Cyclophosphamide combined with Methotrexate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neutropenic Sepsis Hospitalization 4/4/2006 74 Female 7/12/2006 United Kingdom
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 43 Female 10/13/2006 Physician India
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 61 Male 10/19/2006
Primary
Secondary
Lobar Pneumonia Hospitalization 10/4/2006 Female 206 lb 10/17/2006 United States
Primary
Secondary
Escherichia Infection Hospitalization 10/2/2006 56 Female 115 lb 10/13/2006 Physician France
Primary
Secondary
Osteonecrosis Hospitalization 2/28/2005 58 Female 173 lb 10/25/2006 Physician United Kingdom
Primary
Concomitant
Weight Decreased Life Threatening 63 Female 174 lb 10/25/2006 Other Health Professional Germany
Primary
Secondary
Hospitalisation Other Serious 1/19/2006 Female 179 lb 10/30/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 4/10/2006 22 Male 10/30/2006 Japan
Primary
Concomitant
Thoracic Vertebral Fracture Other Serious 11/1/1998 43 Male 12/13/2006 Other Health Professional United Kingdom
Primary
Secondary
Weight Increased Death 2/14/2007 39 Female 5/17/2007 Japan
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 3/4/2005 69 Male 5/18/2007 Switzerland
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/27/2007 Female 134 lb 5/25/2007 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/16/2006 59 Female 5/31/2007 Other Health Professional United Kingdom
Primary
Secondary
Deep Vein Thrombosis Hospitalization 4/4/2007 64 Male 6/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 12/1/2004 58 Female 173 lb 6/2/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 5/14/2007 59 Female 146 lb 6/2/2007 Physician France
Primary
Secondary
Malignant Neoplasm Progression Death 13 Male 6/7/2007 Japan
Primary
Secondary
Concomitant
Wound Infection Hospitalization 7/11/2007 27 Female 120 lb 7/24/2007 Other Health Professional United States
Primary
Concomitant
Myeloid Leukaemia Other Serious 1 Male 7/31/2007 Other Health Professional United Kingdom
Primary
Secondary
Maculopathy Required Intervention 65 Unknown 7/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Disturbance Required Intervention 66 Unknown 7/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Required Intervention 66 Unknown 7/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Maculopathy Required Intervention 73 Unknown 7/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Maculopathy Required Intervention 34 Unknown 7/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Hospitalization 6/20/2008 Female 7/24/2008 Physician United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 3 Male 7/25/2008 Consumer Canada
Primary
Concomitant
Spinal Compression Fracture Hospitalization 11/1/1998 43 Male 8/12/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Death 39 Female 8/9/2008 United States
Primary
Secondary
Subarachnoid Haemorrhage Life Threatening 0 Female 8/11/2008 United Kingdom
Primary
Secondary
Wheezing Hospitalization 7/24/2008 Female 251 lb 8/12/2008 United States
Primary
Secondary
Hodgkin's Disease Other Serious 10 Female 8/18/2008 Physician United States
Primary
Secondary
Pulmonary Fibrosis Life Threatening 5/7/2007 39 Male 8/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fungal Sepsis Death 8/19/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocythaemia Other Serious 36 Female 8/19/2008 Other Health Professional Japan
Primary
Concomitant
Pneumonia Aspiration Death 75 Female 8/13/2008 Japan
Primary
Secondary
Osteoporosis Other Serious 11/1/1998 43 Male 8/20/2008 United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Disability 39 Female 8/20/2008 Physician United States
Primary
Secondary
Spinal Compression Fracture Hospitalization 11/1/1998 43 Male 8/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Serotonin Syndrome Life Threatening 8/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hodgkin's Disease Other Serious 10 Female 8/28/2008 United States
Primary
Secondary
Concomitant
Cytomegalovirus Colitis Other Serious 42 Male 8/29/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious Male 8/29/2008 Other Health Professional Japan
Primary
Secondary
Tuberculosis Test Positive Other Serious 42 Male 8/29/2008
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 48 Female 9/24/2008 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 19 Male 9/26/2008 Germany
Primary
Concomitant
Pancytopenia Other Serious 0 Female 10/3/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Herpes Viral Other Serious 44 Male 10/6/2008 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 44 Female 10/7/2008 Japan
Primary
Secondary
Post Transplant Distal Limb Syndrome Other Serious 18 Male 10/8/2008 Other Health Professional Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 7/4/2008 51 Female 10/8/2008 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenia Hospitalization 9/1/2008 Female 10/9/2008 Pharmacist United Kingdom
Primary
Concomitant
Mucosal Inflammation Other Serious 10 11/25/2008 United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 4/1/2005 2/24/2009 Physician Denmark
Primary
Secondary
Diverticulitis Hospitalization 1/2/2009 Male 3/5/2009 Physician United Kingdom
Primary
Secondary
Leukoencephalopathy Other Serious 3/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 4/1/2005 3/20/2009 Physician Denmark
Primary
Secondary
Malaise Other Serious 12/13/2008 3/31/2009 Other Health Professional France
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 4/6/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Acute Promyelocytic Leukaemia Other Serious 53 Male 4/23/2009 Other Health Professional France
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious 51 Male 4/23/2009 Other Health Professional France
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious 48 Female 4/23/2009 Other Health Professional France
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious Male 4/23/2009 Other Health Professional France
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious 20 Male 4/23/2009 Other Health Professional France
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious 36 Male 4/23/2009 Other Health Professional France
Primary
Secondary
Venoocclusive Disease Death 4/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Death 4/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Death 1 5/21/2009 Other Health Professional United Kingdom
Primary
Secondary
Neoplasm Malignant Death 3/3/2003 66 5/27/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Screaming Hospitalization 6/22/2009 Male 50 lb 6/24/2009 Physician United States
Primary
Secondary
Pneumonia Other Serious 30 Male 7/13/2009 Consumer Japan
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 8/10/2009 Male 79 lb 8/19/2009 United States
Primary
Secondary
Concomitant
Transplant Other Serious 13 Male 8/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 1/1/2009 13 Male 8/27/2009 Consumer France
Primary
Concomitant
Toothache Life Threatening 6/1/2009 Male 213 lb 9/18/2009 Physician Germany
Primary
Concomitant
Pulmonary Hypertension Required Intervention 11/19/2008 32 Female 108 lb 11/24/2008 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/24/2009 Male 52 lb 11/6/2009 United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 1/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Rheumatoid Lung Other Serious 11/1/2009 79 Male 117 lb 4/6/2010 Physician Brazil
Primary
Concomitant
Thrombocytopenia Other Serious 3/12/2010 45 Female 4/28/2010 Physician Italy
Primary
Secondary
Concomitant
Subdural Haematoma Other Serious 2/29/2008 86 Female 5/5/2010 Physician United States
Primary
Secondary
Thrombocytopenia Other Serious 3/12/2010 45 Female 7/16/2010 Physician Italy
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 2/8/2010 3 Female 31 lb 9/20/2010 Physician Japan
Primary
Concomitant
Temperature Intolerance Other Serious 1/1/2009 45 Male 9/23/2010 Other Health Professional Japan
Primary
Concomitant
Venous Thrombosis Other Serious 4/3/2007 60 Female 172 lb 9/23/2010 Physician Greece
Primary
Secondary
Dermatofibrosarcoma Hospitalization 8/1/2010 34 Male 9/23/2010 Other Health Professional France
Primary
Secondary
Hepatic Enzyme Increased Other Serious 11/28/2006 46 Female 101 lb 9/23/2010 Physician Greece
Primary
Secondary
Concomitant
Pain Other Serious 7/21/2006 57 Female 172 lb 9/24/2010 Physician Greece
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 6/17/2010 7 Male 9/27/2010 Physician Japan
Primary
Secondary
Urinary Tract Infection Other Serious 4/29/2006 48 Female 163 lb 9/27/2010 Physician Greece
Primary
Secondary
Concomitant
Spinal Cord Disorder Other Serious 45 Male 10/12/2010 Other Health Professional Japan
Primary
Secondary
Deafness Neurosensory Disability 8/1/2009 50 Female 172 lb 10/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Headache Hospitalization 10/15/2010 19 Male 155 lb 10/18/2010 United States
Primary
Secondary
Deafness Neurosensory Disability 8/1/2009 50 Female 172 lb 10/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/1/2010 78 Male 194 lb 10/27/2010 Physician Australia
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 1 10/26/2010 Physician Saudi Arabia
Primary
Concomitant
Cytomegalovirus Infection Other Serious 1 10/26/2010 Physician Saudi Arabia
Primary
Concomitant
Cytomegalovirus Infection Other Serious 3 10/26/2010 Physician Saudi Arabia
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 8 Male 11/9/2010 Physician United States
Primary
Concomitant
T-cell Lymphoma Refractory Other Serious Male 12/31/2010 Other Health Professional Japan
Primary
Secondary
Polyomavirus-associated Nephropathy Other Serious 55 Male 1/5/2011 Other Health Professional Japan
Primary
Secondary
Inappropriate Antidiuretic Hormone Secretion Other Serious 2 Male 12/26/2010 Physician Japan
Primary
Concomitant
Renal Disorder Other Serious 40 Male 1/6/2011 Physician Japan
Primary
Secondary
Thrombotic Microangiopathy Other Serious 2 Male 1/18/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Toxicity To Various Agents Death 55 Male 4/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Burkitt's Lymphoma Death 55 Male 4/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Bone Marrow Failure Death 57 Female 4/27/2011 Physician Japan
Primary
Secondary
Toxicity To Various Agents Death 55 Male 5/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Bacterial Sepsis Life Threatening 1/1/2010 52 Male 5/9/2011 Other Health Professional France
Primary
Secondary
Concomitant
Bacterial Sepsis Other Serious 8/22/2010 52 Male 5/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 55 Male 5/23/2011 Consumer United Kingdom
Primary
Secondary
Cerebral Venous Thrombosis Hospitalization 11/5/2010 42 Male 5/24/2011 Other Health Professional France
Primary
Secondary
Concomitant
Burkitt's Lymphoma Other Serious 55 Male 5/27/2011 Consumer United Kingdom
Primary
Secondary
Pneumonia Hospitalization 1/11/2011 65 Male 5/31/2011 Physician Japan
Primary
Secondary
Cerebral Venous Thrombosis Hospitalization 11/5/2010 42 Male 6/1/2011 Other Health Professional France
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/11/2011 65 Male 6/3/2011 Physician Japan
Primary
Secondary
Anaemia Other Serious 4/27/2009 68 Female 6/17/2011 Physician Japan
Primary
Secondary
Multi-organ Failure Death 7/17/2009 74 Male 154 lb 7/1/2011 Other Health Professional Ukraine
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/17/2009 74 Male 154 lb 7/5/2011 Other Health Professional Ukraine
Primary
Secondary
Concomitant
Pulmonary Veno-occlusive Disease Other Serious 5 Male 7/18/2011 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 1/11/2011 66 Male 8/2/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 1/11/2011 66 Male 8/9/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 31 Male 8/16/2011 Other Health Professional Japan
Primary
Secondary
Pulmonary Fibrosis Death 73 8/26/2011 Other Health Professional Japan
Primary
Secondary
Pulmonary Fibrosis Death 81 8/30/2011 Other Health Professional Japan
Primary
Secondary
Encephalitis Viral Hospitalization 8/19/2011 68 Male 127 lb 9/7/2011 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 9/12/2011 55 Female 95 lb 9/23/2011 Physician Japan
Primary
Secondary
Concomitant
Enterocolitis Hospitalization 8/8/2011 70 Male 124 lb 9/26/2011 Physician Japan
Primary
Secondary
Concomitant
Device Related Sepsis Death 9/12/2011 55 Female 95 lb 9/27/2011 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 9/12/2011 55 Female 95 lb 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 40 Male 10/6/2011 Physician Japan
Primary
Secondary
Acute Pulmonary Oedema Other Serious 5/28/2009 47 Female 10/3/2011 Other Health Professional France
Primary
Secondary
Cholecystitis Hospitalization 9/26/2011 60 Female 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Hospitalization 10/8/2011 9 Male 57 lb 10/21/2011 Physician Czech Republic
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 1/11/2011 66 Male 10/24/2011 Physician Japan
Primary
Secondary
Concomitant
Colitis Ischaemic Hospitalization 10/14/2011 74 Male 10/26/2011 Physician Japan
Primary
Secondary
Concomitant
Colitis Ischaemic Hospitalization 10/14/2011 74 Male 11/9/2011 Physician Japan
Primary
Secondary
Concomitant
Enterocolitis Infectious Hospitalization 6/17/2011 22 Female 11/10/2011 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Hospitalization 8/22/2011 65 Male 121 lb 11/11/2011 Physician Japan
Primary
Secondary
Ovarian Failure Other Serious 20 Female 12/12/2011 Physician Japan
Primary
Secondary
Breath Sounds Abnormal Hospitalization 13 Female 12/14/2011 Other Health Professional Turkey
Primary
Secondary
Leukoencephalopathy Other Serious 10/26/2011 9 Female 12/14/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Diplopia Other Serious 3/1/2011 61 Male 12/19/2011 Physician France
Primary
Secondary
Concomitant
Bladder Cancer Other Serious 3/1/2011 61 Male 12/25/2011 Physician France
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 39 Female 12/29/2011 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 1/1/2011 9 Female 1/27/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Bladder Cancer Other Serious 12/1/2004 61 Male 1/27/2012 Other Health Professional France
Primary
Secondary
Concomitant

Drug Data