Digoxin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sepsis Hospitalization 71 Male 1/2/2006
Primary
Concomitant
Pancytopenia Hospitalization 84 Female 1/3/2006
Primary
Concomitant
Pancytopenia Hospitalization 82 Female 1/3/2006
Primary
Concomitant
Neoplasm Malignant Hospitalization 3/1/2000 48 Female 150 lb 1/23/2006 Lawyer United States
Primary
Concomitant
Pruritus Death 7/22/2004 Male 187 lb 1/25/2006 United Kingdom
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Death Female 129 lb 2/3/2006 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/1/2006 Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/8/2006 Physician Japan
Primary
Concomitant
Urine Flow Decreased 1/3/2006 72 Male 2/27/2006 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/27/2006 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 3/2/2006 Physician Japan
Primary
Concomitant
Breast Cancer Other Serious 12/16/2005 Female 135 lb 3/28/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Dysfunction Other Serious 81 Male 4/6/2006 United States
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 3/6/2006 Female 4/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Systemic Mycosis Hospitalization 72 Female 4/12/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Other Serious 1/21/2006 81 Female 4/28/2006 Physician Spain
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Artery Stenosis Hospitalization 11/15/2005 Female 5/12/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pancytopenia Hospitalization 82 Female 5/19/2006
Primary
Concomitant
Sepsis Hospitalization 71 Male 5/19/2006 Physician United Kingdom
Primary
Concomitant
Sepsis Hospitalization 84 Female 5/19/2006 Physician United Kingdom
Primary
Concomitant
Carotid Artery Occlusion Other Serious 5/14/2006 Male 156 lb 6/5/2006 Consumer United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 7/1/2005 Male 6/9/2006 Physician United States
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/22/2006 Physician United States
Primary
Secondary
Concomitant
Skin Nodule Hospitalization 10/1/2003 Female 119 lb 6/22/2006 Germany
Primary
Concomitant
Basal Cell Carcinoma Other Serious 6/9/2006 Female 156 lb 6/23/2006 Consumer United States
Primary
Concomitant
Blood Creatinine Increased 5/10/2006 71 Female 6/30/2006 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Pericarditis Constrictive Hospitalization 10/1/2003 Female 119 lb 7/20/2006 Germany
Primary
Concomitant
Basal Cell Carcinoma Other Serious 6/9/2006 Female 156 lb 8/10/2006 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization Female 110 lb 8/24/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 9/13/2006 Physician United States
Primary
Concomitant
Throat Tightness Other Serious 1/1/2006 Male 320 lb 9/14/2006 Physician United States
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Life Threatening 5/5/2002 Male 265 lb 10/3/2006 Physician Spain
Primary
Secondary
Concomitant
Vascular Calcification Life Threatening 5/5/2002 Male 265 lb 10/16/2006 Physician Spain
Primary
Secondary
Concomitant
Scar Other Serious 8/1/2006 Female 10/16/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 12/28/2006 Physician United States
Primary
Concomitant
Convulsion Hospitalization 10/15/2006 Male 141 lb 1/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/1/2006 Female 128 lb 8/17/2006 Pharmacist United States
Primary
Concomitant
Dry Throat 59 Female 205 lb 10/24/2006 Qatar
Primary
Concomitant
Osteonecrosis Other Serious 5/1/2005 63 Female 157 lb 11/28/2006 Physician United States
Primary
Concomitant
Fatigue 9/1/2006 85 Female 11/7/2006 Consumer United States
Primary
Concomitant
Embolism Other Serious 1/25/2007 54 Male 164 lb 2/6/2007 Consumer United States
Primary
Concomitant
Pulmonary Fibrosis Other Serious 79 Male 220 lb 3/7/2007 Physician United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Death 79 Male 3/9/2007 United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Death 79 Male 3/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Death 79 Male 220 lb 3/13/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
B-cell Lymphoma Other Serious 2/13/2007 Male 181 lb 3/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Death 79 Male 3/12/2007 United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Required Intervention 9/28/2004 53 Male 183 lb 11/17/2005 Physician United States
Primary
Secondary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 4/18/2007 Physician United States
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 4/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Hospitalization 11/9/2006 Female 5/17/2007 Physician Greece
Primary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 5/17/2007 Physician United States
Primary
Concomitant
Pulmonary Fibrosis Other Serious 79 Male 220 lb 5/14/2007 Physician United Kingdom
Primary
Concomitant
Pneumonia Death 79 Male 220 lb 5/15/2007 Physician United Kingdom
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/15/2007 59 Male 234 lb 5/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Death 79 Male 220 lb 5/23/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Death 79 Male 220 lb 5/25/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 6/8/2007 Physician Italy
Primary
Concomitant
Hypergammaglobulinaemia Benign Monoclonal Other Serious 4/10/2007 Female 110 lb 6/11/2007 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Hospitalization 11/9/2006 Female 6/18/2007 Physician Greece
Primary
Secondary
Concomitant
Cardiac Flutter Other Serious 3/1/2003 68 Female 6/21/2007 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/13/2007 70 Female 132 lb 6/28/2007 Physician United States
Primary
Concomitant
Soft Tissue Infection Other Serious 1/17/2007 Male 271 lb 7/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 7/5/2007 Physician Italy
Primary
Concomitant
Cerebrovascular Accident Other Serious Male 187 lb 7/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Type Iii Immune Complex Mediated Reaction Other Serious 5/7/2007 1 Male 13 lb 7/19/2007 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2006 74 Male 7/26/2007 Consumer United Kingdom
Primary
Concomitant
Tibia Fracture Hospitalization 4/1/2006 76 Female 8/14/2007 Germany
Primary
Concomitant
Pain 78 Female 8/3/2007 Consumer United States
Primary
Concomitant
Cerebrovascular Accident Other Serious Male 187 lb 8/21/2007 Other Health Professional United Kingdom
Primary
Concomitant
Cerebrovascular Accident Other Serious 6/21/2006 Male 187 lb 8/21/2007 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 3/1/2003 68 Female 8/31/2007 Consumer United States
Primary
Secondary
Concomitant
Tremor Hospitalization 8/15/2007 Female 227 lb 9/4/2007 United States
Primary
Secondary
Concomitant
Peroneal Nerve Palsy Hospitalization 8/15/2007 Female 227 lb 9/6/2007 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/4/2007 69 Male 284 lb 9/17/2007 Physician United States
Primary
Concomitant
Tremor Hospitalization 8/15/2007 Female 227 lb 10/4/2007 United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious Male 187 lb 10/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 7/1/2007 62 Female 126 lb 10/25/2007 Greece
Primary
Concomitant
Pyrexia Hospitalization 8/1/2007 Male 560 lb 11/20/2007 Physician United States
Primary
Concomitant
Surgery Hospitalization 4/1/2007 Female 190 lb 12/5/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Mitral Valve Incompetence Other Serious 6/1/2006 Female 12/7/2007 Belgium
Primary
Concomitant
Injection Site Irritation 1/1/2007 Female 170 lb 12/14/2007 Consumer United States
Primary
Concomitant
Oedema Peripheral 6/1/2007 Female 130 lb 12/14/2007 Pharmacist United States
Primary
Concomitant
Hip Fracture Other Serious 11/27/2006 Male 218 lb 12/26/2007 Consumer United Kingdom
Primary
Concomitant
Splenomegaly Other Serious 6/1/2007 Female 144 lb 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 4/1/2006 76 Female 2/8/2008 Germany
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 8/29/2007 74 Male 101 lb 2/12/2008 Physician Japan
Primary
Secondary
Concomitant
Oropharyngeal Blistering Other Serious 1/7/2008 Male 161 lb 3/4/2008 Physician United Kingdom
Primary
Concomitant
Tuberculosis Other Serious 7/19/2004 Female 163 lb 3/5/2008 United Kingdom
Primary
Concomitant
Streptococcal Sepsis Other Serious 4/1/2007 Female 190 lb 3/7/2008 United Kingdom
Primary
Secondary
Concomitant
Hyperlipidaemia Other Serious 8/13/2004 Female 135 lb 3/14/2008 United States
Primary
Concomitant
Pain 12/1/2007 Female 135 lb 3/15/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 4/16/2008 Physician Italy
Primary
Concomitant
Oropharyngeal Blistering Other Serious 1/7/2008 Male 161 lb 4/18/2008 Physician United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 10/1/2007 Male 4/23/2008 Consumer United States
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 9/30/2007 Female 4/28/2008 Physician France
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 9/30/2007 Female 5/13/2008 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Peripheral Vascular Disorder Other Serious 4/8/2003 Female 6/6/2008 Physician
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/19/2008 Lawyer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/23/2008 Lawyer United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 4/8/2003 Female 7/2/2008 Physician
Primary
Secondary
Concomitant
Toe Amputation Hospitalization 12/12/2005 Female 7/3/2008 Physician
Primary
Concomitant
Pulmonary Fibrosis Death 7/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2008 81 Female 7/3/2008 Consumer Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 79 Male 220 lb 7/14/2008 Physician United Kingdom
Primary
Concomitant
Pneumonia Death 79 Male 220 lb 7/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Carcinoma In Situ Of Skin Other Serious 4/4/2007 Female 137 lb 7/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Ischaemia Death 3/28/2008 Female 163 lb 8/13/2008 United Kingdom
Primary
Concomitant
Skin Ulcer Other Serious 4/8/2003 53 Female 8/22/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 61 Female 136 lb 8/25/2008 United States
Primary
Concomitant
Sinus Bradycardia Hospitalization 5/15/2008 73 Female 8/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Insomnia 6/4/2008 Female 150 lb 9/12/2008 Consumer United States
Primary
Concomitant
Pain 6/27/2008 Male 210 lb 9/12/2008 Consumer United States
Primary
Concomitant
Procedural Complication 8/11/2008 Male 250 lb 9/13/2008 Consumer United States
Primary
Concomitant
Endocrine Ophthalmopathy Other Serious 7/1/2008 Female 242 lb 9/15/2008 Physician United States
Primary
Concomitant
Vomiting Life Threatening 61 Female 136 lb 9/8/2008 United States
Primary
Concomitant
Swelling Face Other Serious Male 9/24/2008 Consumer United Kingdom
Primary
Concomitant
Oesophageal Ulcer Hospitalization 5/15/2008 73 Female 119 lb 9/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination Other Serious 9/17/2008 Male 158 lb 10/1/2008 Consumer United States
Primary
Concomitant
Dementia Other Serious 1/1/2006 Female 126 lb 11/4/2008 Physician United States
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Sepsis Other Serious 1/1/2008 Female 11/14/2008 Netherlands
Primary
Concomitant
Melaena Hospitalization 2/13/2008 61 Female 234 lb 11/11/2008 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/15/2008 Male 218 lb 12/1/2008 Consumer United Kingdom
Primary
Concomitant
Sepsis Other Serious 1/1/2008 Female 12/4/2008 Netherlands
Primary
Concomitant
Vomiting 52 Male 12/2/2008 United States
Primary
Secondary
Procedural Complication 8/11/2008 Male 250 lb 12/12/2008 Consumer United States
Primary
Concomitant
Subdural Haematoma Other Serious 1/1/2008 76 Male 12/18/2008 Pharmacist United States
Primary
Concomitant
Haematochezia Hospitalization 11/22/2008 Male 12/29/2008 Pharmacist United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 11/25/2008 62 Female 163 lb 1/23/2009 Consumer France
Primary
Secondary
Concomitant
Visual Impairment 84 Male 1/27/2009 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Death 11/25/2008 62 Female 163 lb 1/27/2009 Consumer France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/25/2008 62 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Concomitant
Hypertriglyceridaemia Other Serious 2/11/2005 Female 2/12/2009 Other Health Professional Spain
Primary
Concomitant
Meningioma Other Serious 7/5/2001 Female 2/17/2009 Other Health Professional Spain
Primary
Concomitant
Tooth Infection Other Serious 12/1/2008 Male 153 lb 2/25/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 71 Female 2/23/2009 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 74 Female 4/3/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 4/3/2008 71 Female 4/21/2009 United States
Primary
Concomitant
Sarcoidosis Other Serious 1/21/2008 Female 158 lb 4/28/2009 Other Health Professional Canada
Primary
Concomitant
Dizziness Other Serious 4/2/2009 Female 130 lb 5/6/2009 Physician United States
Primary
Concomitant

Drug Data