Coumadin combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Malaise Other Serious 6/1/2004 69 Male 145 lb 2/1/2006 Physician United States
Primary
Concomitant
Blindness Other Serious 1/1/2000 62 Male 190 lb 1/17/2006 United States
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 1/1/2001 64 Male 198 lb 3/30/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2006 79 Female 4/12/2006 United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/26/2006 64 Female 195 lb 4/13/2006 Physician United States
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 2/27/2006 Male 258 lb 5/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 9/29/2003 Male 5/16/2006 United States
Primary
Secondary
Concomitant
Nausea Hospitalization 9/26/2004 65 Female 370 lb 5/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Haematemesis Hospitalization 6/14/2006 72 Male 123 lb 7/7/2006 Pharmacist United States
Primary
Concomitant
Tachycardia 2/2/2006 Male 180 lb 8/4/2006 Physician United States
Primary
Concomitant
Swelling 12/1/2005 77 Male 12/28/2006 Consumer United States
Primary
Concomitant
Syncope Other Serious 71 Male 1/17/2007 Pharmacist United States
Primary
Concomitant
Nausea Other Serious 6/22/2004 Male 145 lb 1/26/2007 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint 2/1/2007 56 Female 320 lb 2/23/2007 Other Health Professional United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/8/2007 56 Female 320 lb 3/2/2007 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/8/2007 56 Female 320 lb 3/12/2007 Consumer United States
Primary
Concomitant
Renal Disorder Hospitalization 2/16/2007 51 Female 3/12/2007 Consumer United States
Primary
Concomitant
Syncope Other Serious 12/31/2006 71 Male 3/13/2007 Physician United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/8/2007 56 Female 320 lb 3/28/2007 Consumer United States
Primary
Concomitant
Urticaria Other Serious 1/20/2007 63 Male 337 lb 1/25/2007 Pharmacist United States
Primary
Concomitant
Syncope Other Serious 12/31/2006 71 Male 4/2/2007 Physician United States
Primary
Concomitant
Renal Disorder Hospitalization 2/16/2007 51 Female 4/27/2007 Consumer United States
Primary
Concomitant
Visual Acuity Reduced 3/1/2006 80 Male 138 lb 2/22/2007 United States
Primary
Concomitant
Lobar Pneumonia Disability 82 Female 124 lb 6/14/2007 United States
Primary
Secondary
Pneumonia Hospitalization 82 Female 123 lb 6/26/2007 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2006 Male 162 lb 7/11/2007 Other Health Professional United States
Primary
Concomitant
Interacting
Vision Blurred Other Serious 1/1/2006 Male 162 lb 8/21/2007 Other Health Professional United States
Primary
Concomitant
Interacting
Drug Ineffective 57 Male 11/13/2007 Consumer United States
Primary
Concomitant
Pleural Effusion Other Serious 6/22/2004 Male 145 lb 12/27/2007 Other Health Professional United States
Primary
Concomitant
Troponin I Increased Other Serious 6/22/2004 Male 145 lb 12/28/2007 Other Health Professional United States
Primary
Concomitant
Vertigo Other Serious 6/22/2004 Male 145 lb 1/11/2008 Other Health Professional
Primary
Concomitant
Vertigo Other Serious 6/22/2004 Male 145 lb 1/18/2008 Other Health Professional United States
Primary
Concomitant
Rash Other Serious 8/1/2007 71 Male 210 lb 12/12/2007 United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 Female 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Injection Site Reaction Hospitalization 1/1/2008 Female 2/28/2008 Physician United States
Primary
Concomitant
Vertigo Other Serious 6/22/2004 Male 145 lb 3/11/2008 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Required Intervention 87 Male 3/13/2008 Physician Israel
Primary
Secondary
Concomitant
Nausea Hospitalization 12/1/2007 Female 3/12/2008 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 Female 3/21/2008 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 12/1/2007 Female 3/21/2008 Physician United States
Primary
Secondary
Concomitant
Fatigue Other Serious 82 Female 124 lb 4/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 5/25/2007 80 Male 7/29/2008 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 12/11/2007 73 Female 7/29/2008 Consumer France
Primary
Secondary
Concomitant
International Normalised Ratio Fluctuation 81 Female 172 lb 7/29/2008 Consumer United States
Primary
Secondary
Concomitant
Pericarditis Hospitalization 7/29/2008 Female 8/14/2008 Pharmacist United States
Primary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 9/17/2008 Lawyer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 1/1/2008 74 Female 179 lb 9/29/2008 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 4/4/2005 Male 225 lb 10/17/2008 Lawyer United States
Primary
Secondary
Concomitant
Lethargy Other Serious 4/18/2005 Male 10/17/2008 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 4/4/2005 Male 225 lb 10/23/2008 Lawyer United States
Primary
Secondary
Concomitant
Lethargy Other Serious 4/18/2005 Male 10/24/2008 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 1/1/2008 74 Female 179 lb 11/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Haemoglobin Decreased 9/1/2008 Female 250 lb 12/12/2008 United States
Primary
Secondary
Concomitant
Product Quality Issue Hospitalization 1/1/2008 63 Male 12/9/2008 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/1/2008 82 Male 157 lb 12/10/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 11/24/2008 74 Female 12/10/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 9/1/2008 78 Female 225 lb 12/12/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 1/1/2008 90 Female 130 lb 12/16/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 10/1/2008 59 Male 285 lb 12/17/2008 Consumer United States
Primary
Concomitant
Renal Function Test Abnormal Other Serious 10/5/2008 55 Male 12/19/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 3/1/2008 83 Male 160 lb 12/19/2008 Consumer United States
Primary
Concomitant
Pulmonary Oedema Other Serious 1/1/2008 74 Female 179 lb 12/24/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Product Quality Issue Hospitalization 5/1/2008 67 Male 254 lb 12/22/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 1/1/2008 80 Male 12/22/2008 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 8/6/2008 84 Male 160 lb 12/23/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 5/8/2008 83 Male 220 lb 12/30/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 10/14/2008 68 Female 175 lb 12/30/2008 Consumer United States
Primary
Concomitant
Sepsis Death 10/1/2008 73 Male 1/2/2009 Consumer United States
Primary
Concomitant
Stent Placement Hospitalization 4/1/2008 49 Female 255 lb 1/21/2009 Consumer United States
Primary
Concomitant
Hypotension Other Serious 2/9/2008 76 Male 205 lb 2/20/2009 Lawyer United States
Primary
Secondary
Concomitant
Product Quality Issue Death 9/11/2008 67 Male 2/23/2009 Consumer United States
Primary
Concomitant
Hypotension Other Serious 2/9/2008 76 Male 205 lb 3/6/2009 Lawyer United States
Primary
Secondary
Concomitant
Headache 2/12/2009 Male 173 lb 3/5/2009 Physician United States
Primary
Concomitant
Ocular Toxicity 12/26/2005 73 Male 3/25/2009 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 6/1/2008 63 Male 3/12/2009 Consumer United States
Primary
Concomitant
Dry Mouth 2/1/2009 Male 4/22/2009 Consumer
Primary
Concomitant
Right Ventricular Failure Other Serious 2/9/2008 76 Male 205 lb 4/23/2009 Lawyer United States
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious 2/9/2008 76 Male 205 lb 4/24/2009 Lawyer United States
Primary
Secondary
Concomitant
Myocardial Infarction Death 3/27/2009 Male 4/29/2009 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 4/14/2009 73 Male 167 lb 5/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
International Normalised Ratio Decreased 10/22/2008 82 Female 161 lb 7/22/2009 Consumer United States
Primary
Concomitant
Drug Ineffective Other Serious 7/1/2008 59 Male 7/23/2009 Consumer United States
Primary
Concomitant
International Normalised Ratio Decreased 10/22/2008 82 Female 161 lb 7/22/2009 Consumer United States
Primary
Concomitant
Vertigo Hospitalization 80 Male 8/14/2009 Lawyer United States
Primary
Concomitant
Visual Impairment Other Serious 82 Female 9/7/2009 Lawyer United States
Primary
Concomitant
Ulcer Haemorrhage Other Serious 11/1/2008 75 Male 9/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 4/1/2009 Female 9/17/2009 Physician United States
Primary
Concomitant
Right Ventricular Failure Other Serious 2/9/2008 76 Male 205 lb 10/6/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 82 Female 10/18/2009 United States
Primary
Concomitant
Vertigo Hospitalization 79 Male 10/22/2009 United States
Primary
Concomitant
Vomiting Other Serious 82 Female 10/26/2009 United States
Primary
Concomitant
Vomiting Other Serious 82 Female 11/16/2009 United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 10/30/2009 80 Female 147 lb 12/8/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 163 lb 1/25/2010 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 11/27/2006 76 Female 145 lb 1/20/2010 Lawyer United States
Primary
Concomitant
Visual Impairment Other Serious 82 Female 1/21/2010 United States
Primary
Concomitant
Urinary Tract Obstruction Hospitalization 76 Male 1/22/2010 United States
Primary
Concomitant
Vitrectomy Other Serious 3/1/2006 Male 2/10/2010 Physician United States
Primary
Concomitant
Fatigue Hospitalization 8/1/2009 Male 2/9/2010 Consumer United States
Primary
Concomitant
Vertigo Hospitalization 79 Male 142 lb 1/27/2010 Lawyer United States
Primary
Concomitant
Urinary Tract Obstruction Hospitalization 76 Male 2/19/2010 United States
Primary
Concomitant
Wheezing Hospitalization 11/27/2006 76 Female 145 lb 3/3/2010 Lawyer United States
Primary
Concomitant
Wound Infection Hospitalization 82 Female 167 lb 3/9/2010 Lawyer United States
Primary
Concomitant
Haemorrhoids Other Serious 12/22/2009 73 Female 165 lb 4/7/2010 Consumer United States
Primary
Secondary
Concomitant
Haemorrhoids Other Serious 12/22/2009 73 Female 165 lb 4/9/2010 Consumer United States
Primary
Secondary
Concomitant
Haemorrhoids Other Serious 12/22/2009 73 Female 165 lb 4/13/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/13/2010 72 Female 176 lb 4/27/2010 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/27/2010 72 Female 176 lb 5/5/2010 Physician United Kingdom
Primary
Concomitant
Product Quality Issue Death 1/22/2010 92 Female 105 lb 5/7/2010 Consumer United States
Primary
Concomitant
Fatigue Hospitalization 8/1/2009 83 Male 5/10/2010 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/27/2010 72 Female 176 lb 5/18/2010 Physician United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 79 Male 142 lb 5/26/2010 Lawyer United States
Primary
Concomitant
Stent Placement Hospitalization 8/1/2009 83 Male 6/14/2010 Consumer United States
Primary
Concomitant
Prostatic Specific Antigen Increased Hospitalization 9/1/2009 65 Male 216 lb 6/30/2010 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 11/1/2008 8/3/2010 Other Health Professional Algeria
Primary
Secondary
Concomitant
Stent Placement Hospitalization 8/1/2009 83 Male 9/21/2010 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 8/8/2010 82 Female 9/29/2010 Physician Italy
Primary
Concomitant
Skin Ulcer Other Serious 10/23/2007 63 Female 141 lb 10/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 2/10/2004 60 Female 141 lb 11/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 2/4/2011 66 Female 237 lb 3/17/2011 Other Health Professional United States
Primary
Concomitant
Diabetes Mellitus Death 1/6/2009 56 Male 220 lb 3/21/2011 Consumer United States
Primary
Concomitant
Pancreatitis Other Serious 12/1/2010 84 Male 4/8/2011 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/9/2011 77 Female 93 lb 4/12/2011 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 3/17/2011 85 Female 128 lb 3/29/2011 Pharmacist United States
Primary
Concomitant
Anxiety Other Serious 10/22/2006 69 Female 141 lb 4/21/2011 Other Health Professional United States
Primary
Concomitant
Fear Other Serious 1/27/2003 64 Male 310 lb 4/29/2011 Other Health Professional United States
Primary
Concomitant
Death Hospitalization 10/1/2006 70 Male 295 lb 5/28/2011 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness Disability 1/1/2004 79 Male 150 lb 6/8/2011 Physician United States
Primary
Concomitant
Depression Other Serious 10/22/2006 69 Female 141 lb 6/11/2011 Consumer United States
Primary
Concomitant
Renal Failure Death Male 190 lb 6/24/2011 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 1/1/2006 77 Male 199 lb 6/21/2011 Other Health Professional United States
Primary
Concomitant
Skin Induration Other Serious 10/1/2002 64 Female 293 lb 6/28/2011 Physician United States
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 7/1/2008 84 Female 153 lb 6/23/2011 United States
Primary
Concomitant
Renal Failure Death Male 190 lb 7/5/2011 Consumer United States
Primary
Concomitant
Constipation Hospitalization 8/1/2009 83 Male 7/8/2011 Consumer United States
Primary
Concomitant
Accommodation Disorder Other Serious 10/22/2006 69 Female 141 lb 7/13/2011 Physician United States
Primary
Concomitant
Mobility Decreased Other Serious 12/1/2006 79 Male 187 lb 7/14/2011 Lawyer United States
Primary
Concomitant
Renal Failure Chronic Other Serious 11/1/2009 64 Male 230 lb 7/13/2011 Physician United States
Primary
Concomitant
Prothrombin Time Ratio Increased 3/29/2011 85 Female 7/25/2011 Consumer United States
Primary
Concomitant
Prothrombin Level Decreased 73 Female 7/25/2011 Consumer United States
Primary
Concomitant
Haemorrhage Other Serious 87 Female 7/25/2011 Consumer United States
Primary
Concomitant
Abdominal Pain Upper 83 Female 7/25/2011 Consumer United States
Primary
Concomitant
Oedema Other Serious Male 8/4/2011 Physician United States
Primary
Concomitant
Gait Disturbance 4/1/2011 49 Male 180 lb 8/6/2011 Consumer United States
Primary
Concomitant
Oedema Peripheral 6/25/2011 84 Female 8/18/2011 Consumer United States
Primary
Concomitant
Nausea Other Serious Male 8/30/2011 United States
Primary
Concomitant
Interacting
Lung Neoplasm Hospitalization 7/5/2011 79 Male 208 lb 9/2/2011 Physician United States
Primary
Concomitant
Malaise Other Serious Male 9/2/2011 Consumer United States
Primary
Concomitant
Interacting
Pain 6/25/2011 84 Female 183 lb 9/13/2011 Other Health Professional United States
Primary
Concomitant
Cardiac Disorder Other Serious Male 9/14/2011 Physician United States
Primary
Concomitant
Interacting

Drug Data