Diazepam combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rash Other Serious 9/19/2005 54 Female 150 lb 1/17/2006 Consumer Portugal
Primary
Concomitant
Aneurysm Death 43 Male 1/11/2006 United States
Primary
Concomitant
Quadriparesis Other Serious 1/1/2005 47 Female 1/25/2006 Turkey
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Female 2/9/2006 United Kingdom
Primary
Concomitant
Sedation Hospitalization 1/1/2005 Male 2/11/2006 Other Health Professional Australia
Primary
Concomitant
Jaundice Life Threatening 2/10/2006 Male 205 lb 3/22/2006 Physician Germany
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 3/13/2006 Female 132 lb 3/23/2006 Physician Brazil
Primary
Secondary
Stevens-johnson Syndrome Other Serious 3/12/2006 11 Male 3/27/2006 Physician Romania
Primary
Concomitant
Ventricular Tachycardia Hospitalization 6/30/2004 48 Male 3/17/2006
Primary
Secondary
Concomitant
Somnolence Other Serious 1/1/1994 32 Female 121 lb 3/29/2006 Physician Germany
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 10/8/2005 25 Female 3/31/2006 Physician Germany
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Other Serious 32 Male 4/6/2006 Japan
Primary
Concomitant
Treatment Noncompliance Hospitalization 1/31/2006 Male 4/10/2006 Physician France
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Other Serious 32 Male 4/12/2006 Japan
Primary
Concomitant
Pancreatitis Other Serious 14 Female 4/19/2006 Physician Spain
Primary
Concomitant
Sinus Tachycardia Other Serious 3/3/2006 30 Female 6/4/2006 Physician Ireland
Primary
Concomitant
Pyrexia Hospitalization 4/26/2006 46 Male 121 lb 6/20/2006 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 4/26/2006 46 Male 121 lb 7/5/2006 Physician Japan
Primary
Concomitant
Conversion Disorder Other Serious 3/25/2006 58 Female 198 lb 7/3/2006 Physician United Kingdom
Primary
Concomitant
Granulocytopenia Required Intervention 8/2/2005 56 Male 244 lb 1/11/2006 Consumer United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 3/25/2006 58 Female 198 lb 7/27/2006 Physician United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 1/13/2005 Male 8/14/2006 Physician Japan
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 11/28/2005 50 Female 2/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/30/2006 43 Male 118 lb 5/15/2006 Consumer United States
Primary
Concomitant
Status Epilepticus Death 1 Female 8/29/2006 Germany
Primary
Concomitant
Sudden Death Death 8/24/2006 43 Female 9/8/2006 Physician Czech Republic
Primary
Concomitant
Respiratory Failure Hospitalization 1/13/2005 Male 10/9/2006 Physician Japan
Primary
Secondary
Concomitant
Dyspnoea Other Serious 3/29/2006 60 Female 10/25/2006 Physician United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 3/29/2006 60 Female 11/5/2006 Physician United Kingdom
Primary
Concomitant
Neutropenia Hospitalization 8/31/2006 44 Female 11/17/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/27/2005 3 Male 29 lb 12/14/2006 Physician Japan
Primary
Concomitant
Mydriasis Hospitalization 39 Female 1/4/2007 Consumer Ireland
Primary
Secondary
Drug Ineffective Hospitalization 5/31/2006 28 Male 214 lb 1/23/2007 Physician Germany
Primary
Secondary
Concomitant
Lactic Acidosis Death 1 Female 1/23/2007 Germany
Primary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 12/4/2006 21 Male 2/5/2007 Physician United Kingdom
Primary
Concomitant
Interacting
Neuroleptic Malignant Syndrome Other Serious 12/4/2006 21 Male 2/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Nephrolithiasis Hospitalization 8/11/2006 5 Female 1/29/2007 Physician Japan
Primary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/7/2007 32 Male 183 lb 3/10/2007 Physician United Kingdom
Primary
Concomitant
Sedation Other Serious 1/1/2006 63 Male 3/22/2007 Physician Germany
Primary
Concomitant
Sedation Other Serious 1/1/2006 63 Male 3/29/2007 Physician Germany
Primary
Concomitant
Nasopharyngitis Other Serious 12/1/2006 Female 4/2/2007 Physician Japan
Primary
Concomitant
Speech Disorder Hospitalization 11/1/2006 43 Female 179 lb 4/9/2007 Physician United Kingdom
Primary
Concomitant
Mania Hospitalization 12/11/2006 Male 119 lb 5/1/2007 Physician Malaysia
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 4/17/2007 Male 5/2/2007 Physician Japan
Primary
Concomitant
Ventricular Dysfunction Death 36 Female 6/14/2007 Physician United States
Primary
Concomitant
Respiratory Arrest Other Serious 6/21/2003 32 Male 6/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Cardio-respiratory Arrest Death 4/17/2007 Male 6/25/2007 Physician Japan
Primary
Concomitant
Sudden Death Death 4/5/2005 2 Female 22 lb 6/20/2007 Physician Japan
Primary
Concomitant
Neutropenia Hospitalization 2/26/2007 57 Female 6/29/2007 Other Health Professional Germany
Primary
Concomitant
Cardio-respiratory Arrest Death 4/17/2007 Male 6/29/2007 Physician Japan
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 Female 26 lb 6/29/2007 Physician Japan
Primary
Concomitant
Tremor Other Serious 67 Female 7/24/2007
Primary
Secondary
Weight Decreased Hospitalization 11/4/2005 Male 7/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Mania Hospitalization 12/11/2006 Male 119 lb 8/6/2007 Physician Malaysia
Primary
Concomitant
Suicide Attempt 8/19/2003 27 Female 8/9/2007 Australia
Primary
Concomitant
Neck Pain Hospitalization 6/29/2007 58 Female 8/10/2007 Canada
Primary
Concomitant
Transient Hypogammaglobulinaemia Of Infancy Other Serious 3 Male 8/28/2007
Primary
Secondary
White Blood Cell Count Increased Life Threatening 34 Male 9/4/2007 Other Health Professional Singapore
Primary
Concomitant
Somnolence Hospitalization 22 Female 9/8/2007 Japan
Primary
Concomitant
Clavicle Fracture Hospitalization 12/21/2006 Male 130 lb 9/14/2007 United Kingdom
Primary
Concomitant
Somnolence Hospitalization 22 Female 9/20/2007 Japan
Primary
Concomitant
Respiratory Tract Infection Hospitalization 11/22/2006 Male 9/23/2007 Physician Japan
Primary
Concomitant
Necrotising Colitis Life Threatening 34 Male 9/21/2007 Physician Singapore
Primary
Concomitant
Necrosis Ischaemic Life Threatening 34 Male 9/14/2007 Physician Singapore
Primary
Concomitant
Hypogammaglobulinaemia Required Intervention 3 Male 9/26/2007 Japan
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 10/9/2007 Female 10/15/2007 Pharmacist United Kingdom
Primary
Concomitant
Neck Pain Hospitalization 6/29/2007 58 Female 10/17/2007 Canada
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 10/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Other Serious 9/19/2006 50 Female 10/25/2007 Physician Germany
Primary
Secondary
Concomitant
Tremor Other Serious 10/9/2007 Female 11/16/2007 Pharmacist United Kingdom
Primary
Concomitant
Tremor Hospitalization 10/9/2007 Female 11/15/2007 United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 10/9/2007 Female 11/28/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Somnolence Other Serious 9/19/2006 50 Female 173 lb 11/26/2007 Germany
Primary
Secondary
Concomitant
Tremor Other Serious 10/9/2007 Female 12/7/2007 Pharmacist United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Other Serious 15 Female 12/18/2007 Other Health Professional Greece
Primary
Concomitant
Interacting
Upper Respiratory Tract Inflammation Hospitalization 11/16/2006 Female 12/21/2007 Physician Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 4/1/2007 Female 1/24/2008 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 2/1/2008 Consumer Germany
Primary
Secondary
Thrombocytopenia Other Serious 1/29/2008 50 Female 2/4/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/11/2007 Female 2/6/2008 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 77 Female 1/25/2008 Physician Germany
Primary
Secondary
Syncope Hospitalization 11/23/2007 56 Male 2/11/2008 Other Health Professional Australia
Primary
Concomitant
Weight Increased Other Serious 44 Female 2/29/2008 France
Primary
Secondary
Tachycardia Other Serious 2/15/2008 36 Female 110 lb 3/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 36 Female 3/19/2008 Other Health Professional France
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 2/1/1999 Female 3/26/2008 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 26 lb 3/26/2008 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 2/13/2008 Other Health Professional Germany
Primary
Secondary
Suicidal Ideation Other Serious 2/1/1999 Female 4/11/2008 Physician United Kingdom
Primary
Concomitant
Femoral Neck Fracture Hospitalization 11/10/2006 5 Male 33 lb 4/8/2008 Physician Japan
Primary
Concomitant
Tachycardia Hospitalization 5/6/2008 45 Female 143 lb 5/9/2008 Physician Germany
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 19 Male 5/30/2008 Hong Kong
Primary
Concomitant
Weight Increased Other Serious 44 Female 6/5/2008 France
Primary
Secondary
Weight Increased Other Serious 44 Female 6/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Unevaluable Event Other Serious Male 6/6/2008 Lawyer Norway
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/2/2000 51 Female 6/18/2008 United Kingdom
Primary
Concomitant
Hospitalisation Hospitalization 12/26/2007 37 Male 6/20/2008 Physician Germany
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/1/2007 Female 7/11/2008 Physician United Kingdom
Primary
Concomitant
Hospitalisation Hospitalization 1/1/2008 Female 165 lb 7/8/2008 Physician Romania
Primary
Concomitant
Serotonin Syndrome Other Serious 44 Male 7/9/2008 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Obstruction Hospitalization 1/1/1991 47 Male 7/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachycardia Other Serious 5/6/2008 45 Female 143 lb 7/30/2008 Physician Germany
Primary
Secondary
Tearfulness Hospitalization 12/26/2007 37 Male 7/31/2008 Physician Germany
Primary
Concomitant
Overdose Other Serious 6/18/2008 Female 8/4/2008 Physician Australia
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 3/12/2008 Male 8/26/2008 Physician United States
Primary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 9/5/2008 Physician United Kingdom
Primary
Secondary
Generalised Anxiety Disorder Death 6/7/2008 31 Female 122 lb 9/11/2008 Physician United Kingdom
Primary
Secondary
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 9/4/2008 Physician United Kingdom
Primary
Concomitant
Sudden Cardiac Death Death 6/7/2008 31 Female 9/19/2008 Other Health Professional France
Primary
Secondary
Femoral Neck Fracture Hospitalization 11/10/2006 5 Male 33 lb 9/19/2008 Physician Japan
Primary
Concomitant
Cardiac Arrest Death 39 Male 9/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/23/2008 United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/23/2008 United Kingdom
Primary
Secondary
Concomitant
Intentional Overdose Hospitalization 11/16/2007 Female 126 lb 10/2/2008 United Kingdom
Primary
Secondary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 10/1/2008 Physician United Kingdom
Primary
Concomitant
Generalised Anxiety Disorder Other Serious 6/7/2008 31 Female 122 lb 10/3/2008 Physician United Kingdom
Primary
Secondary
Generalised Anxiety Disorder Death 6/7/2008 31 Female 122 lb 10/7/2008 Physician United Kingdom
Primary
Secondary
Urticaria Hospitalization 10/18/2007 Female 10/1/2008 Physician Australia
Primary
Concomitant
Femoral Neck Fracture Hospitalization 11/10/2006 5 Male 33 lb 10/27/2008 Physician Japan
Primary
Concomitant
Dementia Other Serious 35 Male 11/5/2008 Pharmacist France
Primary
Concomitant
Pleurothotonus Other Serious 2/6/2008 53 Female 11/18/2008 Physician Germany
Primary
Secondary
Concomitant
Intentional Self-injury Hospitalization 9/28/2008 29 Female 11/26/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Cardiac Death Death 6/7/2008 31 Female 12/4/2008 Other Health Professional France
Primary
Secondary
Pleurothotonus Hospitalization 2/12/2008 53 Female 12/29/2008 Physician Germany
Primary
Secondary
Liver Function Test Abnormal Hospitalization 5/2/2008 55 Female 12/29/2008 Physician Germany
Primary
Secondary
White Blood Cell Count Decreased Other Serious Female 1/7/2009 Pharmacist United Kingdom
Primary
Concomitant
Upper Respiratory Tract Inflammation Life Threatening 11/2/2008 0 Male 18 lb 1/5/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 38 Male 1/13/2009 Other Health Professional Hong Kong
Primary
Concomitant
Upper Respiratory Tract Inflammation Life Threatening 11/2/2006 0 Male 18 lb 1/22/2009 Physician Japan
Primary
Concomitant
Overdose Hospitalization 1/13/2009 Male 2/2/2009 Physician United Kingdom
Primary
Secondary
Status Epilepticus Death 12/27/2008 7 Female 37 lb 2/3/2009 Physician Japan
Primary
Concomitant
Status Epilepticus Death 7 Female 37 lb 2/6/2009 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/2/2009 Male 2/19/2009 Physician United Kingdom
Primary
Concomitant
Pyrexia Death 7 Female 37 lb 2/23/2009 Physician Japan
Primary
Concomitant
Drug Level Decreased 3/4/2009 Physician United States
Primary
Interacting
Neutropenia Other Serious 2/2/2009 15 Female 161 lb 2/25/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Female 3/27/2009 Physician United Kingdom
Primary
Concomitant
Pleurothotonus Hospitalization 2/12/2008 52 Female 3/31/2009 Physician Germany
Primary
Secondary
Spinal Compression Fracture Hospitalization 2/3/2009 Male 198 lb 4/8/2009 Physician Australia
Primary
Concomitant
Speech Disorder Other Serious 37 Male 4/29/2009 Physician Ireland
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 12 Female 5/12/2009
Primary
Secondary
Concomitant
Wheezing Other Serious 3/2/2009 Male 5/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 5/19/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 5/25/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 6/16/2009 Physician United Kingdom
Primary
Concomitant
Status Epilepticus Death 81 Female 6/12/2009 Physician Germany
Primary
Secondary
Overdose Hospitalization 1/15/2009 Male 7/1/2009 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data