Cyclophosphamide combined with Trastuzumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Syncope Hospitalization 2/18/2007 Female 196 lb 4/18/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/18/2007 Female 196 lb 4/25/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 1/17/2007 Female 176 lb 5/16/2007 Physician Germany
Primary
Secondary
Cardiac Failure Hospitalization 9/25/2002 66 Female 5/21/2007 Japan
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 9/25/2002 66 Female 5/25/2007 Japan
Primary
Secondary
Concomitant
Tachycardia Death 1/17/2007 Female 176 lb 6/7/2007 Physician Germany
Primary
Secondary
Chest Pain Hospitalization 12/14/2006 Female 150 lb 6/30/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Polyarthritis Other Serious 36 Female 7/6/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 63 Female 7/13/2007 Japan
Primary
Concomitant
Osteonecrosis Other Serious 10/1/2004 63 Female 7/17/2007 Japan
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2004 63 Female 7/20/2007 Japan
Primary
Concomitant
Acute Monocytic Leukaemia Other Serious 4/11/2007 44 Female 206 lb 10/12/2007 Physician United States
Primary
Secondary
Concomitant
Acute Monocytic Leukaemia Other Serious 4/11/2007 Female 10/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2004 60 Female 11/17/2007 Japan
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2004 60 Female 11/20/2007 Japan
Primary
Secondary
Concomitant
Polyneuropathy Hospitalization 10/21/2007 Female 154 lb 12/11/2007 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2004 60 Female 12/19/2007 Japan
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 4/11/2007 44 Female 206 lb 12/31/2007 Physician United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 4/11/2007 Female 206 lb 1/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy 29 Female 1/10/2008 United States
Primary
Secondary
Hepatocellular Injury Other Serious 31 Female 1/26/2008 Consumer United Kingdom
Primary
Concomitant
Waist Circumference Increased Other Serious 1/1/2004 29 Female 2/15/2008
Primary
Secondary
Concomitant
Liver Injury Other Serious 31 Female 3/12/2008 Other Health Professional Spain
Primary
Secondary
Liver Injury Other Serious 31 Female 3/13/2008 Other Health Professional Spain
Primary
Secondary
Skin Exfoliation Other Serious 1/1/2008 48 Female 3/20/2008 United States
Primary
Secondary
Concomitant
Rash Other Serious 41 Female 4/15/2008 Other Health Professional Japan
Primary
Secondary
Pain Other Serious 41 Female 4/18/2008 Other Health Professional Japan
Primary
Secondary
Pain 41 Female 4/23/2008 Other Health Professional United States
Primary
Secondary
Pain Other Serious 41 Female 4/25/2008 Consumer United States
Primary
Secondary
Pain 41 Female 4/28/2008 Other Health Professional United States
Primary
Secondary
Hepatotoxicity Other Serious 31 Female 5/15/2008
Primary
Secondary
Pain Hospitalization 4/5/2008 44 Female 5/22/2008 Consumer United States
Primary
Secondary
Blood Triglycerides Increased Female 5/22/2008 Other Health Professional United States
Primary
Secondary
Pain Hospitalization 44 Female 5/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Weight Increased Other Serious Female 8/29/2008 Consumer France
Primary
Concomitant
Angina Pectoris Hospitalization 9/20/2008 Female 10/2/2008 Physician United Kingdom
Primary
Secondary
Angina Pectoris Hospitalization 9/19/2008 Female 10/17/2008 Physician United Kingdom
Primary
Secondary
Chills Hospitalization 11/2/2007 44 Female 11/4/2008 United States
Primary
Secondary
Concomitant
Dehydration Hospitalization 9/15/2008 11/18/2008 Physician United Kingdom
Primary
Secondary
Dehydration Hospitalization 9/15/2008 11/18/2008 Physician United Kingdom
Primary
Secondary
Neutropenia Hospitalization 9/19/2008 Female 12/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/18/2008 Female 168 lb 12/9/2008 Physician United States
Primary
Secondary
Angina Pectoris Hospitalization 9/19/2008 Female 12/12/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/12/2008 54 Female 182 lb 12/19/2008 Physician United States
Primary
Secondary
Skin Ulcer Haemorrhage Hospitalization 46 Female 12/31/2008 Other Health Professional Japan
Primary
Secondary
Sciatica Other Serious 65 Female 1/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transfusion Reaction Hospitalization 12/12/2008 54 Female 182 lb 1/12/2009 Physician United States
Primary
Secondary
Metastases To Ovary Other Serious 56 Female 1/12/2009 Netherlands
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 44 Female 1/14/2009 Netherlands
Primary
Secondary
Concomitant
Metastases To Ovary Other Serious 56 Female 1/22/2009 Netherlands
Primary
Secondary
Concomitant
Blood Triglycerides Increased Female 1/26/2009 Other Health Professional United States
Primary
Secondary
Asthenia Other Serious 2/6/2009 Consumer United Kingdom
Primary
Secondary
Rash Other Serious 2/9/2009 Consumer United States
Primary
Secondary
Concomitant
Sciatica Other Serious 65 Female 3/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Angina Pectoris Hospitalization 9/19/2008 Female 3/27/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 3/27/2009 Female 4/15/2009 Physician United Kingdom
Primary
Secondary
Leukocytoclastic Vasculitis Hospitalization Female 4/23/2009 Physician Germany
Primary
Secondary
Concomitant
Visual Impairment Other Serious 31 Female 5/5/2009 Other Health Professional Canada
Primary
Secondary
Pneumothorax Hospitalization 7/7/2008 44 Female 5/5/2009 Physician United Kingdom
Primary
Secondary
Gastric Ulcer Perforation Other Serious 3/7/2009 60 Female 5/7/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 5/12/2009 Physician United States
Primary
Secondary
Pyrexia Other Serious 4/30/2008 55 Female 5/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Disease Progression Death 78 Male 6/3/2009 Consumer United Kingdom
Primary
Concomitant
Pleuropericarditis Hospitalization 5/9/2009 65 Female 6/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 31 Female 6/22/2009 Other Health Professional Spain
Primary
Concomitant
Hepatotoxicity Other Serious 31 Female 7/1/2009 Other Health Professional Spain
Primary
Concomitant
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 7/14/2009 Physician United States
Primary
Secondary
Dysthymic Disorder Life Threatening Female 8/6/2009 Other Health Professional Germany
Primary
Secondary
Trisomy 21 Congenital Anomaly Female 8/12/2009 Physician United Kingdom
Primary
Secondary
Enteritis Hospitalization 8/14/2009 Female 8/26/2009 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 7/20/2009 Female 137 lb 9/9/2009 Physician Japan
Primary
Secondary
Concomitant
Enteritis Hospitalization 8/14/2009 Female 9/10/2009 Consumer United Kingdom
Primary
Secondary
Abortion Spontaneous Other Serious 36 Female 9/15/2009 Consumer United Kingdom
Primary
Concomitant
Dysthymic Disorder Life Threatening 35 Female 134 lb 9/16/2009 Other Health Professional Germany
Primary
Secondary
Nervous System Disorder Hospitalization 3/27/2009 Female 9/22/2009 Physician Germany
Primary
Secondary
Overdose Other Serious 5/11/2009 46 Female 10/8/2009 Physician United Kingdom
Primary
Secondary
Oesophagitis Hospitalization 8/14/2009 Female 10/9/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 4/1/2004 42 Female 10/12/2009 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 10/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/13/2009 Female 150 lb 10/15/2009 Physician Germany
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 46 10/19/2009 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 6/12/2008 49 Female 10/20/2009 Physician Venezuela
Primary
Concomitant
Diarrhoea Death 4/12/2008 63 Female 10/20/2009 Physician Venezuela
Primary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 10/22/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 10/22/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 46 10/26/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 11/2/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 11/2/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 10/8/2009 Female 11/6/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 1/4/2002 39 Female 179 lb 11/9/2009 Other Health Professional United States
Primary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 11/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 11/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 10/8/2009 Female 11/23/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/24/2009 Female 101 lb 12/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 46 Female 12/10/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 111 lb 12/10/2009 Physician Thailand
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/6/2009 40 Female 193 lb 12/16/2009 Physician United States
Primary
Secondary
Oesophagitis Hospitalization 8/14/2009 Female 111 lb 12/21/2009 Physician Thailand
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/15/2009 37 Female 135 lb 12/21/2009 Physician United States
Primary
Secondary
Pneumonia Hospitalization 11/24/2009 Female 101 lb 1/15/2010 Physician Belgium
Primary
Secondary
Concomitant
Diarrhoea Other Serious 12/29/2009 Female 132 lb 1/15/2010 Physician France
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 8/14/2009 Female 111 lb 1/21/2010 Physician Thailand
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/14/2009 37 Female 134 lb 1/22/2010 Physician United States
Primary
Secondary
Urinary Tract Infection Hospitalization 1/14/2010 34 Female 251 lb 1/25/2010 Physician United States
Primary
Secondary
Bronchitis Hospitalization 12/31/2009 Female 1/27/2010 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Hospitalization 12/10/2009 51 Female 2/5/2010 Other Health Professional France
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 5/29/2008 65 Female 123 lb 2/9/2010 Other Health Professional United States
Primary
Secondary
Febrile Bone Marrow Aplasia Hospitalization 1/30/2010 Female 161 lb 2/16/2010 Physician France
Primary
Secondary
Neuropathy Peripheral Other Serious 5/29/2008 65 Female 123 lb 2/18/2010 Other Health Professional United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 4/11/2007 Female 206 lb 2/22/2010 Physician United States
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 10/20/2008 Female 2/25/2010 Physician United Kingdom
Primary
Secondary
Pyrexia Hospitalization 10/9/2009 69 Female 2/25/2010 Physician France
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 6/2/2008 Female 2/26/2010 Physician United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 2/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Depression Hospitalization 11/16/2008 43 Female 3/4/2010 Other Health Professional United States
Primary
Secondary
Wound Infection Hospitalization 7/22/2009 52 3/5/2010 Physician United States
Primary
Secondary
Hypertriglyceridaemia Other Serious 2/11/2009 47 Female 3/5/2010 Physician United States
Primary
Secondary
Incision Site Infection Hospitalization 9/3/2008 46 3/5/2010 Physician United States
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/8/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Myositis Hospitalization 6/21/2009 54 3/8/2010 Physician United States
Primary
Secondary
Haemoglobin Hospitalization 3/7/2008 75 Female 3/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/8/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Syncope Other Serious 12/25/2009 44 Female 3/9/2010 Other Health Professional United States
Primary
Secondary
Metastatic Neoplasm Other Serious 61 Female 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 Female 101 lb 3/10/2010 Physician Belgium
Primary
Secondary
Concomitant
Erythema Multiforme Other Serious 9/9/2009 Female 194 lb 3/11/2010 Physician United States
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/11/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 54 Female 3/12/2010 Physician United States
Primary
Secondary
Sepsis Hospitalization 7/21/2008 68 Female 3/15/2010 Other Health Professional United States
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization 12/22/2009 Female 183 lb 3/15/2010 Physician Ireland
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 12/1/2009 60 Female 223 lb 3/15/2010 Physician Egypt
Primary
Concomitant
Hypertriglyceridaemia Other Serious 2/11/2009 47 Female 3/16/2010 Physician United States
Primary
Secondary
Myositis Hospitalization 6/21/2009 54 3/16/2010 Physician United States
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Eosinophilia Hospitalization 54 Female 3/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Depression Hospitalization 11/16/2008 43 Female 3/18/2010 Other Health Professional United States
Primary
Secondary
Pulmonary Embolism Life Threatening 9/24/2003 Female 159 lb 3/19/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 3/3/2010 Female 150 lb 3/19/2010 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/21/2008 68 Female 3/22/2010 Other Health Professional United States
Primary
Secondary
Withdrawal Syndrome Life Threatening 33 Female 3/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Erythema Multiforme Other Serious 9/9/2009 Female 194 lb 3/24/2010 Physician United States
Primary
Secondary
Myositis Hospitalization 6/21/2009 54 3/24/2010 Physician United States
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/6/2010 Female 3/29/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 12/14/2009 37 Female 134 lb 4/1/2010 Physician United States
Primary
Secondary
Deep Vein Thrombosis Hospitalization Female 183 lb 4/21/2010 Physician United States
Primary
Secondary
Deep Vein Thrombosis Hospitalization 4/8/2010 49 Female 183 lb 4/29/2010 Physician United States
Primary
Secondary
Pulmonary Embolism Hospitalization 4/16/2010 58 Female 132 lb 4/29/2010 Physician Germany
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 56 Female 4/29/2010 United States
Primary
Secondary

Drug Data