Cyclophosphamide combined with Mabthera

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Subacute Endocarditis Other Serious 9/1/2004 82 Male 157 lb 1/18/2006 Other Health Professional Germany
Primary
Concomitant
Hepatitis Other Serious 10/25/2005 56 Male 2/10/2006 Sweden
Primary
Concomitant
Local Swelling Other Serious Male 3/7/2006 United Kingdom
Primary
Secondary
Skin Exfoliation Hospitalization 12/15/2005 61 Male 3/15/2006 Consumer Netherlands
Primary
Secondary
Concomitant
Hypogammaglobulinaemia Death 75 Male 3/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Hospitalization Male 3/30/2006 Physician France
Primary
Concomitant
Ileitis Required Intervention 7/19/2005 59 Female 3/30/2006 Physician Portugal
Primary
Concomitant
Sinus Bradycardia Hospitalization 3/22/2006 67 Female 148 lb 4/10/2006 Physician Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/27/2006 52 Male 138 lb 4/21/2006 Other Health Professional Australia
Primary
Secondary
Kyphosis Hospitalization 10/20/2005 4/21/2006 Physician Germany
Primary
Secondary
Sepsis Hospitalization 75 Male 5/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Somnolence Death 75 Male 5/5/2006 Consumer United Kingdom
Primary
Secondary
Viraemia Death 4/7/2006 58 Male 183 lb 5/23/2006 Physician Belgium
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/25/2005 55 Female 105 lb 5/23/2006 Physician Poland
Primary
Secondary
Renal Failure Chronic Death 3/16/2006 Male 5/24/2006 Physician Poland
Primary
Secondary
Pyrexia Death 32 Female 5/24/2006 Physician South Africa
Primary
Secondary
Guillain-barre Syndrome Other Serious Female 5/24/2006 Physician Portugal
Primary
Secondary
Vasodilatation Hospitalization 4/16/2006 75 Male 5/24/2006 Physician Germany
Primary
Secondary
Therapy Non-responder Death 66 Male 6/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Local Swelling Male 7/28/2006 United Kingdom
Primary
Secondary
Constipation Hospitalization 3/24/2006 42 Female 108 lb 8/3/2006 Physician France
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/19/2005 74 Female 123 lb 8/22/2006 Physician Belgium
Primary
Secondary
Concomitant
Viral Myocarditis Hospitalization 8/22/2006 45 Male 9/8/2006 Physician Ireland
Primary
Secondary
Septic Shock Life Threatening 8/29/2006 50 Male 9/18/2006 Physician Israel
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/22/2006 60 Male 9/25/2006 Physician France
Primary
Concomitant
Renal Failure Hospitalization 11/1/2006 Male 12/5/2006 Consumer United States
Primary
Secondary
Central Nervous System Lymphoma Hospitalization 70 Female 12/1/2006 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Central Pontine Myelinolysis Hospitalization 70 Female 12/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Other Serious 6/9/2006 87 Female 101 lb 12/18/2006 Physician France
Primary
Secondary
Concomitant
Central Pontine Myelinolysis Hospitalization 70 Female 1/16/2007 Consumer United States
Primary
Secondary
Pancytopenia Hospitalization Female 1/16/2007 Physician France
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2006 67 Female 3/1/2007 Russian Federation
Primary
Concomitant
Pancytopenia Other Serious 1/2/2007 70 Female 154 lb 2/28/2007 Physician France
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 66 Female 4/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myelomonocytic Leukaemia Death 53 Male 4/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Myelodysplastic Syndrome Death 52 Female 4/12/2007 Other Health Professional United Kingdom
Primary
Secondary
Pancytopenia Other Serious Male 4/18/2007 Australia
Primary
Concomitant
Red Blood Cell Count Decreased Other Serious 8/1/2004 63 Male 4/23/2007 Physician Germany
Primary
Concomitant
Coma Other Serious Female 4/25/2007 Physician United Kingdom
Primary
Concomitant
Ejection Fraction Decreased Disability 4/3/2007 Male 165 lb 4/25/2007 Physician United Kingdom
Primary
Concomitant
Diplopia Hospitalization 5/15/2006 Male 4/26/2007 Consumer United Kingdom
Primary
Secondary
Sepsis Life Threatening 2/28/2007 Female 134 lb 4/27/2007 Physician Germany
Primary
Concomitant
Transaminases Increased Hospitalization 3/12/2007 49 Female 4/30/2007 Consumer United Kingdom
Primary
Concomitant
Pneumonitis Life Threatening 4/23/2007 22 Male 5/4/2007 Physician United Kingdom
Primary
Secondary
Septic Shock Life Threatening 4/30/2007 60 Male 5/14/2007 Physician
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/1/2007 Male 5/14/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Diplopia Hospitalization 5/15/2006 73 Male 5/17/2007 Consumer United States
Primary
Secondary
Pulmonary Oedema Other Serious Male 5/21/2007 Physician Australia
Primary
Concomitant
Hepatitis Fulminant Death 67 Male 5/25/2007 Physician United Kingdom
Primary
Concomitant
Pneumonitis Life Threatening 4/23/2007 22 Male 5/25/2007 Physician United Kingdom
Primary
Secondary
Pulmonary Fibrosis Life Threatening 5/7/2007 Male 5/31/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 4/4/2007 64 Male 6/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 4/18/2007 Male 6/5/2007 Physician Australia
Primary
Concomitant
Pancytopenia Other Serious 1/1/2007 57 Female 6/5/2007 Physician United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 5/1/2007 71 Male 6/5/2007 Consumer China
Primary
Concomitant
Febrile Neutropenia Hospitalization 10/18/2006 Male 128 lb 6/5/2007 Consumer United Kingdom
Primary
Concomitant
Facial Palsy Hospitalization 1/3/2007 Female 123 lb 6/5/2007 Consumer United Kingdom
Primary
Concomitant
Febrile Neutropenia Hospitalization 2/1/2007 Female 141 lb 6/5/2007 Consumer Korea, Republic Of
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/19/2006 Female 131 lb 6/6/2007 Consumer United Kingdom
Primary
Concomitant
Febrile Neutropenia Hospitalization 8/7/2006 Female 172 lb 6/6/2007 Consumer United Kingdom
Primary
Concomitant
Sensory Disturbance Other Serious 6/27/2005 57 Male 143 lb 6/6/2007 Physician Switzerland
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 110 lb 6/8/2007 Physician Finland
Primary
Secondary
Meningitis Cryptococcal Hospitalization 4/20/2007 Male 6/14/2007 Physician Sweden
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 110 lb 6/14/2007 Physician Finland
Primary
Secondary
Respiratory Failure Other Serious 62 Female 6/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Facial Palsy Hospitalization 1/3/2007 Female 123 lb 6/15/2007 Consumer United Kingdom
Primary
Concomitant
Pulmonary Fibrosis Life Threatening 5/7/2007 39 Male 6/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Coma Hospitalization 75 Male 6/18/2007 Physician France
Primary
Concomitant
Rash Hospitalization 7/17/2005 Male 179 lb 6/19/2007 Physician France
Primary
Concomitant
Meningitis Hospitalization Male 6/20/2007 Physician Sweden
Primary
Concomitant
Prostatic Specific Antigen Increased Other Serious 4/2/2007 58 Male 6/21/2007 Consumer United States
Primary
Secondary
Neutropenia Other Serious Female 6/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious Female 6/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Other Serious 62 Female 6/22/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Meningitis Hospitalization Male 6/25/2007 Physician Sweden
Primary
Secondary
Concomitant
Arachnoiditis Hospitalization 12/10/2006 73 Male 170 lb 6/20/2007 Physician Switzerland
Primary
Concomitant
Prostatic Specific Antigen Increased Life Threatening 58 Male 7/2/2007 Other Health Professional United Kingdom
Primary
Secondary
Gastrointestinal Haemorrhage Life Threatening 10/31/2004 63 Male 7/5/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Other Serious 1/1/2007 57 Female 7/6/2007 Physician United Kingdom
Primary
Concomitant
Death Life Threatening 3/30/2007 Female 7/6/2007 Consumer United Kingdom
Primary
Concomitant
Respiratory Failure Death 6/1/2007 71 Male 7/6/2007 Consumer United Kingdom
Primary
Concomitant
Bladder Cancer Life Threatening 4/13/2007 70 Male 7/9/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Fibrosis Life Threatening 5/7/2007 39 Male 7/11/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Other Serious 60 Male 7/11/2007 Physician France
Primary
Concomitant
Chronic Myeloid Leukaemia Other Serious 71 Female 7/11/2007 Physician France
Primary
Concomitant
Respiratory Failure Other Serious 62 Female 7/13/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 1/1/2006 7/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tracheobronchitis Other Serious 1/1/2007 57 Female 7/17/2007 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 10/31/2004 63 Male 7/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious Female 7/18/2007 Physician United Kingdom
Primary
Secondary
Alveolitis Other Serious 1/1/2007 Male 7/18/2007 Physician Switzerland
Primary
Concomitant
Sepsis Death 1/1/2006 Female 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Iiird Nerve Paralysis Hospitalization 5/31/2007 79 Male 7/20/2007 Other Health Professional Switzerland
Primary
Concomitant
Interacting
Respiratory Failure Hospitalization 2/1/2007 Female 150 lb 7/25/2007 Consumer United Kingdom
Primary
Concomitant
Transitional Cell Carcinoma Life Threatening 4/13/2007 70 Male 7/25/2007 Other Health Professional France
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 3/3/2007 Female 163 lb 7/26/2007 Consumer Germany
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death Female 163 lb 7/26/2007 Consumer Germany
Primary
Concomitant
Paralysis Other Serious Female 7/26/2007 Consumer Germany
Primary
Concomitant
Myocardial Infarction Other Serious 10/8/2007 40 Male 11/2/2007 Consumer Lebanon
Primary
Concomitant
Pyrexia Death Female 11/2/2007 Consumer Australia
Primary
Concomitant
Respiratory Failure Death Female 11/9/2007 Consumer United States
Primary
Secondary
Concomitant
Capillary Leak Syndrome Hospitalization 74 Male 11/12/2007 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 10/15/2007 40 Male 11/12/2007 Consumer Lebanon
Primary
Secondary
Concomitant
Urinary Retention Required Intervention 9/1/2006 52 Female 11/12/2007 Sweden
Primary
Concomitant
Visual Acuity Reduced Other Serious 8/1/2007 50 Male 11/16/2007 Consumer United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 11/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/22/2006 60 Male 11/16/2007 Physician France
Primary
Concomitant
Pneumonia Hospitalization 3/12/2007 Male 114 lb 11/27/2007 Consumer United Kingdom
Primary
Concomitant
Acute Myeloid Leukaemia Hospitalization 9/1/2007 Male 11/28/2007 Other Health Professional United Kingdom
Primary
Secondary
Visual Acuity Reduced Other Serious 8/1/2007 50 Male 11/28/2007 Physician Hungary
Primary
Concomitant
Muscular Weakness Other Serious 10/17/2007 Male 132 lb 11/28/2007 Consumer United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypertensive Encephalopathy Hospitalization 8/16/2007 Male 11/30/2007 Consumer United Kingdom
Primary
Concomitant
Hypertensive Encephalopathy Hospitalization 8/16/2007 Male 12/4/2007 Physician United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 8/1/2007 Male 12/4/2007 Physician Hungary
Primary
Concomitant
Ovarian Cancer Other Serious 1/1/2001 67 Female 12/5/2007 Consumer United States
Primary
Secondary
Hypersensitivity Other Serious 11/6/2007 Male 12/5/2007 Other Health Professional South Africa
Primary
Concomitant
Gingivitis Other Serious 11/1/2007 Male 12/7/2007 Consumer United Kingdom
Primary
Secondary
Pneumonia Hospitalization Male 114 lb 12/7/2007 Consumer United Kingdom
Primary
Concomitant
Pancytopenia Other Serious 1/1/2007 57 Female 12/7/2007 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 10/15/2007 40 Male 12/7/2007 Consumer Lebanon
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 60 Male 12/12/2007 Physician United Kingdom
Primary
Secondary
Sigmoiditis Hospitalization 10/9/2006 Female 12/12/2007 Physician France
Primary
Concomitant
Neutropenia Other Serious 76 Female 12/17/2007 Pharmacist Canada
Primary
Concomitant
Peliosis Hepatis Life Threatening 1/1/2001 Female 12/17/2007 Other Health Professional United Kingdom
Primary
Secondary
Hepatitis B Hospitalization 4/11/2007 65 Male 12/18/2007 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 10/8/2007 40 Male 12/18/2007 Consumer Lebanon
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 9/12/2007 78 Female 143 lb 12/19/2007 Pharmacist Australia
Primary
Concomitant
Pyrexia Life Threatening 8/24/2007 83 Female 12/19/2007 Other Health Professional France
Primary
Secondary
Concomitant
Rales Life Threatening 8/1/2007 83 Female 12/21/2007 Consumer France
Primary
Secondary
Concomitant
Facial Palsy Other Serious 12/16/2007 58 Female 12/27/2007 Consumer United Kingdom
Primary
Concomitant
Neuropathy Peripheral Other Serious Female 12/31/2007 Physician Germany
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatitis B Hospitalization 4/11/2007 65 Male 1/7/2008 Physician United Kingdom
Primary
Concomitant
Death Death 60 Female 1/8/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Infection Death 62 Female 1/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/23/2007 Male 1/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Myocarditis Hospitalization 8/22/2006 45 Male 1/19/2008 Physician Ireland
Primary
Secondary
Hypertensive Encephalopathy Hospitalization 8/16/2007 Male 1/22/2008 Physician United Kingdom
Primary
Concomitant
Cerebral Toxoplasmosis Other Serious 10/10/2007 Female 1/22/2008 Physician France
Primary
Secondary
Jaundice Cholestatic Disability 1/11/2008 83 Male 1/23/2008 Consumer India
Primary
Secondary
Colitis Erosive Other Serious 7/5/2007 Female 110 lb 1/26/2008 Physician United Kingdom
Primary
Concomitant
Acute Respiratory Distress Syndrome Hospitalization Male 1/28/2008 Consumer United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 10/5/2006 Female 121 lb 1/28/2008 Physician France
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/12/2007 78 Female 143 lb 1/29/2008 Pharmacist Australia
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 5/1/2005 Female 1/29/2008 Spain
Primary
Concomitant
Encephalitis Other Serious 1/29/2008 Physician United Kingdom
Primary
Concomitant
Cardiac Arrest Other Serious 1/18/2008 Male 2/1/2008 Consumer United Kingdom
Primary
Concomitant
Viral Skin Infection Other Serious 70 Male 2/5/2008 Physician Australia
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Hospitalization 76 Male 2/6/2008 Other Health Professional Italy
Primary
Concomitant

Drug Data