Cyclosporine combined with Melphalan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ischaemic Stroke Other Serious 82 Female 1/27/2006 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
Urinary Tract Infection Enterococcal 56 Female 3/9/2006 United States
Primary
Secondary
Concomitant
Light Chain Analysis Increased Other Serious 82 Female 2/24/2006 Physician United States
Primary
Concomitant
Nephropathy Toxic Other Serious 65 Male 4/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 65 Male 6/2/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspergillus Other Serious Male 6/14/2006 Consumer Germany
Primary
Secondary
Concomitant
Pneumonia Aspergillus Other Serious Male 6/14/2006 Consumer Germany
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 10 Female 9/1/2006 Spain
Primary
Concomitant
Viral Dna Test Positive Other Serious 1/1/2006 64 Female 10/17/2006 Japan
Primary
Concomitant
Vomiting Other Serious 3 Male 11/6/2006
Primary
Concomitant
Pancreatitis Haemorrhagic Hospitalization 5 Female 1/9/2007 Consumer Australia
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious Female 1/23/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 1/30/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Renal Impairment Other Serious 56 Female 2/22/2007 Consumer Finland
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 2/23/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Somnolence Death 56 Female 2/16/2007 Germany
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Neurotoxicity Other Serious 56 Female 3/22/2007 United States
Primary
Concomitant
Interacting
Spherocytic Anaemia Other Serious 41 Female 5/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Autoimmune Thrombocytopenia Other Serious 41 Female 5/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Haemorrhagic Hospitalization 5 Female 5/22/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Renal Tubular Disorder Death 7 Female 5/24/2007 Physician Italy
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 5/30/2007 Physician Italy
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 9 Female 5/29/2007 Japan
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 9 Female 6/7/2007 Japan
Primary
Secondary
Concomitant
Stomatitis 2/5/2007 47 Male 6/6/2007 Japan
Primary
Concomitant
Transplant Failure 2/5/2007 47 Male 7/13/2007 Japan
Primary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 8/14/2007 Physician Italy
Primary
Secondary
Concomitant
Viraemia Other Serious 12 Male 9/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Stomatitis Other Serious 12 Male 9/26/2007 Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Ureaplasma Infection Hospitalization 28 Male 10/11/2007 Switzerland
Primary
Secondary
Ureaplasma Infection Other Serious 28 Male 11/23/2007 Physician Switzerland
Primary
Secondary
Concomitant
Obliterative Bronchiolitis Death 25 Male 12/7/2007 Physician United Kingdom
Primary
Secondary
Weight Decreased Other Serious 25 Male 12/11/2007 Other Health Professional United Kingdom
Primary
Secondary
Viith Nerve Paralysis Other Serious 39 Female 12/28/2007 Other Health Professional Japan
Primary
Secondary
Weight Decreased Other Serious 25 Male 1/8/2008 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Other Serious 12 Male 1/17/2008 Physician Germany
Primary
Secondary
Skin Papilloma Other Serious 53 Female 2/16/2008 Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 39 Female 2/21/2008
Primary
Secondary
Renal Failure Other Serious 2/22/2008 Other Health Professional United States
Primary
Secondary
Renal Disorder Other Serious 2/29/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Disease Other Serious 11 Male 3/5/2008 Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 39 Female 3/6/2008 Other Health Professional Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/11/2008 Consumer Japan
Primary
Concomitant
Sepsis Other Serious 8/1/2005 51 Male 3/13/2008 Japan
Primary
Secondary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/24/2008 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 14 Male 4/14/2008 Other Health Professional Germany
Primary
Secondary
Neutropenia Other Serious 4 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Graft Versus Host Disease Other Serious 12 Male 4/15/2008 Other Health Professional Germany
Primary
Secondary
Human Herpesvirus 6 Infection Other Serious 11 Female 4/16/2008 Physician Austria
Primary
Secondary
Toxoplasmosis Hospitalization 14 Male 4/23/2008 Germany
Primary
Concomitant
Graft Versus Host Disease Hospitalization 4 Female 4/23/2008 Germany
Primary
Concomitant
Malignant Melanoma Death 53 Male 4/30/2008 Germany
Primary
Secondary
Toxoplasmosis Hospitalization 14 Male 5/5/2008 Germany
Primary
Concomitant
Drug Toxicity Other Serious 4/9/2008 Germany
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Other Serious 5/20/2008 United Kingdom
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 5/22/2008 Japan
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 5/22/2008 United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 5/29/2008 Iceland
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 5/30/2008 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 6/2/2008 Iceland
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 6/2/2008 United Kingdom
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 6/5/2008 Germany
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 6/9/2008 Germany
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 57 6/26/2008 Other Health Professional Australia
Primary
Secondary
Concomitant
Infection Death 6/26/2008 Spain
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious 7/3/2008 Germany
Primary
Secondary
Sepsis Other Serious 7/3/2008 Germany
Primary
Secondary
Venoocclusive Disease Other Serious 7/3/2008 Germany
Primary
Secondary
Pulmonary Toxicity Other Serious 7/7/2008 Germany
Primary
Secondary
Retinal Haemorrhage Other Serious 26 Female 7/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/30/2008 45 Male 163 lb 7/16/2008 Physician Spain
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 7/21/2008 Other Health Professional Japan
Primary
Concomitant
Visual Acuity Reduced Other Serious 26 Female 7/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/30/2008 45 Male 163 lb 7/22/2008 Physician Spain
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 3 Female 7/24/2008 United States
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Other Serious 38 Male 7/24/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 1 Male 7/25/2008 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 39 Male 7/25/2008 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 39 Male 7/28/2008 Other Health Professional Germany
Primary
Secondary
Thrombotic Microangiopathy Other Serious 50 Female 8/1/2008 Consumer Japan
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 37 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Spider Naevus Required Intervention 53 Male 7/30/2008 Physician Germany
Primary
Secondary
Thrombotic Microangiopathy Other Serious 50 Female 8/7/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 59 Female 8/8/2008 Other Health Professional Italy
Primary
Concomitant
Venoocclusive Liver Disease Other Serious Male 8/20/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious Male 8/22/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 9/2/2008 Other Health Professional Iran (Islamic Republic Of)
Primary
Secondary
Human Herpesvirus 6 Infection Other Serious 7/9/2002 11 Female 9/2/2008 Other Health Professional Austria
Primary
Secondary
Concomitant
Rash Hospitalization 6/30/2008 45 Male 163 lb 9/17/2008 Physician Spain
Primary
Secondary
Concomitant
Sinus Disorder Other Serious 62 Male 9/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 45 Male 9/26/2008 Other Health Professional United States
Primary
Concomitant
Infection Death 51 6/14/2008 Other Health Professional Australia
Primary
Secondary
Concomitant
Nephritis Interstitial Other Serious 9 Male 9/30/2008 Other Health Professional Germany
Primary
Secondary
Renal Failure Other Serious 12 Male 9/27/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 29 Female 9/27/2008 Physician United States
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 9 Male 10/3/2008 Other Health Professional Germany
Primary
Secondary
Obstructive Airways Disorder Death 62 Male 10/10/2008 Consumer United Kingdom
Primary
Secondary
Epstein-barr Virus Infection Hospitalization 61 Female 10/10/2008 United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 0 Male 10/21/2008 Other Health Professional Poland
Primary
Concomitant
Epstein-barr Virus Infection Hospitalization 61 Female 10/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Epstein-barr Virus Infection Other Serious 61 Female 10/29/2008 United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 0 Male 10/31/2008 Other Health Professional Poland
Primary
Concomitant
Pneumonia Cytomegaloviral Death 9 10/31/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 43 Female 11/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Splenectomy Hospitalization 7 Female 11/24/2008
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 11/5/2008 63 Male 11/20/2008 Other Health Professional Spain
Primary
Concomitant
Sepsis Syndrome Other Serious 14 Male 11/28/2008 Other Health Professional Germany
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 4 Female 12/2/2008 Other Health Professional Japan
Primary
Concomitant
Respiratory Disorder Death 43 Female 12/2/2008 Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 11/5/2008 63 Male 12/4/2008 Other Health Professional Spain
Primary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Pyrexia Other Serious 61 Female 12/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Pyrexia Hospitalization 61 Female 12/22/2008 Consumer United Kingdom
Primary
Secondary
Pseudomembranous Colitis Other Serious 43 Male 12/22/2008 Other Health Professional Japan
Primary
Secondary
Pseudomembranous Colitis Other Serious 43 Male 12/30/2008 Other Health Professional Japan
Primary
Secondary
Meningoencephalitis Herpetic Other Serious 4 Male 1/5/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 1/1/2004 4 Female 1/7/2009 Italy
Primary
Secondary
Pancreatitis Other Serious 1/16/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 1/1/2006 49 Male 1/29/2009 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 11/5/2008 63 Male 1/26/2009 Other Health Professional Spain
Primary
Concomitant
Rash Other Serious 8 Male 2/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pancreatitis Haemorrhagic Hospitalization 2/11/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/18/2008 58 Male 132 lb 3/3/2009 Physician Spain
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/18/2008 58 Male 132 lb 3/5/2009 Physician Spain
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Death 3/5/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Other Serious 1/27/2009 59 Male 2/25/2009 Other Health Professional Spain
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 3/6/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 8/18/2008 58 Male 3/6/2009 Other Health Professional Spain
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 9/1/2008 21 Male 146 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/21/2008 45 Male 3/18/2009 Other Health Professional Spain
Primary
Concomitant
Staphylococcal Infection Other Serious 2/1/2009 59 Male 3/26/2009 Other Health Professional Spain
Primary
Concomitant
Ulcer Hospitalization 19 3/31/2009 Other Health Professional United Kingdom
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 101 lb 4/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 3/18/2009 59 Male 4/1/2009 Other Health Professional Spain
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 101 lb 4/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Immune System Disorder Death 1/15/2008 43 Female 101 lb 4/22/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 3/18/2009 59 Male 4/20/2009 Other Health Professional Spain
Primary
Concomitant
Sinusitis Fungal Other Serious 8/1/2006 28 Male 4/24/2009 Other Health Professional Italy
Primary
Concomitant
Graft Versus Host Disease Other Serious 2 4/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Death 20 5/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Systemic Mycosis Death 17 5/7/2009 United Kingdom
Primary
Secondary
Concomitant
Drug Resistance Death 17 5/8/2009 United Kingdom
Primary
Secondary
Systemic Mycosis Death 17 5/12/2009 United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Death 56 5/23/2009 Other Health Professional Tunisia
Primary
Secondary
Concomitant

Drug Data