Cyclosporine combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Required Intervention 12/15/2005 Female 117 lb 12/28/2005 United States
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Other Serious 29 Female 1/13/2006 United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 10/21/2004 Female 176 lb 1/13/2006 United Kingdom
Primary
Concomitant
Polyneuropathy Other Serious 56 Male 1/19/2006 Germany
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 47 Male 1/19/2006 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 7/5/2005 58 Male 1/20/2006 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 1/4/2006 31 Female 128 lb 1/25/2006 Physician Mexico
Primary
Concomitant
Transplant Failure Hospitalization 11/21/2005 Male 176 lb 2/1/2006 Physician Germany
Primary
Concomitant
Therapy Non-responder Hospitalization 56 Male 1/27/2006 Physician Germany
Primary
Concomitant
Pancreatic Disorder Hospitalization 12/1/2004 63 Female 2/6/2006 Sweden
Primary
Secondary
Concomitant
Haemorrhagic Cerebral Infarction Hospitalization 2/14/2004 60 Female 2/7/2006 Other Health Professional Sweden
Primary
Concomitant
Leukaemia Other Serious 12/28/2005 Male 2/7/2006 Physician Taiwan, Province Of China
Primary
Concomitant
Hepatitis Fulminant Other Serious Unknown 1/31/2006 Germany
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious Unknown 1/31/2006 Germany
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 2/14/2004 60 Female 2/10/2006 Other Health Professional Sweden
Primary
Concomitant
Rheumatoid Arthritis Other Serious 10/15/2004 Female 176 lb 2/10/2006 United Kingdom
Primary
Concomitant
Stent Placement Other Serious 33 Female 2/11/2006 Other Health Professional Hong Kong
Primary
Secondary
Tracheostomy Other Serious 36 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Tracheostomy Hospitalization 40 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 1/18/2006 57 Female 2/16/2006 Physician Colombia
Primary
Concomitant
Leukaemia Other Serious 12/28/2005 Male 2/23/2006 Physician Taiwan, Province Of China
Primary
Concomitant
Wound Dehiscence Hospitalization 63 Male 3/1/2006 Consumer United Kingdom
Primary
Secondary
Transaminases Increased Other Serious 19 Female 3/4/2006 Physician Korea, Republic Of
Primary
Concomitant
Neurotoxicity Other Serious 26 Female 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 19 Male 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 17 Female 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 38 Female 3/4/2006 Physician United States
Primary
Concomitant
Hodgkin's Disease Other Serious 61 Male 3/7/2006 Other Health Professional United States
Primary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/9/2006 Japan
Primary
Concomitant
Visual Field Defect Other Serious 1/1/2005 49 Female 3/14/2006 Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
Weight Decreased Other Serious 15 Male 3/14/2006 Japan
Primary
Concomitant
Transplant Rejection Other Serious 1 Male 3/15/2006 Japan
Primary
Secondary
Concomitant
Spinal Myelogram Abnormal Other Serious 34 Female 3/21/2006 Physician Japan
Primary
Concomitant
Cytomegalovirus Viraemia Life Threatening 4/21/2004 1 Male 18 lb 3/23/2006 Physician Japan
Primary
Secondary
Concomitant
Libido Decreased Disability 1/1/2005 Male 3/24/2006 Physician Finland
Primary
Concomitant
Sepsis Other Serious 9/1/2001 Female 159 lb 3/27/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/1/2006 Male 168 lb 3/28/2006 Physician Germany
Primary
Concomitant
Stem Cell Transplant Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Vomiting Disability 11/4/2005 9 Male 53 lb 3/29/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Wound Dehiscence Life Threatening 63 Male 3/24/2006 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Hospitalization 3/10/2006 61 Male 4/4/2006 Consumer United Kingdom
Primary
Concomitant
Visual Field Defect Other Serious 1/1/2005 49 Female 4/11/2006 Japan
Primary
Secondary
Concomitant
Wound Secretion Other Serious 8/1/2005 Female 4/3/2006 United States
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 3/10/2006 61 Male 4/13/2006 Consumer United Kingdom
Primary
Concomitant
Pancreatic Disorder Hospitalization 12/1/2004 Female 4/21/2006 Physician Sweden
Primary
Secondary
Concomitant
Myoclonus Other Serious 9/1/2005 Male 95 lb 4/24/2006 Physician United Kingdom
Primary
Concomitant
T-cell Lymphoma Other Serious 76 Female 4/26/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 62 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 69 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 47 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 59 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 51 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 55 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Adenovirus Infection Death 14 Male 4/25/2006 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 40 Male 5/5/2006 Other Health Professional Switzerland
Primary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 11/23/2003 5 Female 4/28/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 38 Female 5/9/2006 Other Health Professional Turkey
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 32 Female 5/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 14 Male 5/19/2006 Other Health Professional Poland
Primary
Concomitant
Pneumonitis Other Serious Male 5/23/2006 Physician Spain
Primary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/23/2006 Physician Germany
Primary
Concomitant
Psoriatic Arthropathy Hospitalization 3/1/2006 62 Male 181 lb 5/26/2006 Physician Germany
Primary
Concomitant
T-cell Lymphoma Death 76 Female 5/26/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 33 Female 6/6/2006 Other Health Professional China
Primary
Secondary
Right Ventricular Failure Death 2/26/2006 Female 101 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Nervous System Disorder Death 38 Female 6/9/2006 France
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 3 Unknown 4/27/2006 Japan
Primary
Secondary
Concomitant
Trigeminal Nerve Disorder Death 38 Female 6/7/2006 Physician France
Primary
Secondary
Concomitant
Tri-iodothyronine Free Increased Other Serious 42 Male 6/16/2006 Physician Japan
Primary
Concomitant
Thyroxine Free Increased Other Serious 32 Female 6/16/2006 Other Health Professional Japan
Primary
Concomitant
Visual Disturbance Hospitalization 11/1/2002 46 Female 230 lb 6/19/2006 Physician United States
Primary
Secondary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/8/2006 Physician France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/5/2002 42 Female 112 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Photophobia Hospitalization 5/1/2006 28 Female 6/16/2006 Physician Australia
Primary
Concomitant
Skin Lesion Other Serious 33 Female 6/12/2006 China
Primary
Secondary
Concomitant
T-cell Lymphoma Other Serious 76 Female 6/22/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/17/2005 7 Female 75 lb 6/28/2006 Physician Brazil
Primary
Concomitant
Skin Exfoliation Other Serious 2 Male 6/29/2006 United States
Primary
Concomitant
Malaise Hospitalization 1/1/2005 12 Female 6/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/23/2006 Physician France
Primary
Secondary
Concomitant
Vascular Skin Disorder Other Serious 35 Male 7/6/2006 Other Health Professional Poland
Primary
Secondary
Treatment Related Secondary Malignancy Hospitalization 77 Female 7/6/2006 Other Health Professional Italy
Primary
Secondary
Visual Disturbance Hospitalization 11/1/2002 46 Female 230 lb 7/13/2006 Physician United States
Primary
Secondary
Concomitant
Vascular Skin Disorder Other Serious 35 Male 7/6/2006 Physician Poland
Primary
Secondary
Pneumonia Fungal Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 61 Male 7/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Synovial Disorder Required Intervention 5/1/1998 53 Female 7/12/2006 United Kingdom
Primary
Secondary
Pneumonitis Other Serious Male 7/18/2006 Physician Spain
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 61 Male 7/15/2006 Physician United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Hospitalization 5/1/2006 28 Female 7/17/2006 Physician Switzerland
Primary
Concomitant
Visual Field Defect Other Serious Female 7/13/2006
Primary
Secondary
Concomitant
Haemangioma Other Serious 35 Male 7/27/2006 Other Health Professional Poland
Primary
Secondary
Injection Site Pain 10 Female 7/31/2006 Physician United States
Primary
Concomitant
Synovitis Other Serious 10/1/1999 77 Female 7/13/2006
Primary
Secondary
Hepatotoxicity Other Serious 2 Male 7/26/2006 China
Primary
Secondary
Concomitant
T-cell Lymphoma Other Serious Female 194 lb 8/3/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/3/2006 Consumer United States
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 33 Female 8/4/2006 Hong Kong
Primary
Secondary
Pneumonitis Other Serious Male 8/7/2006 Physician Spain
Primary
Concomitant
Stem Cell Transplant Other Serious 2 Male 8/7/2006 China
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 4/16/2006 53 Female 8/14/2006 Other Health Professional Sweden
Primary
Concomitant
Vomiting Life Threatening 10/1/2003 26 Female 8/12/2006 Lawyer France
Primary
Secondary
Vomiting Other Serious 17 Female 8/15/2006 Other Health Professional India
Primary
Secondary
Vomiting Other Serious 17 Female 8/15/2006 Other Health Professional India
Primary
Secondary
Vomiting Other Serious 17 Female 8/15/2006 Physician India
Primary
Secondary
Oedema Other Serious 54 Male 8/16/2006 Canada
Primary
Secondary
Meningitis Cryptococcal Hospitalization 5/1/2006 28 Female 8/22/2006 Physician Australia
Primary
Concomitant
Renal Tubular Acidosis Other Serious 5/5/2005 20 Male 8/30/2006 Consumer United States
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 7 Female 9/1/2006 Spain
Primary
Concomitant
Therapy Non-responder Other Serious 35 Male 8/24/2006
Primary
Secondary
Renal Impairment Other Serious 35 Male 9/5/2006 Japan
Primary
Secondary
Concomitant
Sepsis Death 4/16/2006 Female 154 lb 9/8/2006 Physician United Kingdom
Primary
Concomitant
Toxic Induced Encephalopathy Other Serious 4 Male 9/11/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Hyperaesthesia Other Serious 5/1/2004 57 Female 9/6/2006 Physician Germany
Primary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Physician Japan
Primary
Secondary
Concomitant
Encephalitis Post Varicella Other Serious 35 Male 10/3/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Viraemia Other Serious 28 Male 10/2/2006 Japan
Primary
Concomitant
Malignant Melanoma Life Threatening 60 Female 10/6/2006 Physician Greece
Primary
Concomitant
Therapy Non-responder Other Serious 76 Female 10/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Trichosporon Infection Death 42 Male 10/9/2006 Japan
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 76 Female 10/6/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Pharyngeal Oedema Other Serious 1/1/2006 64 Female 10/9/2006 Japan
Primary
Concomitant
Weight Increased Other Serious 10/9/2006 Japan
Primary
Concomitant
Histiocytosis Haematophagic Other Serious 4 Female 10/9/2006 Japan
Primary
Concomitant
Yellow Skin Other Serious 1/1/2004 30 Female 10/11/2006 Other Health Professional India
Primary
Concomitant
Pneumomediastinum Other Serious 35 Male 10/11/2006
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 55 Female 10/5/2006 Germany
Primary
Secondary
Concomitant
Serum Ferritin Increased Other Serious 4 Female 10/17/2006 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 1/1/2006 64 Female 10/17/2006 Japan
Primary
Concomitant
Melaena Other Serious 1/1/2004 41 Female 10/17/2006 Japan
Primary
Secondary
Concomitant
Trichosporon Infection Death 42 Male 10/17/2006 Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 10/17/2006 Japan
Primary
Concomitant
Vomiting Life Threatening 10/1/2003 26 Female 121 lb 10/20/2006 Lawyer France
Primary
Secondary
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious Female 194 lb 11/2/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombophlebitis Other Serious 8/1/2005 64 Female 11/7/2006 Japan
Primary
Secondary
Thrombophlebitis Hospitalization 8/1/2005 64 Female 11/14/2006 Japan
Primary
Secondary
Tuberculosis Other Serious 6/1/1994 38 Male 11/15/2006 Other Health Professional Turkey
Primary
Secondary
Concomitant

Drug Data