Cyclophosphamide combined with Thiotepa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Septic Shock Death 12/28/2005 64 Male 1/30/2006 Germany
Primary
Concomitant
Hypertonia Required Intervention 21 Female 3/29/2006 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 9 Male 41 lb 5/8/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 2/1/2004 1 Male 6/7/2006 Other Health Professional Japan
Primary
Secondary
Neoplasm Recurrence Hospitalization 1/1/2006 21 Female 6/7/2006 Other Health Professional Netherlands
Primary
Secondary
Respiratory Disorder Death 2/26/2004 6 Male 6/16/2006 Consumer Japan
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 2/1/2004 5 Male 7/6/2006 Other Health Professional Japan
Primary
Secondary
Stem Cell Transplant Other Serious 4 Female 7/14/2006 Other Health Professional Japan
Primary
Secondary
Myelitis Transverse Other Serious 5 Male 9/6/2006 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 18 Female 9/6/2006 United States
Primary
Secondary
Concomitant
Paraplegia Required Intervention 5 Male 9/29/2006 Physician United States
Primary
Secondary
Walking Aid User Required Intervention 18 Female 9/29/2006 Physician United States
Primary
Secondary
Concomitant
Myelitis Other Serious 18 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 18 Female 10/25/2006 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 5 Male 10/25/2006 Physician United States
Primary
Secondary
Myelitis Transverse Other Serious 5 Male 11/2/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Death 45 Female 2/9/2007 Physician Japan
Primary
Concomitant
Myelitis Other Serious 18 Female 3/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Myelitis Other Serious 5 Male 3/23/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/5/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/16/2006 58 Male 4/3/2007 France
Primary
Concomitant
Myelitis Transverse Other Serious 18 Female 5/28/2007 Physician United States
Primary
Secondary
Sinus Tachycardia Other Serious 57 Male 10/24/2007 Japan
Primary
Concomitant
Pyrexia Other Serious 15 Female 11/30/2007 Other Health Professional United States
Primary
Secondary
Skin Fissures Other Serious 1/1/2007 64 Female 11/30/2007 Physician France
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Hospitalization 15 Female 12/7/2007
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 8/7/2006 4 Male 28 lb 1/29/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 2/3/2008 Male 167 lb 2/6/2008 United States
Primary
Secondary
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 11 Male 3/1/2008 Consumer Hong Kong
Primary
Secondary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/11/2008 Consumer Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 15 Unknown 3/13/2008 Japan
Primary
Concomitant
Stem Cell Transplant Death 1 3/13/2008 Japan
Primary
Concomitant
Therapeutic Agent Toxicity Death 3/20/2008 Italy
Primary
Secondary
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 15 3/24/2008 Physician Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 3/17/2008 United States
Primary
Secondary
Therapeutic Agent Toxicity Death 3/26/2008 Italy
Primary
Secondary
Urinary Tract Infection Other Serious Female 3/28/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious Female 3/28/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Vomiting Other Serious Female 3/28/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Sepsis Other Serious Female 3/28/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization 2/12/2008 Male 231 lb 4/16/2008 United States
Primary
Secondary
Drug Interaction Other Serious 52 Female 5/12/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Serositis Hospitalization 12/15/2007 Female 104 lb 5/2/2008 United States
Primary
Secondary
Concomitant
Serositis Hospitalization 12/15/2007 Female 104 lb 5/9/2008 United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 48 Male 6/20/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 7/1/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Sepsis Life Threatening 6/1/2004 51 Male 7/7/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 32 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Viral Infection Other Serious 54 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Fungal Infection Other Serious 9/10/2008 Other Health Professional Italy
Primary
Secondary
Bone Sarcoma Other Serious 8 Male 12/1/2008 Consumer Japan
Primary
Secondary
Nervous System Disorder Other Serious 12 Female 11/27/2008 Physician United States
Primary
Secondary
Staphylococcal Sepsis Other Serious 32 Male 12/1/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 12 Female 12/2/2008 Physician United States
Primary
Secondary
Neuropathy Peripheral Other Serious 15 Male 12/29/2008 Other Health Professional United States
Primary
Secondary
Stem Cell Transplant Other Serious 12 Female 12/23/2008 Other Health Professional United States
Primary
Secondary
Spinal Disorder Other Serious 12 Female 1/6/2009 Other Health Professional United States
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 15 Male 1/5/2009 Other Health Professional United States
Primary
Secondary
Stem Cell Transplant Other Serious 12 Female 1/6/2009 Physician United States
Primary
Secondary
Spinal Disorder Other Serious 12 Female 1/9/2009 United States
Primary
Secondary
Neuropathy Peripheral Other Serious 12 Female 1/22/2009 United States
Primary
Secondary
Non-small Cell Lung Cancer Death 42 Unknown 1/21/2009 Physician United States
Primary
Secondary
Stem Cell Transplant Other Serious 38 1/21/2009 Physician United States
Primary
Secondary
Neuropathy Peripheral Other Serious 12 Female 1/28/2009 United States
Primary
Secondary
Somnolence Hospitalization 1/30/2009 Male 166 lb 2/6/2009 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/30/2009 Male 166 lb 2/17/2009 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/30/2009 Male 166 lb 2/19/2009 United States
Primary
Secondary
Vomiting Other Serious 52 Female 2/26/2009
Primary
Secondary
Drug Interaction Other Serious 52 Female 3/2/2009 Netherlands
Primary
Concomitant
Interacting
Neuropathy Peripheral Hospitalization 1/1/2008 12 Female 3/6/2009 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 52 Female 3/5/2009 Netherlands
Primary
Secondary
Concomitant
Somnolence Hospitalization 1/30/2009 Male 166 lb 3/10/2009 United States
Primary
Secondary
Concomitant
Zygomycosis Other Serious 46 Male 3/17/2009 Other Health Professional Italy
Primary
Concomitant
Somnolence Hospitalization 1/30/2009 Male 166 lb 3/20/2009 United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 3/6/2009 Female 31 lb 4/1/2009 United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 23 Male 4/7/2009 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 4/5/2009 Female 87 lb 4/9/2009 United States
Primary
Secondary
Pancytopenia Hospitalization 3/6/2009 Female 31 lb 4/14/2009 United States
Primary
Secondary
Visual Impairment Other Serious 31 Female 5/5/2009 Other Health Professional Canada
Primary
Secondary
Visual Impairment Other Serious 31 Female 5/12/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 52 Female 5/20/2009 Netherlands
Primary
Secondary
Concomitant
Vomiting Other Serious Female 5/22/2009 Physician Netherlands
Primary
Secondary
Concomitant
Urine Output Decreased Hospitalization 5/17/2008 Male 132 lb 6/1/2009 United States
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/1/2009 United States
Primary
Secondary
Graft Versus Host Disease Death 57 6/5/2009 Physician Italy
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 6/5/2009 Italy
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/5/2009 Female 87 lb 6/2/2009 United States
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/5/2009 United States
Primary
Secondary
Weight Increased Hospitalization 5/17/2009 Male 132 lb 6/5/2009 United States
Primary
Secondary
Weight Increased Hospitalization 5/17/2009 Male 132 lb 6/15/2009 United States
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/15/2009 United States
Primary
Secondary
Bone Sarcoma Other Serious 11 Male 8/14/2009 Consumer Japan
Primary
Secondary
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/18/2009 United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 16 Male 8/21/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 0 Female 8/27/2009 Other Health Professional Italy
Primary
Secondary
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/24/2009 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization 8/11/2009 Male 39 lb 9/16/2009 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 33 Male 9/30/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious Unknown 10/2/2009 Korea, Republic Of
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 9/29/2009 United States
Primary
Secondary
Rash Other Serious 41 Female 10/23/2009 Other Health Professional Italy
Primary
Concomitant
Venoocclusive Disease Death 18 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 6 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 20 Female 12/7/2009 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 18 Female 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 9 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 11 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 7 Male 12/7/2009 Physician United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 10 Female 12/7/2009 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 10 Male 12/7/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Death 1 Female 12/7/2009 Physician United States
Primary
Concomitant
Capillary Leak Syndrome Death Unknown 12/14/2009 Italy
Primary
Secondary
Venoocclusive Liver Disease Hospitalization 12/30/2009 Male 34 lb 12/31/2009 United States
Primary
Secondary
Respiratory Failure Death 12/8/2009 29 Female 1/13/2010 Physician Italy
Primary
Secondary
Venoocclusive Liver Disease Hospitalization 12/30/2009 Male 34 lb 1/8/2010 United States
Primary
Secondary
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Sepsis Death 17 Male 2/23/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Death 13 Female 2/23/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Zygomycosis Other Serious 1/1/2006 Male 2/12/2010 Physician Italy
Primary
Concomitant
Weight Increased Hospitalization 7/21/2009 Male 48 lb 2/24/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 7 Male 3/10/2010 Physician United States
Primary
Secondary
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/17/2010 Physician Italy
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Death 3/25/2010 Italy
Primary
Secondary
Concomitant
Neoplasm Malignant Hospitalization 12/1/2009 14 Female 4/9/2010 Consumer France
Primary
Secondary
Wernicke's Encephalopathy Disability 5/9/2008 4/13/2010 Physician United States
Primary
Secondary
Weight Increased Hospitalization 4/8/2010 6 Female 44 lb 4/12/2010 United States
Primary
Secondary
Concomitant
Wernicke's Encephalopathy Disability 5/9/2008 4/20/2010 Physician United States
Primary
Secondary
Tumour Necrosis Hospitalization 1/27/2010 14 Female 4/16/2010 Other Health Professional France
Primary
Secondary
Pyrexia Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 13 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 1 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Death 17 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Death 7 5/4/2010 United States
Primary
Secondary
Concomitant

Drug Data