Coumadin combined with Rebif

Reports:

---

Reaction	Outcome	Event Date	Age	Sex	Weight	Reported	Reporter	Country	Treatment
									Role	Name
Multiple Sclerosis Relapse	Hospitalization	1/1/2005	42	Female		6/5/2006	Physician	United States	Primary Secondary Concomitant
Vomiting	Other Serious	11/10/2006	50	Female	128 lb	12/20/2006	Physician	United States	Primary Secondary Concomitant
Urinary Tract Infection	Hospitalization	11/30/2006	65	Female		12/21/2006		United States	Primary Concomitant
Lung Disorder	Other Serious	11/30/2006	65	Female		2/6/2007		United States	Primary Concomitant
Diabetes Mellitus	Hospitalization		52	Female		2/23/2007		United States	Primary Concomitant
Pulmonary Hypertension	Hospitalization	10/1/2006	68	Female		3/12/2007	Other Health Professional	United States	Primary Concomitant
Pyrexia	Hospitalization	10/1/2006	40	Female		3/15/2007		United States	Primary Concomitant
Urinary Incontinence	Hospitalization	1/1/2007	77	Male		5/4/2007		United States	Primary Concomitant
Weight Decreased	Other Serious	4/1/2007	57	Female		5/11/2007	Other Health Professional	United States	Primary Concomitant
Pericardial Effusion	Hospitalization	4/25/2007	31	Male		5/14/2007		United States	Primary Concomitant
Rotator Cuff Syndrome	Hospitalization	1/1/2007	47	Female	296 lb	5/29/2007		United States	Primary Concomitant
Red Blood Cell Count Decreased	Other Serious	7/19/2006	48	Female		4/16/2007		United States	Primary Concomitant
Nasopharyngitis	Hospitalization	12/10/2006	73	Male	210 lb	6/11/2007	Consumer	United States	Primary Concomitant
Rotator Cuff Syndrome	Hospitalization	1/1/2007	47	Female	296 lb	6/12/2007	Physician	United States	Primary Concomitant
Nasopharyngitis	Hospitalization	12/10/2006	73	Male	210 lb	6/18/2007		United States	Primary Concomitant
Pericardial Effusion	Hospitalization	4/25/2007	31	Male	300 lb	6/25/2007		United States	Primary Concomitant
Red Blood Cell Count Decreased	Hospitalization	3/7/2007	58	Female	163 lb	7/3/2007		United States	Primary Concomitant
Metastases To Lymph Nodes	Hospitalization	3/7/2007	58	Female	163 lb	7/20/2007	Physician	United States	Primary Concomitant
Hip Fracture	Hospitalization	5/21/2007	70	Female		7/23/2007		United States	Primary Concomitant
Small Intestinal Obstruction	Hospitalization	6/29/2007	49	Female		8/7/2007		United States	Primary Concomitant
Haematocrit Decreased	Hospitalization	10/1/2006	40	Female		8/9/2007		United States	Primary Concomitant
Convulsion	Hospitalization	1/1/2007	64	Female		8/22/2007		United States	Primary Secondary Concomitant
Shared Psychotic Disorder	Hospitalization	9/3/2007	64	Female		10/2/2007		United States	Primary Secondary Concomitant
Convulsion	Hospitalization	1/1/2007	64	Female		10/9/2007	Physician	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007	64	Female		10/18/2007	Consumer	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	9/3/2007	64	Female		10/18/2007	Physician	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007		Female		10/24/2007	Consumer	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007		Female		10/25/2007	Other Health Professional	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007		Female		11/2/2007	Other Health Professional	United States	Primary Secondary Concomitant
Pharyngeal Injury	Hospitalization	9/6/2007	48	Female	300 lb	11/1/2007	Consumer	United States	Primary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007	64	Female		11/6/2007	Consumer	United States	Primary Secondary Concomitant
Psychotic Disorder	Hospitalization	6/1/2007		Female		11/8/2007	Physician	United States	Primary Secondary Concomitant
Intestinal Perforation	Hospitalization	9/21/2007	42	Female	180 lb	11/8/2007		United States	Primary Concomitant
Multiple Sclerosis	Hospitalization	1/1/2007	77	Female		11/9/2007	Consumer	United States	Primary Concomitant
Pancreatitis	Hospitalization	4/13/2007	59	Female	170 lb	11/30/2007	Physician	United States	Primary Concomitant
Convulsion	Hospitalization	1/1/2007	64	Female		12/12/2007	Physician	United States	Primary Secondary Concomitant
Staring	Other Serious	12/3/2007	70	Female		12/14/2007		United States	Primary Concomitant
Deep Vein Thrombosis	Other Serious	9/1/2007	30	Female		1/4/2008		United States	Primary Concomitant
Deep Vein Thrombosis	Other Serious	9/1/2007	30	Female		1/17/2008		United States	Primary Concomitant
Unresponsive To Stimuli	Other Serious	12/3/2007	70	Female		1/25/2008	Physician	United States	Primary Secondary Concomitant
Unresponsive To Stimuli	Other Serious	12/3/2007	70	Female		2/7/2008	Physician	United States	Primary Secondary Concomitant
Deep Vein Thrombosis	Other Serious	9/27/2007	30	Female		1/30/2008		United States	Primary Concomitant
Thrombophlebitis Superficial	Hospitalization	1/8/2008	48	Female	160 lb	2/4/2008		United States	Primary Concomitant
Hip Fracture	Hospitalization	5/21/2007	70	Female		2/11/2008	Other Health Professional	United States	Primary Concomitant
Rash Erythematous	Hospitalization	1/1/2008	44	Male	230 lb	2/11/2008		United States	Primary Concomitant
Hip Fracture	Hospitalization	5/21/2007	70	Female		2/11/2008	Other Health Professional	United States	Primary Concomitant
Intestinal Perforation	Hospitalization	9/21/2007	42	Female	180 lb	3/10/2008		United States	Primary Concomitant
Multiple Sclerosis Relapse	Hospitalization	2/1/2008	39	Female		3/7/2008		United States	Primary Concomitant
Nasopharyngitis	Other Serious		74	Male	210 lb	3/24/2008		United States	Primary Concomitant
Prothrombin Time Prolonged	Hospitalization	3/1/2008	50	Female		3/28/2008		United States	Primary Concomitant
Red Blood Cell Count Decreased	Hospitalization	3/7/2007	58	Female	163 lb	4/1/2008	Physician	United States	Primary Concomitant
Multiple Sclerosis Relapse	Hospitalization	2/4/2008	39	Female	167 lb	4/1/2008	Physician	United States	Primary Concomitant
Frustration	Other Serious	2/1/2008	56	Male	270 lb	4/7/2008	Consumer	United States	Primary Concomitant
Small Cell Carcinoma	Hospitalization	11/14/2007	56	Male	188 lb	4/22/2008		United States	Primary Concomitant
Muscle Tightness	Hospitalization	9/1/2007	30	Female		5/1/2008		United States	Primary Concomitant
Pulmonary Fibrosis	Other Serious	5/1/2008	58	Female		6/12/2008		United States	Primary Concomitant
Skin Ulcer	Other Serious	10/1/2007	49	Female	140 lb	7/14/2008		United States	Primary Concomitant
Surgery	Hospitalization	6/1/2008	74	Female	185 lb	7/16/2008		United States	Primary Concomitant
Presyncope	Other Serious	8/8/2008	47	Female	163 lb	8/21/2008		United States	Primary Concomitant
Condition Aggravated	Other Serious		38	Female	215 lb	8/22/2008		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	6/2/2008	66	Female	220 lb	8/22/2008		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	8/15/2008	61	Female	250 lb	8/26/2008		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	8/15/2008	61	Female	250 lb	9/4/2008	Physician	United States	Primary Concomitant
Memory Impairment	Other Serious		38	Female	215 lb	9/2/2008	Other Health Professional	United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	8/1/2008	54	Female	201 lb	9/11/2008		United States	Primary Concomitant
Vomiting	Hospitalization	8/1/2008	49	Female	276 lb	9/19/2008		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	1/1/2008	56	Female		9/25/2008		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	8/1/2008	54	Female	201 lb	9/23/2008	Physician	United States	Primary Concomitant
Diabetes Mellitus	Other Serious	8/8/2008	47	Female		10/3/2008		United States	Primary Concomitant
Vitamin D Decreased	Hospitalization	7/1/2008	51	Male	161 lb	10/10/2008	Physician	United States	Primary Concomitant
Pulmonary Fibrosis	Other Serious	5/1/2008	58	Female		10/7/2008		United States	Primary Concomitant
Pulmonary Fibrosis	Other Serious	5/1/2008	58	Female		10/7/2008		United States	Primary Concomitant
Prothrombin Time Abnormal	Other Serious	1/1/2008	44	Male		10/31/2008	Pharmacist	United States	Primary Concomitant
Loss Of Consciousness	Other Serious	8/8/2008	47	Female	163 lb	11/5/2008		United States	Primary Concomitant
Type 2 Diabetes Mellitus	Other Serious	1/25/2008	74	Male	209 lb	11/5/2008	Other Health Professional	United States	Primary Concomitant
Subdural Haematoma	Other Serious	11/28/2007	56	Female		11/12/2008		United States	Primary Concomitant
Prothrombin Time Prolonged	Hospitalization	3/1/2008	50	Female		11/21/2008	Physician	United States	Primary Secondary Concomitant
Urinary Tract Infection	Hospitalization	9/1/2007	30	Female	190 lb	12/9/2008		United States	Primary Concomitant
Small Cell Lung Cancer Stage Unspecified	Hospitalization	11/5/2007	56	Male	187 lb	12/15/2008	Other Health Professional	United States	Primary Concomitant
Off Label Use	Other Serious	6/1/2008	26	Male		1/16/2009	Physician	United States	Primary Concomitant
Wrong Technique In Drug Usage Process	Hospitalization	2/1/2008	46	Male		2/11/2009		United States	Primary Concomitant
Thinking Abnormal	Other Serious	1/1/2007		Female		3/24/2009	Consumer	United States	Primary Secondary Concomitant
No Adverse Event			42	Male		3/18/2009		United States	Primary Concomitant
Thyroid Neoplasm	Other Serious	3/7/2007	58	Female	159 lb	3/19/2009	Physician	United States	Primary Concomitant
Breast Sarcoma	Other Serious	3/1/2009	63	Female		3/24/2009		United States	Primary Concomitant
Weight Decreased		10/1/2008	27	Male	260 lb	4/3/2009		United States	Primary Concomitant
Vascular Rupture	Hospitalization	3/11/2009				4/3/2009	Physician	United States	Primary Secondary Concomitant
Thrombosis	Other Serious	1/1/2007		Female		4/22/2009	Consumer	United States	Primary Secondary Concomitant
Pneumonia	Hospitalization	1/1/2008	60	Female		4/17/2009		United States	Primary Concomitant
Lung Infection	Hospitalization	3/7/2007	58	Female	159 lb	4/28/2009	Physician	United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	1/1/2008	56	Female		6/17/2009	Physician	United States	Primary Concomitant
Diabetes Mellitus	Other Serious	8/8/2008	47	Female		6/25/2009		United States	Primary Concomitant
Rotator Cuff Syndrome	Other Serious	1/1/2007	47	Female	300 lb	7/6/2009	Consumer	United States	Primary Concomitant
Pulmonary Thrombosis	Other Serious	6/1/2009	39	Female		7/6/2009		United States	Primary Concomitant
Pulmonary Thrombosis	Other Serious	6/1/2009	39	Female	143 lb	7/29/2009	Physician	United States	Primary Concomitant
Renal Failure	Hospitalization	8/1/2009	51	Female	269 lb	9/17/2009		United States	Primary Concomitant
Scleroderma	Hospitalization	10/1/2006	68	Female		9/28/2009	Other Health Professional	United States	Primary Concomitant
Breast Sarcoma	Other Serious	3/1/2009	63	Female		11/3/2009	Other Health Professional	United States	Primary Concomitant
Renal Cyst	Other Serious	1/1/2009	67	Male		11/18/2009	Consumer	United States	Primary Concomitant
Dyspepsia	Other Serious	9/1/2009	60	Male	240 lb	11/25/2009		United States	Primary Concomitant
Intervertebral Disc Protrusion	Other Serious		52	Female		11/25/2009		United States	Primary Concomitant
No Adverse Event			52	Female		12/8/2009	Consumer	United States	Primary Concomitant
Verbal Abuse	Other Serious	2/1/2008	56	Male	271 lb	12/7/2009		United States	Primary Concomitant
Small Cell Lung Cancer Stage Unspecified	Hospitalization	11/5/2007	56	Male	187 lb	12/7/2009	Physician	United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	1/1/2009	61	Female		12/29/2009	Physician	United States	Primary Concomitant
Pneumonia	Hospitalization	1/1/2008	60	Female	231 lb	12/16/2009	Other Health Professional	United States	Primary Concomitant
Skin Ulcer	Hospitalization	4/9/2008	55	Male		1/12/2010		Canada	Primary Concomitant
Urinary Tract Infection	Other Serious	11/1/2009	78	Male		1/21/2010	Consumer	United States	Primary Concomitant
Myocardial Infarction	Life Threatening			Female		1/28/2010	Consumer	United States	Primary Concomitant
Cardiac Output Decreased	Hospitalization	12/1/2009	61	Male	170 lb	2/4/2010		United States	Primary Concomitant
Muscle Spasms	Hospitalization	12/14/2009	61	Male	181 lb	2/17/2010	Other Health Professional	United States	Primary Concomitant
Tibia Fracture	Hospitalization	2/15/2010	38	Female		3/2/2010		United States	Primary Concomitant
Thrombosis	Hospitalization	11/24/2008	65	Male		3/4/2010	Physician	United States	Primary Concomitant
Tibia Fracture	Hospitalization	2/15/2010	38	Female		3/9/2010		United States	Primary Concomitant
Suicide Attempt	Hospitalization	3/8/2010	48	Male		3/17/2010		United States	Primary Concomitant
Movement Disorder	Other Serious	1/1/2007	52	Female	214 lb	3/17/2010		United States	Primary Concomitant
International Normalised Ratio Increased	Hospitalization	1/1/2010	49	Male		3/29/2010		United States	Primary Secondary Concomitant
Weight Increased	Hospitalization		55	Female		4/6/2010		United States	Primary Secondary
Urinary Tract Infection	Other Serious	11/1/2009	78	Male		4/19/2010		United States	Primary Concomitant
Urinary Tract Infection	Hospitalization	1/1/2009	61	Female	198 lb	5/5/2010	Physician	United States	Primary Concomitant
Treatment Noncompliance	Hospitalization	11/20/2009	28			4/29/2010	Physician	United States	Primary Secondary Concomitant
Influenza Like Illness	Other Serious	4/24/2010	61	Female	181 lb	5/6/2010		United States	Primary Concomitant
Prothrombin Time Abnormal	Other Serious		44	Female	249 lb	7/2/2010		United States	Primary Secondary Concomitant
Ulcer	Hospitalization	4/9/2008	55	Male		7/2/2010		Canada	Primary Concomitant
Musculoskeletal Stiffness	Hospitalization	11/10/2009	57	Female	201 lb	7/30/2010		United States	Primary Concomitant
Sensory Loss	Hospitalization	1/1/2010	44	Female	359 lb	8/2/2010		United States	Primary Concomitant
Stress	Hospitalization	7/19/2010	53	Female		8/5/2010		United States	Primary Concomitant
Pain		1/1/2010	34	Female		9/3/2010	Consumer	United States	Primary Concomitant
Syncope	Hospitalization	11/1/2008	56	Male	216 lb	9/13/2010	Other Health Professional	United States	Primary Concomitant
Pustular Psoriasis		1/1/2010	58	Female		9/14/2010	Consumer	United States	Primary Concomitant
Vision Blurred	Hospitalization	1/1/2009	54	Female		9/27/2010	Consumer	United States	Primary Concomitant
Thrombosis	Other Serious	9/1/2009	45	Female	201 lb	10/5/2010	Consumer	United States	Primary Concomitant
Pyrexia	Hospitalization	10/8/2010	29	Female		10/15/2010	Consumer	United States	Primary Concomitant
Tooth Erosion	Other Serious	1/1/2010	51	Female		10/15/2010	Consumer	United States	Primary Concomitant
Tooth Erosion	Other Serious	1/1/2010	51	Female		10/22/2010	Consumer	United States	Primary Concomitant
Urinary Retention	Hospitalization	10/8/2010	29	Female	265 lb	10/28/2010	Physician	United States	Primary Concomitant
Pneumonia	Hospitalization	1/1/2010	55	Male	260 lb	10/29/2010	Other Health Professional	United States	Primary Concomitant
Vision Blurred	Hospitalization	1/1/2009	54	Female		11/1/2010	Consumer	United States	Primary Concomitant
Staphylococcal Infection	Hospitalization	12/1/2009	61	Male	181 lb	11/2/2010	Other Health Professional	United States	Primary Concomitant
Suicidal Ideation	Hospitalization	11/20/2009	28	Female		11/8/2010	Physician	United States	Primary Secondary Concomitant
Musculoskeletal Stiffness	Hospitalization	11/10/2009	57	Female	201 lb	11/12/2010	Consumer	United States	Primary Concomitant
Tremor	Hospitalization	7/19/2010	53	Female	139 lb	11/15/2010	Other Health Professional	United States	Primary Concomitant
Tooth Erosion	Other Serious	1/1/2010	51	Female	309 lb	11/22/2010	Other Health Professional	United States	Primary Concomitant
Dyspepsia	Other Serious	1/1/2009	59	Male	240 lb	11/23/2010	Physician	United States	Primary Concomitant
Urinary Tract Infection	Other Serious	10/1/2010	65	Female		11/23/2010	Consumer	United States	Primary Concomitant
Renal Cyst	Other Serious	10/1/2009	67	Male		11/24/2010	Consumer	United States	Primary Concomitant
Prothrombin Time Abnormal	Other Serious	1/1/2010	44	Female	249 lb	11/24/2010	Consumer	United States	Primary Secondary Concomitant
Urinary Tract Infection	Other Serious	10/1/2010	65	Female		11/30/2010	Physician	United States	Primary Concomitant
Ventricular Tachycardia	Other Serious	1/1/2007	49	Female	214 lb	12/8/2010	Consumer	United States	Primary Concomitant
Tremor	Other Serious	1/1/2010	52	Female	139 lb	12/8/2010	Other Health Professional	United States	Primary