Clozaril combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Splenomegaly Other Serious 5/13/2005 62 Male 250 lb 2/10/2006 Physician United States
Primary
Concomitant
Schizophrenia Other Serious 1/1/2005 Female 5/1/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/21/2000 40 Female 6/1/2006 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/1/2005 55 Female 160 lb 6/22/2006 Canada
Primary
Concomitant
Swelling Face Other Serious 9/1/2005 49 Female 174 lb 7/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Vision Blurred Other Serious Male 7/19/2006 Physician Korea, Republic Of
Primary
Concomitant
Ventricular Hypertrophy Death 8/6/2005 53 Male 154 lb 1/1/2007 Canada
Primary
Concomitant
Pyrexia Hospitalization 11/17/2006 72 Female 1/4/2007 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 1/4/2005 Female 1/26/2007 Physician Canada
Primary
Concomitant
Somnolence Other Serious 2/2/2007 46 Female 4/11/2007 Physician Canada
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 53 Male 5/10/2007 Physician Canada
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 2/16/2002 40 Female 5/26/2007 Physician Canada
Primary
Secondary
Concomitant
Pancreatitis Necrotising Other Serious 3/27/1999 32 5/31/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
White Blood Cell Disorder Other Serious 1/27/2003 28 Male 225 lb 6/7/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Pancreatitis Necrotising 3/27/1999 32 8/14/2007 Canada
Primary
Secondary
Concomitant
Renal Impairment Other Serious 35 Male 1/15/2008 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 6/4/2007 27 Male 2/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/19/2008 35 Male 4/17/2008 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/18/2008 35 Male 4/22/2008 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/29/2005 24 Female 5/1/2008 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/29/2005 24 Female 5/10/2008 Physician Australia
Primary
Concomitant
Thrombocytopenia Other Serious Female 7/30/2008 Physician Canada
Primary
Concomitant
Thrombocytopenia Other Serious Female 8/6/2008 Physician Canada
Primary
Concomitant
Orchitis Noninfective Other Serious 1/21/2008 Male 11/12/2008 Physician Canada
Primary
Concomitant
Postoperative Wound Infection Hospitalization Male 1/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 Male 2/6/2009 Physician United Kingdom
Primary
Concomitant
Multiple Drug Overdose Other Serious 61 Male 2/11/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 Male 2/14/2009 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 Male 2/26/2009 Physician United Kingdom
Primary
Concomitant
Postoperative Wound Infection Hospitalization 1/6/2009 Male 3/3/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Incontinence Other Serious 12/15/2008 Female 3/6/2009 Canada
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 Male 3/9/2009 Physician United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Death 10/4/2008 44 Female 225 lb 2/9/2009 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/21/2009 Male 3/17/2009 Physician United Kingdom
Primary
Concomitant
Urinary Incontinence Other Serious 12/15/2008 Female 4/13/2009 Physician Canada
Primary
Concomitant
Suicide Attempt Other Serious 8/2/1999 33 Female 125 lb 5/15/2009 United States
Primary
Secondary
Concomitant
Tachycardia Life Threatening 21 Male 7/7/2009 Physician Canada
Primary
Secondary
Concomitant
Tachycardia Life Threatening 21 Male 7/9/2009 Physician Canada
Primary
Secondary
Concomitant
Overdose Other Serious 5/7/2009 33 Female 7/14/2009 Physician United Kingdom
Primary
Concomitant
Weight Increased 4/28/1999 Female 250 lb 7/24/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1998 41 Male 303 lb 7/30/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2009 Female 9/2/2009 Pharmacist Canada
Primary
Concomitant
Red Blood Cell Count Decreased Life Threatening 3/26/2009 Male 9/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Red Blood Cell Count Decreased Life Threatening 3/26/2009 Male 9/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Diabetic Ketoacidosis Other Serious Female 194 lb 9/23/2009 United States
Primary
Concomitant
Suicidal Ideation Other Serious 1/1/2000 41 Female 230 lb 9/23/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/21/2009 Male 9/24/2009 Physician United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1999 44 Male 265 lb 10/14/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/21/2009 Male 10/14/2009 Physician United Kingdom
Primary
Concomitant
Overdose Hospitalization 1/15/2009 61 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 11/2/2009 United States
Primary
Concomitant
Overdose Hospitalization 61 Male 11/5/2009 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 20 Female 11/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cervix Carcinoma Other Serious 11/2/2009 Female 11/16/2009 Other Health Professional Canada
Primary
Concomitant
Nasal Congestion Other Serious 11/2/2009 Female 11/19/2009 Other Health Professional Canada
Primary
Concomitant
Renal Failure Chronic Life Threatening 3/26/2009 Male 12/8/2009 Pharmacist United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/2/2009 Female 12/30/2009 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Increased Other Serious Female 1/22/2010 Physician United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 1/25/2010 United States
Primary
Concomitant
Prostatic Disorder Other Serious Male 2/8/2010 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 12/1/2009 Female 2/19/2010 Physician United Kingdom
Primary
Concomitant
Renal Failure Chronic Other Serious 3/26/2009 Male 3/22/2010 Pharmacist United Kingdom
Primary
Concomitant
Renal Failure Chronic Other Serious 3/26/2009 Male 3/26/2010 Pharmacist United Kingdom
Primary
Concomitant
Salivary Hypersecretion Hospitalization Female 4/6/2010 Other Health Professional United Kingdom
Primary
Concomitant
Stress Other Serious Female 4/7/2010 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Failure Death Male 4/26/2010 Physician United Kingdom
Primary
Concomitant
Pulmonary Oedema Other Serious 3/1/2010 47 Male 5/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Platelet Count Decreased Other Serious 4/13/2010 69 Female 6/3/2010 Physician Denmark
Primary
Concomitant
Suicidal Behaviour Hospitalization 12/26/2009 33 Female 6/9/2010 Other Health Professional Australia
Primary
Concomitant
Intestinal Stoma Hospitalization 31 Male 6/11/2010 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 5/25/2010 27 Male 6/28/2010 Other Health Professional United Kingdom
Primary
Secondary
Suicidal Behaviour Hospitalization 12/26/2009 33 Female 7/2/2010 Other Health Professional Australia
Primary
Concomitant
Grand Mal Convulsion Other Serious 5/7/2009 33 Female 7/15/2010 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/30/2010 44 Male 8/24/2010 Pharmacist Denmark
Primary
Secondary
Concomitant
Death Death 7/8/2010 52 Male 8/31/2010 Physician Canada
Primary
Concomitant
Platelet Count Increased Other Serious 6/1/2010 48 Female 9/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious Male 9/13/2010 Other Health Professional United Kingdom
Primary
Concomitant
Suicidal Ideation Other Serious 1/1/2000 41 Female 230 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 1/1/2008 35 Female 184 lb 9/20/2010 United States
Primary
Concomitant
Platelet Count Increased Other Serious 6/1/2010 48 Female 9/27/2010 Other Health Professional United Kingdom
Primary
Concomitant
Subacute Endocarditis Other Serious 4/30/2010 44 Male 9/22/2010 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/30/2010 44 Male 9/22/2010 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/8/2010 31 Male 10/5/2010 Pharmacist Australia
Primary
Concomitant
Thrombocytopenia Other Serious 6/1/2008 29 Male 10/7/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 3/26/2009 35 Male 10/18/2010 Pharmacist United Kingdom
Primary
Concomitant
Pain Other Serious Male 10/27/2010 Physician Canada
Primary
Concomitant
Pain Other Serious 9/13/2010 36 Male 11/1/2010 Physician Canada
Primary
Concomitant
Urinary Tract Infection Other Serious Male 11/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Multiple Drug Overdose Hospitalization 10/2/2010 34 Male 10/28/2010 United Kingdom
Primary
Secondary
Pneumonia Death 10/25/2010 53 Male 11/26/2010 Pharmacist Canada
Primary
Concomitant
Syncope Hospitalization Male 12/28/2010 Other Health Professional Canada
Primary
Concomitant
Anxiety Other Serious 3/26/2009 35 Male 2/4/2011 Physician United Kingdom
Primary
Concomitant
Mental Disorder Hospitalization 3/26/2009 35 Male 2/9/2011 Physician United Kingdom
Primary
Concomitant
Anxiety Hospitalization 3/26/2009 35 Male 2/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Other Serious 4/30/2010 44 Male 2/27/2011 Physician Denmark
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 3/26/2009 35 Male 3/15/2011 Pharmacist United Kingdom
Primary
Concomitant
Hypertension Hospitalization 3/26/2009 35 Male 3/23/2011 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/26/2009 35 Male 3/29/2011 Pharmacist United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 3/26/2009 35 Male 4/15/2011 Physician United Kingdom
Primary
Concomitant
Tooth Infection Other Serious 42 Male 5/19/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Mass Hospitalization 2/22/2011 72 Male 5/25/2011 Physician United Kingdom
Primary
Concomitant
Drug Interaction Other Serious Male 5/27/2011 Physician Canada
Primary
Concomitant
Red Blood Cell Count Decreased Hospitalization Male 6/3/2011 Physician United Kingdom
Primary
Concomitant
Myocardial Infarction Death 12/3/2004 49 Male 6/6/2011 Physician Canada
Primary
Concomitant
Aspiration Death 1/28/2005 57 Female 6/7/2011 Other Health Professional Canada
Primary
Concomitant
Dyspnoea Hospitalization 4/11/2011 53 Female 6/20/2011 Physician Denmark
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 4/11/2011 53 Female 7/1/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Depressed Mood Hospitalization 3/21/1998 19 Female 196 lb 8/26/2011 Physician Ireland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/1/2011 30 Male 9/30/2011 Physician Denmark
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 7/27/2011 38 Female 10/13/2011 Physician Ireland
Primary
Concomitant
Affective Disorder Other Serious 4/9/2011 27 Female 10/18/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Eosinophil Count Increased Other Serious 7/23/2011 44 Male 10/19/2011 Other Health Professional Ireland
Primary
Concomitant
Metastases To Central Nervous System Hospitalization 6/18/2011 58 Female 10/19/2011 Other Health Professional Ireland
Primary
Concomitant
Pneumonia Other Serious 4/6/2011 72 Female 154 lb 10/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Affective Disorder Hospitalization 27 Female 10/19/2011 Pharmacist Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/1/2011 30 Male 10/20/2011 Physician Denmark
Primary
Secondary
Concomitant
Asthenia Hospitalization 6/29/2011 59 Female 10/31/2011 Other Health Professional Ireland
Primary
Concomitant
Respiratory Tract Infection Other Serious 7/27/2011 38 Female 10/31/2011 Physician Ireland
Primary
Concomitant
Osteoarthritis Other Serious Female 154 lb 10/31/2011 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 3/8/2011 41 Male 10/31/2011 Physician United Kingdom
Primary
Concomitant
Drug Administration Error Hospitalization Male 11/11/2011 Physician United Kingdom
Primary
Concomitant
Allergy To Metals Other Serious 7/23/2011 46 Male 11/11/2011 Physician United Kingdom
Primary
Concomitant
Oesophageal Stenosis Hospitalization 1/1/2008 45 Male 11/11/2011 Pharmacist Ireland
Primary
Concomitant
Oesophageal Stenosis Hospitalization 1/1/2008 45 Male 11/18/2011 Pharmacist Ireland
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 45 Male 11/22/2011 Physician Ireland
Primary
Concomitant
Drug Interaction Hospitalization 1/1/2011 61 Male 12/1/2011 Other Health Professional Australia
Primary
Secondary
Fall Hospitalization 1/1/2011 61 Male 12/1/2011 Pharmacist Australia
Primary
Secondary
Persecutory Delusion Other Serious 11/1/2011 30 Male 11/28/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/20/2007 59 Male 157 lb 12/16/2011 Physician United Kingdom
Primary
Concomitant
Blood Bicarbonate Decreased Hospitalization Female 12/19/2011 Physician Canada
Primary
Concomitant
Congenital Cystic Kidney Disease Hospitalization 3/26/2009 35 Male 12/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious Female 12/27/2011 Physician Ireland
Primary
Concomitant
Drug Administration Error Hospitalization Male 12/29/2011 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 11/24/2010 50 Male 12/29/2011 Physician Ireland
Primary
Concomitant
Infection Other Serious Female 12/29/2011 Physician Ireland
Primary
Concomitant
Anisocytosis Other Serious 11/24/2010 50 Male 1/9/2012 Physician Ireland
Primary
Concomitant
Drug Interaction Hospitalization 1/1/2011 61 Male 1/9/2012 Other Health Professional Australia
Primary
Secondary
Death Death 1/1/2011 61 Male 1/9/2012 Pharmacist Australia
Primary
Secondary
Cellulitis Hospitalization 1/1/2011 61 Male 1/20/2012 Other Health Professional Australia
Primary
Secondary
Cellulitis Hospitalization 1/1/2011 61 Male 1/20/2012 Pharmacist Australia
Primary
Secondary
Groin Pain Other Serious 31 Male 1/12/2012 Physician Denmark
Primary
Secondary
Concomitant
Cardiac Arrest Death Male 2/6/2012 Pharmacist Canada
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 10/25/2011 50 Female 2/9/2012 Physician United Kingdom
Primary
Concomitant
Condition Aggravated Death 12/9/2011 46 Female 2/14/2012 Other Health Professional United Kingdom
Primary
Concomitant
Balance Disorder Other Serious 1/1/2008 45 Male 2/17/2012 Pharmacist Ireland
Primary
Concomitant
Renal Failure Life Threatening 11/8/2011 38 Female 2/21/2012 Other Health Professional Canada
Primary
Concomitant
Thrombocytopenia Other Serious 6/16/2010 48 Male 2/22/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 10/25/2011 50 Female 2/22/2012 Other Health Professional United Kingdom
Primary
Concomitant
Psychotic Disorder Hospitalization 6/16/2010 48 Male 2/22/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 10/25/2011 50 Female 2/22/2012 Physician United Kingdom
Primary
Concomitant

Drug Data