Diflucan combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tumour Lysis Syndrome Required Intervention 10/14/2005 55 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 10/14/2005 55 Male 2/8/2006 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 10/14/2005 55 Male 2/21/2006 Other Health Professional United States
Primary
Concomitant
Toe Deformity Other Serious 12/1/2001 Female 286 lb 3/7/2006 Other Health Professional United States
Primary
Concomitant
Cytomegalovirus Viraemia Life Threatening 4/21/2004 1 Male 18 lb 3/23/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/1/2006 Male 168 lb 3/28/2006 Physician Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2002 Female 131 lb 4/7/2006 Physician United States
Primary
Concomitant
Urticaria Other Serious 11/27/2003 Female 95 lb 4/20/2006 Physician Japan
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 6/3/2002 70 Male 130 lb 4/25/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 8/3/2005 43 Male 4/28/2006 Physician Japan
Primary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/5/2006 Physician United States
Primary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/19/2006 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Infection Other Serious 3/14/2005 Male 121 lb 5/26/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/22/2003 61 Male 95 lb 5/16/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Life Threatening 8/3/2005 43 Male 6/8/2006 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 6/23/2006 Physician Japan
Primary
Secondary
Concomitant
Mucous Membrane Disorder Hospitalization 8/26/2004 8 Male 51 lb 7/21/2006 Physician Japan
Primary
Concomitant
Weight Increased Hospitalization 6/11/2006 Male 198 lb 8/9/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 6/11/2006 Male 198 lb 8/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Feeling Drunk Other Serious 1/1/2006 48 Female 7/19/2006 Pharmacist United States
Primary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 8/23/2006 Physician United States
Primary
Concomitant
Oral Mucosal Disorder Hospitalization 2/9/2006 10 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/1/2006 Female 165 lb 10/9/2006 Physician Belgium
Primary
Concomitant
Renal Failure Life Threatening 1/28/2005 54 Female 106 lb 11/9/2006 Physician Japan
Primary
Concomitant
Retroperitoneal Neoplasm Life Threatening 1/28/2005 54 Female 106 lb 11/20/2006 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 7/12/2006 Female 165 lb 12/12/2006 Physician Belgium
Primary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/26/2007 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 2/6/2007 5 Female 3/15/2007 Finland
Primary
Concomitant
Meningitis Aseptic Other Serious 3/10/2007 59 Female 4/9/2007 Physician Switzerland
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 6/11/2006 Male 198 lb 4/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 1/27/2006 8 Male 46 lb 4/20/2007 Physician Japan
Primary
Secondary
Concomitant
Transplant Rejection Death 5/16/2006 49 Female 109 lb 4/29/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/21/2006 54 Male 157 lb 6/12/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/21/2006 54 Male 157 lb 7/24/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 8/27/2007 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 12/5/2006 70 Female 9/3/2007 Pharmacist Japan
Primary
Secondary
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 8/28/2007 Physician Japan
Primary
Secondary
Concomitant
Melaena Other Serious 3/2/2007 43 Male 132 lb 9/17/2007 Physician Japan
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 7/19/2007 Female 10/2/2007 Physician United States
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 7/19/2007 Female 10/12/2007 Physician United States
Primary
Concomitant
Leukoencephalopathy Other Serious Female 124 lb 10/15/2007 Physician Japan
Primary
Secondary
Status Epilepticus Life Threatening 2/10/2005 39 Male 10/26/2007 Japan
Primary
Secondary
Concomitant
Renal Cell Carcinoma Other Serious 10/10/2007 50 Female 168 lb 1/8/2008 Physician Canada
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Death 3/5/2005 64 Female 121 lb 1/9/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/29/2005 49 Male 366 lb 1/11/2008 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 9/27/2004 70 Female 117 lb 1/14/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/25/2008 Physician United States
Primary
Secondary
Concomitant
Shock Hospitalization 11/19/2007 Female 37 lb 1/28/2008 United States
Primary
Secondary
Concomitant
Renal Cell Carcinoma Other Serious 10/10/2007 50 Female 168 lb 2/7/2008 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 2/12/2008 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 7/17/2007 65 Male 161 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/20/2007 Male 117 lb 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/13/2006 74 Male 198 lb 4/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 5/6/2008 Physician United States
Primary
Secondary
Concomitant
Pneumothorax Other Serious 5/31/2006 54 Male 123 lb 5/9/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Death 7/17/2007 65 Male 161 lb 5/20/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/14/2008 Female 70 lb 5/27/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 6/25/2008 Physician United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 6/27/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/20/2007 Male 117 lb 7/1/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/22/2008 Female 103 lb 7/8/2008 Consumer United States
Primary
Secondary
Concomitant
Pain Hospitalization 7/13/2007 77 Female 7/3/2008 Physician Belgium
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/11/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/29/2008 Consumer United States
Primary
Secondary
Concomitant
Drug Hypersensitivity Other Serious 6/13/2008 Female 8/11/2008 Physician United Kingdom
Primary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 8/25/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/20/2007 Male 117 lb 8/28/2008 Physician Japan
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 9/11/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/17/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 10/23/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/29/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 11/4/2008 Physician Japan
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/5/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 11/18/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/24/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/22/2008 23 Female 137 lb 12/1/2008 Physician Japan
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/3/2008 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 12/10/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Life Threatening 9/27/2004 70 Female 117 lb 12/10/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Death 3/5/2005 64 Female 121 lb 12/12/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/29/2005 49 Male 366 lb 12/12/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 12/9/2008 Physician Japan
Primary
Secondary
Concomitant
Bursitis Infective Hospitalization 5/14/2007 Female 121 lb 12/26/2008 Italy
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/29/2008 Consumer United States
Primary
Secondary
Concomitant
Loss Of Consciousness Life Threatening 11/13/2008 62 Male 12/22/2008 Japan
Primary
Concomitant
Weight Increased Life Threatening 8/6/2007 23 Female 121 lb 1/9/2009 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Life Threatening 11/13/2008 62 Male 12/23/2008 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 9/2/2008 Male 2/9/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/16/2008 51 Male 97 lb 2/13/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/19/2008 Male 48 lb 2/13/2009 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 9/15/2008 Male 3/6/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/3/2008 60 Female 106 lb 3/12/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/20/2008 45 Male 128 lb 3/12/2009 Physician Japan
Primary
Secondary
Concomitant
Oliguria Life Threatening 2/1/2009 58 Female 3/16/2009 Physician Switzerland
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 3/26/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/6/2009 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/21/2008 56 Male 132 lb 4/15/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/17/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/21/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 5/1/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 5/4/2009 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 7/10/2008 Male 137 lb 5/21/2009 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 1/16/2009 53 Male 112 lb 5/28/2009 Japan
Primary
Concomitant
Bursitis Infective Hospitalization 5/14/2007 Female 121 lb 7/2/2009 Italy
Primary
Concomitant
Leukaemia Death Female 7/9/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/19/2006 9 Male 51 lb 7/10/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 6/25/2009 Female 154 lb 7/17/2009 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/27/2007 8 Male 44 lb 7/27/2009 Physician Japan
Primary
Secondary
Concomitant
Mycobacterium Avium Complex Infection Other Serious 5/11/2009 Female 143 lb 7/31/2009 Other Health Professional United States
Primary
Concomitant
Weight Decreased Death Female 8/3/2009 United States
Primary
Concomitant
Weight Decreased Death Female 8/4/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/14/2009 62 Male 8/17/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/19/2008 Male 48 lb 8/31/2009 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Life Threatening 6/9/2008 62 Male 154 lb 9/1/2009 Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/8/2008 51 Male 97 lb 9/3/2009 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/11/2008 56 Male 132 lb 9/24/2009 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 6/4/2008 62 Male 154 lb 10/7/2009 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 8/8/2008 51 Male 97 lb 10/14/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Perforation Other Serious 4/1/2009 Female 185 lb 10/16/2009 United States
Primary
Concomitant
Vomiting Life Threatening 9/26/2009 Female 116 lb 10/8/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/14/2009 62 Male 11/20/2009 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 6/4/2008 62 Male 154 lb 11/23/2009 Physician Japan
Primary
Secondary
Concomitant
Syncope Other Serious 9/1/2009 56 Male 243 lb 12/1/2009 Consumer United States
Primary
Secondary
Concomitant
Neck Pain 1/1/2008 Female 12/1/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 11/11/2009 71 Female 266 lb 11/25/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/9/2009 Female 121 lb 12/16/2009 Physician United States
Primary
Concomitant
Swelling Face Other Serious 1/1/2009 Female 110 lb 12/29/2009 Other Health Professional Canada
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 10/1/2009 52 Male 12/22/2009 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 6/25/2009 Female 154 lb 2/5/2010 Physician Germany
Primary
Concomitant
No Therapeutic Response Death 10/1/2009 52 Male 132 lb 1/29/2010 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 9/25/2008 39 Male 157 lb 3/3/2010 Physician Japan
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 11/9/2009 Female 121 lb 2/10/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/17/2010 Physician Italy
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/19/2010 Physician Italy
Primary
Secondary
Concomitant

Drug Data