Digoxin combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Oesophageal Carcinoma Death Male 195 lb 1/3/2006 Physician United States
Primary
Concomitant
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Rectal Haemorrhage Required Intervention 9/6/2005 50 Male 194 lb 1/3/2006 United States
Primary
Concomitant
Renal Failure Other Serious 9/1/2005 78 Male 1/19/2006 Physician Netherlands
Primary
Secondary
Concomitant
Sepsis Death 12/1/2005 60 Male 187 lb 1/26/2006 United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 1/1/2005 78 Male 1/23/2006 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/28/2005 65 Male 1/30/2006 France
Primary
Secondary
Vomiting Other Serious 12/12/2005 78 Male 151 lb 12/30/2005 Pharmacist United States
Primary
Concomitant
Retroperitoneal Haematoma Required Intervention 12/1/2005 81 Male 190 lb 1/18/2006 Physician United States
Primary
Secondary
Concomitant
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Aortic Dissection Death 4/5/2005 Male 2/1/2006 Consumer United Kingdom
Primary
Secondary
Treatment Noncompliance Hospitalization 11/30/2005 Male 153 lb 1/3/2006 Other Health Professional United States
Primary
Concomitant
Restlessness Hospitalization 1/10/2006 78 Male 198 lb 2/8/2006
Primary
Concomitant
Weight Decreased Hospitalization 10/27/2005 87 Male 127 lb 12/1/2005 Pharmacist United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 60 2/13/2006 Consumer Australia
Primary
Secondary
Concomitant
Restlessness Hospitalization 1/10/2006 78 Male 2/10/2006 United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 89 Male 2/21/2006 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/2/2005 Male 2/22/2006 Pharmacist United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 12/1/2005 Male 2/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Hepatotoxicity Hospitalization 1/30/2006 71 Female 3/10/2006 Pharmacist United Kingdom
Primary
Concomitant
Catheter Site Haemorrhage Hospitalization 10/11/2004 65 Male 217 lb 12/21/2005 United States
Primary
Secondary
Concomitant
Pain In Extremity Hospitalization 1/1/2002 74 Male 145 lb 12/29/2005 United States
Primary
Concomitant
Aortic Dissection Death Male 3/29/2006
Primary
Secondary
Rhabdomyolysis Hospitalization 2/4/2006 Female 126 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2/9/2006 70 Male 170 lb 4/10/2006 Physician Canada
Primary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Hypotension Hospitalization 2/9/2006 82 Male 3/1/2006 Pharmacist United States
Primary
Secondary
Concomitant
Subdural Haematoma Death 1/28/2006 63 Male 1/31/2006 Pharmacist United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 1/22/2006 83 Female 4/26/2006 Sweden
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 73 Male 5/5/2006 Physician United Kingdom
Primary
Secondary
Renal Impairment Hospitalization 1/1/2005 78 Male 5/12/2006 Physician Netherlands
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 1/1/2006 63 Male 121 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Movement Disorder Life Threatening 1/26/2006 Male 236 lb 5/22/2006 Pharmacist United States
Primary
Concomitant
Cardiac Failure Other Serious 73 Male 5/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Initial Insomnia 2/17/2006 81 Male 215 lb 4/3/2006 Consumer United States
Primary
Concomitant
Blood Parathyroid Hormone Increased 8/22/2005 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Blood Parathyroid Hormone Increased 8/22/2005 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 4/19/2006 Male 6/1/2006 Physician United States
Primary
Secondary
Concomitant
Rales Other Serious 73 Male 6/1/2006 Consumer United Kingdom
Primary
Secondary
Weight Decreased Other Serious 1/1/2006 72 Male 190 lb 6/3/2006 Consumer Brazil
Primary
Concomitant
Syncope Hospitalization 3/1/2006 80 Male 6/5/2006 Other Health Professional
Primary
Secondary
Concomitant
Carotid Artery Occlusion Other Serious 5/14/2006 Male 156 lb 6/5/2006 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 3/1/2006 80 Male 6/8/2006 Other Health Professional
Primary
Secondary
Concomitant
Telangiectasia Hospitalization 9/19/2005 73 Female 111 lb 6/13/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 3/10/2006 75 Male 219 lb 6/1/2006 Pharmacist United States
Primary
Concomitant
Drug Ineffective 1/1/2006 77 Male 5/5/2006 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious 73 Male 6/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Cardiac Failure Other Serious 1/1/2000 73 Male 6/12/2006 United Kingdom
Primary
Secondary
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/22/2006 Physician United States
Primary
Secondary
Concomitant
Hypothyroidism Life Threatening 6/19/2005 53 Male 242 lb 6/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 7/5/2005 58 Male 201 lb 6/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 3/22/2005 57 Female 143 lb 6/23/2006 Belgium
Primary
Concomitant
Nausea Hospitalization 5/1/2006 60 Male 128 lb 5/4/2006 Pharmacist United States
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Feeling Abnormal 3/2/2006 82 Male 5/19/2006 United States
Primary
Concomitant
Gastritis Hospitalization 2/25/2006 79 Female 7/5/2006 Denmark
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/12/2006 80 Female 6/29/2006 Consumer Spain
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 2/25/2006 79 Female 7/18/2006 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/2/2006 76 Male 7/19/2006 Physician Italy
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/5/2001 77 Male 7/21/2006 United States
Primary
Concomitant
Rhabdomyolysis Other Serious 34 Male 7/21/2006 Other Health Professional Spain
Primary
Concomitant
Liver Function Test Abnormal Other Serious 77 Female 7/21/2006 New Zealand
Primary
Secondary
Concomitant
International Normalised Ratio Decreased 11/15/2005 74 Male 183 lb 8/1/2006 Pharmacist United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 2/25/2006 79 Female 7/27/2006 Denmark
Primary
Secondary
Concomitant
Weight Decreased 6/1/2005 Male 215 lb 8/8/2006 Consumer United States
Primary
Concomitant
Bone Marrow Disorder Hospitalization 7/5/2006 79 Male 8/11/2006 Other Health Professional France
Primary
Concomitant
Skin Swelling Other Serious 1/1/2006 77 Male 158 lb 7/19/2006 United States
Primary
Concomitant
Gastritis Hospitalization 2/25/2006 Female 154 lb 8/21/2006 Physician Denmark
Primary
Secondary
Concomitant
Stupor Hospitalization 3/16/2006 58 Male 8/23/2006
Primary
Secondary
Concomitant
Neurotoxicity Required Intervention 77 Female 8/18/2006 Physician New Zealand
Primary
Concomitant
Retching Hospitalization 5/14/2006 74 Male 243 lb 6/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hypoaesthesia Hospitalization 8/9/2006 69 Male 155 lb 8/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Lactic Acidosis Hospitalization 77 Male 8/22/2006 United Kingdom
Primary
Concomitant
Lactic Acidosis Hospitalization 77 Male 8/23/2006 United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 2/25/2006 79 Female 8/29/2006 Denmark
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 6/28/2006 54 Male 9/1/2006 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 9/13/2006 Physician United States
Primary
Concomitant
Acute Leukaemia Hospitalization 7/5/2006 79 Male 9/15/2006 Other Health Professional France
Primary
Concomitant
Pneumonia Hospitalization 3/2/2006 Female 9/18/2006 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/25/2006 Male 203 lb 4/26/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Speech Disorder Hospitalization 77 Female 9/15/2006 Other Health Professional New Zealand
Primary
Concomitant
Circulatory Collapse Death 69 Male 9/30/2006 Physician Singapore
Primary
Secondary
Sudden Death Death 4/5/2005 Male 9/28/2006 Physician United Kingdom
Primary
Secondary
Hyperkalaemia Hospitalization 78 Male 10/5/2006
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 78 Male 8/9/2006 Other Health Professional United States
Primary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/9/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 10/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Required Intervention 78 Male 10/10/2006 Other Health Professional Denmark
Primary
Concomitant
Neurotoxicity Hospitalization 1/1/2006 77 10/12/2006 Physician New Zealand
Primary
Concomitant
Culture Urine Positive Hospitalization 9/16/2006 71 Female 10/18/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 9/23/2006 59 Male 10/26/2006 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/21/2005 80 Male 121 lb 11/1/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/21/2005 80 Male 121 lb 11/2/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Dyspnoea 6/1/2006 80 Male 11/13/2006 Consumer United States
Primary
Concomitant
Myocardial Ischaemia Death 69 Male 11/14/2006 Physician Singapore
Primary
Concomitant
Heparin-induced Thrombocytopenia Other Serious 7/29/2006 70 Male 215 lb 9/18/2006 Pharmacist United States
Primary
Concomitant
Retinal Artery Occlusion Disability 10/23/2006 75 Male 174 lb 12/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Required Intervention 9/6/2006 75 Male 144 lb 10/2/2006 Consumer United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/18/2006 62 Male 12/6/2006 Physician Spain
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2006 89 Male 183 lb 12/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pleural Effusion Death 9/29/2006 81 Female 143 lb 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 12/6/2006 58 Male 182 lb 12/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urine Output Increased Other Serious 6/13/2006 89 Male 183 lb 12/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/18/2006 62 Male 187 lb 12/18/2006 Physician Spain
Primary
Secondary
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 12/28/2006 Physician United States
Primary
Concomitant
Tachycardia Life Threatening 10/2/2006 85 Male 12/18/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 11/18/2006 62 Male 187 lb 1/3/2007 Physician Spain
Primary
Secondary
Cardiogenic Shock Death 3/11/2006 91 Male 154 lb 10/6/2006 United States
Primary
Secondary
Concomitant
Paradoxical Drug Reaction 8/3/2006 88 Male 152 lb 10/11/2006 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Life Threatening 7/13/2006 72 Male 172 lb 10/23/2006 Pharmacist United States
Primary
Secondary
Concomitant
Platelet Count Decreased Death 9/29/2006 81 Female 143 lb 1/12/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Insomnia 1/1/2006 77 Female 174 lb 10/24/2006 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/9/2007 80 Male 234 lb 1/12/2007 Pharmacist United States
Primary
Concomitant
Drug Interaction Other Serious 8/31/2006 74 Male 1/11/2007 Sweden
Primary
Secondary
Concomitant
Urine Sodium Increased Hospitalization 78 Male 1/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 10/18/2006 80 Male 191 lb 1/9/2007 Pharmacist United States
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 1/29/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Death 9/29/2006 81 Female 143 lb 1/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 78 Male 1/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Subdural Haemorrhage Life Threatening 1/4/2007 66 Male 1/26/2007 Pharmacist United States
Primary
Secondary
Concomitant
Parkinsonism Hospitalization 77 Female 2/2/2007 Other Health Professional New Zealand
Primary
Concomitant
Treatment Noncompliance Hospitalization 10/6/2006 77 Male 123 lb 12/12/2006 Pharmacist United States
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 11/15/2006 60 Male 335 lb 12/19/2006 Pharmacist United States
Primary
Concomitant
Feeling Abnormal 3/2/2006 82 Male 11/21/2006 United States
Primary
Concomitant
Subdural Haematoma Life Threatening 1/28/2007 56 Male 2/6/2007 Pharmacist United States
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 2/3/2007 53 Male 173 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Haematochezia Hospitalization 1/10/2007 80 Male 243 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Sinus Tachycardia Death 55 Male 2/13/2007 Physician United States
Primary
Concomitant
Subdural Haematoma Life Threatening 2/19/2007 85 Female 2/26/2007 Pharmacist United States
Primary
Secondary
Concomitant
Drug Interaction Life Threatening 2/8/2007 86 Female 3/1/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Life Threatening 2/8/2007 86 Female 3/7/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Septic Shock Hospitalization 11/18/2006 62 NotSpecified 187 lb 3/6/2007 Physician Spain
Primary
Secondary
Haemoglobin Decreased Hospitalization 2/8/2007 86 Male 3/12/2007 Physician
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 2/7/2007 71 Male 3/16/2007 United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 2/8/2007 86 Male 3/19/2007 United Kingdom
Primary
Secondary
Concomitant
Pain Hospitalization 2/15/2007 85 Female 99 lb 3/23/2007 United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 3/11/2007 80 Male 219 lb 3/28/2007 Pharmacist United States
Primary
Concomitant
Insomnia 11/1/2006 85 Male 162 lb 1/12/2007 Consumer United States
Primary
Concomitant
Gangrene Required Intervention 2/3/2007 54 Male 241 lb 2/9/2007 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 2/6/2007 79 Male 187 lb 2/21/2007 United States
Primary
Secondary
Concomitant
Melaena Hospitalization 10/1/2005 55 Female 136 lb 12/13/2006 Consumer United States
Primary
Secondary
Concomitant
Haematuria Other Serious 6/1/2006 77 Male 12/13/2006 Consumer United States
Primary
Secondary
Concomitant

Drug Data