Cyclophosphamide combined with Melphalan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tooth Extraction Other Serious 1/1/2005 Female 2/2/2006 Physician Germany
Primary
Concomitant
Surgery Other Serious 6/27/2005 Female 2/18/2006 Spain
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
Wound Drainage Other Serious 1/1/2001 52 Male 3/15/2006 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2001 52 Male 3/24/2006 United States
Primary
Secondary
Concomitant
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Ventricular Arrhythmia Other Serious 5/11/2006 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 5/11/2006 Consumer United States
Primary
Secondary
Concomitant
Melaena Other Serious 60 Female 5/22/2006 Australia
Primary
Secondary
Concomitant
Wound Drainage Other Serious 1/1/2001 52 Male 5/31/2006 United States
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Other Serious 2/1/2004 1 Male 6/7/2006 Other Health Professional Japan
Primary
Secondary
Blood Bilirubin Increased Other Serious 1/7/2005 3 Female 5/24/2006 Spain
Primary
Concomitant
Streptococcal Infection Hospitalization 6/7/2006 Male 135 lb 6/8/2006 United States
Primary
Secondary
Concomitant
Pneumonia Required Intervention 64 Male 6/16/2006 Physician Germany
Primary
Concomitant
Vertigo Hospitalization 5/1/2005 Female 163 lb 6/30/2006 Germany
Primary
Concomitant
Pneumonia Fungal Other Serious 7/3/2006 Consumer Finland
Primary
Concomitant
Tooth Extraction Other Serious 80 Female 7/5/2006 Other Health Professional Italy
Primary
Concomitant
Treatment Related Secondary Malignancy Other Serious 2/1/2004 5 Male 7/6/2006 Other Health Professional Japan
Primary
Secondary
Wound Debridement Other Serious 1/1/2003 61 Male 187 lb 7/21/2006 Physician Germany
Primary
Concomitant
Rash Hospitalization 11/11/2005 Male 123 lb 8/11/2006 Physician Belgium
Primary
Concomitant
Status Epilepticus Other Serious 10 Female 9/1/2006 Spain
Primary
Concomitant
Plasmacytoma Other Serious 54 Male 9/21/2006 Consumer United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 5/22/2006 60 Male 9/25/2006 Physician France
Primary
Concomitant
Osteonecrosis Hospitalization 5/5/2005 61 Female 10/3/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 5/1/2005 Female 163 lb 10/26/2006 Germany
Primary
Concomitant
Wound Debridement Other Serious 79 Female 10/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/29/2006 Male 189 lb 10/25/2006 United States
Primary
Secondary
Tooth Disorder Other Serious 1/18/2006 75 Female 12/5/2006 Physician Spain
Primary
Concomitant
Wound Debridement Other Serious 2/1/2005 74 Female 12/7/2006 Physician Belgium
Primary
Concomitant
Osteonecrosis Other Serious 80 Female 12/12/2006
Primary
Secondary
Concomitant
Viral Infection Hospitalization 10/22/2006 Female 144 lb 12/27/2006 United States
Primary
Secondary
Treatment Related Secondary Malignancy 54 Male 1/16/2007 United States
Primary
Secondary
Malignant Neoplasm Progression Other Serious 4 Female 1/19/2007 Other Health Professional Belgium
Primary
Secondary
Transient Ischaemic Attack Other Serious 10/17/2006 NotSpecified 1/19/2007 Other Health Professional Norway
Primary
Concomitant
Tenderness Other Serious 4 Female 1/26/2007
Primary
Secondary
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 1/30/2007 Japan
Primary
Concomitant
Osteonecrosis Other Serious 10/20/2005 63 Male 1/31/2007 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 73 Male 2/2/2007 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 10/17/2006 1/29/2007 Physician Germany
Primary
Secondary
Stem Cell Transplant Death 4 Female 1/26/2007 Belgium
Primary
Secondary
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Stem Cell Transplant Death 4 Female 2/7/2007 Belgium
Primary
Secondary
Neutropenic Sepsis Death 2/20/2007 Consumer Australia
Primary
Secondary
Thrombocytopenia Other Serious 2/20/2007 Consumer Australia
Primary
Secondary
Tooth Disorder Other Serious 1/18/2006 75 Female 2/27/2007 Physician Spain
Primary
Concomitant
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Tremor Hospitalization 2/1/2007 Female 190 lb 2/20/2007 United States
Primary
Secondary
Concomitant
Spinal Compression Fracture Other Serious 8/18/2006 68 Male 176 lb 3/7/2007 Physician United States
Primary
Secondary
Concomitant
Tremor Hospitalization 2/1/2007 Female 190 lb 3/19/2007 United States
Primary
Secondary
Concomitant
Drug Resistance Other Serious 67 Female 5/1/2007 Consumer Japan
Primary
Secondary
Concomitant
Drug Resistance Other Serious 54 Male 5/1/2007 Consumer Japan
Primary
Secondary
Concomitant
Drug Resistance Other Serious 55 Male 5/1/2007 Consumer Japan
Primary
Secondary
Concomitant
Drug Resistance Other Serious 78 Male 5/1/2007 Consumer Japan
Primary
Secondary
Concomitant
Multiple Myeloma Life Threatening 4/4/2004 Male 82 lb 5/3/2007 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 59 Female 5/10/2007 Other Health Professional India
Primary
Secondary
Tooth Extraction Other Serious 5/23/2006 78 Male 161 lb 5/26/2007 Physician United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 5/23/2006 78 Male 161 lb 5/26/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/25/2007 Male 256 lb 5/30/2007 United States
Primary
Secondary
Osteonecrosis Other Serious 76 Female 6/5/2007 Other Health Professional Italy
Primary
Concomitant
Osteonecrosis Other Serious 58 Female 6/5/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 4/17/2007 Male 174 lb 5/31/2007 United States
Primary
Secondary
Renal Impairment Other Serious 2/1/2006 76 Male 6/20/2007 Other Health Professional Finland
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Rash Pustular Other Serious 65 Female 7/26/2007
Primary
Secondary
Toxic Epidermal Necrolysis Other Serious 9/14/2007 Consumer United States
Primary
Secondary
West Nile Viral Infection Other Serious 8/18/2006 68 Male 176 lb 9/26/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/15/2007 Consumer Switzerland
Primary
Secondary
Ureaplasma Infection Other Serious 28 Male 10/15/2007 Switzerland
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 28 Male 10/17/2007
Primary
Secondary
Concomitant
Ureaplasma Infection Hospitalization 28 Male 10/11/2007 Switzerland
Primary
Secondary
Myelodysplastic Syndrome Death 10/25/2007 Physician Italy
Primary
Secondary
Concomitant
Pneumonia Death 10/25/2007 Physician Italy
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 75 Male 10/29/2007 Japan
Primary
Secondary
Hypersensitivity Other Serious 16 Female 11/20/2007 Other Health Professional Australia
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 5/22/2006 60 Male 11/16/2007 Physician France
Primary
Concomitant
Vomiting Hospitalization 12/28/2007 Female 197 lb 1/8/2008 United States
Primary
Secondary
Venoocclusive Liver Disease Death 8/7/2006 4 Male 28 lb 1/29/2008 Physician Japan
Primary
Secondary
Concomitant
Acute Myocardial Infarction Other Serious Male 2/7/2008 Consumer United Kingdom
Primary
Concomitant
Pancytopenia Other Serious Male 2/7/2008 Consumer United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 4 Male 2/15/2008 Japan
Primary
Secondary
Concomitant
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/11/2008 Consumer Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/11/2008 Consumer Japan
Primary
Concomitant
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 15 3/24/2008 Physician Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Cytomegalovirus Enteritis Other Serious 12 3/24/2008 Physician Japan
Primary
Concomitant
Parkinson's Disease Other Serious 12 Female 4/10/2008 Other Health Professional Germany
Primary
Secondary
Acute Myocardial Infarction Other Serious Male 4/11/2008 Other Health Professional Greece
Primary
Concomitant
Pancytopenia Other Serious Male 4/11/2008 Other Health Professional Greece
Primary
Concomitant
Parkinson's Disease Other Serious 12 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Graft Versus Host Disease Other Serious 14 Male 4/14/2008 Other Health Professional Germany
Primary
Secondary
Neutropenia Other Serious 4 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Graft Versus Host Disease Other Serious 12 Male 4/15/2008 Other Health Professional Germany
Primary
Secondary
Hypercalcaemia Hospitalization 4/16/2008 Other Health Professional Japan
Primary
Concomitant
Hypercalcaemia Other Serious 4/16/2008 Other Health Professional Japan
Primary
Concomitant
Skin Haemorrhage Other Serious 58 Male 4/24/2008 Russian Federation
Primary
Secondary
Respiratory Moniliasis Death 55 Female 4/25/2008 Physician United Kingdom
Primary
Secondary
Hypertension Other Serious 7 Female 4/28/2008 Physician Japan
Primary
Concomitant
Rash Other Serious 1/16/2008 Female 128 lb 4/30/2008 Physician Germany
Primary
Concomitant
Transplant Rejection Death 6/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Bacterial Sepsis Death 6/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastric Cancer Death 6/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 64 Female 6/13/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Viraemia Other Serious 6/20/2008 South Africa
Primary
Secondary
Concomitant
Viraemia Other Serious 6/23/2008 South Africa
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 57 6/26/2008 Other Health Professional Australia
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 4/25/2008 Male 164 lb 7/3/2008 United States
Primary
Secondary
Retinal Haemorrhage Other Serious 26 Female 7/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Swelling Other Serious 8/2/2001 Male 200 lb 7/14/2008 United States
Primary
Secondary
Concomitant
Swelling Other Serious 8/2/2001 Male 200 lb 7/14/2008 United States
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 4/25/2008 Male 164 lb 7/11/2008 United States
Primary
Secondary
Visual Acuity Reduced Other Serious 26 Female 7/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Swelling Other Serious 8/2/2001 Male 200 lb 7/31/2008 United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Hospitalization 47 Male 8/4/2008 Other Health Professional United States
Primary
Secondary
Vasculitis Hospitalization 1/13/2006 59 Female 8/5/2008 France
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 37 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Splenic Rupture Death 2/1/2001 53 Male 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 47 Male 8/11/2008 United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 47 Male 8/9/2008 United States
Primary
Secondary
Stem Cell Transplant Other Serious 47 Male 8/20/2008 Physician United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious Male 8/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious Male 8/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Fungal Infection Other Serious 9/10/2008 Other Health Professional Italy
Primary
Secondary
Infection Death 51 6/14/2008 Other Health Professional Australia
Primary
Secondary
Concomitant
Nephritis Interstitial Other Serious 9 Male 9/30/2008 Other Health Professional Germany
Primary
Secondary
Tubulointerstitial Nephritis Other Serious 9 Male 10/3/2008 Other Health Professional Germany
Primary
Secondary
Multi-organ Failure Death 10/13/2008 Consumer Italy
Primary
Secondary
Concomitant
Sinus Tachycardia Required Intervention 7/19/2006 65 Female 1/22/2007 Physician United States
Primary
Secondary
Weight Decreased Other Serious 10/1/2007 54 Male 209 lb 10/14/2008 Other Health Professional France
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 8/1/2008 Female 32 lb 10/15/2008 United States
Primary
Concomitant
Vascular Occlusion Other Serious 10/6/2008 40 Female 10/28/2008 Other Health Professional France
Primary
Concomitant
Weight Increased Other Serious 43 Female 11/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 26 Female 11/18/2008 Other Health Professional Japan
Primary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 26 Female 11/18/2008 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 11/26/2007 43 Female 11/26/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/26/2007 43 Female 11/26/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/22/2008 56 Female 12/1/2008 Physician Germany
Primary
Secondary
Concomitant
Bone Sarcoma Other Serious 8 Male 12/1/2008 Consumer Japan
Primary
Secondary
Sepsis Syndrome Other Serious 14 Male 11/28/2008 Other Health Professional Germany
Primary
Concomitant
Nervous System Disorder Other Serious 12 Female 11/27/2008 Physician United States
Primary
Secondary

Drug Data