Cyclophosphamide combined with Itraconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Bradycardia Hospitalization 3/22/2006 67 Female 148 lb 4/10/2006 Physician Italy
Primary
Secondary
Concomitant
Sinus Bradycardia Hospitalization 3/22/2006 67 Female 148 lb 9/28/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 20 Male 2/2/2007 Other Health Professional China
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 3/21/2007 63 Male 4/2/2007 Physician United Kingdom
Primary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 2/26/2007 2 Male 7/27/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Mycobacterial Infection Hospitalization 65 Male 10/16/2007
Primary
Secondary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 10/16/2007 Physician United States
Primary
Secondary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 11/21/2007 Consumer United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 20 Male 12/14/2007 Other Health Professional China
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 3/21/2007 63 Male 3/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/13/2008 47 Male 141 lb 5/14/2008 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 48 Male 6/20/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 7/1/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 3/17/2008 77 Female 176 lb 8/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 3/17/2008 77 Female 176 lb 8/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Mucosal Inflammation Death 6 40 lb 6/18/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Trichosporon Infection Death 4/15/2008 53 Male 123 lb 9/30/2008 Physician Japan
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 59 Female 10/27/2008
Primary
Secondary
Concomitant
Septic Shock Death 10/27/2008 78 Male 11/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Virus Urine Test Positive Hospitalization 7/16/2007 Male 12/5/2008 Physician Japan
Primary
Secondary
Concomitant
Trichosporon Infection Death 4/15/2008 53 Male 123 lb 12/5/2008 Physician Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 2/19/2009 Male 3/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 69 Male 3/10/2009 Italy
Primary
Secondary
Mucosal Inflammation Other Serious 69 Male 3/20/2009 Other Health Professional Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 8/12/2003 0 Male 13 lb 3/19/2009 France
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 2/19/2009 Male 3/24/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Infection Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Ileus Life Threatening 6/22/2008 Male 4/17/2009 Physician Japan
Primary
Secondary
Concomitant
Viral Infection Life Threatening 8/12/2008 70 Male 4/16/2009 Japan
Primary
Secondary
Concomitant
Renal Failure Life Threatening 8/12/2008 70 Male 4/13/2009 Japan
Primary
Secondary
Concomitant
Ileus Paralytic Life Threatening 6/22/2008 Male 4/22/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Life Threatening 8/12/2008 70 Male 4/21/2009 Japan
Primary
Secondary
Concomitant
Engraft Failure Other Serious 5 5/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 5/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 1 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 8 Male 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Engraft Failure Other Serious 5 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypothyroidism Other Serious 15 5/12/2009 United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 16 5/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 5/15/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 5/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection 16 5/21/2009 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia 8 Male 5/21/2009 United Kingdom
Primary
Concomitant
Procedural Complication 5 5/21/2009 France
Primary
Concomitant
Multi-organ Failure Other Serious 18 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 3 6/1/2009 Physician United Kingdom
Primary
Secondary
Obliterative Bronchiolitis 4 6/3/2009 France
Primary
Concomitant
Bile Duct Stenosis Other Serious 4 6/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Anti-thyroid Antibody Positive Other Serious 3 6/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Acute Graft Versus Host Disease In Skin Other Serious 1 6/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Cytomegalovirus Infection Other Serious 8 6/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Acute Graft Versus Host Disease Other Serious 2 6/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Hyperthyroidism Other Serious 14 6/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Virus Serology Test Positive Death 4/17/2009 58 Female 97 lb 6/2/2009 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Death 57 6/5/2009 Physician Italy
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 6/5/2009 Italy
Primary
Secondary
Concomitant
Hyperthyroidism Other Serious 14 6/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Hypothyroidism Other Serious 16 6/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 16 6/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 2 6/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Oedema Death 18 6/12/2009 France
Primary
Concomitant
Anti-thyroid Antibody Positive 3 6/18/2009 France
Primary
Concomitant
Pyrexia Required Intervention 16 Female 7/16/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Virus Serology Test Positive Death 4/17/2009 58 Female 97 lb 7/10/2009 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 38 Male 7/31/2009 Other Health Professional Australia
Primary
Concomitant
Pneumonia Life Threatening 7/17/2009 Male 169 lb 8/6/2009 Physician Mexico
Primary
Secondary
Concomitant
Pneumonia Death 7/17/2009 Male 169 lb 8/7/2009 Physician Mexico
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 16 8/10/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Life Threatening 10/1/2008 70 Male 8/13/2009 Japan
Primary
Secondary
Pleural Effusion Life Threatening 9/3/2009 Female 10/2/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 9/24/2009 2 10/21/2009 Other Health Professional United Kingdom
Primary
Interacting
Drug Interaction Other Serious 2 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Viral Infection Life Threatening 9/17/2008 70 Male 11/3/2009 Japan
Primary
Secondary
Concomitant
Drug Interaction 2 Unknown 11/12/2009 France
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Life Threatening Male 11/25/2009 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening Male 12/18/2009 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 17 Male 12/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 1/4/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 29 Male 1/4/2010
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 1/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 9/1/2009 Female 145 lb 1/19/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Neutropenia Other Serious 17 Male 1/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 1/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 1/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/22/2009 Male 2/8/2010 Physician Italy
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/22/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/10/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/12/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/22/2009 Male 3/18/2010 Physician Italy
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 3/29/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious Male 3/19/2010 United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 17 Male 3/31/2010 Other Health Professional United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 4/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Visual Impairment Disability 3/11/2009 48 Female 84 lb 4/29/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Other Serious 69 Male 7/1/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Visual Impairment Other Serious 3/11/2009 49 Female 84 lb 7/21/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 3/11/2009 49 Female 84 lb 7/27/2010 Physician Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 3/11/2009 48 Female 84 lb 7/19/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 1/1/2008 78 Male 117 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Sebaceous Carcinoma Other Serious 10/1/2009 46 Male 203 lb 9/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 3/11/2009 48 Female 84 lb 11/8/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 3/19/2010 31 Male 139 lb 12/27/2010 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Febrile Neutropenia Death 8/11/2010 24 Male 141 lb 1/7/2011 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 2/26/2010 56 Male 134 lb 1/10/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 2/26/2010 56 Male 134 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 13 Male 1/28/2011 Other Health Professional China
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Renal Tubular Disorder Hospitalization 3/13/2010 40 Male 207 lb 2/16/2011 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 2/17/2011 Physician United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemodialysis Death 7/10/2010 60 Male 163 lb 2/18/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 17 Male 2/25/2011 Consumer United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Autoimmune Thrombocytopenia Death 3/2/2011 Physician Mexico
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 3/3/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 17 Male 3/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 17 Male 3/7/2011 Consumer United Kingdom
Primary
Secondary
Renal Impairment Other Serious 17 Male 3/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/24/2010 19 Male 115 lb 3/10/2011 Physician Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 17 Male 3/14/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 17 Male 3/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 29 Male 3/18/2011 Physician Japan
Primary
Concomitant
Thrombocytopenia Death 3/14/2011 4 Male 33 lb 3/24/2011 Consumer Mexico
Primary
Secondary
Concomitant
Neutropenia Other Serious 3/29/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Bronchiectasis Hospitalization 35 Male 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 3/14/2011 4 Male 33 lb 4/7/2011 Physician Mexico
Primary
Secondary
Concomitant

Drug Data