/2009 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2008 81 Female 7/24/2009 Physician Spain
Primary
Concomitant
Hepatitis Acute Other Serious 6/25/2009 Male 9/9/2009 Physician United States
Primary
Concomitant
Myocardial Infarction Life Threatening 1/1/2001 Female 110 lb 10/20/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 10/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 10/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 10/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/4/2009
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 359 lb 11/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 11/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/30/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatitis Acute Other Serious 6/25/2009 58 Male 12/3/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 359 lb 12/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ear Discomfort Disability 12/6/2009 76 Male 12/22/2009 Physician United Kingdom
Primary
Concomitant
Ear Discomfort Disability 12/6/2009 76 Male 2/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Ischaemia Other Serious 4/15/2010 49 Male 143 lb 7/6/2010 Consumer United Kingdom
Primary
Concomitant
Tremor 3/8/2007 80 Female 153 lb 7/12/2010 Consumer United States
Primary
Concomitant
Flushing 10/22/2009 65 Male 210 lb 8/28/2010 United States
Primary
Concomitant
Vomiting Other Serious 5/25/2007 66 Female 9/21/2010 Other Health Professional United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 9/30/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 11/1/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 56 Female 11/11/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 9/1/2010 56 Male 212 lb 11/12/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Glossodynia Death 8/24/2006 12/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 67 Female 11/22/2010 Physician Greece
Primary
Concomitant
Ventricular Arrhythmia Other Serious 10/5/2010 57 Male 12/21/2010 Other Health Professional
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 12/21/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 12/27/2010 Physician United Kingdom
Primary
Concomitant
Interacting
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 12/29/2010 Physician United Kingdom
Primary
Concomitant
Interacting
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 12/29/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 9/1/2010 56 Male 212 lb 1/4/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/5/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Rib Fracture Other Serious 8/6/2010 81 Female 1/5/2011 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 1/17/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Life Threatening 8/31/2000 80 Male 1/21/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 1/24/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/25/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 8/31/2000 80 Male 1/27/2011 Physician United Kingdom
Primary
Concomitant
Interacting
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 1/28/2011 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 2/7/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 12/20/2010 77 Male 2/7/2011 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data