Cyclophosphamide combined with Melphalan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/5/2009 United States
Primary
Secondary
Leukopenia Death 67 Female 6/23/2009 Other Health Professional Germany
Primary
Secondary
Malignant Neoplasm Progression Other Serious 8/1/2006 51 Male 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Mucosal Inflammation Other Serious 8/1/2006 51 Male 7/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Osteonecrosis Other Serious 75 Female 7/9/2009 Other Health Professional Italy
Primary
Concomitant
Bone Sarcoma Other Serious 11 Male 8/14/2009 Consumer Japan
Primary
Secondary
Thrombosis Death 7/5/2009 Female 8/17/2009 Pharmacist United Kingdom
Primary
Concomitant
Transplant Failure Other Serious 69 Male 8/17/2009 United States
Primary
Secondary
Renal Impairment Other Serious 1 Female 8/24/2009 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 2 Male 8/25/2009 United Kingdom
Primary
Secondary
Transaminases Increased Other Serious 0 Female 8/27/2009 Other Health Professional Italy
Primary
Secondary
Renal Impairment Death 12/1/2008 61 Male 115 lb 9/8/2009 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 2 Female 9/25/2009 United Kingdom
Primary
Secondary
Graft Versus Host Disease Required Intervention 1 Female 9/25/2009 United Kingdom
Primary
Secondary
Graft Versus Host Disease Required Intervention 2 Female 9/25/2009 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 2 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious Unknown 10/2/2009 Korea, Republic Of
Primary
Secondary
Renal Impairment Other Serious 1 Female 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Other Serious Unknown 12/14/2009 Germany
Primary
Secondary
Capillary Leak Syndrome Death Unknown 12/14/2009 Italy
Primary
Secondary
Weight Decreased Other Serious 12/1/2005 Male 136 lb 1/15/2010 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 5/1/2008 Male 172 lb 2/4/2010 Other Health Professional United States
Primary
Concomitant
Renal Impairment Death 12/1/2008 61 Male 115 lb 2/12/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Death 2/12/2010 Physician Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/9/2002 Male 136 lb 2/15/2010 Physician United States
Primary
Concomitant
Pneumonia Death 2/18/2010 Physician Italy
Primary
Secondary
Concomitant
Septic Shock Death 2/18/2010 Physician Italy
Primary
Secondary
Concomitant
Weight Increased Hospitalization 7/21/2009 Male 48 lb 2/24/2010 United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/28/2009 74 Male 3/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Vitamin B12 Increased Other Serious 74 Male 3/6/2010 United Kingdom
Primary
Secondary
Concomitant
Lymphocytosis Other Serious 54 Male 3/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 5/12/2005 Male 136 lb 3/18/2010 Physician United States
Primary
Concomitant
Paraproteinaemia Other Serious 8/28/2009 74 Male 3/18/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Septic Shock Life Threatening 6/17/2007 Male 3/18/2010 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/28/2009 74 Male 3/15/2010 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Death 12/22/2006 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 16 Male 3/23/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Death 12/22/2006 Female 3/25/2010 Consumer Italy
Primary
Secondary
Concomitant
Paraproteinaemia Other Serious 74 Male 3/20/2010 United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 Male 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 57 Female 3/26/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Septic Shock Life Threatening 3/16/2007 57 Male 3/26/2010 Physician Italy
Primary
Secondary
Concomitant
Septic Shock Death 6/26/2007 76 Male 3/26/2010 Physician Italy
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Renal Failure Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Weight Decreased Other Serious 5/12/2005 Male 136 lb 3/30/2010 Physician United States
Primary
Concomitant
Acute Graft Versus Host Disease Death 3/25/2010 Italy
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 7/6/2009 16 Male 110 lb 4/5/2010 Physician Japan
Primary
Concomitant
Testis Cancer Male 4/1/2010 Australia
Primary
Concomitant
Weight Decreased Other Serious 11/1/2001 50 Female 4/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 4/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 50 Female 4/8/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 5/12/2005 60 Male 136 lb 4/9/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 4/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2001 50 Female 4/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 6 Female 4/20/2010 Other Health Professional Germany
Primary
Concomitant
Thrombocytopenia Other Serious 16 Female 4/26/2010 Physician Germany
Primary
Concomitant
Non-small Cell Lung Cancer Death 6/29/2009 68 Male 4/30/2010 Physician United Kingdom
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 48 Male 5/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 13 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 1 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Death 7 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 2 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 5/10/2010 Italy
Primary
Secondary
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death Unknown 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sweat Gland Tumour Required Intervention 32 Male 6/2/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Female 6/15/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Pneumonia Death 11/4/2007 46 Male 6/23/2010 Physician Italy
Primary
Secondary
Concomitant
Sweat Gland Tumour Other Serious 32 Male 6/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Varicella Virus Test Positive Other Serious 9 Male 6/23/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/23/2010 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/25/2010 Physician United States
Primary
Secondary
Sweat Gland Tumour Required Intervention 28 Male 6/17/2010 Consumer United Kingdom
Primary
Secondary
Myelodysplastic Syndrome Other Serious 57 Female 199 lb 6/29/2010 Consumer United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/30/2010 Consumer United States
Primary
Secondary
Urinary Tract Infection Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sweat Gland Tumour Other Serious 6/1/2002 32 Male 7/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 6/1/2002 32 Male 7/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Neuropathy Peripheral Other Serious 7/8/2010 Physician Italy
Primary
Secondary
No Therapeutic Response Disability 64 Male 8/24/2010 United Kingdom
Primary
Concomitant
Radial Nerve Palsy Disability 62 Male 8/24/2010 United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 56 Male 9/10/2010 Consumer United Kingdom
Primary
Secondary
Sebaceous Carcinoma Other Serious 10/1/2009 46 Male 203 lb 9/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1995 57 Male 9/17/2010 United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 50 Male 9/17/2010 Consumer Japan
Primary
Secondary
Concomitant
Pancreatic Disorder Other Serious 6 Female 9/16/2010 Physician Germany
Primary
Concomitant
Wheezing Other Serious 5/9/1997 37 Female 193 lb 9/22/2010 United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 51 Female 9/29/2010 Other Health Professional Italy
Primary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 9/30/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2001 50 Female 10/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Injury Other Serious 59 Female 10/4/2010 Consumer Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2001 50 Female 10/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 31 Female 10/15/2010 Other Health Professional United States
Primary
Secondary
Stenotrophomonas Infection Hospitalization 5/17/2010 59 Male 126 lb 10/27/2010 Physician Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 15 Female 10/27/2010 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 3/14/1999 48 Male 10/29/2010 United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 10/20/2010 Physician United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 11/10/2010 Physician Italy
Primary
Secondary
Stomatitis Other Serious 8/12/2009 50 Male 10/29/2010 Japan
Primary
Secondary
Concomitant
Colitis Other Serious 33 Female 11/16/2010 Other Health Professional Czech Republic
Primary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Other Serious 5 Male 11/9/2010 Physician United Kingdom
Primary
Concomitant
Wheezing Other Serious 5/9/1997 37 Female 193 lb 11/19/2010 United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 15 Female 11/26/2010 Other Health Professional Japan
Primary
Concomitant
Autoimmune Thrombocytopenia Other Serious Male 11/16/2010 Netherlands
Primary
Concomitant
Sepsis Other Serious 15 Male 12/10/2010 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 4/20/2010 1 Male 15 lb 12/10/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 15 Male 12/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 12/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 31 Female 11/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 14 Female 12/19/2010 Physician Germany
Primary
Concomitant
Epstein-barr Virus Infection Other Serious 2 Male 12/19/2010 Physician Germany
Primary
Concomitant
Epstein-barr Virus Infection Other Serious 8 Male 12/19/2010 Physician Germany
Primary
Concomitant
Epstein-barr Virus Infection Other Serious 1 Male 12/19/2010 Physician Germany
Primary
Concomitant
Pneumonia Hospitalization 11 Male 1/27/2011 Other Health Professional Japan
Primary
Secondary
Intestinal Obstruction Other Serious 22 Male 1/28/2011 Greece
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 39 Female 2/28/2011 Other Health Professional Australia
Primary
Secondary
Febrile Neutropenia Other Serious 22 Male 2/28/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Pulmonary Oedema Death 59 Female 2/28/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Failure Acute Other Serious 1/1/2009 63 Female 3/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Lymphopenia Death 10 Female 4/11/2011 Physician United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Liver Other Serious 53 Female 5/11/2011 Physician United States
Primary
Secondary
Concomitant

Drug Data