Dabrafenib combined with Trametinib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Chorioretinopathy Other Serious 1/10/2013 Female 2/26/2013 Other Health Professional Es
Primary
Secondary
Ejection Fraction Decreased Other Serious 5/10/2013 31 Male 203 lb 6/11/2013 Physician Au
Primary
Secondary
Pyrexia Other Serious 4/19/2013 66 Male 186 lb 6/4/2013 Physician Us
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Hospitalization 4/19/2013 66 Male 186 lb 6/4/2013 Physician Us
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 3/29/2013 66 Male 143 lb 7/30/2013 Physician Ch
Primary
Secondary
Influenza Like Illness Hospitalization 4/22/2013 47 Male 186 lb 6/4/2013 Physician Ch
Primary
Secondary
Confusional State Hospitalization 5/3/2013 75 Female 119 lb 9/16/2013 Physician Fr
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 5/28/2013 42 Female 146 lb 8/27/2013 Physician Nl
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 5/24/2013 66 Female 122 lb 8/19/2013 Physician Us
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/1/2013 62 Female 230 lb 7/26/2013 Physician Au
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 10/17/2012 87 Female 123 lb 6/6/2013 Physician Fr
Primary
Secondary
Pyrexia Hospitalization 6/1/2013 64 Female 115 lb 6/6/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/16/2013 65 Male 183 lb 6/6/2013 Physician Nl
Primary
Secondary
Nausea Hospitalization 1/16/2013 78 Female 139 lb 6/6/2013 Physician Au
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 2/6/2013 65 Female 161 lb 6/6/2013 Physician Es
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 5/20/2013 70 Male 149 lb 9/30/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 2/2/2013 27 Male 181 lb 7/22/2013 Physician Au
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 3/18/2013 56 Female 200 lb 6/6/2013 Physician Nz
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/22/2013 64 Female 143 lb 6/10/2013 Physician De
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/2/2013 47 Female 109 lb 10/14/2013 Physician Au
Primary
Secondary
Hypertransaminasaemia Other Serious 4/1/2013 53 Female 122 lb 6/14/2013 Physician Es
Primary
Secondary
Pyrexia Hospitalization 4/16/2013 63 Female 179 lb 6/6/2013 Physician De
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 5/28/2013 43 Male 174 lb 6/14/2013 Physician Kr
Primary
Secondary
Vomiting Hospitalization 3/26/2013 72 Female 119 lb 8/5/2013 Physician Nl
Primary
Secondary
Concomitant
Sepsis Hospitalization 5/13/2013 38 Male 197 lb 6/5/2013 Physician De
Primary
Secondary
Pyrexia Hospitalization 2/28/2013 60 Male 234 lb 10/28/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 1/29/2013 63 Male 187 lb 6/7/2013 Physician Gb
Primary
Secondary
Pyrexia Hospitalization 3/22/2013 36 Female 141 lb 6/7/2013 Physician Fr
Primary
Secondary
Hepatic Encephalopathy Hospitalization 4/25/2013 30 Female 142 lb 8/8/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 6/1/2013 55 Female 187 lb 10/23/2013 Physician Ca
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/1/2013 40 Male 175 lb 6/7/2013 Physician Fi
Primary
Secondary
Pneumonia Hospitalization 6/3/2013 70 Male 232 lb 8/14/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 4/24/2013 70 Female 218 lb 6/14/2013 Physician Nl
Primary
Secondary
Concomitant
Hypercreatinaemia Hospitalization 5/7/2013 50 Male 190 lb 6/26/2013 Physician It
Primary
Secondary
Renal Failure Hospitalization 4/29/2013 76 Male 165 lb 6/10/2013 Physician De
Primary
Secondary
Pyrexia Other Serious 5/25/2013 42 Female 152 lb 6/10/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 5/29/2013 39 Female 258 lb 7/9/2013 Physician De
Primary
Secondary
Concomitant
Urosepsis Hospitalization 4/28/2013 53 Female 140 lb 6/20/2013 Physician Au
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 6/1/2013 53 Female 140 lb 8/2/2013 Physician Au
Primary
Secondary
Concomitant
Sepsis Hospitalization 11/18/2012 62 Female 119 lb 6/12/2013 Physician Fr
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 1/10/2013 56 Male 227 lb 6/12/2013 Physician Au
Primary
Secondary
Thrombocytopenia Hospitalization 1/20/2013 78 Female 139 lb 6/12/2013 Physician Au
Primary
Secondary
Pyrexia Other Serious 2/4/2013 58 Male 287 lb 9/26/2013 Physician Us
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 6/5/2013 70 Female 218 lb 6/17/2013 Physician Nl
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 5/6/2013 74 Female 106 lb 9/4/2013 Physician De
Primary
Secondary
Squamous Cell Carcinoma Other Serious 4/4/2013 70 Male 8/8/2013 Physician Us
Primary
Secondary
Ejection Fraction Decreased Other Serious 2/27/2013 62 Male 202 lb 6/13/2013 Physician Ca
Primary
Secondary
Pyrexia Hospitalization 4/21/2013 70 Female 132 lb 6/13/2013 Physician Fr
Primary
Secondary
Chorioretinopathy Other Serious 4/2/2013 57 Male 260 lb 10/28/2013 Physician At
Primary
Secondary
Pyrexia Hospitalization 6/7/2013 77 Female 263 lb 9/26/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 6/11/2013 30 Male 133 lb 6/26/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/10/2013 42 Female 152 lb 7/1/2013 Physician Au
Primary
Secondary
Superficial Spreading Melanoma Stage Unspecified Other Serious 5/20/2013 67 Male 198 lb 8/14/2013 Physician Us
Primary
Secondary
Retinal Detachment Other Serious 6/7/2013 65 Male 204 lb 8/8/2013 Physician Gb
Primary
Secondary
Urinary Tract Infection Hospitalization 6/14/2013 71 Female 188 lb 9/30/2013 Physician Us
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 6/3/2013 37 Female 143 lb 7/10/2013 Physician De
Primary
Secondary
Pyrexia Hospitalization 3/13/2013 65 Male 183 lb 6/19/2013 Physician Nl
Primary
Secondary
Pyrexia Hospitalization 6/16/2013 32 Female 118 lb 11/19/2013 Physician Gb
Primary
Secondary
Pyrexia Hospitalization 3/16/2013 72 Female 146 lb 6/21/2013 Physician Us
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/18/2013 75 Male 162 lb 8/23/2013 Physician Ar
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 5/29/2013 77 Female 147 lb 6/24/2013 Physician Us
Primary
Secondary
Pyrexia Other Serious 5/28/2013 41 Male 190 lb 8/16/2013 Physician Us
Primary
Secondary
Dehydration Hospitalization 1/24/2013 37 Male 265 lb 6/24/2013 Physician Ie
Primary
Secondary
Pyrexia Other Serious 2/3/2013 79 Male 170 lb 6/26/2013 Physician Gr
Primary
Secondary
Ejection Fraction Decreased Life Threatening 5/8/2013 63 Female 172 lb 7/17/2013 Physician Us
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/20/2013 70 Female 229 lb 6/28/2013 Physician Us
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 10/2/2012 73 Female 132 lb 10/4/2013 Physician Fr
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 4/3/2013 64 Female 123 lb 7/17/2013 Physician Us
Primary
Secondary
Pyrexia Disability 4/22/2013 65 Male 190 lb 7/8/2013 Physician Gb
Primary
Secondary
Confusional State Hospitalization 7/4/2013 76 Female 147 lb 7/26/2013 Physician Gb
Primary
Secondary
Concomitant
Pneumonitis Other Serious 5/6/2013 60 Female 192 lb 8/8/2013 Physician Pl
Primary
Secondary
Ejection Fraction Decreased Other Serious 7/4/2013 31 Male 203 lb 10/3/2013 Physician Au
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/26/2012 46 Female 304 lb 7/10/2013 Physician Us
Primary
Secondary
Squamous Cell Carcinoma Hospitalization 6/11/2013 75 Male 219 lb 9/26/2013 Physician De
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 6/28/2013 65 Female 120 lb 9/4/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 4/30/2013 61 Male 200 lb 10/22/2013 Physician Au
Primary
Secondary
Ejection Fraction Decreased Other Serious 7/5/2013 79 Male 166 lb 9/20/2013 Physician Es
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 4/28/2013 30 Female 142 lb 7/16/2013 Physician Au
Primary
Secondary
Hyponatraemia Hospitalization 5/7/2013 77 Female 263 lb 10/28/2013 Physician Us
Primary
Secondary
Pyrexia Other Serious 6/19/2013 61 Male 202 lb 7/17/2013 Physician Us
Primary
Secondary
Vomiting Other Serious 7/10/2013 54 Female 187 lb 8/16/2013 Physician Us
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/30/2013 40 Male 175 lb 7/22/2013 Physician Fi
Primary
Secondary
Vomiting Other Serious 7/8/2013 36 Female 7/18/2013 Physician Us
Primary
Secondary
Pyrexia Hospitalization 10/5/2012 62 Male 204 lb 7/24/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 10/27/2012 62 Male 204 lb 7/24/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 12/7/2012 62 Male 204 lb 7/24/2013 Physician Au
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/22/2013 54 Male 218 lb 8/26/2013 Physician Ie
Primary
Secondary
Vomiting Hospitalization 9/5/2012 64 Male 196 lb 7/25/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 5/19/2013 42 Female 146 lb 8/19/2013 Physician Nl
Primary
Secondary
Concomitant
Vomiting Other Serious 7/15/2013 70 Female 229 lb 7/30/2013 Physician Us
Primary
Secondary
Diarrhoea Hospitalization 11/20/2012 53 Female 313 lb 7/26/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 7/9/2013 56 Female 129 lb 7/26/2013 Physician Se
Primary
Secondary
Pyrexia Hospitalization 8/8/2012 57 Male 224 lb 7/26/2013 Physician Se
Primary
Secondary
Pyrexia Hospitalization 8/27/2012 57 Male 224 lb 7/29/2013 Physician Se
Primary
Secondary
Diarrhoea Hospitalization 7/15/2013 55 Female 187 lb 8/7/2013 Physician Ca
Primary
Secondary
Pyrexia Hospitalization 7/2/2013 71 Female 162 lb 8/30/2013 Physician Gb
Primary
Secondary
Pyrexia Disability 7/25/2013 48 Female 132 lb 9/16/2013 Physician Gb
Primary
Secondary
Migraine Disability 7/27/2013 48 Female 132 lb 9/30/2013 Physician Gb
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 9/27/2012 47 Male 184 lb 8/2/2013 Physician Gb
Primary
Secondary
Transaminases Increased Other Serious 9/27/2012 47 Male 184 lb 8/2/2013 Physician Gb
Primary
Secondary
Pyrexia Other Serious 7/26/2013 56 Female 153 lb 8/6/2013 Physician Us
Primary
Secondary
Pyrexia Other Serious 2/14/2013 32 Male 187 lb 8/6/2013 Physician Es
Primary
Secondary
General Physical Health Deterioration Other Serious 8/2/2013 74 Male 155 lb 9/19/2013 Physician De
Primary
Secondary
Concomitant
Pyrexia Other Serious 7/29/2013 61 Female 177 lb 8/6/2013 Physician Au
Primary
Secondary
Sudden Death Hospitalization 5/4/2013 45 Male 154 lb 8/7/2013 Physician Ch
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/9/2013 64 Female 115 lb 8/8/2013 Physician Gb
Primary
Secondary
Concomitant
Influenza Like Illness Hospitalization 7/5/2013 71 Female 134 lb 9/3/2013 Physician Gb
Primary
Secondary
Pyrexia Other Serious 1/27/2013 45 Female 123 lb 8/14/2013 Physician Us
Primary
Secondary
Concomitant
Sudden Death Hospitalization 5/8/2013 44 Male 154 lb 8/29/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Pyrexia Other Serious 8/9/2013 63 Female 230 lb 8/21/2013 Physician Au
Primary
Secondary
Concomitant
Hypertriglyceridaemia Other Serious 8/2/2013 63 Female 8/21/2013 Physician Es
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 12/7/2012 65 Male 229 lb 8/21/2013 Physician Au
Primary
Secondary
Pyrexia Hospitalization 8/13/2013 65 Male 183 lb 9/11/2013 Physician Nl
Primary
Secondary
Infection Hospitalization 8/13/2013 70 Male 300 lb 8/29/2013 Physician Fi
Primary
Secondary
Pyrexia Other Serious 3/24/2013 47 Female 109 lb 8/22/2013 Physician Au
Primary
Secondary
Glioblastoma Hospitalization 7/26/2012 55 Female 181 lb 8/26/2013 Physician Us
Primary
Secondary
Concomitant
Vomiting Life Threatening 8/15/2013 29 Female 115 lb 8/30/2013 Physician Gb
Primary
Secondary
Pyrexia Hospitalization 8/12/2013 42 Female 273 lb 9/25/2013 Physician Au
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/27/2013 55 Male 9/16/2013 Physician Gb
Primary
Secondary
Pyrexia Hospitalization 8/13/2013 53 Female 207 lb 9/11/2013 Physician Au
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 11/19/2012 75 Female 147 lb 8/26/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/30/2012 64 Female 80 lb 8/27/2013 Physician Us
Primary
Secondary
Prostate Cancer Other Serious 8/7/2013 67 Male 159 lb 9/9/2013 Physician Ca
Primary
Secondary
Rhabdomyolysis Hospitalization 8/20/2013 53 Male 8/28/2013 Physician Us
Primary
Secondary
Concomitant
Dehydration Hospitalization 8/14/2013 54 Female 213 lb 9/26/2013 Physician Us
Primary
Secondary
Subdural Hygroma Other Serious 8/13/2013 43 Male 9/4/2013 Physician Es
Primary
Secondary
Concomitant
Pyrexia Other Serious 8/23/2012 64 Male 196 lb 9/5/2013 Physician Au
Primary
Secondary
Concomitant
Panniculitis Other Serious 8/9/2013 31 Female 123 lb 9/30/2013 Physician Fr
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 8/31/2012 79 Female 142 lb 9/9/2013 Physician Gr
Primary
Secondary
Pyrexia Other Serious 8/30/2013 61 Female 177 lb 9/16/2013 Physician Au
Primary
Secondary
Squamous Cell Carcinoma Other Serious 8/29/2013 63 Male 170 lb 9/9/2013 Physician Au
Primary
Secondary
Cellulitis Hospitalization 9/1/2013 34 Female 114 lb 9/30/2013 Physician Gb
Primary
Secondary
Vomiting Other Serious 2/26/2013 37 Male 265 lb 9/13/2013 Physician Ie
Primary
Secondary
Pyrexia Hospitalization 8/19/2012 51 Male 274 lb 9/16/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/7/2012 38 Male 203 lb 9/16/2013 Physician Us
Primary
Secondary
Pyrexia Other Serious 8/7/2013 61 Female 177 lb 9/16/2013 Physician Au
Primary
Secondary
Hypoglycaemia Hospitalization 8/17/2013 59 Male 287 lb 9/17/2013 Physician Us
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization 9/9/2013 54 Female 212 lb 9/30/2013 Physician Us
Primary
Secondary
Pulmonary Embolism Hospitalization 9/8/2013 64 Female 9/30/2013 Physician Es
Primary
Secondary
Pyrexia Hospitalization 10/22/2012 64 Male 204 lb 9/18/2013 Physician Gb
Primary
Secondary
Pyrexia Death 5/2013 44 Male 154 lb 9/18/2013 Pharmacist Ch
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/22/2012 39 Female 258 lb 9/25/2013 Physician De
Primary
Secondary
Concomitant
Pneumonitis Hospitalization 3/12/2013 39 Female 258 lb 9/25/2013 Physician De
Primary
Secondary
Pyrexia Hospitalization 9/15/2013 49 Male 176 lb 9/25/2013 Physician Gb
Primary
Secondary
Ejection Fraction Decreased Other Serious 2/11/2013 70 Male 149 lb 9/27/2013 Physician Us
Primary
Secondary
Chorioretinopathy Other Serious 11/26/2012 57 Male 207 lb 9/27/2013 Physician De
Primary
Secondary
Thrombocytopenia Hospitalization 9/19/2013 59 Female 9/30/2013 Physician Au
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 1/17/2013 77 Male 226 lb 9/30/2013 Physician Au
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 2/28/2013 77 Male 226 lb 9/30/2013 Physician Au
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/8/2013 73 Female 151 lb 9/30/2013 Physician Us
Primary
Secondary
Concomitant

Drug Data