Didanosine combined with Efavirenz

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Abortion Induced Other Serious 5/1/2001 28 Female 1/5/2006 Japan
Primary
Concomitant
Rash Maculo-papular Other Serious 10/11/2005 77 Male 1/18/2006 Physician Spain
Primary
Concomitant
Pulmonary Embolism Life Threatening 7/1/2001 Male 1/19/2006 Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 10/15/2004 47 Male 1/20/2006 Japan
Primary
Concomitant
Shock Other Serious 11/9/2005 58 Female 1/20/2006 France
Primary
Secondary
Hepatic Failure Death 47 Female 1/25/2006 Other Health Professional France
Primary
Secondary
Shock Other Serious 11/9/2005 58 Female 1/27/2006 France
Primary
Secondary
Vomiting Hospitalization 2/8/2001 Male 1/27/2006 Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Hospitalization 5/13/2002 56 Male 1/31/2006 Physician Japan
Primary
Secondary
Concomitant
Premature Menopause Other Serious 2/1/1998 36 Female 2/6/2006 Consumer France
Primary
Secondary
Lactic Acidosis Other Serious 10 Female 2/8/2006 Other Health Professional India
Primary
Secondary
Sleep Disorder Other Serious 42 Male 104 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 7/1/2004 Male 2/10/2006 Japan
Primary
Secondary
Concomitant
Gynaecomastia Other Serious 6/1/2005 26 Male 2/14/2006 Physician United Kingdom
Primary
Secondary
Therapy Non-responder Hospitalization 15 Male 2/17/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Oesophageal Infection Hospitalization 3/18/2005 Male 3/2/2006 France
Primary
Concomitant
Therapy Non-responder Hospitalization 15 Male 2/28/2006 Physician United Kingdom
Primary
Secondary
Gynaecomastia Other Serious 15 Male 3/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Anaemia Other Serious 12/30/2005 46 Male 3/10/2006 Other Health Professional South Africa
Primary
Secondary
Concomitant
Pancytopenia Other Serious 10/1/1999 Male 3/13/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/3/2002 Male 3/20/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/1/2005 51 Female 108 lb 3/20/2006 Other Health Professional France
Primary
Secondary
Renal Impairment Hospitalization 7/1/2004 Male 4/6/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/2/2003 36 Male 4/7/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/3/2002 Male 4/13/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/2/2003 36 Male 4/20/2006 Physician Japan
Primary
Secondary
Concomitant
Hyperlipidaemia 4/30/1998 41 Male 4/21/2006 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 7/1/2001 Male 4/26/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 4/11/2006 30 Male 125 lb 4/27/2006 United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 58 Male 5/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/11/2006 30 Male 125 lb 5/8/2006 United States
Primary
Secondary
Concomitant
Hypospadias Congenital Anomaly 5/19/2006 Other Health Professional United States
Primary
Secondary
Urine Sodium Increased Hospitalization 3/12/2004 26 Male 6/1/2006 Japan
Primary
Secondary
Concomitant
Hepatitis C Other Serious Male 6/2/2006 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Disability 1/30/2006 35 Male 6/2/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Overdose Other Serious 1 Male 6/21/2006 United States
Primary
Concomitant
Sepsis Other Serious 50 6/22/2006 Spain
Primary
Concomitant
Tuberculosis Hospitalization 36 Male 7/5/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/26/1999 41 Male 7/5/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/1998 Male 7/7/2006 Physician Japan
Primary
Secondary
Concomitant
Hyperlipidaemia Other Serious 9/27/2001 Male 7/7/2006 Physician Japan
Primary
Secondary
Concomitant
Rectal Cancer Other Serious 10/15/2004 47 Male 7/7/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/1998 Male 7/19/2006 Physician Japan
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/26/2005 Male 8/10/2006 Physician Japan
Primary
Concomitant
Respiratory Failure Hospitalization 1/13/2005 Male 8/14/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 31 Female 8/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Load Increased Other Serious 4/1/2002 Male 123 lb 8/21/2006 Other Health Professional France
Primary
Secondary
Concomitant
Shock Other Serious 30 Female 8/23/2006 Other Health Professional Portugal
Primary
Secondary
Mitochondrial Toxicity Other Serious 6/1/1998 36 Female 8/18/2006 Physician France
Primary
Concomitant
Myocarditis Hospitalization 7/1/2002 Male 8/25/2006 Physician Japan
Primary
Secondary
Concomitant
Hypospadias Congenital Anomaly Male 8/22/2006 Other Health Professional United States
Primary
Secondary
Von Willebrand's Disease Other Serious 38 Female 9/8/2006 Belgium
Primary
Concomitant
Sick Sinus Syndrome Other Serious 10/1/1999 Male 9/8/2006 Physician Japan
Primary
Secondary
Concomitant
Vasodilatation Life Threatening 10/24/2001 Male 9/13/2006 Physician Japan
Primary
Secondary
Concomitant
Walking Disability Other Serious 10/14/1996 Male 9/14/2006 Physician Japan
Primary
Secondary
Concomitant
Lipohypertrophy Other Serious 9/26/2002 Male 9/14/2006 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/22/2006 31 Male 125 lb 9/15/2006 United States
Primary
Secondary
Concomitant
Lipohypertrophy Other Serious 9/26/2002 Male 9/25/2006 Japan
Primary
Secondary
Concomitant
Subcutaneous Nodule Other Serious 55 Male 9/26/2006 Consumer France
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 6/22/2005 46 Male 143 lb 9/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Subcutaneous Nodule Other Serious 55 Male 9/29/2006 Consumer France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9 Female 10/6/2006
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/13/2005 Male 10/9/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/22/2006 31 Male 125 lb 10/17/2006 United States
Primary
Secondary
Concomitant
Death Death 9/13/2004 Male 10/26/2006 Brazil
Primary
Concomitant
Hypospadias Congenital Anomaly Male 10/27/2006 Other Health Professional United States
Primary
Secondary
Kaposi's Sarcoma Other Serious 46 Male 10/20/2006 Physician Spain
Primary
Concomitant
Hyperlipidaemia Other Serious 7/1/2002 Male 11/1/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Death 2/15/2001 Male 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Death 2/15/2001 Male 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Death 2/15/2001 Male 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Death 2/15/2001 Male 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Death 2/15/2001 Male 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/25/2002 Male 11/22/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/12/2001 39 Male 11/29/2006 Consumer France
Primary
Secondary
Concomitant
Drug Effect Decreased Disability 9/1/2003 64 Male 11/29/2006
Primary
Secondary
Neutropenia Hospitalization 1/31/2001 Female 6 lb 12/1/2006 Other Health Professional France
Primary
Secondary
General Physical Health Deterioration Hospitalization 9/22/2006 Male 12/1/2006 Physician Chile
Primary
Concomitant
Uterine Cyst Hospitalization Female 7 lb 12/12/2006 Consumer France
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/1/2006 57 Male 143 lb 12/14/2006 Physician Germany
Primary
Secondary
Concomitant
Viral Load Increased Other Serious 4/1/2002 Male 128 lb 12/27/2006 Other Health Professional France
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 10/1/1999 Male 12/29/2006 Physician Japan
Primary
Secondary
Concomitant
Somnolence Life Threatening 12/12/2006 32 Female 132 lb 1/3/2007 Consumer Brazil
Primary
Concomitant
Abortion Spontaneous Other Serious 5/1/2006 35 Female 1/5/2007 Other Health Professional United States
Primary
Secondary
Viral Load Increased Other Serious 4/1/2002 Male 128 lb 1/17/2007 Other Health Professional France
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 10/3/2006 Male 130 lb 1/18/2007 Physician France
Primary
Secondary
Concomitant
Meningitis Aseptic Hospitalization 8/1/2006 44 Male 1/19/2007 Physician United States
Primary
Concomitant
General Physical Health Deterioration Other Serious 9/22/2006 Male 1/19/2007 Physician Chile
Primary
Concomitant
Renal Colic Other Serious 10/1/2005 38 Male 154 lb 1/22/2007 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/8/2001 Male 1/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/25/2002 Male 2/5/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Nodular Regenerative Hyperplasia Hospitalization 39 Male 2/7/2007 Physician France
Primary
Secondary
Hypokalaemia Other Serious 48 Male 132 lb 2/8/2007 Other Health Professional United States
Primary
Secondary
Nephropathy Toxic Other Serious 51 Female 108 lb 2/8/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/10/1999 Male 2/22/2007 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/1/2006 57 Male 143 lb 3/1/2007 Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 31 Female 3/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatitis C Other Serious Male 3/16/2007 Physician Japan
Primary
Secondary
Concomitant
Walking Disability Other Serious 10/14/1996 Male 3/16/2007 Physician Japan
Primary
Secondary
Concomitant
Meningitis Aseptic Hospitalization 8/1/2006 Male 156 lb 3/19/2007 Physician United States
Primary
Concomitant
Renal Impairment Hospitalization 7/1/2004 Male 3/23/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Life Threatening 3/16/1998 Male 3/24/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Life Threatening 3/16/1998 Male 4/27/2007 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Life Threatening 3/18/2000 24 Male 5/4/2007 Physician Japan
Primary
Secondary
Concomitant
Abortion Spontaneous Other Serious 2/14/2006 32 Female 5/17/2007 Other Health Professional United States
Primary
Secondary
Visual Disturbance Life Threatening 3/16/1998 Male 5/17/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatitis B Other Serious 24 Male 5/21/2007 Consumer France
Primary
Secondary
Concomitant
Walking Disability Other Serious 2/23/1998 Male 6/6/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Life Threatening 3/16/1998 Male 6/7/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/10/2001 Male 6/7/2007 Physician Japan
Primary
Secondary
Concomitant
Talipes Other Serious 9/9/1999 Female 7 lb 6/8/2007 Consumer France
Primary
Secondary
Concomitant
Pulmonary Hypertension Life Threatening 3/18/2000 24 Male 6/5/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/10/2001 Male 6/14/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Life Threatening 3/16/1998 Male 6/15/2007 Physician Japan
Primary
Secondary
Concomitant
Lipoatrophy Other Serious 62 Male 6/20/2007 Physician United Kingdom
Primary
Secondary
Pyrexia Hospitalization 5/2/2003 36 Male 6/26/2007 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 2/23/2006 Male 167 lb 6/29/2007 Brazil
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/1/2004 Male 6/29/2007 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/25/2002 Male 7/11/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Other Serious 35 Male 7/17/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Other Serious 35 Male 7/13/2007 Germany
Primary
Secondary
Walking Disability Other Serious 2/23/1998 Male 7/31/2007 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/1/2004 Male 8/2/2007 Physician Japan
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 6/1/1999 31 Male 8/3/2007 Physician Spain
Primary
Secondary
Pyrexia Hospitalization 5/2/2003 36 Male 8/7/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Disability Female 8/8/2007 United States
Primary
Secondary
Concomitant
Abortion Spontaneous Other Serious 2/14/2006 32 Female 8/9/2007 Other Health Professional United States
Primary
Secondary
Sick Sinus Syndrome Other Serious 10/1/1999 Male 8/9/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/10/1999 Male 8/10/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 34 Male 8/10/2007 Other Health Professional Brazil
Primary
Secondary
Liver Disorder Hospitalization 9/27/2006 Male 8/22/2007 Japan
Primary
Secondary
Concomitant
Liver Disorder Other Serious 1/1/2006 53 Male 8/27/2007 Consumer United States
Primary
Secondary
Concomitant
Premature Baby Congenital Anomaly 1/1/2000 0 Male 9 lb 8/31/2007 Other Health Professional United States
Primary
Secondary
Drug Resistance Other Serious Male 9/10/2007 Czech Republic
Primary
Secondary
Osteonecrosis Hospitalization 2/23/2006 Male 167 lb 9/27/2007 Brazil
Primary
Secondary
Concomitant
Hepatitis B Death 1/1/2004 24 Male 10/8/2007
Primary
Secondary
Hyperlactacidaemia Other Serious 8/17/2006 48 Male 10/10/2007 Physician Japan
Primary
Secondary
Concomitant
Visceral Leishmaniasis Other Serious 3/1/2000 46 Male 10/19/2007 Other Health Professional Italy
Primary
Secondary
Visceral Leishmaniasis Other Serious 3/1/2000 46 Male 10/22/2007 Other Health Professional Italy
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/10/1999 Male 10/29/2007 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/26/1999 Male 11/1/2007 Physician United States
Primary
Secondary
Concomitant
Visceral Leishmaniasis Other Serious 10/1/1996 46 Male 11/1/2007
Primary
Secondary
Concomitant
Premature Baby Congenital Anomaly 1/1/2000 0 Male 9 lb 11/2/2007 Other Health Professional United States
Primary
Secondary
Premature Baby Congenital Anomaly 1/1/2000 0 Male 9 lb 11/9/2007 Other Health Professional United States
Primary
Secondary
Stillbirth Other Serious 7/15/2007 23 Female 11/12/2007 United States
Primary
Secondary
Type 2 Diabetes Mellitus Other Serious 1/1/1999 40 Male 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperlactacidaemia Other Serious 8/18/2006 Male 11/21/2007 Physician Japan
Primary
Secondary
Concomitant
Viral Load Increased Hospitalization Female 11/15/2007 Japan
Primary
Secondary
Vomiting Death 30 Male 11/26/2007 Other Health Professional Brazil
Primary
Secondary
Premature Rupture Of Membranes Other Serious Female 12/5/2007 Other Health Professional Netherlands
Primary
Secondary

Drug Data