Cyclophosphamide combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Treatment Related Secondary Malignancy Other Serious 62 Female 1/5/2006 Other Health Professional Korea, Republic Of
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 62 Female 1/5/2006 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Weight Increased Required Intervention 12/15/2005 Female 117 lb 12/28/2005 United States
Primary
Secondary
Disseminated Intravascular Coagulation Other Serious 12/21/2005 Female 42 lb 12/27/2005 United States
Primary
Secondary
Productive Cough Other Serious 10/18/2004 Male 183 lb 1/13/2006 United States
Primary
Secondary
Respiratory Syncytial Virus Infection Other Serious 12/16/2005 Male 160 lb 1/13/2006 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 47 Male 1/19/2006 Physician United States
Primary
Concomitant
Respiratory Distress Hospitalization 12/12/2005 72 Male 1/12/2006 France
Primary
Secondary
Concomitant
Stomatitis Other Serious 11/21/2005 Female 138 lb 1/17/2006 United States
Primary
Secondary
Concomitant
Deafness Hospitalization 12/2/2005 57 Female 1/17/2006 France
Primary
Secondary
Viral Infection Hospitalization 9/9/2005 40 Female 119 lb 1/20/2006 Physician Germany
Primary
Secondary
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/20/2006 Physician France
Primary
Secondary
Concomitant
Pancreatitis Necrotising Hospitalization 9/30/2005 7 Female 53 lb 1/23/2006 United States
Primary
Concomitant
Vomiting Other Serious 8/17/2004 Female 132 lb 1/17/2006 United States
Primary
Secondary
Refusal Of Treatment By Relative Other Serious 1/5/2006 Female 124 lb 1/19/2006 United States
Primary
Secondary
Pyrexia Other Serious 10/2/2005 Male 160 lb 1/18/2006 United States
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Other Serious Female 1/30/2006 Other Health Professional France
Primary
Secondary
Deafness Unilateral Hospitalization 12/2/2005 57 Female 1/24/2006 Physician France
Primary
Secondary
Speech Disorder Hospitalization 11/14/2005 20 Female 218 lb 1/26/2006 Pharmacist United Kingdom
Primary
Concomitant
Hemiparesis Hospitalization 12/4/2005 21 Male 159 lb 1/26/2006 Pharmacist United Kingdom
Primary
Concomitant
Transplant Failure Hospitalization 11/21/2005 Male 176 lb 2/1/2006 Physician Germany
Primary
Concomitant
Weight Decreased Death 6 Male 1/27/2006 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/19/2006 Female 125 lb 1/26/2006 United States
Primary
Secondary
Respiratory Disorder Other Serious 17 Male 2/2/2006 Other Health Professional Ireland
Primary
Secondary
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Weight Decreased Other Serious 6 Female 1/28/2006 Physician United States
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 2/3/2006 Other Health Professional Ireland
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 2/3/2006 Physician Japan
Primary
Secondary
Pancytopenia Hospitalization 8/12/2005 67 Female 181 lb 2/6/2006 Physician Germany
Primary
Secondary
Neoplasm Malignant Death 1/1/2005 51 Female 2/8/2006 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Tracheostomy Other Serious 36 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Tracheostomy Hospitalization 40 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Post Procedural Complication Death 34 Male 2/7/2006 Physician Japan
Primary
Concomitant
Psychomotor Skills Impaired Other Serious 64 Male 2/2/2006
Primary
Secondary
Febrile Neutropenia Other Serious 2/4/2006 Male 163 lb 2/14/2006 United States
Primary
Secondary
Tachycardia Hospitalization 10/6/2005 Female 129 lb 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Incontinence Hospitalization 4/1/1998 16 Male 2/15/2006 Physician Spain
Primary
Secondary
Concomitant
Hemiplegia Death 34 Male 2/16/2006 Physician Japan
Primary
Concomitant
Pleural Effusion Life Threatening 1/30/2006 56 Female 146 lb 2/17/2006 Physician Serbia And Montenegro
Primary
Secondary
Concomitant
Tongue Paralysis Life Threatening 17 Male 2/15/2006
Primary
Secondary
Pleural Effusion Death 2/12/2006 61 Female 2/23/2006 Physician Serbia And Montenegro
Primary
Secondary
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/2/2006 Physician Japan
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 3/1/2006 Physician Ireland
Primary
Concomitant
Pleural Effusion Hospitalization 2/12/2006 61 Female 2/27/2006 Physician Serbia And Montenegro
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 1/30/2006 56 Female 146 lb 2/27/2006 Physician Yugoslavia
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 46 Male 2/22/2006 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 19 Female 3/4/2006 Physician Korea, Republic Of
Primary
Concomitant
Urinary Incontinence Hospitalization 4/1/1998 16 Male 3/1/2006 Physician Spain
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/8/2006 Physician Japan
Primary
Secondary
Concomitant
Prostration Hospitalization 12/1/2005 Male 168 lb 3/9/2006 Physician Portugal
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 2/11/2006 Female 179 lb 3/3/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/1/2004 6 Male 40 lb 3/10/2006 Physician Japan
Primary
Secondary
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/9/2006 Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/10/2004 68 Male 152 lb 3/7/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 15 Male 3/14/2006 Japan
Primary
Concomitant
Therapy Non-responder Hospitalization 2/14/2006 Female 23 lb 3/7/2006 United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 7/1/2005 14 Male 3/21/2006 Japan
Primary
Secondary
Spinal Myelogram Abnormal Other Serious 34 Female 3/21/2006 Physician Japan
Primary
Concomitant
Tremor Required Intervention 3/14/2006 67 Male 159 lb 3/17/2006 United States
Primary
Secondary
Myocardial Infarction Death 5/24/2005 51 Female 3/14/2006 Brazil
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 4/17/2002 46 Male 143 lb 3/10/2006 Physician Japan
Primary
Concomitant
Metastases To Liver Death 2/18/2000 57 Female 3/24/2006 Other Health Professional Switzerland
Primary
Secondary
Vith Nerve Paralysis Other Serious 2/24/2006 Female 3/24/2006 Physician Japan
Primary
Concomitant
Urinary Incontinence Hospitalization 48 Female 3/15/2006
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 2/19/2005 0 Male 12 lb 3/20/2006 Physician Japan
Primary
Secondary
Concomitant
Polyuria Other Serious 13 Female 3/17/2006 United States
Primary
Concomitant
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2005 63 Female 3/22/2006 Physician France
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Vomiting Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Sepsis Other Serious 15 Male 3/30/2006 Japan
Primary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/29/2006 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/4/2005 49 Female 3/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 4/17/2002 46 Male 143 lb 3/29/2006 Physician Japan
Primary
Concomitant
Tachyarrhythmia Hospitalization 1/1/2006 Male 150 lb 4/7/2006 Physician Germany
Primary
Concomitant
Vith Nerve Paralysis Other Serious 2/24/2006 59 Female 4/10/2006 Physician Japan
Primary
Concomitant
Platelet Count Decreased Hospitalization 1/13/2006 71 Male 137 lb 4/3/2006 Physician France
Primary
Secondary
Concomitant
Productive Cough Hospitalization 2/8/2006 68 Female 126 lb 4/7/2006 United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 4/18/2006 Physician Germany
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 3/3/2006 Male 23 lb 4/12/2006 United States
Primary
Secondary
Vomiting Hospitalization 3/25/2006 60 Female 152 lb 4/19/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Eosinophilic Pustular Folliculitis Other Serious 60 Female 4/20/2006 Other Health Professional Ireland
Primary
Secondary
Refractoriness To Platelet Transfusion Hospitalization 2/12/2005 0 Male 12 lb 4/7/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decrease Neonatal Hospitalization 2/12/2005 0 Male 12 lb 4/7/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Death 2/13/2004 63 Male 4/14/2006 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/22/2006 49 Male 165 lb 4/18/2006 Physician France
Primary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 3/1/2004 38 Female 4/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Toothache Other Serious 10/3/2005 39 Female 128 lb 5/1/2006 Physician United Kingdom
Primary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/21/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Death 46 Male 5/2/2006 Norway
Primary
Secondary
Ventricular Hypertrophy Life Threatening 3/27/2006 Female 116 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/2006 49 Male 165 lb 5/1/2006 Physician France
Primary
Concomitant
Skin Lesion Other Serious 60 Female 5/1/2006
Primary
Secondary
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/5/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/5/2006 Physician Germany
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 10 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Respiratory Failure Death 8/3/2005 43 Male 4/28/2006 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/8/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 11/23/2003 5 Female 4/28/2006 Physician Japan
Primary
Secondary
Concomitant
Prostration Hospitalization 12/1/2005 Male 168 lb 5/9/2006 Physician Portugal
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 38 Female 5/9/2006 Other Health Professional Turkey
Primary
Concomitant
Therapy Non-responder Hospitalization 66 Male 5/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatitis Toxic Hospitalization 2/24/2006 31 Male 5/8/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 5/8/2006 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/1/2003 43 Male 5/5/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Metastasis Other Serious 10/15/2001 60 Male 5/12/2006 United States
Primary
Secondary
Concomitant
T-cell Lymphoma Death 66 Male 5/12/2006 Consumer United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 32 Female 5/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 11/17/2005 52 Female 272 lb 5/11/2006 Physician Spain
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 3/1/1997 16 Male 5/1/2006 Physician Spain
Primary
Secondary
Septic Shock Life Threatening 2/7/2006 40 Female 209 lb 5/15/2006 Physician France
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 2/13/2005 66 Female 5/15/2006 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 14 Male 5/19/2006 Other Health Professional Poland
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/20/2006 70 Female 117 lb 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 4/1/2006 Female 181 lb 5/23/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 12/1/2004 74 Male 5/23/2006 Other Health Professional Czech Republic
Primary
Concomitant
Vitamin B12 Increased Hospitalization 1/1/2001 43 Male 5/16/2006
Primary
Secondary
Burkitt's Lymphoma Death 38 Female 5/12/2006
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Toothache Other Serious 63 Female 132 lb 5/24/2006 Portugal
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/24/2006 Physician United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Other Serious 17 Male 5/18/2006
Primary
Secondary
Swelling Other Serious 4/13/2006 51 Female 5/24/2006 Physician Portugal
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Death Death 50 Male 5/23/2006 United States
Primary
Secondary
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 5/31/2006 Physician United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/21/2001 47 Male 148 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 6/7/2006 Physician Germany
Primary
Concomitant
Toothache Other Serious 8/1/2005 63 Female 132 lb 6/8/2006 Portugal
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Nervous System Disorder Death 38 Female 6/9/2006 France
Primary
Secondary
Human Herpesvirus 6 Infection Death 34 Male 5/23/2006 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 3 Unknown 4/27/2006 Japan
Primary
Secondary
Concomitant
Dizziness Other Serious 6/5/2006 Male 196 lb 6/7/2006 United States
Primary
Secondary

Drug Data