Diazepam combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Arrest Death 37 Male 2/7/2006 Pharmacist United States
Primary
Secondary
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Lung Disorder Other Serious Male 6/28/2006 Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Haemodynamic Instability Required Intervention 9 Male 8/31/2006 Physician Belgium
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Serotonin Syndrome Required Intervention 10/5/2006 38 Male 11/10/2006 United Kingdom
Primary
Concomitant
Haemoglobin Decreased Other Serious 74 Female 12/8/2006 Pharmacist Canada
Primary
Concomitant
Tongue Biting Other Serious 4/19/2007 Male 225 lb 5/1/2007 Physician Romania
Primary
Concomitant
Rhabdomyolysis Death 36 Female 6/18/2007 Other Health Professional United States
Primary
Concomitant
Stress Other Serious 6/12/2007 47 Male 8/30/2007 Consumer United States
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Hospitalization 8/6/2007 Male 112 lb 8/20/2007 Pharmacist United States
Primary
Concomitant
Urine Ketone Body Present Death 36 Female 8/23/2007 United States
Primary
Secondary
Concomitant
Stress Other Serious 6/12/2007 47 Male 9/17/2007 Consumer United States
Primary
Secondary
Concomitant
Stress Other Serious 6/12/2007 47 Male 10/16/2007 Consumer United States
Primary
Secondary
Concomitant
Stress Other Serious 6/12/2007 47 Male 10/22/2007 Consumer United States
Primary
Secondary
Concomitant
Wheezing 9/1/2006 53 Female 10/25/2007 Consumer United States
Primary
Concomitant
Stress Other Serious 6/12/2007 47 Male 11/13/2007 Consumer United States
Primary
Secondary
Concomitant
Stress Other Serious 6/12/2007 47 Male 11/14/2007 Consumer United States
Primary
Secondary
Concomitant
Somnolence Other Serious 10/29/2006 58 Male 11/22/2007 Physician Germany
Primary
Concomitant
Interacting
Stress Other Serious 6/12/2007 47 Male 12/13/2007 Consumer United States
Primary
Secondary
Concomitant
Convulsion Other Serious 60 Male 1/11/2008 Pharmacist United States
Primary
Concomitant
Stress Other Serious 6/12/2007 47 Male 3/10/2008 Consumer United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 3/19/2008 Germany
Primary
Secondary
Stress Other Serious 6/12/2007 47 Male 3/25/2008 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/2/2000 51 Female 5/29/2008 Physician United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 8/1/2007 42 Male 130 lb 6/25/2008 Pharmacist United States
Primary
Concomitant
Stress Other Serious 6/12/2007 Male 7/2/2008 Consumer United States
Primary
Secondary
Concomitant
Drug Level Decreased Other Serious 4 Male 44 lb 8/5/2008 Pharmacist Spain
Primary
Concomitant
Interacting
Drug Interaction Other Serious 4 Male 44 lb 8/8/2008 Pharmacist Spain
Primary
Concomitant
Interacting
Generalised Anxiety Disorder Death 6/7/2008 31 Female 122 lb 9/5/2008 Other Health Professional United Kingdom
Primary
Secondary
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 9/10/2008 United Kingdom
Primary
Secondary
Diabetes Mellitus Inadequate Control Hospitalization 6/7/2008 31 Female 9/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/16/2008 United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 121 lb 10/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Cardiac Death Other Serious 6/7/2008 31 Female 122 lb 9/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Panic Attack Other Serious 6/7/2008 31 Female 121 lb 10/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 55 Male 10/9/2008
Primary
Secondary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 121 lb 10/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Cardiac Death Other Serious 6/7/2008 31 Female 122 lb 10/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Sudden Cardiac Death Other Serious 6/7/2008 31 Female 121 lb 10/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Completed Suicide Death 39 Female 12/29/2008 Pharmacist United States
Primary
Secondary
Vitamin B6 Decreased Other Serious 1/1/2007 81 Female 99 lb 1/5/2009
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 1/1/2007 81 Female 99 lb 1/5/2009
Primary
Secondary
Concomitant
Pleurothotonus Hospitalization 2/12/2008 53 Female 12/23/2008 Physician Germany
Primary
Secondary
Liver Function Test Abnormal Hospitalization 5/2/2008 55 Female 12/23/2008 Physician Germany
Primary
Secondary
Liver Function Test Abnormal Hospitalization 5/2/2008 55 Female 12/30/2008 Other Health Professional Germany
Primary
Secondary
Drug Toxicity Death 39 Female 1/8/2009 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 39 Female 1/16/2009 United States
Primary
Secondary
Schizoaffective Disorder Hospitalization 1/18/2001 38 Female 165 lb 1/20/2009 Other Health Professional United States
Primary
Concomitant
Drug Toxicity Death 39 Female 1/23/2009 Other Health Professional United States
Primary
Secondary
Respiratory Arrest Other Serious 39 Female 1/23/2009 Physician United States
Primary
Secondary
Completed Suicide Death 39 Female 1/28/2009 Other Health Professional United States
Primary
Secondary
Pulmonary Oedema Death 38 Male 1/26/2009 Other Health Professional Hong Kong
Primary
Concomitant
Respiratory Arrest Death 39 Female 1/26/2009 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 1/1/2007 39 Female 2/3/2009 Pharmacist United States
Primary
Secondary
Respiratory Arrest Death 39 Female 2/13/2009 Physician United States
Primary
Secondary
Metabolic Acidosis Other Serious 9 Male 2/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 39 Female 3/5/2009 Physician United States
Primary
Secondary
Drug Level Decreased Other Serious 0 Female 3/27/2009 Other Health Professional Spain
Primary
Interacting
Status Epilepticus Other Serious 30 Male 4/21/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3 Male 4/28/2009 Other Health Professional Germany
Primary
Secondary
Hepatomegaly Other Serious 13 Female 110 lb 5/11/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Delusional Disorder, Persecutory Type Other Serious Female 5/14/2009 Physician Spain
Primary
Concomitant
Hepatomegaly Other Serious 13 Female 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious Male 220 lb 8/29/2009 Physician United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 1/1/2001 38 Female 165 lb 9/2/2009 United States
Primary
Concomitant
No Adverse Event 8/8/2009 Female 62 lb 9/4/2009 Other Health Professional Brazil
Primary
Concomitant
Toxic Encephalopathy Other Serious Male 220 lb 9/17/2009 Pharmacist United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 7/31/2009 52 Male 10/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 19 Female 10/20/2009 Other Health Professional Poland
Primary
Secondary
Concomitant
Hemiparesis Other Serious 12 Female 10/20/2009 Other Health Professional Poland
Primary
Secondary
Overdose Hospitalization 1/15/2009 61 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Overdose Hospitalization 61 Male 11/5/2009 United Kingdom
Primary
Secondary
Concomitant
Overdose Death 45 Female 11/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multiple Drug Overdose Death 45 Female 11/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
No Adverse Event 8/8/2009 Female 62 lb 12/3/2009 Other Health Professional Brazil
Primary
Concomitant
Somnolence Other Serious 10/29/2006 58 Male 11/30/2009 Physician Germany
Primary
Concomitant
Interacting
Multiple Drug Overdose Death 45 Female 12/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Multiple Drug Overdose Death 45 Female 12/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Multiple Drug Overdose Death 45 Female 12/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Fluid Retention Other Serious Female 161 lb 1/5/2010 Physician Spain
Primary
Concomitant
Drug Dose Omission Other Serious 44 Female 1/7/2010 Consumer United States
Primary
Concomitant
No Therapeutic Response Hospitalization 9 Male 1/21/2010 Physician United States
Primary
Concomitant
Multiple Drug Overdose Death 45 Female 1/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Prostatic Disorder Other Serious Male 2/8/2010 Consumer United Kingdom
Primary
Concomitant
Multiple Drug Overdose Death 9/27/2003 Male 182 lb 2/28/2010 Physician United States
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 3/23/2010 Other Health Professional Germany
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 3/26/2010 Other Health Professional Germany
Primary
Secondary
Weight Increased Other Serious 1/1/2010 40 Female 4/23/2010 Consumer Brazil
Primary
Concomitant
Respiratory Failure Death Male 4/26/2010 Physician United Kingdom
Primary
Concomitant
Somatoform Disorder Other Serious 42 Male 6/3/2010 Physician United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 10/24/2008 15 Male 6/22/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 7/1/2010 40 Female 198 lb 7/9/2010 Physician Germany
Primary
Secondary
Neuroleptic Malignant Syndrome Hospitalization 36 Male 7/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Sedation Other Serious 6/14/2010 45 Female 7/27/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 4 Female 8/2/2010
Primary
Secondary
Pancreatitis Acute Hospitalization 10/24/2008 15 Male 8/4/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/30/2010 44 Male 8/24/2010 Pharmacist Denmark
Primary
Secondary
Concomitant
Subacute Endocarditis Other Serious 4/30/2010 44 Male 9/22/2010 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/30/2010 44 Male 9/22/2010 Physician Denmark
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Life Threatening 39 Female 10/12/2010
Primary
Secondary
Neuroleptic Malignant Syndrome Other Serious 36 Male 11/1/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Concomitant
Interacting
Neuroleptic Malignant Syndrome Hospitalization 36 Male 11/9/2010
Primary
Secondary
Trismus Other Serious 36 Male 11/10/2010 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Concomitant
Overdose Death 45 Female 11/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Overdose Death 23 Female 12/16/2010 Other Health Professional Australia
Primary
Secondary
Overdose Death 23 Female 12/20/2010 Physician Australia
Primary
Secondary
Drug Interaction Death 23 Female 12/27/2010 Other Health Professional Australia
Primary
Concomitant
Interacting
Overdose Death 23 Female 12/28/2010 Physician Australia
Primary
Secondary
Overdose Death 23 Female 1/14/2011 Physician Australia
Primary
Secondary
Anxiety Hospitalization 3/26/2009 35 Male 2/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Other Serious 4/30/2010 44 Male 2/27/2011 Physician Denmark
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 3/26/2009 35 Male 3/15/2011 Pharmacist United Kingdom
Primary
Concomitant
Hypertension Hospitalization 3/26/2009 35 Male 3/23/2011 Physician United Kingdom
Primary
Concomitant
Optic Neuropathy Disability Male 3/16/2011 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/26/2009 35 Male 3/29/2011 Pharmacist United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 3/26/2009 35 Male 4/15/2011 Physician United Kingdom
Primary
Concomitant
Bone Marrow Disorder Other Serious Male 4/5/2011 Physician Ireland
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 42 Female 4/14/2011 Physician Korea, Republic Of
Primary
Concomitant
Drug Interaction Other Serious 36 Female 4/21/2011 Physician France
Primary
Interacting
Hyperammonaemia Other Serious 4/29/2011 Australia
Primary
Secondary
Hemiparesis Disability 29 Male 4/29/2011 Other Health Professional Australia
Primary
Secondary
Mental Disorder Other Serious 4/1/2011 39 5/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Interaction Death 23 Female 5/9/2011 Other Health Professional Australia
Primary
Secondary
Interacting
Respiratory Depression Disability 29 Male 5/12/2011 Other Health Professional Australia
Primary
Secondary
Cerebral Infarction Disability 29 Male 5/12/2011 Other Health Professional Australia
Primary
Secondary
Gaze Palsy Hospitalization 29 Male 5/16/2011 Other Health Professional Australia
Primary
Secondary
Tooth Infection Other Serious 42 Male 5/19/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 29 Male 5/20/2011 Other Health Professional Australia
Primary
Secondary
Hypercholesterolaemia Other Serious Male 228 lb 5/23/2011 Physician Canada
Primary
Concomitant
Hemiparesis Hospitalization 1/1/2011 29 Male 5/20/2011 Other Health Professional Australia
Primary
Secondary
Balance Disorder Death Female 6/5/2011 Ireland
Primary
Concomitant
Obesity Death 1/18/2008 49 Male 6/4/2011 Physician United Kingdom
Primary
Concomitant
Cerebral Infarction Hospitalization 29 Male 6/2/2011 Other Health Professional Australia
Primary
Secondary
Platelet Count Decreased Hospitalization 3/26/2009 35 Male 6/13/2011 Physician United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 4/11/2011 53 Female 212 lb 6/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Dyspnoea Hospitalization 4/11/2011 53 Female 212 lb 6/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fall Other Serious Female 6/10/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Medication Error Other Serious 1/24/2011 26 Female 6/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 4/11/2011 53 Female 6/20/2011 Physician Denmark
Primary
Secondary
Concomitant
Hyperventilation Hospitalization 4/11/2011 53 Female 212 lb 6/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Fall Other Serious 12/22/2010 47 Female 6/27/2011 Physician Ireland
Primary
Concomitant
Gastrointestinal Hypomotility Hospitalization 39 Female 6/21/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 4/11/2011 53 Female 212 lb 7/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Clumsiness Other Serious 51 Female 191 lb 6/24/2011 Lawyer United States
Primary
Concomitant

Drug Data