Digoxin combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pericarditis Other Serious 1/1/2005 Male 237 lb 1/11/2006 Physician United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 9/4/2005 89 Male 170 lb 1/10/2006 United States
Primary
Concomitant
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 1/17/2006 United States
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 1/7/2006 74 Male 1/18/2006 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 1/3/2006 81 Male 176 lb 1/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2000 83 Female 99 lb 1/25/2006 United Kingdom
Primary
Concomitant
Treatment Noncompliance Required Intervention 8/30/2005 Female 9/2/2005 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 1/3/2006 81 Male 176 lb 1/26/2006 United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 11/30/2005 Male 153 lb 1/3/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased Life Threatening 3/1/2005 71 Female 2/21/2006 Other Health Professional Germany
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 10/1/2004 94 Female 103 lb 12/27/2005 Consumer United States
Primary
Concomitant
Swelling Face Other Serious 3/20/2005 72 Male 278 lb 12/21/2005 Consumer United States
Primary
Concomitant
Rash Pruritic Other Serious 1/30/2005 75 Female 165 lb 12/21/2005 Consumer United States
Primary
Concomitant
Gravitational Oedema Hospitalization 11/26/2005 80 Female 132 lb 3/9/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 79 Male 3/10/2006 United Kingdom
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 79 Male 3/15/2006 United Kingdom
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 79 Male 3/14/2006 United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Congestive Other Serious 79 Male 3/16/2006 United Kingdom
Primary
Secondary
Concomitant
Haemolysis Other Serious 89 Male 3/23/2006 Pharmacist Japan
Primary
Concomitant
Tinnitus Hospitalization 8/1/2001 78 Female 3/31/2006 Lawyer Poland
Primary
Concomitant
Troponin Increased Hospitalization 10/5/2003 73 Female 4/7/2006 Physician Australia
Primary
Secondary
Concomitant
Tinnitus Hospitalization 8/1/2001 78 Female 4/7/2006 Physician Poland
Primary
Concomitant
Nodal Arrhythmia Other Serious 10/27/2005 82 Female 4/4/2006 France
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Required Intervention 12/1/2005 77 Female 12/2/2005 Pharmacist United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 9/29/2003 Male 5/16/2006 United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 6/11/2003 71 Male 121 lb 5/23/2006 Physician Japan
Primary
Secondary
Concomitant
Bradycardia Hospitalization 3/10/2006 75 Male 219 lb 6/1/2006 Pharmacist United States
Primary
Concomitant
Chest Pain Hospitalization 10/31/2004 89 Female 6/8/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 6/1/2006 79 Male 143 lb 6/15/2006 Physician Norway
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 2/23/2006 77 Female 6/23/2006 Physician United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Other Serious 2/23/2006 77 Female 6/27/2006 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 5/5/2001 77 Male 7/21/2006 United States
Primary
Concomitant
Multi-organ Failure Other Serious 7/2/2006 77 Female 99 lb 7/21/2006 Physician United Kingdom
Primary
Concomitant
Pancytopenia Hospitalization 6/30/2006 Male 8/3/2006 Other Health Professional Japan
Primary
Concomitant
Pericarditis Other Serious 1/1/2005 Male 237 lb 8/25/2006 Physician United States
Primary
Secondary
Concomitant
Ischaemic Stroke Life Threatening 5/29/2006 86 Female 8/25/2006 United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/25/2006 79 Female 8/29/2006 Denmark
Primary
Secondary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 9/11/2006 Other Health Professional Netherlands
Primary
Concomitant
Blood Amylase Increased Other Serious 5/1/2005 78 Male 9/5/2006 United Kingdom
Primary
Concomitant
Intracranial Aneurysm Hospitalization 6/21/2006 Male 9/11/2006 Pharmacist United States
Primary
Concomitant
Sudden Death Death Male 9/14/2006 Physician Japan
Primary
Concomitant
Vomiting Disability 8/26/2006 54 Female 9/20/2006 Physician Philippines
Primary
Concomitant
Vomiting Disability 8/26/2006 54 Female 9/22/2006 Physician Philippines
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 9/29/2006 Other Health Professional Netherlands
Primary
Concomitant
Death Death 67 Female 162 lb 1/30/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/26/2005 76 Female 110 lb 10/18/2006 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 3/1/2006 Female 162 lb 10/27/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2005 65 Female 180 lb 11/1/2006 United States
Primary
Concomitant
Vomiting Hospitalization 10/5/2006 91 Female 11/3/2006 Sweden
Primary
Secondary
Concomitant
Sudden Death Hospitalization 7/4/2005 Male 11/13/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/26/2005 76 Female 110 lb 11/17/2006 Physician Japan
Primary
Secondary
Concomitant
Death Death 10/17/2006 71 Male 11/17/2006 Other Health Professional United States
Primary
Concomitant
Milk-alkali Syndrome Hospitalization 72 Male 11/29/2006
Primary
Secondary
Concomitant
Vomiting Hospitalization 60 Male 12/15/2006 Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 8/10/2006 80 Male 12/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 12/1/2006 79 Male 1/18/2007 Physician China
Primary
Concomitant
Chest Pain Other Serious 12/22/2006 1/30/2007 Consumer United Kingdom
Primary
Concomitant
Drug Interaction Hospitalization 10/12/2006 80 Female 2/16/2007 Pharmacist Spain
Primary
Concomitant
Interacting
Renal Impairment Other Serious 12/1/2006 79 Male 3/6/2007 Physician China
Primary
Concomitant
Vision Blurred Hospitalization 12/1/2006 Male 155 lb 3/27/2007 Consumer United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 2/24/2007 72 Male 3/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Melaena Hospitalization 1/22/2007 61 Male 3/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2005 80 Female 4/5/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Retinopathy Other Serious 3/1/2006 Female 4/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Required Intervention 3/6/2007 62 4/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 12/1/2006 Male 155 lb 5/14/2007 Consumer United States
Primary
Concomitant
Retinopathy Other Serious 3/1/2006 Female 5/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Diabetic Retinopathy Other Serious 3/1/2006 Female 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Hospitalization 4/28/2007 77 Male 5/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Hospitalization 3/4/2006 56 Female 120 lb 12/13/2006 Pharmacist United States
Primary
Concomitant
Visual Acuity Reduced 3/1/2006 80 Male 138 lb 2/22/2007 United States
Primary
Concomitant
Rash Hospitalization 4/28/2007 77 Male 183 lb 6/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 5/24/2007 Female 119 lb 6/8/2007 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Hospitalization 78 Male 4/30/2007 Other Health Professional United States
Primary
Concomitant
Tachycardia Other Serious 82 Female 6/14/2007 Other Health Professional United States
Primary
Secondary
Pneumonia Hospitalization 82 Female 123 lb 6/26/2007 United States
Primary
Concomitant
Skin Hypertrophy Other Serious 70 Male 6/29/2007 Other Health Professional Greece
Primary
Concomitant
Drug Interaction Death 82 Female 8/16/2007 Sweden
Primary
Concomitant
Interacting
Blood Glucose Increased Hospitalization 7/17/2007 83 Male 8/17/2007 Consumer United States
Primary
Concomitant
Fracture Other Serious 94 Female 9/28/2007 Physician United Kingdom
Primary
Concomitant
Hypotension 1/18/2006 83 Male 11/13/2007 Consumer United States
Primary
Concomitant
Application Site Dermatitis Other Serious 10/12/2007 87 Female 11/29/2007 Physician United Kingdom
Primary
Concomitant
Syncope Other Serious 11/30/2007 76 Female 154 lb 12/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 9/8/2007 75 Female 12/17/2007 United Kingdom
Primary
Concomitant
Syncope Other Serious 11/30/2007 76 Female 154 lb 12/28/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Death 12/7/2007 65 Male 1/10/2008 Other Health Professional Korea, Republic Of
Primary
Concomitant
Rash Other Serious 8/1/2007 71 Male 210 lb 12/12/2007 United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 Female 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 2/4/2008 Norway
Primary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 2/8/2008 Sweden
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2006 73 Male 120 lb 12/3/2007 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 1/1/2007 79 Male 2/13/2008 Other Health Professional Israel
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 3/6/2008 Sweden
Primary
Concomitant
Rhabdomyolysis Hospitalization 1/1/2001 73 Male 3/5/2008 Physician United Kingdom
Primary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 3/11/2008 Other Health Professional Netherlands
Primary
Concomitant
Syncope Vasovagal Hospitalization 9/8/2007 75 Female 3/7/2008 United Kingdom
Primary
Concomitant
Mass 1/1/2008 Female 114 lb 3/15/2008 Consumer United States
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 3/19/2008 Sweden
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 Female 3/21/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 3/28/2008 Sweden
Primary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 3/27/2008 Other Health Professional Netherlands
Primary
Concomitant
Prothrombin Level Decreased Hospitalization 2/14/2008 67 Female 4/9/2008 Other Health Professional Sweden
Primary
Concomitant
Interacting
Peritonitis Hospitalization 3/15/2008 71 Male 201 lb 4/10/2008 Physician United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 3/6/2008 80 Male 5/20/2008 United Kingdom
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 1/1/2004 80 Male 5/23/2008 United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/7/2008 62 Female 6/6/2008 Sweden
Primary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Vision Blurred 12/1/2007 78 Female 145 lb 6/19/2008 United States
Primary
Concomitant
Sepsis Hospitalization 7/16/2008 70 Female 143 lb 7/31/2008 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 73 Female 7/29/2008 Consumer France
Primary
Secondary
Concomitant
Pancytopenia Death 5/6/2008 Female 8/7/2008 Other Health Professional Finland
Primary
Secondary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 8/18/2008 Other Health Professional Netherlands
Primary
Concomitant
Sepsis Hospitalization 7/16/2008 70 Female 143 lb 8/19/2008 Other Health Professional United States
Primary
Concomitant
Productive Cough 2/1/2008 67 Female 8/15/2008 United States
Primary
Concomitant
Rash Macular 7/11/2008 Female 8/29/2008 United States
Primary
Concomitant
Trigger Finger Hospitalization 5/3/2007 77 Male 9/3/2008 Japan
Primary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 9/17/2008 Lawyer United States
Primary
Concomitant
Sepsis Hospitalization 7/16/2008 70 Female 143 lb 9/18/2008 Other Health Professional United States
Primary
Concomitant
Allergic Granulomatous Angiitis Hospitalization 8/13/2006 75 Female 9/19/2008 Other Health Professional Netherlands
Primary
Concomitant
Trigger Finger Hospitalization 5/3/2007 77 Male 9/22/2008 Japan
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 9/23/2008 Sweden
Primary
Concomitant
Palpitations Other Serious 64 Female 9/19/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/16/2008 70 Female 143 lb 11/4/2008 Other Health Professional United States
Primary
Concomitant
Trigger Finger Hospitalization 5/3/2007 77 Male 11/21/2008 Japan
Primary
Concomitant
Product Quality Issue Other Serious 11/1/2008 66 Female 165 lb 12/3/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Death 3/1/2008 81 Female 12/15/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 12/23/2008 Physician Spain
Primary
Concomitant
Product Quality Issue Death 4/7/2007 72 Male 170 lb 12/19/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 5/7/2008 71 Female 106 lb 12/22/2008 Consumer United States
Primary
Concomitant
Sudden Death Death 12/7/2008 72 Male 1/6/2009 Physician United Kingdom
Primary
Concomitant
Syncope Death 9/18/2008 75 Male 1/9/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 1/28/2009 Physician Spain
Primary
Concomitant
Thrombocytopenia Hospitalization 1/21/2009 Male 174 lb 2/11/2009 Physician Argentina
Primary
Secondary
Concomitant
Sudden Death Death 12/7/2008 72 Male 2/13/2009 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 9/27/2006 48 Male 110 lb 2/19/2009 Lawyer United States
Primary
Concomitant
Hallucination, Visual Other Serious 2/19/2005 83 Female 2/23/2009 Other Health Professional Poland
Primary
Concomitant
Thrombosis Other Serious 5/1/2008 67 Female 141 lb 3/13/2009 Consumer Brazil
Primary
Concomitant
Anaphylactic Shock Life Threatening 3/11/2009 71 Male 3/19/2009 Physician Japan
Primary
Concomitant
Sudden Death Death 12/7/2008 Male 245 lb 3/30/2009 Physician United Kingdom
Primary
Concomitant
Acute Myocardial Infarction Death 74 Male 4/7/2009 Physician Greece
Primary
Secondary
Concomitant
Acute Myocardial Infarction Death 3/16/2007 74 Male 4/8/2009 Other Health Professional Greece
Primary
Secondary
Concomitant
Transfusion-related Acute Lung Injury Other Serious 3/14/2009 Female 189 lb 4/17/2009 Other Health Professional United States
Primary
Concomitant

Drug Data