Cyclophosphamide combined with Cyclosporine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Death 36 Female 1/5/2006 United States
Primary
Secondary
Concomitant
Weight Increased Required Intervention 12/15/2005 Female 117 lb 12/28/2005 United States
Primary
Secondary
Transaminases Increased Other Serious 47 Male 1/19/2006 Physician United States
Primary
Concomitant
Transplant Failure Hospitalization 11/21/2005 Male 176 lb 2/1/2006 Physician Germany
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 1 Male 1/25/2006 Physician Japan
Primary
Concomitant
Rales Other Serious 55 Female 2/9/2006 Physician France
Primary
Concomitant
Tracheostomy Other Serious 36 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Tracheostomy Other Serious 65 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Tracheostomy Hospitalization 40 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Vasculitis Cerebral Other Serious 15 Male 2/10/2006 Canada
Primary
Secondary
Transaminases Increased Other Serious 19 Female 3/4/2006 Physician Korea, Republic Of
Primary
Concomitant
Viraemia Other Serious 28 Male 3/10/2006 Japan
Primary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/9/2006 Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
Weight Decreased Other Serious 15 Male 3/14/2006 Japan
Primary
Concomitant
Pancreatic Disorder Other Serious 10/1/2004 18 Female 3/15/2006 Japan
Primary
Concomitant
Spinal Myelogram Abnormal Other Serious 34 Female 3/21/2006 Physician Japan
Primary
Concomitant
Respiratory Failure Required Intervention 55 Female 3/15/2006 France
Primary
Concomitant
Stem Cell Transplant Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Vomiting Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Vomiting Hospitalization 1/1/2001 42 Male 3/27/2006 Physician United States
Primary
Secondary
Concomitant
Viral Load Increased Other Serious 23 Male 3/31/2006 Other Health Professional Turkey
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 4/7/2006 Physician Germany
Primary
Concomitant
Pancreatic Disorder Other Serious 10/1/2004 18 Female 4/25/2006 Japan
Primary
Concomitant
Thrombocytopenia Other Serious 27 Female 5/5/2006 Other Health Professional Australia
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/5/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Transaminases Increased Other Serious 9 Male 41 lb 5/8/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Tenosynovitis Other Serious 68 Female 5/1/2006 United States
Primary
Secondary
Weight Increased Hospitalization 11/23/2003 5 Female 4/28/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 38 Female 5/9/2006 Other Health Professional Turkey
Primary
Concomitant
Viral Vasculitis Other Serious 4/10/2005 34 Male 159 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Other Serious 11/1/2005 61 Male 157 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Viral Vasculitis Other Serious 4/10/2005 34 Male 159 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 32 Female 5/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 14 Male 5/19/2006 Other Health Professional Poland
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/17/2006 61 Male 6/2/2006 Physician United States
Primary
Secondary
Concomitant
Nervous System Disorder Death 38 Female 6/9/2006 France
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 3 Unknown 4/27/2006 Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 3/28/2003 31 Male 4/27/2006 Japan
Primary
Concomitant
Trigeminal Nerve Disorder Death 38 Female 6/7/2006 Physician France
Primary
Secondary
Concomitant
Tri-iodothyronine Free Increased Other Serious 42 Male 6/16/2006 Physician Japan
Primary
Concomitant
Thyroxine Free Increased Other Serious 32 Female 6/16/2006 Other Health Professional Japan
Primary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/8/2006 Physician France
Primary
Secondary
Concomitant
Urine Protein/creatinine Ratio Increased Other Serious Male 6/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/26/2006 Other Health Professional France
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 2 Male 6/29/2006 United States
Primary
Concomitant
Urine Protein/creatinine Ratio Increased Other Serious Male 6/22/2006 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease In Skin Other Serious 61 Female 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 62 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Obliterative Bronchiolitis Other Serious 59 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 61 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 53 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 45 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Trigeminal Nerve Disorder Death 1/1/2003 38 Female 6/23/2006 Physician France
Primary
Secondary
Concomitant
Renal Necrosis Other Serious 6 Female 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2005 61 Male 157 lb 7/6/2006 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Other Serious 11/1/2005 61 Male 157 lb 7/6/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 20 Male 7/6/2006 Physician France
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 62 Male 7/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Superficial Spreading Melanoma Stage Ii Other Serious 59 Male 7/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 61 Male 7/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Neoplasm Excision Other Serious 53 Male 7/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Of Skin Other Serious 61 Male 7/15/2006 Physician United States
Primary
Secondary
Concomitant
Photosensitivity Reaction Other Serious 53 Male 7/15/2006 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 45 Male 7/15/2006 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 61 Female 7/14/2006 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 62 Male 7/14/2006 Physician United States
Primary
Secondary
Concomitant
Superficial Spreading Melanoma Stage Ii Other Serious 59 Male 7/15/2006 Physician United States
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 11 Female 7/8/2006 Physician United States
Primary
Secondary
Renal Cell Carcinoma Stage Unspecified Other Serious 6 Female 7/13/2006 United States
Primary
Secondary
Visual Field Defect Other Serious Female 7/13/2006
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 2 Male 7/26/2006 China
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/1/2003 16 Female 7/28/2006 United Kingdom
Primary
Concomitant
Stem Cell Transplant Other Serious 2 Male 8/7/2006 China
Primary
Secondary
Concomitant
Oedema Other Serious 54 Male 8/16/2006 Canada
Primary
Secondary
Urinary Bladder Haemorrhage Other Serious 14 Male 8/24/2006 Other Health Professional France
Primary
Concomitant
Thrombocytopenia Life Threatening 12/1/2000 Female 8/14/2006
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 10 Female 9/1/2006 Spain
Primary
Concomitant
Status Epilepticus Other Serious 5 Male 9/1/2006 Spain
Primary
Concomitant
Status Epilepticus Other Serious 7 Female 9/1/2006 Spain
Primary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Japan
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Other Serious 4 Male 9/11/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Hyperaesthesia Other Serious 5/1/2004 57 Female 9/6/2006 Physician Germany
Primary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 6/27/2006 38 Female 9/8/2006 Physician United States
Primary
Secondary
Concomitant
Viral Infection Other Serious 45 Female 9/20/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Viraemia Other Serious 28 Male 9/23/2006 Japan
Primary
Concomitant
Viral Infection Other Serious 45 Female 9/20/2006 Physician Germany
Primary
Secondary
Concomitant
Encephalitis Post Varicella Other Serious 35 Male 10/3/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Kidney Transplant Rejection Other Serious Male 10/2/2006 Japan
Primary
Secondary
Concomitant
Viraemia Other Serious 28 Male 10/2/2006 Japan
Primary
Concomitant
Histiocytosis Haematophagic Other Serious 4 Female 10/9/2006 Japan
Primary
Concomitant
Surgery Hospitalization Male 10/11/2006 Japan
Primary
Secondary
Concomitant
Yellow Skin Other Serious 1/1/2004 30 Female 10/11/2006 Other Health Professional India
Primary
Concomitant
Pneumomediastinum Other Serious 35 Male 10/11/2006
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 55 Female 10/5/2006 Germany
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Life Threatening 16 Male 10/14/2006 Japan
Primary
Concomitant
Serum Ferritin Increased Other Serious 4 Female 10/17/2006 Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 10/17/2006 Japan
Primary
Concomitant
Malignant Melanoma Other Serious 59 Male 10/12/2006 United States
Primary
Secondary
Graft Versus Host Disease Other Serious 61 Female 10/19/2006
Primary
Secondary
Malignant Melanoma Other Serious 59 Male 10/19/2006
Primary
Secondary
Squamous Cell Carcinoma Other Serious 62 Male 10/19/2006
Primary
Secondary
Squamous Cell Carcinoma Other Serious 45 Male 10/19/2006
Primary
Secondary
Malignant Melanoma Other Serious 53 Male 10/19/2006
Primary
Secondary
Squamous Cell Carcinoma Other Serious 61 Male 10/19/2006
Primary
Secondary
Malignant Melanoma Other Serious 53 Male 10/12/2006 United States
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 9 Female 10/31/2006 Netherlands
Primary
Secondary
Concomitant
Tuberculosis Other Serious 6/1/1994 38 Male 11/15/2006 Other Health Professional Turkey
Primary
Secondary
Concomitant
Thrombophlebitis Other Serious 1/1/2003 34 Female 11/21/2006 Japan
Primary
Concomitant
Wound Debridement Other Serious 1/1/2005 70 Male 12/7/2006 Physician Belgium
Primary
Secondary
Concomitant
Weight Increased Hospitalization 56 Female 12/9/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Life Threatening 5/6/2006 33 Female 12/5/2006 Physician Japan
Primary
Secondary
Concomitant
Mucous Stools Other Serious 4 Female 12/14/2006 Japan
Primary
Concomitant
Urine Output Decreased Other Serious 21 Female 12/16/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Proteinuria Other Serious 9 Male 12/19/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 12/19/2006 Other Health Professional Japan
Primary
Concomitant
Transplant Rejection Other Serious 28 Female 12/28/2006 Australia
Primary
Concomitant
Toxoplasma Serology Positive Death 22 Male 1/23/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Death 25 Male 1/22/2007 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Impairment Other Serious 73 Female 1/27/2007 Japan
Primary
Secondary
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 1/30/2007 Japan
Primary
Concomitant
Vasculitis Death 15 Male 2/6/2007 Physician Canada
Primary
Secondary
Concomitant
Viral Infection Other Serious 52 Male 2/7/2007 Other Health Professional India
Primary
Secondary
Pyrexia Other Serious 12/1/2004 49 Male 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 2/8/2007 Japan
Primary
Concomitant
Skin Papilloma Other Serious 52 Male 2/6/2007 Physician India
Primary
Secondary
Vasculitis Death 15 Male 2/12/2007 Physician Canada
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization Female 2/10/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization Female 2/10/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Ocular Neoplasm Other Serious 52 Male 2/21/2007
Primary
Secondary
Pyrexia Other Serious 22 Male 2/22/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Somnolence Other Serious 13 Male 3/3/2007 Japan
Primary
Secondary
Chronic Graft Versus Host Disease Other Serious 48 Male 3/3/2007 Japan
Primary
Concomitant
Skin Papilloma Other Serious 52 Male 3/6/2007 Other Health Professional India
Primary
Secondary
Weight Decreased Other Serious 48 Male 3/10/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 44 Male 3/14/2007 Japan
Primary
Concomitant
Respiratory Failure Other Serious 58 Female 3/14/2007 Japan
Primary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/14/2007 Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 13 Male 3/14/2007 Japan
Primary
Secondary

Drug Data