Cyclophosphamide combined with Ursodiol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Hospitalization 7/19/2006 Male 198 lb 8/1/2006 Pharmacist United States
Primary
Concomitant
Vaginal Cellulitis Required Intervention 11/17/2006 26 Female 12/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/17/2006 26 Female 12/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vaginal Cellulitis Required Intervention 11/17/2006 26 Female 1/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Urticaria Hospitalization 2/26/2007 Female 119 lb 3/30/2007 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/9/2007 19 Male 164 lb 5/24/2007 Physician United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 4/9/2007 19 Male 167 lb 6/4/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/9/2007 19 Male 167 lb 6/7/2007 Physician United States
Primary
Secondary
Concomitant
Sensory Disturbance Other Serious 1/1/2007 80 Female 116 lb 7/27/2007 Consumer United States
Primary
Concomitant
Somnolence Hospitalization 8/1/2007 8 Male 88 lb 9/11/2007 Pharmacist Canada
Primary
Secondary
Concomitant
Somnolence Other Serious 8/1/2007 8 Male 88 lb 10/12/2007 Pharmacist Canada
Primary
Secondary
Concomitant
Staphylococcal Infection Life Threatening 1/1/2007 8 Male 88 lb 10/31/2007 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 8/1/2007 8 Male 88 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/28/2007 14 Female 126 lb 11/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Life Threatening 8/18/2007 8 Male 88 lb 11/12/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 10/28/2007 14 Female 126 lb 11/21/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 1/21/2008 Female 21 lb 1/23/2008 United States
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 1/21/2008 Female 21 lb 1/28/2008 Canada
Primary
Secondary
Concomitant
Venous Pressure Jugular Increased Hospitalization 1/21/2008 Female 21 lb 2/8/2008 United States
Primary
Secondary
Concomitant
Cytolytic Hepatitis Other Serious 30 Male 7/14/2008 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 3/27/2008 21 Male 7/11/2008 Physician France
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/29/2008 Female 114 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/29/2008 Female 114 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Ventricular Tachycardia Required Intervention 4/12/2007 19 Male 165 lb 10/10/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Shock Other Serious 11/30/2007 Male 35 lb 11/3/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Other Serious 5/21/2008 Male 194 lb 11/4/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Hypertrophic Cardiomyopathy Other Serious 0 Male 11/19/2008 Japan
Primary
Concomitant
White Blood Cell Count Decreased Required Intervention 4/12/2007 19 Male 165 lb 11/18/2008 Physician United States
Primary
Secondary
Concomitant
Hypertrophic Cardiomyopathy Other Serious 0 Male 12/1/2008 Japan
Primary
Concomitant
Myeloma Recurrence Other Serious 4/1/2006 41 Male 117 lb 1/23/2009
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 12/28/2008 62 Male 2/9/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 12/3/2008 55 Male 158 lb 2/24/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/12/2003 0 Male 13 lb 3/19/2009 France
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/31/2006 22 Male 137 lb 6/22/2009 Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 48 Female 9/9/2009 Other Health Professional Japan
Primary
Concomitant
Hepatitis C Rna Increased 1/24/2009 62 Female 11/5/2009 Other Health Professional Japan
Primary
Concomitant
Weight Increased Hospitalization Male 1/11/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious Male 1/11/2010 Consumer United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Required Intervention 4/12/2007 19 Male 165 lb 3/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/14/2010 Male 180 lb 3/18/2010 United States
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 5/14/2010 78 Male 165 lb 6/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 5/14/2010 78 Male 165 lb 6/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Varicella Virus Test Positive Other Serious 9 Male 6/23/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious 5/14/2010 78 Male 165 lb 6/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 78 Male 6/24/2010 Consumer United Kingdom
Primary
Concomitant
Staphylococcal Skin Infection Hospitalization 8 Male 7/28/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 5/3/2010 2 Male 8/16/2010 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 22 Male 9/7/2010
Primary
Secondary
Venoocclusive Disease Other Serious 9/24/2010 Physician United States
Primary
Concomitant
Encephalitis Herpes Hospitalization 9/27/2009 74 Male 10/4/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 3/15/2009 38 Male 128 lb 9/30/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 1/5/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatosplenomegaly Death 1/27/2011 68 Male 2/15/2011 Other Health Professional United States
Primary
Concomitant
Cystitis Haemorrhagic Death 10/14/2010 49 Male 2/23/2011 Physician United States
Primary
Concomitant
Abdominal Distension Other Serious 10/7/2010 49 Male 3/10/2011 Other Health Professional United States
Primary
Concomitant
Bacterial Test Positive Other Serious 11/20/2010 57 Female 3/11/2011 Other Health Professional United States
Primary
Concomitant
Nephropathy Hospitalization 3/17/2011 2 Female 32 lb 3/21/2011 Physician United States
Primary
Secondary
Concomitant
Atelectasis Hospitalization 3/17/2011 2 Female 32 lb 3/23/2011 United States
Primary
Secondary
Concomitant
Delirium Other Serious 6/16/2010 53 Male 154 lb 4/8/2011 Physician Japan
Primary
Concomitant
Rash Hospitalization 3/15/2010 54 Female 95 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5/16/2011 Physician Serbia
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5/16/2011 Physician Serbia
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 9 Male 5/10/2011 Other Health Professional United States
Primary
Concomitant
Diarrhoea Hospitalization 3/12/2010 54 Female 95 lb 5/19/2011 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 3/12/2010 54 Female 95 lb 5/20/2011 Physician Japan
Primary
Secondary
Concomitant
Petechiae Other Serious 1/29/2010 49 Male 110 lb 5/20/2011 Physician Japan
Primary
Concomitant
Candida Test Positive Hospitalization 3/12/2010 54 Female 95 lb 5/25/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 22 Male 4/1/2011 Physician United States
Primary
Concomitant
Hyperuricaemia Hospitalization 3/15/2010 54 Female 95 lb 6/1/2011 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 3/26/2010 54 Female 95 lb 6/3/2011 Physician Japan
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 3/17/2011 2 Female 32 lb 6/2/2011 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/7/2010 49 Male 6/29/2011 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 1/21/2011 68 Male 6/30/2011 Other Health Professional United States
Primary
Concomitant
Pulseless Electrical Activity Death 1/25/2011 66 Male 6/30/2011 Other Health Professional United States
Primary
Concomitant
Myocardial Ischaemia Other Serious 1/21/2011 68 Male 7/15/2011 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Hospitalization 11/17/2010 57 Female 7/21/2011 Other Health Professional United States
Primary
Concomitant
Rash Hospitalization 3/15/2010 54 Female 95 lb 8/4/2011 Physician Japan
Primary
Secondary
Concomitant
Haematocrit Decreased Hospitalization 2/1/2010 38 Female 132 lb 8/9/2011 Physician Japan
Primary
Concomitant
Dizziness Hospitalization 9/27/2010 8/22/2011 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/7/2011 20 Male 196 lb 8/22/2011 Physician Japan
Primary
Concomitant
Mucosal Inflammation Disability Female 120 lb 9/12/2011 Pharmacist Brazil
Primary
Concomitant
Sudden Death Death 1/21/2011 68 Male 9/8/2011 Other Health Professional United States
Primary
Concomitant
Haemolytic Anaemia Hospitalization 2/3/2010 6 Male 35 lb 9/19/2011 Physician Japan
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Death 11/17/2009 6 Male 33 lb 9/19/2011 Physician Japan
Primary
Concomitant
Pruritus Other Serious 2/13/2011 21 Female 120 lb 9/19/2011 Pharmacist Brazil
Primary
Concomitant
Cough Hospitalization 1/1/2010 55 Female 134 lb 9/22/2011 Physician Australia
Primary
Concomitant
Pleural Effusion Hospitalization 8/3/2011 67 Female 101 lb 9/22/2011 Consumer Japan
Primary
Secondary
Concomitant
Haematuria Other Serious 1/1/2011 21 Female 119 lb 9/23/2011 Pharmacist Brazil
Primary
Concomitant
Hypertension Other Serious 6/12/2010 53 Male 154 lb 10/5/2011 Physician Japan
Primary
Concomitant
Pneumonia Death 6/24/2009 49 Female 237 lb 9/19/2011 Other Health Professional Australia
Primary
Concomitant
Malignant Pleural Effusion Hospitalization 8/3/2011 67 Female 101 lb 10/10/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 1/1/2011 4 Male 37 lb 10/11/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 11/17/2010 57 Female 10/10/2011 Physician United States
Primary
Concomitant
Haematemesis Other Serious 4 Male 38 lb 10/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 2/11/2011 55 Female 123 lb 11/11/2011 Physician Japan
Primary
Concomitant
Aspergillus Test Positive Hospitalization 1/1/2010 55 Female 134 lb 11/14/2011 Physician Australia
Primary
Concomitant
Hypoxia Other Serious 5/18/2011 50 Female 84 lb 11/23/2011 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 3/2/2011 12 Male 84 lb 12/9/2011 Physician Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 11/29/2010 7 Male 51 lb 12/12/2011 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 7/28/2010 71 Male 159 lb 12/12/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 10/25/2010 11 Male 66 lb 12/12/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Hepatitis Hospitalization 2/25/2011 2 Male 33 lb 12/12/2011 Physician Japan
Primary
Concomitant
Graft Versus Host Disease In Intestine Other Serious 1/1/2010 27 Male 12/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cytomegalovirus Chorioretinitis Hospitalization 8/24/2009 21 Male 104 lb 12/20/2011 Physician Japan
Primary
Concomitant
Candidiasis Hospitalization 1/1/2010 23 Male 117 lb 12/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemolytic Anaemia Life Threatening 11/17/2009 6 Male 33 lb 12/30/2011 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 2/7/2011 20 Male 196 lb 2/7/2012 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 6/8/2009 6 Male 33 lb 2/9/2012 Physician Japan
Primary
Concomitant
Infection Other Serious 8/21/2009 6 Male 35 lb 2/9/2012 Physician Japan
Primary
Concomitant
Haemolytic Anaemia Other Serious 8/21/2009 6 Male 35 lb 2/9/2012 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 8/24/2009 21 Male 104 lb 2/22/2012 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 27 Male 2/23/2012 Physician Japan
Primary
Concomitant
Chronic Graft Versus Host Disease Other Serious 55 Male 2/23/2012 Physician Japan
Primary
Concomitant
Dizziness Hospitalization 9/27/2010 60 Male 151 lb 3/8/2012 Physician Japan
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 6/8/2009 6 Male 33 lb 3/9/2012 Physician Japan
Primary
Concomitant
Nausea Other Serious 6/12/2010 53 Male 154 lb 3/15/2012 Physician Japan
Primary
Concomitant
Mucosal Inflammation Other Serious 1/31/2011 66 Male 3/14/2012 Other Health Professional United States
Primary
Concomitant
Acute Respiratory Failure Hospitalization 11/18/2011 56 Female 3/25/2012 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/25/2010 11 Male 66 lb 3/26/2012 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Death 3/2/2011 12 Male 84 lb 3/28/2012 Physician Japan
Primary
Concomitant
Memory Impairment Hospitalization 1/1/2010 23 Male 117 lb 3/28/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/12/2010 6 Female 62 lb 3/30/2012 Physician Japan
Primary
Concomitant
Infection Death 4/18/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 1/1/2010 36 Male 128 lb 4/19/2012 Physician Japan
Primary
Concomitant
Venoocclusive Disease Death 4/20/2012 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Infection Death 4/20/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 4/20/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Venoocclusive Disease Death 4/20/2012 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 4/20/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Other Serious 1 Female 4/28/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 9/9/2011 52 Female 110 lb 4/30/2012 Physician Japan
Primary
Concomitant
Oxygen Saturation Decreased Other Serious 9/18/2011 1 Male 24 lb 5/15/2012 Physician Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease In Intestine Other Serious 11/29/2010 7 Male 51 lb 5/16/2012 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 11/1/2010 6 Female 42 lb 5/17/2012 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/25/2011 2 Male 33 lb 5/21/2012 Physician Japan
Primary
Concomitant
Serum Ferritin Increased Death 11/1/2010 6 Female 42 lb 5/22/2012 Physician Japan
Primary
Concomitant
Dry Eye Other Serious 6/12/2010 53 Male 154 lb 5/30/2012 Physician Japan
Primary
Concomitant
Hyperbilirubinaemia Life Threatening 5/20/2012 16 Male 117 lb 5/24/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Death 2/11/2011 55 Female 123 lb 6/8/2012 Physician Japan
Primary
Secondary
Concomitant
Engraftment Syndrome Hospitalization 11/1/2010 6 Female 42 lb 7/19/2012 Physician Japan
Primary
Concomitant

Drug Data