Depakote combined with Metformin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Arrest Death 40 Female 2/7/2006 Pharmacist United States
Primary
Secondary
Photosensitivity Reaction 6/1/2005 48 Male 267 lb 2/28/2006 Consumer United States
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 11/1/2004 39 Female 12/20/2004 Other Health Professional United States
Primary
Concomitant
Cardiomyopathy Hospitalization 3/17/2006 45 Male 192 lb 3/31/2006 Pharmacist United States
Primary
Concomitant
Sepsis Life Threatening 3/24/2006 22 Male 287 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Other Serious 3/12/2005 61 Male 193 lb 3/15/2006 Pharmacist United States
Primary
Secondary
Concomitant
Blood Glucose Increased 58 Male 7/21/2006 Consumer United States
Primary
Secondary
Concomitant
Walking Disability Hospitalization 5/1/2006 74 Female 7/3/2006 Pharmacist United Kingdom
Primary
Concomitant
Movement Disorder Hospitalization 6/1/2006 68 Female 236 lb 7/27/2006 Consumer United States
Primary
Concomitant
Ocular Hyperaemia Other Serious 10/9/2006 Male 200 lb 10/27/2006 Physician United States
Primary
Concomitant
Hyperglycaemia Hospitalization Female 154 lb 11/16/2006 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 10/20/2006 Male 231 lb 2/19/2007 Pharmacist France
Primary
Concomitant
Weight Decreased 10/1/2005 49 Male 199 lb 10/16/2006 Consumer United States
Primary
Concomitant
Rash Pruritic Other Serious 2/1/2007 58 Female 183 lb 3/1/2007 Other Health Professional United States
Primary
Concomitant
Malaise Other Serious 6/12/2007 40 Male 9/10/2007 United Kingdom
Primary
Secondary
Concomitant
Hemianopia Homonymous Other Serious 4/17/2007 Female 9/11/2007 Physician United States
Primary
Concomitant
Treatment Noncompliance Disability 1/27/2007 50 Male 274 lb 10/25/2007 Consumer United States
Primary
Concomitant
Arthralgia 9/28/2007 40 Female 2/15/2008 United States
Primary
Concomitant
Depression Other Serious 4/1/2008 Female 180 lb 6/20/2008 United States
Primary
Concomitant
Weight Increased Other Serious 1/1/1994 Male 7/24/2008 Consumer United States
Primary
Concomitant
Somnolence Hospitalization 4/1/2007 Male 215 lb 7/24/2008 Consumer United States
Primary
Secondary
Concomitant
Unevaluable Event Other Serious 7/1/2008 Male 210 lb 8/25/2008 Consumer United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 44 Male 230 lb 10/15/2008 United States
Primary
Concomitant
Renal Failure Other Serious 1/15/2009 Physician United States
Primary
Secondary
Syncope Hospitalization Female 2/27/2009 Consumer United States
Primary
Concomitant
Sepsis Hospitalization 3/11/2009 62 Male 179 lb 3/18/2009 Pharmacist United States
Primary
Concomitant
Oedema Peripheral Other Serious 3/3/2009 60 Female 3/23/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 44 Male 230 lb 3/25/2009 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 2/11/2009 Female 173 lb 3/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 6/11/2004 53 Male 204 lb 4/1/2009 United States
Primary
Secondary
Concomitant
Tooth Abscess Other Serious 11/19/2001 42 Male 210 lb 4/13/2009 United States
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 9/21/1999 26 Female 210 lb 4/13/2009 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 3/28/2009 Male 4/23/2009 United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 3/28/2009 Male 174 lb 5/7/2009 Physician United States
Primary
Concomitant
Diabetic Neuropathy Other Serious 9/26/2001 45 Female 6/2/2009 United States
Primary
Concomitant
Diabetic Neuropathy Other Serious 1/1/1995 40 Male 193 lb 6/11/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 45 Male 224 lb 6/25/2009 United States
Primary
Concomitant
Weight Increased Other Serious 5/2/2001 40 Female 321 lb 6/29/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 2/28/2006 44 Female 7/1/2009 Consumer United States
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 1/1/1999 39 Male 258 lb 7/30/2009 United States
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 12/18/2008 Male 7/31/2009 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2001 44 Female 269 lb 8/5/2009 United States
Primary
Concomitant
Tardive Dyskinesia Other Serious 1/1/2004 51 Male 305 lb 8/5/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 7/16/2002 47 Male 212 lb 8/6/2009 United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/7/2004 36 Female 229 lb 8/12/2009 United States
Primary
Concomitant
Vision Blurred Other Serious 6/20/2000 42 Male 285 lb 8/13/2009 United States
Primary
Concomitant
Gastric Ulcer Other Serious 1/1/2009 50 Female 317 lb 8/17/2009 Consumer United States
Primary
Concomitant
Headache Female 8/19/2009 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 8/7/2009 Female 245 lb 9/24/2009 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 8/7/2009 Female 245 lb 10/28/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 11/2/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 Male 11/6/2009 Physician United States
Primary
Concomitant
Myalgia 8/1/2009 68 Male 190 lb 12/9/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 41 Male 12/30/2009 United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 1/25/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Male 206 lb 1/26/2010 Physician United States
Primary
Concomitant
Ventricular Hypokinesia Other Serious 62 Male 229 lb 1/22/2010 United States
Primary
Concomitant
Vocal Cord Polyp Other Serious 2/17/2004 57 Female 192 lb 4/23/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 29 Female 274 lb 6/3/2010 United States
Primary
Concomitant
Respiratory Arrest Death 12/19/2009 39 Male 5/31/2010 Other Health Professional United States
Primary
Concomitant
Somnolence 3/10/2007 42 Male 225 lb 7/12/2010 Consumer United States
Primary
Concomitant
Nausea 5/1/2007 60 Female 211 lb 7/13/2010 Consumer United States
Primary
Concomitant
Tardive Dyskinesia Other Serious 1/1/2006 48 Female 198 lb 7/14/2010 United States
Primary
Concomitant
Nausea 8/7/2007 55 Female 245 lb 7/15/2010 Consumer United States
Primary
Concomitant
Inappropriate Schedule Of Drug Administration Hospitalization 1/1/2010 Male 200 lb 7/19/2010 Other Health Professional United States
Primary
Concomitant
Psychiatric Symptom Hospitalization 6/1/2010 42 Male 200 lb 8/18/2010 Other Health Professional United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2002 55 Female 185 lb 8/25/2010 United States
Primary
Concomitant
Pruritus 10/1/2009 68 Male 8/27/2010 Consumer United States
Primary
Concomitant
Flushing 10/22/2009 65 Male 210 lb 8/28/2010 United States
Primary
Concomitant
Flushing 3/1/2010 51 Male 8/29/2010 Consumer United States
Primary
Concomitant
Tremor Hospitalization 1/30/2003 55 Female 198 lb 9/3/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 10/11/2006 46 Male 249 lb 9/9/2010 Consumer United States
Primary
Secondary
Concomitant
Interacting
Therapeutic Agent Toxicity 2/26/2010 25 Female 3/16/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious Male 249 lb 9/14/2010 Consumer United States
Primary
Concomitant
Tardive Dyskinesia Other Serious 10/1/2000 40 Male 279 lb 9/17/2010 United States
Primary
Concomitant
Visual Impairment Other Serious 1/26/2005 32 Female 175 lb 9/17/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 7/16/2002 34 Male 243 lb 9/17/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 1/1/2003 43 Female 98 lb 9/17/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 7/16/2005 49 Female 330 lb 9/20/2010 United States
Primary
Concomitant
Suicidal Ideation Other Serious 1/1/2000 41 Female 230 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 10/30/2007 55 Female 162 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 1/1/2004 59 Female 294 lb 9/20/2010 United States
Primary
Concomitant
Therapeutic Response Unexpected 56 Male 186 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 60 Female 150 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 11/1/2005 52 Male 255 lb 9/20/2010 United States
Primary
Secondary
Concomitant
Restlessness Hospitalization 7/17/2010 59 Male 287 lb 9/8/2010 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 10/24/2005 43 Male 299 lb 9/20/2010 United States
Primary
Concomitant
Weight Increased 1/1/1997 55 Female 180 lb 9/20/2010 United States
Primary
Secondary
Concomitant
Weight Increased 1/31/2003 31 Male 393 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 2/6/2004 41 Male 181 lb 9/21/2010 United States
Primary
Concomitant
Wound Other Serious 1/31/2003 31 Male 160 lb 9/21/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 10/11/2006 46 Male 249 lb 9/21/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 249 lb 9/28/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 49 Male 10/5/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 296 lb 10/6/2010 United States
Primary
Concomitant
Sepsis Other Serious 1/1/2007 49 Male 10/13/2010 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 30 Male 10/18/2010 Physician United States
Primary
Concomitant
Drug Ineffective 5/1/2010 21 Male 298 lb 10/29/2010 Consumer United States
Primary
Concomitant
Tremor Other Serious 1/1/2010 47 Male 220 lb 11/1/2010 Consumer United States
Primary
Concomitant
Confusional State Hospitalization 7/21/2009 65 Male 255 lb 11/12/2010 Consumer United States
Primary
Secondary
Concomitant
Nausea Female 167 lb 11/16/2010 Physician United States
Primary
Concomitant
Tremor Other Serious 6/10/2010 49 Female 324 lb 10/28/2010 Consumer United States
Primary
Secondary
Concomitant
Verbal Abuse Other Serious Female 11/29/2010 Consumer Brazil
Primary
Concomitant
Tremor Hospitalization 4/11/2009 54 Male 165 lb 12/7/2010 Consumer United States
Primary
Secondary
Concomitant
Tremor Other Serious 1/1/2010 47 Male 220 lb 12/9/2010 Consumer United States
Primary
Concomitant
Myocardial Ischaemia Death 12/30/2008 84 Female 12/20/2010 Pharmacist United States
Primary
Concomitant
Abscess Other Serious 6/19/2003 38 Male 220 lb 1/21/2011 Lawyer United States
Primary
Concomitant
Contusion 11/15/2010 56 Female 242 lb 1/30/2011 Consumer United States
Primary
Concomitant
Dysgeusia Other Serious 12/1/2010 43 Female 137 lb 2/7/2011 Consumer Brazil
Primary
Concomitant
Rash 2/28/2006 36 Female 229 lb 3/23/2006 Pharmacist United States
Primary
Concomitant
Multiple Sclerosis Relapse Hospitalization 11/1/2010 33 Male 245 lb 2/18/2011 Consumer United States
Primary
Concomitant
Convulsion Disability 78 Female 1/13/2011 Physician Puerto Rico
Primary
Concomitant
Venous Insufficiency Death 10/7/2002 40 Female 349 lb 2/25/2011 United States
Primary
Concomitant
Cholelithiasis Other Serious 5/2/2001 40 Female 321 lb 3/1/2011 Lawyer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 7/26/1999 49 Female 274 lb 3/2/2011 United States
Primary
Concomitant
Tachycardia Hospitalization 1/1/2011 51 Male 212 lb 3/30/2011 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2007 50 Male 206 lb 4/12/2011 Physician United States
Primary
Concomitant
Pancytopenia Hospitalization 1/1/2011 51 Male 212 lb 4/20/2011 Consumer United States
Primary
Secondary
Concomitant
Conversion Disorder Hospitalization 45 Male 267 lb 4/27/2011 Physician United States
Primary
Secondary
Concomitant
Arthralgia Hospitalization 1/1/2007 55 Female 5/9/2011 United States
Primary
Concomitant
Restless Legs Syndrome Other Serious 55 Female 265 lb 7/21/2011 Consumer United States
Primary
Concomitant
Mental Disorder Other Serious 1/1/2008 42 Male 8/10/2011 Lawyer United States
Primary
Concomitant
Arthralgia 7/16/2005 49 Female 330 lb 9/22/2011 Other Health Professional United States
Primary
Concomitant
Diabetic Complication 12/30/2005 43 Male 189 lb 9/22/2011 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 9/13/2001 44 Male 220 lb 9/22/2011 Consumer United States
Primary
Concomitant
Pain Death 8/1/2005 42 Female 257 lb 9/22/2011 Lawyer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 4/20/2004 49 Female 220 lb 9/22/2011 Consumer United States
Primary
Concomitant
Drug Dose Omission 56 Male 198 lb 9/22/2011 United States
Primary
Concomitant
Tonsillar Disorder 1/1/2000 32 Female 243 lb 9/22/2011 Lawyer United States
Primary
Concomitant
Dermal Cyst 1/1/2001 35 Female 195 lb 9/22/2011 Other Health Professional United States
Primary
Concomitant
Panic Attack 36 Female 363 lb 11/1/2011 Other Health Professional United States
Primary
Concomitant
Dyspepsia Other Serious 25 Female 280 lb 11/23/2011 Lawyer United States
Primary
Secondary
Concomitant
Rash Other Serious 1/1/2009 51 Male 235 lb 1/17/2012 Consumer United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/22/2011 68 Male 200 lb 1/23/2012 Physician United States
Primary
Concomitant
Stress Disability Female 280 lb 5/1/2012 Consumer United States
Primary
Concomitant
Increased Appetite 7/1/2012 38 Female 215 lb 8/3/2012 Consumer United States
Primary
Secondary
Concomitant
Abdominal Distension 7/1/2012 39 Female 215 lb 8/8/2012 Consumer United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Death 4/19/2012 54 Male 8/23/2012 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 9/11/2006 49 Female 161 lb 9/21/2012 Other Health Professional Us
Primary
Concomitant
Vomiting Hospitalization 2004 66 Female 210 lb 9/5/2012 Us
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 4/19/2012 55 Male 11/30/2012 Physician Gb
Primary
Concomitant
Hypercalcaemia Life Threatening 9/2/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Somnolence Life Threatening 5/20/2012 53 Female 261 lb 9/11/2012 Consumer Us
Primary
Secondary
Concomitant
Restlessness Hospitalization 9/17/2012 Other Health Professional Us
Primary
Concomitant
Sinus Tachycardia 61 Male 9/28/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Upper Limb Fracture Other Serious Female 10/11/2012 Physician Us
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/12/2012 43 Female 10/16/2012 Physician Us
Primary
Secondary
Concomitant
Mania Other Serious 9/24/2012 65 Female 152 lb 11/27/2012 Consumer De
Primary
Concomitant
Off Label Use Other Serious 2011 Female 11/15/2012 Consumer Us
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/29/2012 64 Female 248 lb 11/29/2012 Other Health Professional Gb
Primary
Secondary
Concomitant

Drug Data