Cyclophosphamide combined with Leucovorin Calcium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Stomatitis Other Serious 11/21/2005 Female 138 lb 1/17/2006 United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/6/2005 Female 152 lb 1/19/2006 United States
Primary
Secondary
Rectal Haemorrhage Life Threatening 10/10/2005 70 Male 181 lb 2/17/2006 Physician France
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 7/31/2006 Male 168 lb 8/1/2006 United States
Primary
Secondary
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
Pain Hospitalization 9/21/2006 Male 168 lb 10/11/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 10/20/2006 United States
Primary
Secondary
Respiratory Failure Required Intervention 31 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Respiratory Failure Required Intervention 6/25/2004 31 Female 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/25/2004 31 Female 11/3/2006 Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 10/21/2006 Male 197 lb 11/6/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/9/2006 Male 52 lb 11/22/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 11/16/2006 Male 136 lb 11/17/2006 United States
Primary
Secondary
Stomatitis Hospitalization 7/2/2006 Female 51 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 5/1/1999 55 Female 12/12/2006
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/10/2006 Female 100 lb 12/13/2006 United States
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/3/2006 Female 147 lb 12/15/2006 United States
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 55 Female 1/9/2007 United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 Female 1/10/2007 United States
Primary
Secondary
Vomiting Hospitalization 12/10/2006 Female 100 lb 1/12/2007 United States
Primary
Secondary
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 8/31/2006 Female 105 lb 2/16/2007 United States
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Weight Increased Other Serious 67 Male 3/23/2007 United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 4/12/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 5/2/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 4/19/2007 Male 198 lb 5/8/2007 United States
Primary
Secondary
Treatment Noncompliance Hospitalization 4/27/2007 Male 194 lb 5/8/2007 United States
Primary
Secondary
Weight Increased Other Serious 67 Male 6/11/2007 Consumer United States
Primary
Secondary
Concomitant
Wound Abscess Hospitalization 6/6/2007 Male 45 lb 6/21/2007 United States
Primary
Secondary
Nephropathy Toxic Hospitalization 13 Male 7/3/2007
Primary
Secondary
Nephropathy Toxic Other Serious 4/1/2005 13 Male 7/2/2007 Other Health Professional United States
Primary
Secondary
Pyrexia Hospitalization 6/10/2007 Male 240 lb 6/26/2007 United States
Primary
Secondary
Squamous Cell Carcinoma Other Serious 5/1/1999 56 Female 7/9/2007 Physician United States
Primary
Secondary
Concomitant
Mucoepidermoid Carcinoma Other Serious 17 Male 8/9/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 3 Male 35 lb 8/28/2007
Primary
Secondary
Urinary Tract Infection Other Serious 21 Female 9/5/2007 Other Health Professional United States
Primary
Secondary
Renal Failure Acute Hospitalization 6/6/2007 Male 200 lb 9/14/2007 United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 9/18/2007 Male 492 lb 10/2/2007 United States
Primary
Secondary
Mucosal Inflammation Hospitalization 10/5/2007 Female 64 lb 10/9/2007 United States
Primary
Secondary
Wound Secretion Hospitalization 9/27/2007 Male 467 lb 10/8/2007 United States
Primary
Secondary
Pharyngolaryngeal Pain Hospitalization 10/5/2007 Female 64 lb 10/30/2007 United States
Primary
Secondary
Pharyngolaryngeal Pain Hospitalization 10/5/2007 Female 64 lb 11/4/2007 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 11/9/2007 Male 175 lb 11/19/2007 United States
Primary
Secondary
Tongue Biting Hospitalization 11/9/2007 Male 203 lb 11/20/2007 United States
Primary
Secondary
Swelling Face Hospitalization 10/31/2007 Male 291 lb 11/20/2007 United States
Primary
Secondary
Drug Toxicity Other Serious 2/22/2007 14 Male 62 lb 11/29/2007 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/29/2007 Male 291 lb 12/4/2007 United States
Primary
Secondary
Pseudomonas Infection Hospitalization 12/12/2007 Female 166 lb 1/2/2008 United States
Primary
Secondary
Refusal Of Treatment By Relative Other Serious 6 Male 1/22/2008 Physician Turkey
Primary
Concomitant
Laboratory Test Abnormal Hospitalization 4/26/2007 Male 139 lb 1/24/2008 United States
Primary
Secondary
Concomitant
Generalised Erythema Other Serious 11/14/2007 Female 132 lb 3/10/2008 Physician Germany
Primary
Concomitant
Haemoglobin Decreased Death 6 Male 3/10/2008
Primary
Secondary
Concomitant
Nephropathy Toxic Other Serious 13 Male 3/21/2008 Pharmacist United States
Primary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2008 Physician United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 2/3/2008 Female 176 lb 4/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 3/20/2008 48 Male 302 lb 4/15/2008 Consumer Canada
Primary
Concomitant
Hypersensitivity Other Serious 3/20/2008 48 Male 302 lb 4/22/2008 Consumer Canada
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 4/4/2008 Male 61 lb 4/18/2008 United States
Primary
Secondary
Hypocalcaemia Hospitalization 3/4/2008 Male 183 lb 5/8/2008 United States
Primary
Secondary
Neutropenic Sepsis Other Serious 4/16/2008 52 Male 157 lb 5/21/2008 Physician Malaysia
Primary
Concomitant
Respiratory Disorder Other Serious 3/20/2008 48 Male 302 lb 5/29/2008 Consumer Canada
Primary
Concomitant
Refusal Of Treatment By Relative Disability 6 Male 5/19/2008 Physician Turkey
Primary
Concomitant
Muscle Disorder Disability 5/13/2006 Male 6/23/2008 Consumer Germany
Primary
Secondary
Concomitant
Odynophagia Hospitalization 9/30/2006 Male 61 lb 7/10/2008 United States
Primary
Secondary
Oedema Peripheral Hospitalization 7/6/2008 Female 134 lb 7/29/2008 United States
Primary
Secondary
Transient Ischaemic Attack Hospitalization 7/22/2008 9 Male 76 lb 8/8/2008 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/29/2008 Female 114 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant
Neutropenia Hospitalization 8/7/2008 44 Male 148 lb 8/21/2008 Belgium
Primary
Secondary
Concomitant
Sinusitis Other Serious 4/1/2002 Male 9/15/2008 Consumer France
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/29/2008 Female 114 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 10/16/2008 Other Health Professional Brazil
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 43 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 56 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 53 Male 10/7/2008 Physician United States
Primary
Concomitant
Gamma-glutamyltransferase Increased 10/20/2008 Male 104 lb 10/22/2008 United States
Primary
Secondary
Stomatitis Hospitalization 10/18/2008 Male 159 lb 10/20/2008 United States
Primary
Secondary
Shock Other Serious 11/30/2007 Male 35 lb 11/3/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Other Serious 5/21/2008 Male 194 lb 11/4/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Sinusitis Other Serious 4/1/2002 Male 11/24/2008 Consumer France
Primary
Secondary
Concomitant
Death Death 67 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 66 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Sinusitis Other Serious 4/1/2002 12/17/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Life Threatening 11/24/2008 55 Male 123 lb 12/30/2008 Physician Ecuador
Primary
Concomitant
Stomatitis Hospitalization 11/24/2008 Male 36 lb 1/13/2009 United States
Primary
Secondary
Renal Failure Other Serious Male 1/21/2009 Consumer United Kingdom
Primary
Secondary
Type 2 Diabetes Mellitus Hospitalization 1/14/2009 Male 260 lb 2/18/2009 United States
Primary
Secondary
Neurotoxicity Other Serious 16 Male 2/25/2009
Primary
Secondary
No Therapeutic Response Hospitalization 2/6/2009 Female 41 lb 3/4/2009 United States
Primary
Secondary
No Therapeutic Response Hospitalization 2/6/2009 Female 41 lb 3/16/2009 United States
Primary
Secondary
Respiratory Failure Other Serious 10/1/2007 Female 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 4/27/2009 Consumer United Kingdom
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 9/3/2008 1 Female 15 lb 4/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Neurotoxicity Hospitalization 16 Male 4/28/2009 Physician United States
Primary
Concomitant
Salivary Gland Mass Other Serious 1/1/2008 38 Female 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/5/2009 Male 163 lb 7/13/2009 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/19/2009 Male 104 lb 7/22/2009 United States
Primary
Secondary
Concomitant
Streptococcal Infection Death 3/1/2004 57 Male 7/29/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 57 Male 8/6/2009
Primary
Secondary
Concomitant
Ventricular Extrasystoles Hospitalization 8/12/2009 Male 254 lb 8/19/2009 United States
Primary
Secondary
Vomiting Hospitalization 10/29/2009 Female 99 lb 11/13/2009 United States
Primary
Secondary
Concomitant
Somnolence Other Serious 1/11/2010 United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Fat Embolism Other Serious 22 Male 4/2/2010 Other Health Professional Greece
Primary
Secondary
Thrombocytopenia Other Serious 4/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 4/29/2010 United States
Primary
Secondary
Skin Toxicity Death 4/30/2010 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 36 Male 5/27/2010
Primary
Secondary
Neutrophil Count Increased Other Serious 5/23/2010 55 Female 108 lb 7/27/2010 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/31/2010 44 Female 250 lb 8/6/2010 United States
Primary
Secondary
Neutropenic Sepsis Death 10/25/2010 Other Health Professional United States
Primary
Secondary
Respiratory Arrest Other Serious 10/25/2010 Other Health Professional United States
Primary
Secondary
Neuropathy Peripheral Other Serious 10/25/2010 Other Health Professional United States
Primary
Secondary
Neuropathy Peripheral Other Serious 10/25/2010 Other Health Professional United States
Primary
Secondary
Interstitial Lung Disease Other Serious 73 Male 11/2/2010 Japan
Primary
Secondary
Concomitant
Respiratory Syncytial Virus Test Positive Life Threatening 11/16/2010 14 Female 130 lb 11/24/2010 Physician United States
Primary
Secondary
Concomitant
Toothache Other Serious 54 Male 2/10/2011 Other Health Professional Israel
Primary
Concomitant
Haemorrhage Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Burning Sensation Hospitalization Male 101 lb 3/3/2011 Other Health Professional Canada
Primary
Concomitant
Renal Failure Death 72 Female 174 lb 3/9/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Anxiety Death 3/8/2011 15 Female 144 lb 3/23/2011 Physician United States
Primary
Secondary
Peripheral Nerve Palsy Other Serious 3/28/2011 Physician Italy
Primary
Secondary
Concomitant
Renal Failure Death 3/29/2011 Physician Italy
Primary
Secondary
Concomitant

Drug Data