Cyclophosphamide combined with Zoledronic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Osteonecrosis Other Serious 56 Male 10/27/2005 Physician United States
Primary
Secondary
Concomitant
Toothache Other Serious 10/3/2005 39 Female 128 lb 5/1/2006 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/24/2006 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 64 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Surgery Other Serious 78 Female 9/19/2006 Italy
Primary
Concomitant
Surgery Other Serious 68 Female 9/19/2006 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Hospitalization 12/21/2004 58 Female 173 lb 10/13/2006 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Hospitalization 2/28/2005 58 Female 173 lb 10/25/2006 Physician United Kingdom
Primary
Concomitant
Wound Debridement Other Serious 68 Female 10/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Debridement Other Serious 62 Female 10/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Debridement Other Serious 79 Female 10/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 12/12/2006 Physician United Kingdom
Primary
Concomitant
Pain In Jaw Other Serious 53 Male 1/13/2007 Consumer United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 67 Male 1/13/2007 United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 73 Male 2/2/2007 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 65 Female 3/25/2007 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious 63 Female 3/25/2007 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/12/2007 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Hospitalization 12/1/2004 58 Female 173 lb 6/2/2007 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 76 Female 6/5/2007 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 58 Female 6/5/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2/1/2006 76 Male 6/20/2007 Other Health Professional Finland
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/1/2007 Female 181 lb 8/10/2007 Physician United Kingdom
Primary
Concomitant
Pain In Jaw Other Serious 1/1/2007 Female 181 lb 8/20/2007 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 66 Male 9/11/2007 Other Health Professional Portugal
Primary
Concomitant
Tooth Extraction Other Serious 7/1/2003 71 Male 9/11/2007 Other Health Professional Portugal
Primary
Concomitant
Tooth Extraction Other Serious 40 Female 9/11/2007 Other Health Professional Portugal
Primary
Concomitant
Weight Decreased Other Serious 51 Female 9/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/1/2007 Female 181 lb 9/18/2007 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 8/21/2007 Female 10/1/2007 Consumer Australia
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 8/21/2007 Female 10/24/2007 Consumer Australia
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy 29 Female 1/10/2008 United States
Primary
Secondary
Tooth Extraction Other Serious 4/1/2004 71 Male 1/2/2008 Other Health Professional Portugal
Primary
Secondary
Tooth Extraction Other Serious 7/1/2005 66 Male 1/2/2008 Physician Portugal
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 51 Female 2/1/2008 United Kingdom
Primary
Concomitant
Interacting
Osteonecrosis Other Serious 51 Female 2/5/2008 Physician United Kingdom
Primary
Secondary
Osteonecrosis Other Serious 51 Female 2/5/2008 United Kingdom
Primary
Interacting
Osteonecrosis Other Serious 51 Female 2/8/2008 United Kingdom
Primary
Concomitant
Interacting
Waist Circumference Increased Other Serious 1/1/2004 29 Female 2/15/2008
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 2/14/2008 Female 183 lb 2/22/2008 Physician Germany
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 51 Female 3/5/2008 United Kingdom
Primary
Concomitant
Interacting
Osteonecrosis Other Serious 51 Female 3/6/2008 Other Health Professional United Kingdom
Primary
Interacting
Weight Decreased Other Serious 51 Female 3/14/2008 Other Health Professional United Kingdom
Primary
Secondary
Osteonecrosis Other Serious 51 Female 3/14/2008 United Kingdom
Primary
Concomitant
Interacting
Weight Decreased Other Serious 51 Female 3/18/2008 Other Health Professional United Kingdom
Primary
Interacting
Weight Decreased Other Serious 51 Female 3/21/2008 Other Health Professional United Kingdom
Primary
Interacting
Suicide Attempt Hospitalization 2/12/2008 Female 183 lb 3/14/2008 Physician Germany
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 40 Female 3/27/2008 Other Health Professional Portugal
Primary
Concomitant
Tooth Extraction Other Serious 66 Male 3/27/2008 Other Health Professional Portugal
Primary
Concomitant
Tooth Extraction Other Serious 7/1/2003 71 Male 3/27/2008 Other Health Professional Portugal
Primary
Concomitant
Weight Decreased Other Serious 51 Female 4/4/2008 Other Health Professional United Kingdom
Primary
Interacting
Weight Decreased Other Serious 51 Female 4/8/2008 Consumer United States
Primary
Secondary
Weight Decreased Other Serious 51 Female 4/14/2008 Other Health Professional United Kingdom
Primary
Interacting
Osteonecrosis Other Serious 3/1/2004 66 Male 4/16/2008 Other Health Professional Portugal
Primary
Concomitant
Osteonecrosis Other Serious 7/1/2003 71 Male 4/16/2008 Other Health Professional Portugal
Primary
Concomitant
Weight Decreased Other Serious 51 Female 4/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Prostate Cancer Stage Iv Other Serious 3/26/2007 73 Male 6/5/2008 Japan
Primary
Concomitant
Tooth Deposit Other Serious 12/1/2005 Female 132 lb 6/5/2008 Physician United Kingdom
Primary
Concomitant
Prostate Cancer Stage Iv Other Serious 3/26/2007 73 Male 115 lb 6/17/2008 Japan
Primary
Concomitant
Prostatic Specific Antigen Increased Hospitalization 9/3/2006 69 Male 8/8/2008 Other Health Professional Japan
Primary
Concomitant
Tooth Deposit Other Serious 12/1/2005 Female 132 lb 9/17/2008 Physician United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 72 Male 12/31/2008 Physician United Kingdom
Primary
Concomitant
Musculoskeletal Pain Hospitalization 7/13/2007 Female 165 lb 1/23/2009 Physician Germany
Primary
Concomitant
Interacting
Drug Ineffective Other Serious 72 Male 2/27/2009 Physician United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 72 Male 2/27/2009 Physician United Kingdom
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion 72 Male 2/27/2009 United Kingdom
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion 72 Male 3/5/2009 United Kingdom
Primary
Concomitant
Tibia Fracture Other Serious 8/1/2003 62 Male 3/18/2009 Physician Australia
Primary
Secondary
Concomitant
Therapy Cessation 72 Male 3/19/2009 United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 9/3/2007 Female 5/8/2009 Physician Belgium
Primary
Secondary
Concomitant
Foot Operation Hospitalization 4/4/2009 Female 141 lb 6/3/2009 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 43 Female 7/8/2009 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 75 Female 7/9/2009 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 38 Female 7/9/2009 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 88 Female 7/10/2009 Other Health Professional Italy
Primary
Concomitant
Respiratory Failure Hospitalization 59 Female 123 lb 7/17/2009 Physician India
Primary
Concomitant
Tooth Extraction Other Serious 2/9/2004 Female 154 lb 9/16/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 51 Female 10/1/2009 Other Health Professional United Kingdom
Primary
Interacting
Osteonecrosis Other Serious 51 Female 10/1/2009 United Kingdom
Primary
Interacting
General Physical Health Deterioration Hospitalization 6/15/2007 Female 131 lb 10/8/2009 Physician Germany
Primary
Secondary
Concomitant
Pancytopenia Other Serious 35 Female 12/14/2009 Consumer Japan
Primary
Secondary
Renal Failure Hospitalization 4/27/2009 3/3/2010 Physician France
Primary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Myocardial Infarction Death 2/1/2010 3/31/2010 Other Health Professional Colombia
Primary
Concomitant
Tooth Extraction Other Serious 7/1/2008 51 Female 4/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Acute Coronary Syndrome Hospitalization 3/10/2010 78 Male 185 lb 5/7/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Acute Coronary Syndrome Hospitalization 3/10/2010 78 Male 185 lb 5/31/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 3/15/2010 70 Male 161 lb 7/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Cardiovascular Disorder Hospitalization 12/6/2010 60 Female 150 lb 1/3/2011 Physician Germany
Primary
Secondary
Obliterative Bronchiolitis Other Serious 41 Male 1/5/2011 Other Health Professional Belgium
Primary
Concomitant
Cardiovascular Disorder Hospitalization 12/6/2010 60 Female 150 lb 1/11/2011 Physician Germany
Primary
Secondary
Metastases To Lung Other Serious 41 Male 1/17/2011 Other Health Professional Belgium
Primary
Concomitant
Renal Tubular Disorder Hospitalization 9/22/2004 59 Female 126 lb 1/19/2011 Other Health Professional France
Primary
Secondary
Dyspnoea Hospitalization 12/6/2010 60 Female 150 lb 2/17/2011 Physician Germany
Primary
Secondary
Bronchiolitis Other Serious 41 Male 3/30/2011 Other Health Professional Belgium
Primary
Secondary
Obliterative Bronchiolitis Other Serious 41 Male 4/4/2011 Physician Belgium
Primary
Secondary
Asthenia Hospitalization 11/17/2010 70 Female 4/6/2011 Physician United States
Primary
Secondary
Concomitant
Cerebral Infarction Death Female 4/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Confusional State Hospitalization 1/1/2010 70 Female 4/14/2011 Consumer United States
Primary
Secondary
Concomitant
Mental Status Changes Other Serious 12/3/2010 70 Female 4/14/2011 Physician United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Other Serious Female 5/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/17/2010 70 Female 130 lb 5/9/2011 Physician United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 1/1/2010 70 Female 130 lb 5/16/2011 Consumer United States
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 12/3/2010 70 Female 128 lb 5/17/2011 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/23/2011 69 Female 6/2/2011 Consumer Germany
Primary
Concomitant
Drug Ineffective Other Serious 72 Male 6/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Tract Infection Other Serious Male 6/6/2011 Other Health Professional Spain
Primary
Secondary
Diabetes Mellitus Other Serious 72 Male 5/31/2011 Physician United Kingdom
Primary
Concomitant
Multiple Myeloma Death 5/26/2007 72 Male 6/12/2011 Physician Japan
Primary
Concomitant
Anaemia Other Serious 4/1/2008 54 Male 6/15/2011 Other Health Professional Spain
Primary
Secondary
Neoplasm Recurrence Other Serious 67 Female 6/20/2011 Other Health Professional Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 60 Male 6/20/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 57 Female 6/21/2011 Other Health Professional Germany
Primary
Concomitant
Tooth Extraction Other Serious 57 Female 6/21/2011 Other Health Professional Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 45 Female 6/20/2011 Other Health Professional Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 43 Female 6/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Decubitus Ulcer Other Serious 62 Female 6/23/2011 Other Health Professional Germany
Primary
Concomitant
Decubitus Ulcer Other Serious 73 Female 6/27/2011 Other Health Professional Germany
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 55 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Abscess Other Serious 63 Female 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Disease Recurrence Other Serious 66 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/12/2011 Male 7/14/2011 Other Health Professional United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious Female 7/19/2011 Other Health Professional Japan
Primary
Concomitant
Neutropenia Hospitalization 6/6/2011 41 Female 8/8/2011 Physician Netherlands
Primary
Secondary
Concomitant
Tooth Loss Disability 7/27/2011 Female 8/26/2011 Physician Netherlands
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/6/2011 41 Female 9/2/2011 Physician Netherlands
Primary
Secondary
Concomitant
Mitral Valve Incompetence Hospitalization 12/6/2010 60 Female 150 lb 9/9/2011 Physician Germany
Primary
Secondary
Haemorrhoids Hospitalization 8/27/2011 54 Female 9/15/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Mitral Valve Incompetence Hospitalization 12/6/2010 60 Female 150 lb 9/21/2011 Physician Germany
Primary
Secondary
Hiv Infection Other Serious 4/1/2010 10/14/2011 Physician Japan
Primary
Concomitant
Bone Marrow Failure Other Serious 81 Female 10/24/2011 Other Health Professional Japan
Primary
Concomitant
Diverticulitis Other Serious 8/1/2010 11/2/2011 Physician Japan
Primary
Concomitant
Infectious Peritonitis Other Serious 8/1/2010 11/18/2011 Physician Japan
Primary
Concomitant
Hypoxia Other Serious 5/18/2011 50 Female 84 lb 11/23/2011 Physician Japan
Primary
Concomitant
Haemorrhoids Hospitalization 8/27/2011 54 Female 11/28/2011 Physician Netherlands
Primary
Secondary
Concomitant
Proctocolitis Hospitalization 8/27/2011 54 Female 11/28/2011 Physician Netherlands
Primary
Secondary
Concomitant
Hypotension Hospitalization 9/28/2011 63 Male 197 lb 11/28/2011 United States
Primary
Concomitant
Febrile Neutropenia Hospitalization 11/16/2011 42 Female 11/29/2011 Physician Netherlands
Primary
Secondary
Haemorrhoids Hospitalization 8/27/2011 54 Female 12/1/2011 Physician Netherlands
Primary
Secondary
Concomitant
Hiv Infection Other Serious 8/1/2010 12/1/2011 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 4/1/2010 58 Female 99 lb 12/26/2011 Other Health Professional Belgium
Primary
Secondary
Concomitant
Acute Coronary Syndrome Hospitalization 3/10/2010 78 Male 185 lb 2/1/2012 Physician Spain
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 3/11/2012 Female 5/10/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Ingrowing Nail Hospitalization 1/1/2011 45 Female 5/18/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 2 Male 6/13/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Multiple Myeloma Death Male 186 lb 8/7/2012 Physician United States
Primary
Concomitant
Rectal Haemorrhage Death 5/1/2012 72 Female 159 lb 8/13/2012 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/17/2010 70 Female 130 lb 10/23/2012 Physician Us
Primary
Secondary
Concomitant
Pneumonia Other Serious 2010 70 Female 130 lb 11/20/2012 Consumer Us
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 1/2012 40 Female 163 lb 10/9/2012 Physician Be
Primary
Secondary

Drug Data