Coumadin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ventricular Tachycardia Hospitalization 1/1/2000 75 Male 181 lb 1/4/2006 Physician United States
Primary
Concomitant
Overdose Required Intervention 10/19/2005 77 Female 127 lb 1/2/2006 Consumer United States
Primary
Concomitant
Metastatic Malignant Melanoma Other Serious 1/1/2005 Female 161 lb 1/25/2006 Physician United States
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 9/15/2005 63 Male 304 lb 1/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death Female 2/3/2006 Physician United States
Primary
Concomitant
Sinus Tachycardia Other Serious 1/1/2003 43 Female 181 lb 2/27/2006 Physician United States
Primary
Concomitant
Gastroenteritis Hospitalization 8/24/2005 Female 3/1/2006 Physician United States
Primary
Concomitant
Vasculitis Hospitalization 12/7/2002 32 Female 170 lb 3/1/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Required Intervention 61 Male 170 lb 2/27/2006 Physician United States
Primary
Concomitant
Vein Disorder Other Serious 9/7/2005 20 Female 121 lb 2/27/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2002 Female 226 lb 3/13/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2002 66 Male 201 lb 3/14/2006 Lawyer United States
Primary
Concomitant
Tinnitus Other Serious 1/1/2003 43 Female 181 lb 3/21/2006 Physician United States
Primary
Concomitant
Tinnitus Other Serious 1/1/2003 43 Female 181 lb 3/24/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/1999 50 Male 240 lb 4/5/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2002 66 Male 201 lb 4/6/2006 Lawyer United States
Primary
Concomitant
Thrombosis Other Serious 11/1/2002 24 Female 165 lb 4/7/2006 Lawyer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2002 Female 131 lb 4/7/2006 Physician United States
Primary
Concomitant
Muscle Spasms Hospitalization 11/17/1999 41 Female 154 lb 4/10/2006 Lawyer United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 9/30/2003 77 Female 134 lb 4/11/2006 Physician United States
Primary
Concomitant
Vasculitis Hospitalization 12/7/2002 32 Female 170 lb 5/1/2006 Physician United States
Primary
Concomitant
Adenocarcinoma Other Serious 5/5/2006 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2003 72 Male 143 lb 5/10/2006 Lawyer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 11/6/2005 78 Female 4/27/2006 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 3/5/2003 70 Male 143 lb 5/15/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/15/2006 Female 5/19/2006 Physician United States
Primary
Concomitant
Somnolence 1/1/2005 42 Female 257 lb 4/25/2006 Other Health Professional United States
Primary
Concomitant
Calculus Bladder Hospitalization 3/1/2004 Male 177 lb 6/9/2006 Physician United States
Primary
Concomitant
Lung Disorder Death Male 6/12/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/15/2006 Female 6/28/2006 Physician United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 12/25/2005 Female 115 lb 7/7/2006 Physician United States
Primary
Concomitant
B-cell Lymphoma Stage I Other Serious 8/4/2004 Female 128 lb 7/11/2006 Other Health Professional United States
Primary
Concomitant
B-cell Lymphoma Stage I Other Serious 8/4/2004 Female 128 lb 8/1/2006 Other Health Professional United States
Primary
Concomitant
Haemorrhage Hospitalization 12/1/2004 60 Male 249 lb 8/1/2006 Consumer United States
Primary
Secondary
Concomitant
Haemoptysis Other Serious 8/1/2004 46 Female 163 lb 8/1/2006 Consumer United States
Primary
Secondary
Concomitant
Prothrombin Time Ratio Increased 1/1/2005 57 Female 201 lb 8/1/2006 Consumer United States
Primary
Concomitant
International Normalised Ratio Decreased Female 8/1/2006 Consumer United States
Primary
Interacting
International Normalised Ratio Decreased Female 8/1/2006 Consumer United States
Primary
Interacting
Respiratory Failure Other Serious 8/1/2002 Male 180 lb 8/7/2006 Physician United States
Primary
Concomitant
Renal Failure Hospitalization Female 110 lb 8/24/2006 Physician United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 8/15/2001 Male 9/6/2006 Physician United States
Primary
Concomitant
Throat Tightness Other Serious 1/1/2006 Male 320 lb 9/14/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/1/2006 46 Female 9/20/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 9/25/2006 Physician United States
Primary
Concomitant
Sepsis Other Serious Female 9/26/2006 Physician United States
Primary
Concomitant
Sepsis Other Serious Female 9/26/2006 Physician United States
Primary
Concomitant
Shock Other Serious 1/22/2004 Female 9/26/2006 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 8/1/2002 Male 180 lb 9/27/2006 Physician United States
Primary
Concomitant
Refusal Of Treatment By Patient Other Serious 1/1/2006 73 Female 9/18/2006 Consumer United States
Primary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 9/29/2006 Physician United States
Primary
Secondary
Concomitant
Cataract Other Serious 51 Male 270 lb 9/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Heart Rate Increased 5/15/2006 55 Female 7/31/2006 Consumer United States
Primary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2002 73 Female 10/11/2006 Consumer United States
Primary
Concomitant
Cataract Other Serious 51 Male 269 lb 11/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/1/2006 59 Female 192 lb 11/1/2006 Physician United States
Primary
Secondary
Concomitant
Incorrect Dose Administered Other Serious 51 Male 270 lb 11/9/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hospitalisation Other Serious 1/19/2006 Female 179 lb 11/20/2006 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 51 Male 270 lb 10/23/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Female 11/29/2006 Consumer France
Primary
Secondary
Concomitant
Synovitis Hospitalization 10/1/2005 Female 185 lb 12/1/2006 Physician
Primary
Concomitant
Pneumonia Hospitalization 5/1/2006 Female 12/11/2006 Physician United States
Primary
Concomitant
Spinal Compression Fracture Hospitalization 3/27/2006 Female 125 lb 12/11/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2005 Female 179 lb 12/12/2006 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis Other Serious 12/6/2005 Male 208 lb 12/13/2006 Physician United States
Primary
Concomitant
Injection Site Pain Hospitalization 12/1/2004 Female 247 lb 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/1/2006 72 Female 12/13/2006 Consumer United States
Primary
Concomitant
Death Death 12/7/2006 70 Female 12/15/2006 Consumer Canada
Primary
Concomitant
Death Death 12/6/2006 70 Female 12/19/2006 Physician Canada
Primary
Concomitant
Ecchymosis 9/9/2006 Female 12/20/2006 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 8/1/2006 60 Female 121 lb 12/22/2006 Consumer France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/1/2006 60 Female 121 lb 1/2/2007 Consumer France
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Osteomyelitis Hospitalization 3/1/2001 Male 218 lb 2/1/2007 Consumer United States
Primary
Secondary
Concomitant
Embolism Other Serious 1/25/2007 54 Male 164 lb 2/6/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/19/2007 53 Female 170 lb 2/7/2007 Consumer United States
Primary
Concomitant
Weight Increased 9/8/2006 70 Male 216 lb 10/16/2006 Consumer United States
Primary
Concomitant
Thrombosis Hospitalization 2/1/2007 Female 2/28/2007 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Required Intervention 9/28/2004 53 Male 183 lb 11/17/2005 Physician United States
Primary
Secondary
Concomitant
Cataract Other Serious 51 Male 270 lb 1/5/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/1/2007 Female 4/13/2007 Consumer United States
Primary
Concomitant
Ovarian Cancer Other Serious 1/5/2004 69 Female 161 lb 5/11/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Scoliosis Other Serious 7/12/2006 14 Female 68 lb 1/4/2007 Physician United States
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 6/8/2007 Physician Italy
Primary
Concomitant
Respiratory Failure Hospitalization 6/13/2007 70 Female 132 lb 6/28/2007 Physician United States
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 6/29/2007 Physician Canada
Primary
Concomitant
Tuberculosis Hospitalization 6/1/2007 Female 235 lb 7/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 7/9/2007 Female 123 lb 7/19/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/6/2007 Physician United States
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 8/13/2007 Physician Canada
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 8/29/2007 Physician Canada
Primary
Concomitant
Anaphylactic Reaction Hospitalization 8/16/2007 42 Female 243 lb 9/10/2007 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2005 Male 154 lb 9/17/2007 Other Health Professional Canada
Primary
Concomitant
Head Injury Other Serious 8/1/2007 84 Female 9/14/2007 Consumer Canada
Primary
Concomitant
Urinary Retention Hospitalization 5/1/2007 84 Female 9/13/2007 Physician Canada
Primary
Concomitant
Death Hospitalization 8/16/2007 42 Female 243 lb 9/26/2007 Other Health Professional United States
Primary
Concomitant
Anaphylactic Reaction Hospitalization 8/16/2007 42 Female 243 lb 10/4/2007 Other Health Professional United States
Primary
Concomitant
Thrombosis Other Serious 1/1/1998 68 Female 115 lb 10/12/2007 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 9/1/2006 Male 11/12/2007 Physician United States
Primary
Concomitant
Rash Macular Hospitalization 11/5/2007 Female 190 lb 11/6/2007 United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 9/17/2007 Female 110 lb 11/29/2007 Other Health Professional Canada
Primary
Concomitant
Glaucoma 1/1/2007 Female 12/11/2007 Physician
Primary
Concomitant
Spinal Fracture 5/1/2007 Male 159 lb 12/12/2007 Physician United States
Primary
Concomitant
Anaphylactic Reaction Hospitalization 8/16/2007 42 Female 243 lb 12/21/2007 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2003 Female 12/21/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 58 Female 12/21/2007 Consumer United States
Primary
Concomitant
Pelvic Fracture Other Serious 1/1/2007 76 Female 89 lb 12/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 8/1/2006 66 Male 232 lb 11/28/2007 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 2/1/2007 77 Female 123 lb 11/28/2007 United States
Primary
Concomitant
Oedema Peripheral Other Serious 9/17/2007 Female 110 lb 1/22/2008 Other Health Professional Canada
Primary
Concomitant
Cataract Other Serious 51 Male 270 lb 1/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 1/1/2007 Male 206 lb 3/4/2008 Physician United States
Primary
Concomitant
Weight Decreased 1/1/2006 72 Female 210 lb 1/10/2008 Consumer United States
Primary
Concomitant
Lymphoma Other Serious Female 3/11/2008 Physician United States
Primary
Concomitant
Hyperhidrosis 12/1/2007 61 Female 154 lb 5/19/2008 Other Health Professional United States
Primary
Concomitant
Swelling Face Other Serious 5/12/2008 82 Female 5/23/2008 Consumer United States
Primary
Concomitant
Medication Residue 3/1/2007 5/13/2008 Consumer United States
Primary
Concomitant
Hyperhidrosis 12/1/2007 61 Female 154 lb 5/29/2008 Other Health Professional United States
Primary
Concomitant
Palpitations Other Serious 3/1/2008 Female 180 lb 6/4/2008 Physician Canada
Primary
Concomitant
Tachycardia Hospitalization 11/1/2001 Male 6/16/2008 Other Health Professional Austria
Primary
Concomitant
Pancreatitis Acute Other Serious 3/19/2005 79 Female 98 lb 6/13/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2003 Female 7/2/2008 Physician United States
Primary
Concomitant
Pelvic Fracture Other Serious 1/1/2007 76 Female 89 lb 7/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Procedural Complication Hospitalization 6/1/2006 Male 7/10/2008 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 11/13/2002 Male 7/21/2008 Other Health Professional United States
Primary
Concomitant
Swelling Face Other Serious 5/12/2008 82 Female 7/28/2008 Consumer United States
Primary
Concomitant
Pneumonia Other Serious 7/25/2008 70 Female 8/5/2008 Consumer Canada
Primary
Concomitant
Optic Neuritis Other Serious 1/1/2007 64 Female 8/13/2008 Physician United States
Primary
Concomitant
Oesophageal Candidiasis Hospitalization 7/17/2008 Female 121 lb 9/3/2008 Physician United States
Primary
Concomitant
Tuberculosis Hospitalization 8/14/2008 53 Male 9/22/2008 Physician Turkey
Primary
Secondary
Concomitant
Stomatitis Required Intervention 8/2/2008 76 Male 180 lb 9/17/2008 Consumer United States
Primary
Concomitant
Tuberculosis Hospitalization 8/14/2008 53 Male 9/30/2008 Physician Turkey
Primary
Secondary
Concomitant
Retinal Artery Occlusion Other Serious 4/5/2006 Male 208 lb 10/22/2008 Physician United States
Primary
Secondary
Concomitant
Retinal Artery Occlusion Other Serious 4/5/2006 Male 208 lb 10/27/2008 Physician United States
Primary
Secondary
Concomitant
Swelling Other Serious Female 10/27/2008 Physician United States
Primary
Concomitant
Swelling Other Serious Female 10/31/2008 Physician United States
Primary
Concomitant
Dementia Other Serious 1/1/2006 Female 126 lb 11/4/2008 Physician United States
Primary
Concomitant
Stomatitis Required Intervention 8/2/2008 76 Male 397 lb 10/23/2008 United States
Primary
Concomitant
Rash Macular Hospitalization 11/5/2007 Female 190 lb 11/10/2008 United States
Primary
Secondary
Concomitant
Drug Ineffective Disability 1/1/2005 Male 320 lb 11/25/2008 United States
Primary
Concomitant
Wound Secretion 3/23/2008 Female 12/11/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 2/15/2008 Female 12/11/2008 Consumer United States
Primary
Concomitant
Tremor 2/8/2008 Male 12/12/2008 Physician United States
Primary
Secondary
Concomitant
Skin Ulcer 7/26/2008 Female 170 lb 12/15/2008 Physician United States
Primary
Concomitant
Injection Site Haemorrhage 10/22/2008 Male 12/17/2008 Pharmacist United States
Primary
Concomitant
Subdural Haematoma Other Serious 1/1/2008 76 Male 12/18/2008 Pharmacist United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious 9/24/2008 78 Male 12/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/1/2008 Female 12/31/2008 Physician United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Hospitalization 1/1/2007 Female 1/5/2009 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 12/14/2008 Female 1/15/2009 Physician United Kingdom
Primary
Concomitant
Constipation 4/1/2008 61 Male 229 lb 1/16/2009 Consumer United States
Primary
Secondary
Concomitant

Drug Data