Clozaril combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rhabdomyolysis Hospitalization 2/1/2001 40 Male 1/3/2006 Physician Germany
Primary
Secondary
Concomitant
Malaise Hospitalization 11/15/2005 58 Female 1/23/2006 Pharmacist New Zealand
Primary
Concomitant
Sedation Hospitalization 1/1/2005 Male 2/11/2006 Other Health Professional Australia
Primary
Concomitant
White Blood Cell Count Increased Other Serious 34 Male 2/14/2006 Other Health Professional New Zealand
Primary
Concomitant
Myocardial Infarction Death 4/1/1998 Male 3/31/2006 Physician Australia
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 12/23/1999 42 Female 4/25/2006 Physician Australia
Primary
Concomitant
Drug Level Decreased Death 7/31/2005 50 Female 6/4/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sinus Tachycardia Other Serious 3/3/2006 30 Female 6/4/2006 Physician Ireland
Primary
Concomitant
Renal Failure Other Serious 8/1/1995 45 Male 7/5/2006 Pharmacist United Kingdom
Primary
Concomitant
Tachycardia Other Serious 6/15/2006 39 Male 7/14/2006 Physician United Kingdom
Primary
Concomitant
Rebound Effect Other Serious 35 Female 7/18/2006 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 53 Male 7/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 7/27/2006 42 Male 8/17/2006 Physician Australia
Primary
Concomitant
Troponin I Increased Hospitalization 7/27/2006 42 Male 8/23/2006 Physician Australia
Primary
Concomitant
Weight Increased Other Serious 3/25/2006 43 Male 10/10/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/25/2006 43 Male 10/12/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Tachycardia Hospitalization 10/28/1999 21 Male 10/26/2006 Physician Australia
Primary
Concomitant
Salivary Hypersecretion Other Serious 21 Male 11/4/2006 Consumer New Zealand
Primary
Concomitant
Tremor Other Serious 8/28/2006 45 Male 11/4/2006 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Restless Legs Syndrome Other Serious Female 11/15/2006 Physician New Zealand
Primary
Concomitant
Thrombophlebitis Superficial Other Serious 4/14/2005 58 Female 11/23/2006 Physician New Zealand
Primary
Secondary
Concomitant
Stress Other Serious 30 Female 12/2/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tachycardia Other Serious 1/1/2006 39 Male 12/7/2006 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 6/15/2006 39 Male 12/16/2006 Physician United Kingdom
Primary
Concomitant
Stress Other Serious 30 Female 12/21/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 30 Female 12/30/2006 United Kingdom
Primary
Secondary
Concomitant
Tongue Biting Death 7/31/2005 50 Female 1/25/2007 Other Health Professional United Kingdom
Primary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 38 Male 2/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/7/2007 32 Male 183 lb 3/10/2007 Physician United Kingdom
Primary
Concomitant
Somnolence Other Serious 4/16/2007 44 Male 227 lb 5/12/2007 Physician United Kingdom
Primary
Concomitant
Surgery Hospitalization Male 5/30/2007 Physician New Zealand
Primary
Concomitant
Respiratory Arrest Other Serious 6/21/2003 32 Male 6/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Otorhinolaryngological Surgery Hospitalization 5/24/2007 48 Male 7/6/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Cellulitis Other Serious 5/12/2007 33 Male 7/25/2007 Pharmacist United Kingdom
Primary
Concomitant
Troponin I Increased Other Serious 5/21/2007 39 Male 8/4/2007 Physician Australia
Primary
Concomitant
Ventricular Dysfunction Other Serious 6/12/2007 37 Male 8/8/2007 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2007 45 Male 377 lb 8/17/2007 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 5/26/2004 31 Female 10/11/2007 Other Health Professional Ireland
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 10/5/2007 56 Male 10/13/2007 Other Health Professional Ireland
Primary
Concomitant
Tachycardia Other Serious 9/1/2007 39 Male 10/27/2007 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2007 45 Male 377 lb 11/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 22 Male 11/3/2007 Physician United Kingdom
Primary
Concomitant
Syncope Other Serious 10/1/2007 22 Male 11/15/2007 Pharmacist United Kingdom
Primary
Concomitant
Tachycardia Other Serious 9/1/2007 39 Male 11/19/2007 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 1/1/2007 39 Male 11/23/2007 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/22/2007 16 Female 234 lb 11/27/2007 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 6/4/2007 27 Male 12/28/2007 Physician United Kingdom
Primary
Secondary
Pulmonary Embolism Hospitalization 11/1/2007 33 Male 12/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Somatisation Disorder Other Serious Female 12/31/2007 Pharmacist New Zealand
Primary
Concomitant
Thrombocytopenia Hospitalization 6/1/2007 27 Male 1/11/2008 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 9/1/2007 52 Male 1/12/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sinus Tachycardia Other Serious 8/1/2003 Female 1/16/2008 Physician Australia
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 8/1/2003 Female 1/16/2008 Physician Australia
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/1/2007 27 Male 1/16/2008 Physician
Primary
Secondary
Thrombocytopenia Hospitalization 6/1/2007 1/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Sinus Tachycardia Other Serious 8/1/2003 19 Female 1/30/2008 Physician Australia
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/4/2007 27 Male 1/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Hospitalization 6/4/2007 27 Male 1/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Urinary Incontinence Other Serious 39 Male 2/15/2008 Consumer United Kingdom
Primary
Concomitant
Somnolence Other Serious 31 Male 2/16/2008 Physician United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Other Serious 12/9/2007 28 Male 2/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interacting
Neutrophil Count Decreased Other Serious 12/9/2007 28 Male 3/6/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interacting
Rash Generalised Other Serious 20 Male 3/9/2008 Consumer
Primary
Secondary
Concomitant
Tachycardia Other Serious 5/26/2004 31 Female 3/12/2008 Other Health Professional Ireland
Primary
Concomitant
Neutrophil Count Decreased Other Serious 12/9/2007 28 Male 3/20/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interacting
Weight Increased Other Serious 1/1/2008 20 Male 4/9/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 3/31/2008 57 Male 4/24/2008 Other Health Professional Ireland
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/29/2005 24 Female 5/1/2008 Physician Australia
Primary
Concomitant
Salivary Hypersecretion Other Serious 6/1/2007 45 Male 5/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/29/2005 24 Female 5/10/2008 Physician Australia
Primary
Concomitant
Sepsis Other Serious 29 Male 5/21/2008 Consumer United Kingdom
Primary
Concomitant
Pyrexia Other Serious 4/24/2006 Male 6/24/2008 Physician Australia
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/1/2007 Female 7/11/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Disorder Other Serious Male 8/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/20/2008 Male 8/27/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious Female 282 lb 9/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Distress Other Serious 8/1/2008 Male 9/11/2008 Physician New Zealand
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/1993 Male 9/12/2008 Physician United States
Primary
Concomitant
Diabetic Coma Other Serious 1/1/2005 28 Male 180 lb 9/16/2008 United States
Primary
Concomitant
Urinary Incontinence Hospitalization 6/8/2007 Female 9/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 7/20/2008 Male 9/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization Male 9/30/2008 Pharmacist United Kingdom
Primary
Concomitant
X-ray Abnormal Hospitalization 6/1/2008 Male 10/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ultrasound Scan Abnormal Other Serious 6/24/2008 Male 10/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious Female 10/20/2008 Physician New Zealand
Primary
Concomitant
Obsessive-compulsive Disorder Hospitalization 1/1/2006 Female 10/21/2008 Other Health Professional United Kingdom
Primary
Concomitant
Left Ventricular Hypertrophy Other Serious Male 10/28/2008 Other Health Professional Australia
Primary
Concomitant
Urinary Incontinence Other Serious Male 11/2/2008 Physician United Kingdom
Primary
Concomitant
Urinary Incontinence Other Serious Male 11/14/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/1/2008 Male 11/26/2008 Physician United Kingdom
Primary
Concomitant
Pulmonary Haematoma Other Serious 9/1/2008 Male 183 lb 12/1/2008 Other Health Professional New Zealand
Primary
Concomitant
Somnolence Hospitalization 9/1/2008 Female 176 lb 12/1/2008 Physician United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/1/2008 Male 12/3/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious Male 12/29/2008 Other Health Professional Ireland
Primary
Concomitant
Varicose Vein Hospitalization 12/16/2008 Female 1/2/2009 Physician New Zealand
Primary
Concomitant
White Blood Cell Count Increased Other Serious Female 1/2/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious Female 1/7/2009 Pharmacist United Kingdom
Primary
Concomitant
Completed Suicide Death Male 1/9/2009 Other Health Professional Ireland
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/1/2008 Male 1/15/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 11/1/2008 Female 1/21/2009 Physician Ireland
Primary
Concomitant
Vomiting Other Serious Male 223 lb 1/29/2009 Physician United Kingdom
Primary
Concomitant
Vision Blurred Hospitalization 8/1/2008 Female 176 lb 1/30/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 7/7/2008 Male 2/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Overdose Hospitalization 1/13/2009 Male 2/2/2009 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/6/2008 Male 93 lb 2/4/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Disorder Other Serious 28 Male 2/5/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Obsessive-compulsive Disorder Other Serious 1/1/1999 Male 2/10/2009 Physician Ireland
Primary
Concomitant
Vomiting Hospitalization 1/2/2009 Male 2/19/2009 Physician United Kingdom
Primary
Concomitant
Nausea Other Serious 1/1/2009 Male 3/3/2009 Physician United Kingdom
Primary
Concomitant
Death Death 1/30/2009 Male 3/5/2009 Physician Australia
Primary
Concomitant
Renal Impairment Other Serious Male 3/6/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Other Serious 11/1/2008 Female 3/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2000 56 Male 3/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Rash Papular Other Serious 7/16/2008 Male 141 lb 3/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Renal Impairment Other Serious Male 3/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious Male 3/16/2009 Physician United Kingdom
Primary
Concomitant
Vision Blurred Other Serious 11/25/2008 Male 205 lb 3/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sedation Other Serious 2/27/2009 Male 3/19/2009 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 2/27/2009 Male 3/20/2009 Physician United Kingdom
Primary
Concomitant
Somnolence Other Serious Male 3/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious Male 256 lb 3/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2003 Male 3/24/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/6/2008 Male 93 lb 3/26/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Female 3/27/2009 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 11/27/2008 Male 4/8/2009 Other Health Professional Ireland
Primary
Concomitant
Neutropenia Other Serious 9/29/1999 Female 126 lb 4/8/2009 Physician New Zealand
Primary
Concomitant
Weight Increased Other Serious 3/17/2009 Male 4/8/2009 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 4/9/2009 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 2/17/2009 Male 4/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Schizophrenia Other Serious 2/11/2009 5/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/17/2009 Male 5/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Failure Death 4/5/2009 Male 5/11/2009 Physician New Zealand
Primary
Concomitant
Wheezing Other Serious 3/2/2009 Male 5/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization Male 5/13/2009 Physician United Kingdom
Primary
Concomitant
Death Other Serious 5/7/2009 Female 5/15/2009 Physician United Kingdom
Primary
Concomitant
Troponin Increased Other Serious 4/6/2009 Male 5/15/2009 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 5/19/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 5/25/2009 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Other Serious 4/6/2009 Male 386 lb 5/26/2009 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/17/2009 Male 6/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Other Serious 4/15/2009 Male 6/3/2009 Pharmacist United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 12/5/2007 Female 6/5/2009 Physician Australia
Primary
Concomitant
Syncope Other Serious 2/1/2009 Female 6/9/2009 Physician United Kingdom
Primary
Concomitant
Death Other Serious 5/7/2009 Female 6/12/2009 Physician United Kingdom
Primary
Concomitant
Thrombin Time Shortened Other Serious 5/15/2009 Female 6/16/2009 Physician New Zealand
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/8/2009 Male 6/16/2009 Physician United Kingdom
Primary
Concomitant
Emotional Distress Other Serious Female 6/18/2009 Physician Ireland
Primary
Concomitant
Tremor Other Serious 8/28/2006 45 Male 6/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant

Drug Data