Coumadin combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hyperkalaemia Required Intervention 1/10/2006 84 Male 144 lb 1/18/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 8/5/2005 75 Male 1/19/2006 United States
Primary
Concomitant
Dizziness Other Serious 11/18/2005 76 Male 189 lb 11/18/2005 Pharmacist United States
Primary
Concomitant
Tremor Hospitalization 10/31/2005 Male 164 lb 12/15/2005 Pharmacist United States
Primary
Concomitant
Nonspecific Reaction Other Serious 12/9/2005 55 Male 211 lb 1/31/2006 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2004 84 Male 130 lb 4/11/2005 Consumer United States
Primary
Secondary
Concomitant
Catheter Site Haemorrhage Hospitalization 10/11/2004 65 Male 217 lb 12/21/2005 United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2004 32 Male 257 lb 12/21/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Hospitalization 7/18/2002 49 Male 12/29/2005 United States
Primary
Secondary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 4/14/2006 Physician United States
Primary
Concomitant
Myalgia Other Serious 8/4/2005 73 Male 209 lb 4/13/2006 Physician United States
Primary
Concomitant
Rhinorrhoea Other Serious 12/19/2005 67 Male 235 lb 4/14/2006 Pharmacist United States
Primary
Concomitant
Urticaria Other Serious 1/2/2006 67 Male 248 lb 2/15/2006 Pharmacist United States
Primary
Concomitant
Plantar Fasciitis Hospitalization 1/1/2006 55 Male 4/24/2006 Consumer Germany
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Hospitalization 4/1/2006 Male 280 lb 4/26/2006 Physician United States
Primary
Concomitant
Myalgia Other Serious 3/7/2006 70 Male 252 lb 3/8/2006 Pharmacist United States
Primary
Concomitant
Drug Interaction Hospitalization 2/27/2006 Male 258 lb 5/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Fall Hospitalization 2/21/2006 74 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Palpitations Hospitalization 1/1/2006 55 Male 5/16/2006 Consumer Germany
Primary
Secondary
Concomitant
Rash Hospitalization 5/15/2006 64 Male 284 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 74 Male 211 lb 5/16/2006 Pharmacist United States
Primary
Concomitant
Insomnia 3/13/2006 72 Female 146 lb 4/3/2006 Consumer United States
Primary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 6/15/2006 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 70 Male 4/5/2006 United States
Primary
Secondary
Concomitant
Nausea Hospitalization 5/1/2006 60 Male 128 lb 5/4/2006 Pharmacist United States
Primary
Concomitant
Urticaria Required Intervention 6/27/2006 61 Male 160 lb 6/28/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/26/2006 61 Male 7/6/2006 Pharmacist United States
Primary
Concomitant
Rash Hospitalization 5/29/2006 81 Male 243 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 8/1/2005 73 Male 7/25/2006 Canada
Primary
Concomitant
Rash Hospitalization 1/12/2006 62 Male 75 lb 5/24/2006 Pharmacist United States
Primary
Concomitant
Lethargy 9/1/2004 79 Male 183 lb 8/1/2006 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 75 Male 128 lb 8/1/2006 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 7/22/2005 74 Male 8/1/2006 Consumer United States
Primary
Concomitant
International Normalised Ratio Decreased 11/15/2005 74 Male 183 lb 8/1/2006 Pharmacist United States
Primary
Concomitant
Rash Pruritic 4/10/2006 67 Male 238 lb 8/1/2006 Pharmacist United States
Primary
Concomitant
Oesophagitis Hospitalization 10/23/2005 74 Male 157 lb 7/31/2006 Physician Canada
Primary
Secondary
Concomitant
Agitation Hospitalization 4/1/2006 Male 280 lb 8/16/2006 Physician United States
Primary
Concomitant
Nightmare 5/1/2006 Male 500 lb 8/16/2006 Pharmacist United States
Primary
Concomitant
Somnolence Other Serious 65 Male 205 lb 8/29/2006 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 8/24/2006 Male 185 lb 9/6/2006 Pharmacist United States
Primary
Concomitant
Dizziness Male 408 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/23/2006 Female 216 lb 4/24/2006 Pharmacist United States
Primary
Concomitant
Diarrhoea Other Serious 7/28/2006 81 Male 180 lb 8/10/2006 Pharmacist United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 1/24/2006 Male 176 lb 10/5/2006 Other Health Professional United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 6/18/2006 87 Male 179 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Death Death 12/27/2005 Male 10/13/2006 Consumer United States
Primary
Concomitant
Swelling Required Intervention 8/13/2006 64 Male 242 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 9/23/2006 59 Male 10/26/2006 United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 7/1/2006 79 Male 11/21/2006 Consumer United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 11/1/2005 50 Male 209 lb 11/13/2006 United States
Primary
Concomitant
Thrombosis Other Serious 1/24/2006 Male 176 lb 11/28/2006 Other Health Professional United States
Primary
Concomitant
Thrombosis Other Serious 7/1/2006 79 Male 11/30/2006 Consumer United States
Primary
Secondary
Concomitant
Myalgia Other Serious 7/12/2006 58 Male 198 lb 8/15/2006 Other Health Professional United States
Primary
Concomitant
Death Death 12/27/2005 Male 12/22/2006 Consumer United States
Primary
Concomitant
Swelling 12/1/2005 77 Male 12/28/2006 Consumer United States
Primary
Concomitant
Thyroid Cancer Hospitalization 12/14/2006 82 Male 177 lb 1/4/2007 Physician United States
Primary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 76 Male 210 lb 1/10/2007 United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/7/2006 78 Male 1/10/2007 Physician France
Primary
Secondary
Concomitant
Rectal Polyp Life Threatening 8/5/2006 Male 166 lb 10/7/2006 Pharmacist United States
Primary
Secondary
Concomitant
Thyroxine Increased Other Serious 6/22/2005 77 Male 179 lb 11/16/2006 Other Health Professional United States
Primary
Concomitant
Pharyngolaryngeal Pain Other Serious 7/1/2006 70 Female 1/9/2007 Consumer United States
Primary
Concomitant
Skin Lesion Other Serious 11/7/2006 78 Male 1/11/2007 France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 11/7/2006 78 Male 1/19/2007 Other Health Professional France
Primary
Secondary
Concomitant
Cough Other Serious 12/28/2006 75 Male 218 lb 12/28/2006 Pharmacist United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 3/2/2006 Male 160 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/28/2006 75 Male 170 lb 1/25/2007 Pharmacist United States
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 12/18/2006 74 Male 2/7/2007 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 10/5/2006 78 Male 2/15/2007 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 10/30/2006 72 Male 217 lb 12/13/2006 Pharmacist United States
Primary
Concomitant
Vascular Encephalopathy Hospitalization 10/18/2006 81 Male 2/15/2007 Physician United States
Primary
Concomitant
Rhabdomyolysis Other Serious 57 Male 2/28/2007 Physician United States
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 10/1/2006 75 Female 3/15/2007 Consumer United States
Primary
Concomitant
Syncope Required Intervention 3/13/2007 81 Male 203 lb 3/13/2007 Pharmacist United States
Primary
Concomitant
Tremor Hospitalization 8/1/2004 81 Male 3/30/2006 Other Health Professional United States
Primary
Concomitant
Papillary Thyroid Cancer Hospitalization 8/10/2006 Male 205 lb 3/27/2007 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 1/1/2005 62 Male 3/27/2007 Physician United States
Primary
Concomitant
Haemoptysis Hospitalization 8/1/2006 74 Male 190 lb 3/29/2007 Consumer United States
Primary
Concomitant
Myalgia Other Serious 1/18/2007 73 Male 195 lb 1/18/2007 Pharmacist United States
Primary
Concomitant
Oesophagitis Hospitalization 10/24/2005 74 Male 157 lb 3/28/2007 Physician Canada
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/18/2007 81 Male 191 lb 4/4/2007 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 10/1/2006 75 Female 4/20/2007 Consumer United States
Primary
Concomitant
Haemolytic Anaemia Other Serious 1/9/2007 Male 198 lb 4/27/2007 Physician United States
Primary
Concomitant
Diarrhoea Other Serious 3/28/2007 84 Male 252 lb 3/29/2007 Pharmacist United States
Primary
Concomitant
Treatment Failure Other Serious 6/10/2006 79 Female 107 lb 5/7/2007 Physician
Primary
Secondary
Concomitant
Anaemia Hospitalization 1/11/2007 68 Male 5/10/2007 Pharmacist United States
Primary
Secondary
Concomitant
Haematuria Other Serious 6/1/2006 77 Male 12/13/2006 Consumer United States
Primary
Secondary
Concomitant
Electrocardiogram Qt Corrected Interval Prolonged Other Serious 10/21/2006 88 Male 162 lb 2/28/2007 Physician United States
Primary
Concomitant
Nephrogenic Fibrosing Dermopathy Other Serious 12/1/2002 75 Male 201 lb 5/25/2007 Physician United States
Primary
Concomitant
Haemoptysis Hospitalization 8/1/2006 74 Male 190 lb 6/1/2007 Consumer United States
Primary
Concomitant
Syncope Hospitalization 6/16/2004 82 Male 3/7/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Glucose Increased 1/23/2007 76 Male 200 lb 4/23/2007 Consumer United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 6/2/2007 69 Female 120 lb 6/10/2007 Other Health Professional United States
Primary
Concomitant
Lobar Pneumonia Disability 82 Female 124 lb 6/14/2007 United States
Primary
Secondary
International Normalised Ratio Increased Hospitalization 6/1/2007 94 Male 6/12/2007 Physician United States
Primary
Concomitant
Pain Hospitalization 6/1/2007 94 Male 7/6/2007 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective 6/1/2003 71 Male 7/16/2007 Other Health Professional United States
Primary
Concomitant
Sinus Operation 3/1/2006 Male 7/23/2007 Consumer United States
Primary
Concomitant
Weight Increased Disability 58 Male 327 lb 7/23/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 6/22/2007 Female 243 lb 7/23/2007 Physician United States
Primary
Concomitant
Jaundice Hospitalization 4/4/2006 78 Female 7/23/2007 Pharmacist United States
Primary
Concomitant
Haemoptysis Hospitalization 8/1/2006 74 Male 190 lb 7/27/2007 Consumer United States
Primary
Concomitant
Skin Cancer Other Serious 7/1/2007 73 Male 8/2/2007 United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/6/2007 Physician United States
Primary
Concomitant
Coronary Artery Occlusion Other Serious Male 150 lb 8/2/2007 Consumer United States
Primary
Concomitant
Urine Colour Abnormal Other Serious 5/15/2007 78 Male 8/6/2007 Physician United States
Primary
Secondary
Concomitant
Rash Papular Hospitalization 5/22/2007 76 8/10/2007 Physician France
Primary
Secondary
Concomitant
Diarrhoea 6/25/2007 67 Male 8/3/2007 Consumer United States
Primary
Concomitant
Haemoptysis Hospitalization 8/1/2006 74 Male 190 lb 8/21/2007 Consumer United States
Primary
Concomitant
Tachycardia Hospitalization 7/30/2007 Male 8/28/2007 Other Health Professional United States
Primary
Concomitant
Urticaria 8/16/2007 81 Female 9/4/2007 Consumer United States
Primary
Concomitant
Syncope Other Serious 8/1/2006 74 Male 190 lb 9/6/2007 Consumer United States
Primary
Secondary
Concomitant
Haemoptysis Hospitalization 8/1/2006 74 Male 190 lb 9/7/2007 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2004 Female 150 lb 9/10/2007 Physician United States
Primary
Concomitant
Ocular Hyperaemia Disability 11/1/2005 85 Male 142 lb 8/31/2007 Other Health Professional United States
Primary
Concomitant
Urticaria 8/16/2007 81 Female 9/18/2007 Consumer United States
Primary
Concomitant
Oesophagitis Hospitalization 10/24/2005 74 Male 157 lb 9/14/2007 Physician Canada
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 8/11/2000 68 Male 190 lb 9/25/2007 Consumer United States
Primary
Secondary
Concomitant
Overdose 6/13/2007 78 Male 7/26/2007 United States
Primary
Secondary
Concomitant
Overdose Hospitalization 6/1/2007 63 Male 9/28/2007 Consumer United States
Primary
Secondary
Concomitant
Gastric Haemorrhage Other Serious Female 9/25/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Urine Colour Abnormal Other Serious 5/15/2007 78 Male 8/6/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 9/11/2007 66 Male 206 lb 9/27/2007 Pharmacist United States
Primary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 12/1/2002 75 Male 201 lb 10/8/2007 Physician United States
Primary
Concomitant
Ocular Hyperaemia Disability 11/1/2005 85 Male 153 lb 9/27/2007 Other Health Professional United States
Primary
Concomitant
Dyspnoea 7/1/2006 76 Male 11/13/2007 Consumer United States
Primary
Concomitant
Dyspnoea Male 11/13/2007 Consumer United States
Primary
Concomitant
Visual Disturbance 3/1/2006 75 Male 11/14/2007 Consumer United States
Primary
Concomitant
Procedural Complication Other Serious Male 150 lb 11/7/2007 Physician United States
Primary
Concomitant
Overdose 6/13/2007 78 Male 10/22/2007 United States
Primary
Secondary
Concomitant
Drug Ineffective 8/1/2007 69 Male 12/5/2007 Consumer United States
Primary
Concomitant
Dry Throat 11/7/2007 Male 12/10/2007 Consumer United States
Primary
Concomitant
Peripheral Motor Neuropathy Hospitalization 12/1/2007 52 Male 198 lb 12/6/2007 Other Health Professional United States
Primary
Concomitant
Neutropenia Other Serious 12/5/2007 Female 12/6/2007 Pharmacist United States
Primary
Concomitant
Pain 86 Male 12/12/2007 Consumer United States
Primary
Concomitant
Tooth Extraction Other Serious 10/2/2002 49 Female 128 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Overdose Hospitalization 9/1/2007 63 Male 12/17/2007 Physician United States
Primary
Secondary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 53 Male 172 lb 12/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Muscle Spasms Other Serious 10/1/2007 Female 130 lb 12/28/2007 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2004 Female 150 lb 1/2/2008 Physician United States
Primary
Concomitant
Dry Throat 11/7/2007 Male 1/2/2008 Consumer United States
Primary
Concomitant
Cardiac Failure Hospitalization 11/20/2007 73 Male 1/7/2008 Other Health Professional Italy
Primary
Concomitant
Drug Ineffective 8/1/2007 69 Male 1/9/2008 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 12/26/2007 70 Female 137 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
Lymphadenopathy Other Serious 1/9/2007 64 Male 198 lb 1/18/2008 Consumer United States
Primary
Secondary
Concomitant
Rash Other Serious 8/1/2007 71 Male 210 lb 12/12/2007 United States
Primary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 53 Male 172 lb 1/22/2008 United States
Primary
Concomitant
Cardiac Failure Hospitalization 11/20/2007 73 Male 1/25/2008 Other Health Professional Italy
Primary
Concomitant
Tooth Extraction Other Serious 10/2/2002 49 Female 128 lb 1/29/2008 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 12/1/2007 70 Female 137 lb 1/29/2008 Physician United States
Primary
Secondary
Concomitant

Drug Data