Cyclosporine combined with Melphalan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hypotension Hospitalization 5/11/2009 55 Male 207 lb 6/22/2009 Physician United States
Primary
Secondary
Concomitant
Systemic Mycosis Death 17 6/23/2009 United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1 Female 8/24/2009 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 2 Male 8/25/2009 United Kingdom
Primary
Secondary
Vomiting Other Serious 11/1/2004 44 Male 8/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2006 64 Male 8/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Death 12/1/2008 61 Male 115 lb 9/8/2009 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Death 9/9/2008 Male 168 lb 9/9/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 7/1/2007 56 Female 9/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 2 Female 9/25/2009 United Kingdom
Primary
Secondary
Graft Versus Host Disease Required Intervention 1 Female 9/25/2009 United Kingdom
Primary
Secondary
Graft Versus Host Disease Required Intervention 2 Female 9/25/2009 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 2 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Ultrasound Kidney Abnormal Other Serious 10/8/2009 50 Female 164 lb 10/29/2009 Physician United States
Primary
Secondary
Renal Impairment Other Serious 1 Female 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Renal Atrophy Other Serious 10/8/2009 50 Female 164 lb 11/8/2009 Physician United States
Primary
Secondary
Viral Infection Hospitalization 11/5/2009 50 Female 163 lb 11/17/2009 Physician United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 50 Female 12/7/2009 Japan
Primary
Secondary
Concomitant
Tonsillitis Hospitalization 5/1/2007 55 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Death 7/2/2007 62 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Sinus Congestion Death 62 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 7/2/2007 62 Male 1/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/1/2005 39 Male 2/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Death 12/1/2008 61 Male 115 lb 2/12/2010 Physician Japan
Primary
Concomitant
Klebsiella Sepsis Death 22 Male 3/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Death 4/1/2008 45 Male 3/25/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Klebsiella Sepsis Death 22 Male 3/29/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Death 3/25/2010 Italy
Primary
Secondary
Concomitant
Quality Of Life Decreased Death 22 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Klebsiella Sepsis Death 22 Male 4/6/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Therapy Responder Other Serious 1/1/2004 55 Female 4/8/2010 Other Health Professional Japan
Primary
Concomitant
Haemolysis Other Serious 58 Male 4/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 24 Female 4/20/2010 Other Health Professional Japan
Primary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 6 Female 4/20/2010 Other Health Professional Germany
Primary
Concomitant
Pneumonia Death Unknown 5/10/2010 France
Primary
Secondary
Pneumonia Bacterial Death 5/10/2010 France
Primary
Secondary
Pancreatitis Death 5/10/2010 France
Primary
Secondary
Staphylococcal Sepsis Other Serious 24 Female 5/18/2010 Other Health Professional Japan
Primary
Concomitant
Sweat Gland Tumour Required Intervention 32 Male 6/2/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Female 6/15/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 42 Male 6/21/2010 Other Health Professional Pakistan
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2009 4 Male 6/23/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Sweat Gland Tumour Other Serious 32 Male 6/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Required Intervention 28 Male 6/17/2010 Consumer United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 6/1/2002 32 Male 7/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 6/1/2002 32 Male 7/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Death 8/5/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 9/17/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Sepsis Other Serious 22 Female 9/20/2010 Other Health Professional France
Primary
Secondary
Pancreatic Disorder Other Serious 6 Female 9/16/2010 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 49 Female 9/23/2010 Other Health Professional Switzerland
Primary
Concomitant
Guillain-barre Syndrome Other Serious 51 Female 9/29/2010 Other Health Professional Italy
Primary
Concomitant
Skin Toxicity Other Serious 0 Female 9/29/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Aspiration Other Serious 1 Male 9/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/5/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 7 Female 9/30/2010 Physician Japan
Primary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Mycobacterium Avium Complex Infection Other Serious 0 Male 10/14/2010 Physician Germany
Primary
Secondary
Concomitant
Encephalitis Viral Death 11/17/2006 63 10/8/2010 Germany
Primary
Concomitant
Leukaemia Recurrent Other Serious 3 Female 10/12/2010 Physician United States
Primary
Concomitant
Varicella Virus Test Positive Other Serious 24 Female 154 lb 10/25/2010 Other Health Professional Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 15 Female 10/27/2010 Other Health Professional Japan
Primary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 16 Female 10/29/2010 Physician Germany
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 1 Male 11/3/2010 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 1 Male 11/3/2010 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 25 Female 11/9/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 20 Female 11/9/2010 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 25 Female 11/15/2010 Physician Japan
Primary
Concomitant
Idiopathic Pneumonia Syndrome Other Serious 6/29/2010 57 Female 99 lb 11/22/2010 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 5/26/2010 Male 18 lb 11/24/2010 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 12/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Nervous System Disorder Death 7 Female 2/3/2011 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 5 Male 2/3/2011 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 5 Female 2/3/2011 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 7 Female 2/7/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 12 Female 2/25/2011 Physician United States
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 20 Female 3/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 28 Female 3/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 1 Male 3/18/2011 Other Health Professional Japan
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 65 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 31 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Dental Caries Death 1/1/2003 50 Female 207 lb 4/19/2011 United States
Primary
Secondary
Concomitant
Renal Impairment Death 10/11/2007 Male 14 lb 5/9/2011 Pharmacist United States
Primary
Secondary
Concomitant
Renal Impairment Death 10/11/2007 Male 14 lb 5/11/2011 Pharmacist United States
Primary
Secondary
Concomitant
Syncope Other Serious 4/27/2011 42 Female 188 lb 5/13/2011 Consumer United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 5/15/2011 Physician United States
Primary
Secondary
Concomitant
Electrocardiogram T Wave Abnormal Other Serious 3/17/2009 66 Female 273 lb 5/16/2011 Consumer United States
Primary
Secondary
Concomitant
Microangiopathy Hospitalization 5/1/2011 46 Female 162 lb 5/17/2011 Consumer United States
Primary
Secondary
Concomitant
Erosive Oesophagitis Hospitalization 1/1/2003 50 Female 207 lb 5/18/2011 United States
Primary
Secondary
Concomitant
Bursitis Hospitalization 8/1/2008 43 Male 5/19/2011 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 5/5/2011 44 Male 163 lb 5/27/2011 Consumer United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 1 5/18/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2 5/18/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Progression Other Serious 3 5/18/2011 Other Health Professional United States
Primary
Concomitant
Pneumonia Adenoviral Death 6/7/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Encephalopathy Death 6/7/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Herpes Viral Death 46 5/31/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Idiopathic Pneumonia Syndrome Death 49 5/31/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neuroblastoma Recurrent Other Serious 7 Female 6/10/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 9 Male 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 7 Male 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Acute Lymphocytic Leukaemia Recurrent Death 10 Male 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cholestasis Other Serious 1 Male 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cystitis Viral Other Serious 14 Female 6/13/2011 Physician Germany
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 14 Female 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 10 Male 6/13/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 8 Female 6/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 14 Female 6/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Infection Life Threatening 4/27/2011 42 Female 188 lb 6/16/2011 Consumer United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Hospitalization 1/1/2003 50 Female 207 lb 6/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 16 Female 6/22/2011 Other Health Professional Japan
Primary
Concomitant
Acute Graft Versus Host Disease Death 7 Male 6/9/2011 Physician Sweden
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Death 5 6/23/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Neoplasm Malignant Death 5 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Acute Graft Versus Host Disease Death 3 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Bone Marrow Disorder Hospitalization 8/1/2008 43 Male 6/27/2011 Lawyer United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 59 Female 6/13/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Haemorrhage Other Serious 1/1/2007 63 Female 6/30/2011 Other Health Professional Japan
Primary
Concomitant
Diabetic Ketoacidosis Hospitalization 8/1/2008 43 Male 166 lb 6/30/2011 Physician United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 15 Female 7/1/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Disorder Other Serious 1 Female 6/23/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Engraft Failure Other Serious 6/9/2010 10 Female 88 lb 7/15/2011 Physician Japan
Primary
Secondary
Concomitant
Congestive Cardiomyopathy Hospitalization 4 Female 6/29/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/9/2010 10 Female 88 lb 7/18/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Lymphocytic Leukaemia Recurrent Other Serious 7 Male 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Acute Lymphocytic Leukaemia Recurrent Death 10 Male 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 14 Female 7/22/2011 Physician Germany
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 14 Female 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neuroblastoma Recurrent Other Serious 7 Female 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastrointestinal Disorder Other Serious 10 Male 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 8 Female 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Colitis Other Serious 9 Male 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cholestasis Other Serious 1 Male 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 14 Female 7/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Wound Infection Hospitalization 1/1/2003 50 Female 207 lb 7/26/2011 United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 4 Female 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 6 Male 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 18 Male 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 37 Female 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 31 Female 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Wheelchair User Other Serious 8/1/2005 36 Male 170 lb 8/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 20 Female 8/8/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 11 Male 8/12/2011 Other Health Professional Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 14 Female 8/12/2011 Other Health Professional Canada
Primary
Concomitant
Septic Shock Other Serious 49 Male 8/23/2011 Physician Portugal
Primary
Secondary
Concomitant
Septic Shock Hospitalization 3/26/2011 56 Male 183 lb 9/20/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Haemolysis Other Serious 29 Female 9/21/2011 Other Health Professional Germany
Primary
Concomitant

Drug Data