Cytarabine combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 6 Male 1/6/2006 Physician Australia
Primary
Concomitant
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Disseminated Intravascular Coagulation Other Serious 12/21/2005 Female 42 lb 12/27/2005 United States
Primary
Secondary
Neurotoxicity Death 36 Female 1/5/2006 Physician Turkey
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/5/2006 Female 110 lb 1/13/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 7/13/2005 57 Female 159 lb 1/13/2006 Physician Germany
Primary
Concomitant
Respiratory Distress Hospitalization 12/12/2005 72 Male 1/12/2006 France
Primary
Secondary
Concomitant
Stomatitis Other Serious 11/21/2005 Female 138 lb 1/17/2006 United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/9/2005 31 Male 1/19/2006 Pharmacist United States
Primary
Secondary
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/20/2006 Physician France
Primary
Secondary
Concomitant
Pancreatitis Necrotising Hospitalization 9/30/2005 7 Female 53 lb 1/23/2006 United States
Primary
Concomitant
Refusal Of Treatment By Relative Other Serious 1/5/2006 Female 124 lb 1/19/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Required Intervention Female 1/23/2006 United States
Primary
Secondary
Subarachnoid Haemorrhage Other Serious Female 1/30/2006 Other Health Professional France
Primary
Secondary
Speech Disorder Hospitalization 11/14/2005 20 Female 218 lb 1/26/2006 Pharmacist United Kingdom
Primary
Concomitant
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Weight Decreased Death 6 Male 1/27/2006 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/19/2006 Female 125 lb 1/26/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/22/2005 Female 138 lb 1/23/2006 United States
Primary
Secondary
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Weight Decreased Other Serious 6 Female 1/28/2006 Physician United States
Primary
Secondary
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 2/3/2006 Physician Japan
Primary
Secondary
Swelling Death 36 Female 1/31/2006 Physician Turkey
Primary
Secondary
Vasculitic Rash Other Serious 10/1/2005 Male 2/7/2006 Physician Australia
Primary
Concomitant
Steroid Withdrawal Syndrome Hospitalization 13 Male 1/27/2006 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 2/6/2006 Female 37 lb 2/6/2006 United States
Primary
Secondary
Tachycardia Death 2/1/2006 Male 42 lb 2/8/2006 United States
Primary
Secondary
Febrile Neutropenia Other Serious 2/4/2006 Male 163 lb 2/14/2006 United States
Primary
Secondary
Weight Decreased Other Serious 5/1/2005 Female 110 lb 2/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Swelling Death 36 Female 2/13/2006 Physician Turkey
Primary
Secondary
Therapy Non-responder Death 36 Female 2/14/2006 Physician Turkey
Primary
Secondary
Paresis Other Serious 13 Male 2/14/2006 Japan
Primary
Secondary
Urinary Incontinence Hospitalization 4/1/1998 16 Male 2/15/2006 Physician Spain
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2/4/2006 61 Male 2/17/2006 Physician Thailand
Primary
Concomitant
Tongue Paralysis Life Threatening 17 Male 2/15/2006
Primary
Secondary
Pyrexia Hospitalization Male 2/16/2006 Physician United States
Primary
Concomitant
Papilloedema Required Intervention Unknown 2/16/2006 Physician United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/2/2006 Physician Japan
Primary
Secondary
Vomiting Hospitalization 2/22/2006 Female 77 lb 2/24/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 4/1/1998 16 Male 3/1/2006 Physician Spain
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/18/2006 14 Female 40 lb 3/2/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/8/2006 Physician Japan
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 2/11/2006 Female 179 lb 3/3/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/10/2006 Physician Japan
Primary
Secondary
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/9/2006 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/10/2004 68 Male 152 lb 3/7/2006 Physician Japan
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 2/14/2006 Female 23 lb 3/7/2006 United States
Primary
Secondary
Transplant Rejection Other Serious 1 Male 3/15/2006 Japan
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 6/27/2005 1 Male 19 lb 3/17/2006 Japan
Primary
Secondary
Concomitant
Vasculitic Rash Other Serious 10/1/2005 Male 168 lb 3/20/2006 Physician Australia
Primary
Concomitant
Tremor Required Intervention 3/14/2006 67 Male 159 lb 3/17/2006 United States
Primary
Secondary
T-cell Lymphoma Hospitalization 36 Female 3/17/2006 Physician Turkey
Primary
Secondary
Urinary Incontinence Disability 18 Male 3/15/2006
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 48 Female 3/15/2006
Primary
Concomitant
Sepsis Other Serious 15 Male 3/17/2006 United States
Primary
Secondary
Concomitant
Polyuria Other Serious 13 Female 3/17/2006 United States
Primary
Concomitant
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 3/1/2005 42 Female 3/28/2006 Consumer United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2005 63 Female 3/22/2006 Physician France
Primary
Secondary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/29/2006 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Performance Status Decreased Other Serious 3/13/2006 Male 216 lb 3/29/2006 United States
Primary
Secondary
Platelet Count Decreased Hospitalization 1/13/2006 71 Male 137 lb 4/3/2006 Physician France
Primary
Secondary
Concomitant
Visual Acuity Reduced Required Intervention 6/20/2005 18 Female 4/5/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 54 Male 4/5/2006 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 3/14/2006 Male 251 lb 4/10/2006 United States
Primary
Secondary
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/3/2004 30 Female 99 lb 4/11/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 3/3/2006 Male 23 lb 4/12/2006 United States
Primary
Secondary
Pyrexia Other Serious 3/1/2006 66 Male 4/21/2006 Consumer Norway
Primary
Secondary
Concomitant
Interacting
Skin Reaction Other Serious 41 Female 4/7/2006 Turkey
Primary
Secondary
Visual Acuity Reduced Required Intervention 6/20/2005 18 Female 4/17/2006 Physician United States
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 10 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Upper Motor Neurone Lesion Other Serious 4/15/2005 47 Female 5/1/2006 Physician Germany
Primary
Concomitant
Wound Drainage Hospitalization 4/24/2006 Male 21 lb 4/27/2006 United States
Primary
Secondary
Vith Nerve Paralysis Hospitalization 69 Female 5/5/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 3/1/1997 16 Male 5/1/2006 Physician Spain
Primary
Secondary
Stem Cell Transplant Other Serious 2/13/2005 66 Female 5/15/2006 Physician Germany
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Hospitalization 69 Female 5/19/2006 Physician United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 17 Male 5/18/2006
Primary
Secondary
Death Death 50 Male 5/23/2006 United States
Primary
Secondary
Nephropathy Hospitalization 2/1/2001 54 Male 176 lb 6/1/2006 Consumer United States
Primary
Secondary
Concomitant
Nephropathy Hospitalization 2/1/2001 54 Male 176 lb 6/6/2006 Consumer United States
Primary
Secondary
Concomitant
Tracheal Haemorrhage Other Serious 3/7/2006 Male 32 lb 3/20/2006 United States
Primary
Secondary
Urinary Retention Other Serious 4/15/2005 47 Female 123 lb 6/2/2006 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 3/1/2006 66 Male 6/12/2006 Consumer Norway
Primary
Secondary
Concomitant
Interacting
Dizziness Other Serious 6/5/2006 Male 196 lb 6/7/2006 United States
Primary
Secondary
Idiopathic Thrombocytopenic Purpura Other Serious 10 Female 6/3/2006 Physician Canada
Primary
Secondary
Plasmacytoma Other Serious 3/1/2002 Female 5/30/2006 Physician Japan
Primary
Secondary
Tri-iodothyronine Free Increased Other Serious 42 Male 6/16/2006 Physician Japan
Primary
Concomitant
Thyroxine Free Increased Other Serious 32 Female 6/16/2006 Other Health Professional Japan
Primary
Concomitant
Haemorrhage Intracranial Hospitalization 6/7/2006 Female 109 lb 6/8/2006 United States
Primary
Secondary
Tachypnoea Death 4/4/2006 43 Male 163 lb 6/20/2006 Physician Spain
Primary
Secondary
Haemorrhage Intracranial Hospitalization 6/7/2006 Female 109 lb 6/16/2006 United States
Primary
Secondary
Liver Function Test Abnormal Other Serious 12/1/2004 23 Female 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/24/2006 Male 21 lb 6/20/2006 United States
Primary
Secondary
Pancytopenia Death 5/10/2006 49 Female 216 lb 6/30/2006 France
Primary
Secondary
Sepsis Hospitalization 5/10/2006 49 Female 6/29/2006 France
Primary
Secondary
Thrombocytopenia Hospitalization 7/2/2006 Male 9 lb 7/5/2006 United States
Primary
Secondary
Concomitant
Pyrexia Death 5/10/2006 49 Female 212 lb 7/7/2006 Physician France
Primary
Secondary
Concomitant
Memory Impairment Other Serious 52 Male 6/30/2006
Primary
Secondary
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/7/2006 United States
Primary
Secondary
Muscular Weakness Hospitalization 7/2/2006 Male 109 lb 7/10/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 5/9/2006 Female 171 lb 7/7/2006 United States
Primary
Secondary
Urosepsis Hospitalization 6/27/2006 Female 176 lb 7/13/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 36 Female 7/14/2006 Other Health Professional Turkey
Primary
Secondary
Renal Disorder Other Serious 1/1/2002 16 Female 95 lb 7/21/2006 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2001 56 Male 7/25/2006 Consumer United States
Primary
Secondary
Concomitant
Septic Embolus 8/24/2005 Male 179 lb 7/19/2006 United States
Primary
Secondary
Urine Output Decreased Hospitalization 3 Female 8/1/2006 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 7/13/2006 Female 165 lb 8/1/2006 Physician Belgium
Primary
Concomitant
Metastasis Other Serious 3 Male 7/25/2006 Physician Turkey
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 13 Female 7/25/2006 Physician Turkey
Primary
Secondary
Primitive Neuroectodermal Tumour Death 10 Male 7/25/2006 Physician Turkey
Primary
Secondary
Insulin-like Growth Factor Decreased Other Serious 15 Male 122 lb 7/28/2006 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Staphylococcal Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Enterobacter Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Bacterial Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 6/28/2006 Female 50 lb 7/27/2006 United States
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 3 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 10 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 13 Female 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 14 Male 8/3/2006 Consumer United States
Primary
Secondary
Blood Growth Hormone Decreased Other Serious 12 Female 8/4/2006 Other Health Professional United States
Primary
Secondary
Epiphyseal Disorder Other Serious 15 Male 8/4/2006 Other Health Professional United States
Primary
Secondary
Idiopathic Thrombocytopenic Purpura Other Serious 13 Female 7/31/2006 Physician Canada
Primary
Secondary
Thrombocytopenic Purpura Other Serious 10 Female 7/31/2006 Physician Canada
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 3/6/2006 64 Male 182 lb 8/3/2006 Other Health Professional United States
Primary
Concomitant
Cerebral Atrophy Hospitalization 11/9/2004 68 Female 106 lb 8/7/2006 Physician France
Primary
Secondary
Type Iv Hypersensitivity Reaction Required Intervention 6/14/2006 12 Female 104 lb 8/8/2006 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary

Drug Data