Cyclophosphamide combined with Lapatinib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Embolism Other Serious 11/1/2007 60 Female 12/20/2007 Physician Ireland
Primary
Concomitant
Hyperpyrexia Hospitalization 6/1/2008 41 Female 121 lb 6/9/2008 Physician Italy
Primary
Secondary
Lymphoedema Hospitalization 9/1/2008 53 Female 130 lb 11/20/2008 Physician Belgium
Primary
Secondary
White Blood Cell Count Decreased Other Serious 64 Female 168 lb 11/25/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 11/18/2008 Female 168 lb 12/9/2008 Physician United States
Primary
Secondary
Sensory Disturbance Hospitalization 12/8/2008 57 Female 159 lb 12/17/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 12/12/2008 54 Female 182 lb 12/19/2008 Physician United States
Primary
Secondary
Surgery Hospitalization 8/1/2008 69 Female 159 lb 12/23/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Swelling Face Other Serious 12/13/2008 48 Female 136 lb 12/23/2008 Physician United States
Primary
Secondary
Surgery Hospitalization 8/1/2008 69 Female 159 lb 1/2/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Transfusion Reaction Hospitalization 12/12/2008 54 Female 182 lb 1/12/2009 Physician United States
Primary
Secondary
Sensory Disturbance Hospitalization 12/8/2008 57 Female 159 lb 1/16/2009 Physician Germany
Primary
Secondary
Rash Other Serious 2/9/2009 Consumer United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 10/24/2008 71 Female 159 lb 2/17/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/14/2009 52 Female 125 lb 2/25/2009 Physician Taiwan, Province Of China
Primary
Secondary
Polyneuropathy Hospitalization 3/11/2009 58 Female 185 lb 3/23/2009 Physician Denmark
Primary
Secondary
Concomitant
Swelling Face Other Serious 12/13/2008 48 Female 136 lb 4/2/2009 Physician United States
Primary
Secondary
Rash Other Serious 12/30/2008 60 Female 168 lb 4/14/2009 Physician United States
Primary
Secondary
Polyneuropathy Hospitalization 3/11/2009 Female 185 lb 4/16/2009 Physician Denmark
Primary
Secondary
Concomitant
Sensory Disturbance Hospitalization 12/8/2008 Female 159 lb 4/28/2009 Physician Germany
Primary
Secondary
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 5/12/2009 Physician United States
Primary
Secondary
Influenza Hospitalization 5/10/2009 Female 126 lb 5/18/2009 Physician Germany
Primary
Secondary
Concomitant
Influenza Hospitalization 5/10/2009 Female 126 lb 6/2/2009 Physician Germany
Primary
Secondary
Concomitant
Leukopenia Hospitalization 6/5/2009 Female 150 lb 6/11/2009 Physician Germany
Primary
Secondary
Concomitant
Gastritis Hospitalization 6/15/2009 Female 137 lb 6/22/2009 Physician Germany
Primary
Secondary
Concomitant
Helicobacter Gastritis Hospitalization 6/15/2009 Female 137 lb 6/23/2009 Physician Germany
Primary
Secondary
Concomitant
Mallory-weiss Syndrome Hospitalization 6/15/2009 Female 137 lb 7/2/2009 Physician Germany
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 7/14/2009 Physician United States
Primary
Secondary
Febrile Neutropenia Hospitalization 7/16/2009 Female 187 lb 7/28/2009 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/18/2009 Female 251 lb 8/3/2009 Physician Germany
Primary
Secondary
Febrile Neutropenia Hospitalization 7/29/2009 Female 170 lb 8/6/2009 Physician Germany
Primary
Secondary
Tonsillitis Hospitalization 7/28/2009 Female 154 lb 8/6/2009 Physician Germany
Primary
Secondary
Concomitant
Rash Other Serious 8/12/2009 Consumer United Kingdom
Primary
Secondary
Leukopenia Hospitalization 6/5/2009 Female 150 lb 8/13/2009 Physician Germany
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/29/2009 Female 170 lb 8/14/2009 Physician Germany
Primary
Secondary
Febrile Neutropenia Hospitalization 7/16/2009 Female 187 lb 8/17/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/8/2009 Female 375 lb 8/19/2009 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 5/18/2009 Female 8/19/2009 Physician Germany
Primary
Secondary
Vomiting Hospitalization 8/10/2009 Female 134 lb 8/26/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/8/2009 Female 375 lb 9/9/2009 Physician Germany
Primary
Secondary
Vomiting Other Serious 8/8/2009 Female 375 lb 10/1/2009 Physician Germany
Primary
Secondary
Ventricular Hypokinesia Other Serious 9/3/2009 Female 128 lb 10/2/2009 Physician Germany
Primary
Concomitant
Pyrexia Hospitalization 1/13/2009 Female 150 lb 10/15/2009 Physician Germany
Primary
Secondary
Pancytopenia Hospitalization 10/1/2009 Female 183 lb 10/15/2009 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/5/2009 Female 152 lb 10/15/2009 Physician Germany
Primary
Secondary
Neutropenia Other Serious 2/27/2009 Female 161 lb 10/19/2009 Physician Peru
Primary
Secondary
Pyrexia Hospitalization 10/5/2009 Female 152 lb 10/19/2009 Physician Germany
Primary
Secondary
Neutropenia Hospitalization 9/1/2008 Female 130 lb 10/22/2009 Physician Belgium
Primary
Secondary
Neutropenia Other Serious 4/6/2009 10/28/2009 Physician France
Primary
Secondary
Concomitant
Neutropenia Hospitalization 9/1/2008 Female 130 lb 10/29/2009 Physician Belgium
Primary
Secondary
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 11/4/2009 Physician Germany
Primary
Secondary
Vomiting Other Serious 8/8/2009 Female 375 lb 11/6/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/24/2009 Female 123 lb 11/6/2009 Physician Germany
Primary
Secondary
Stomatitis Hospitalization 10/29/2009 Female 148 lb 11/6/2009 Physician Germany
Primary
Secondary
Stomatitis Hospitalization 10/29/2009 Female 148 lb 11/9/2009 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 10/23/2009 Female 148 lb 11/9/2009 Physician Germany
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 11/13/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 11/8/2009 Female 153 lb 11/17/2009 Physician Germany
Primary
Secondary
Vomiting Other Serious 8/8/2009 Female 165 lb 11/18/2009 Physician Germany
Primary
Secondary
Swelling Other Serious 10/19/2009 Female 139 lb 11/23/2009 Physician Germany
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 11/23/2009 Physician Germany
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/29/2009 Female 148 lb 11/23/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 11/8/2009 Female 153 lb 11/23/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/24/2009 Female 123 lb 11/25/2009 Physician Germany
Primary
Secondary
General Physical Health Deterioration Hospitalization 11/10/2009 Female 183 lb 11/25/2009 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/24/2009 Female 101 lb 12/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 12/9/2009 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/2/2009 Female 134 lb 12/11/2009 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 12/6/2009 40 Female 193 lb 12/16/2009 Physician United States
Primary
Secondary
Diarrhoea Hospitalization 12/15/2009 37 Female 135 lb 12/21/2009 Physician United States
Primary
Secondary
Mucosal Haemorrhage Hospitalization 12/3/2009 53 Female 190 lb 1/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Pneumonia Hospitalization 11/24/2009 Female 101 lb 1/15/2010 Physician Belgium
Primary
Secondary
Concomitant
Diarrhoea Other Serious 12/29/2009 Female 132 lb 1/15/2010 Physician France
Primary
Secondary
Concomitant
Arthralgia Hospitalization 1/10/2010 Female 154 lb 1/18/2010 Physician Germany
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/14/2009 37 Female 134 lb 1/22/2010 Physician United States
Primary
Secondary
Urinary Tract Infection Hospitalization 1/14/2010 34 Female 251 lb 1/25/2010 Physician United States
Primary
Secondary
Seroma Hospitalization 12/22/2009 Female 1/27/2010 Physician Germany
Primary
Secondary
Concomitant
Seroma Hospitalization 12/22/2009 Female 1/28/2010 Physician Germany
Primary
Secondary
Concomitant
Arthralgia Hospitalization 1/10/2010 Female 154 lb 1/29/2010 Physician Germany
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 1/10/2010 Female 154 lb 2/2/2010 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/30/2008 Female 196 lb 2/9/2010 Physician New Zealand
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/30/2010 Female 134 lb 2/10/2010 Physician Germany
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 2/3/2010 Female 141 lb 2/18/2010 Physician Germany
Primary
Secondary
Neutropenia Other Serious 4/6/2009 Female 119 lb 2/19/2010 Physician France
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 10/20/2008 Female 2/25/2010 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization 48 Female 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 2/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Pneumonia Primary Atypical Hospitalization 12/3/2009 Female 3/2/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/23/2010 Male 176 lb 3/4/2010 Physician Germany
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/8/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/8/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 Female 101 lb 3/10/2010 Physician Belgium
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/11/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/4/2010 Female 150 lb 3/16/2010 Physician Germany
Primary
Secondary
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 3/3/2010 Female 150 lb 3/19/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/16/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/24/2009 Female 161 lb 3/23/2010 Physician Peru
Primary
Secondary
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/18/2010 Female 123 lb 3/26/2010 Physician Germany
Primary
Secondary
Gastroenteritis Hospitalization 12/14/2009 37 Female 134 lb 4/1/2010 Physician United States
Primary
Secondary
Neutropenia Other Serious 4/6/2009 59 Female 119 lb 4/9/2010 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/1/2010 46 Female 373 lb 4/16/2010 Physician Germany
Primary
Secondary
Ejection Fraction Decreased Other Serious 35 Female 4/29/2010 United States
Primary
Secondary
Ejection Fraction Decreased Other Serious 44 Female 4/29/2010 United States
Primary
Secondary
Urinary Tract Infection Hospitalization 1/14/2010 34 Female 251 lb 6/8/2010 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/9/2010 55 Female 165 lb 6/18/2010 Physician Germany
Primary
Secondary
Stomatitis Hospitalization 6/6/2010 59 Female 161 lb 6/21/2010 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 1/13/2009 66 Female 150 lb 6/23/2010 Physician Germany
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/9/2010 55 Female 165 lb 6/24/2010 Physician Germany
Primary
Secondary
Ventricular Hypokinesia Disability 5/18/2010 66 Female 152 lb 6/28/2010 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 12/6/2009 40 Female 193 lb 7/6/2010 Physician United States
Primary
Secondary
Polyneuropathy Hospitalization 10/1/2008 58 Female 185 lb 7/14/2010 Physician Denmark
Primary
Secondary
Concomitant
Tonsillitis Hospitalization 7/28/2009 43 Female 154 lb 7/19/2010 Physician Germany
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/10/2010 55 Female 165 lb 7/21/2010 Physician Germany
Primary
Secondary
Hepatic Enzyme Increased Other Serious 12/29/2009 25 Female 132 lb 7/26/2010 Physician France
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 9/18/2009 63 Female 174 lb 7/29/2010 Physician Italy
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 7/30/2010 Other Health Professional United States
Primary
Secondary
Electrocardiogram Qt Prolonged Hospitalization 7/30/2010 Other Health Professional United States
Primary
Secondary
Organising Pneumonia Hospitalization 11/24/2009 42 Female 101 lb 7/30/2010 Physician Belgium
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 12/29/2009 25 Female 132 lb 8/2/2010 Physician France
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 42 Female 8/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/16/2009 61 Female 251 lb 8/9/2010 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 5/18/2009 61 Female 8/9/2010 Physician Germany
Primary
Secondary
Personality Change Hospitalization 7/24/2010 53 Female 165 lb 8/12/2010 Physician Germany
Primary
Secondary
Concomitant
Personality Change Hospitalization 7/24/2010 53 Female 165 lb 8/16/2010 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/14/2009 52 Female 125 lb 8/30/2010 Physician Taiwan, Province Of China
Primary
Secondary
Suicide Attempt Hospitalization 7/24/2010 53 Female 165 lb 8/30/2010 Physician Germany
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 9/18/2009 63 Female 174 lb 9/1/2010 Physician Italy
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/30/2010 43 Female 134 lb 9/15/2010 Physician Germany
Primary
Secondary
Pericarditis Hospitalization 8/10/2010 59 Female 154 lb 9/15/2010 Physician Germany
Primary
Secondary
Polyneuropathy Hospitalization 10/20/2008 58 Female 185 lb 9/28/2010 Physician Denmark
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 3/3/2010 65 Female 150 lb 10/7/2010 Physician Germany
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/18/2010 54 Female 123 lb 10/20/2010 Physician Germany
Primary
Secondary
Neutropenia Other Serious 2/24/2009 41 Female 161 lb 10/25/2010 Physician Peru
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/11/2010 49 Female 139 lb 11/10/2010 Physician Italy
Primary
Secondary
Neutropenia Other Serious 9/8/2010 47 Female 123 lb 11/12/2010 Physician Italy
Primary
Secondary
Organising Pneumonia Hospitalization 11/24/2009 42 Female 101 lb 11/16/2010 Physician Belgium
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 42 Female 11/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 12/14/2009 37 Female 134 lb 11/18/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 11/12/2010 38 Female 11/19/2010 Physician South Africa
Primary
Secondary
Concomitant
Pyrexia Other Serious 8/11/2010 49 Female 139 lb 11/23/2010 Physician Italy
Primary
Secondary
Neutropenia Other Serious 9/8/2010 47 Female 123 lb 11/24/2010 Physician Italy
Primary
Secondary
Pyrexia Hospitalization 2/23/2010 48 Male 176 lb 12/1/2010 Physician Germany
Primary
Secondary
Malignant Neoplasm Progression Death Female 117 lb 12/3/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/12/2010 38 Female 12/9/2010 Physician South Africa
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/9/2010 38 Female 12/20/2010 Physician South Africa
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/5/2008 62 1/3/2011 Physician Italy
Primary
Secondary

Drug Data