Clonazepam combined with Zonisamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Urine Ketone Body Present Life Threatening 5/3/2006 54 Female 160 lb 5/23/2006 Physician United States
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 6/29/2003 1 Male 13 lb 5/23/2006 Japan
Primary
Concomitant
Rash Pustular Hospitalization 76 Male 7/7/2006 Physician Japan
Primary
Secondary
Thrombocytopenia Other Serious 7/3/2006 53 Male 7/17/2006 Physician Japan
Primary
Concomitant
Toxic Skin Eruption Disability 76 Female 8/2/2006 Physician Japan
Primary
Concomitant
Status Epilepticus Hospitalization 6/29/2003 1 Male 13 lb 11/7/2006 Physician Japan
Primary
Concomitant
Toxic Skin Eruption Disability 76 Female 11/8/2006 Physician Japan
Primary
Concomitant
Toxic Skin Eruption Hospitalization 6/1/2006 76 Female 11/13/2006 Physician Japan
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 8/8/2006 Male 8/15/2006 Pharmacist United States
Primary
Concomitant
Extrapyramidal Disorder Hospitalization 24 Female 3/16/2007 Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 9/13/2006 4 Male 12/22/2006 United States
Primary
Concomitant
Pneumonia Hospitalization 5/23/2006 5 Male 4/19/2007 Physician Japan
Primary
Concomitant
Pyrexia 5/23/2007 51 Female 209 lb 6/25/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 Female 26 lb 6/29/2007 Physician Japan
Primary
Concomitant
Treatment Noncompliance Other Serious 5/3/2007 25 Male 145 lb 7/26/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Level Decreased Other Serious 5/3/2007 Male 145 lb 8/15/2007 Physician United States
Primary
Concomitant
Interacting
Status Epilepticus Hospitalization 6/29/2003 1 Male 13 lb 9/7/2007 Physician Japan
Primary
Concomitant
Torticollis Hospitalization 24 Male 10/13/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Hospitalization 10/26/2007 40 Male 11/8/2007 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 24 Male 11/19/2007
Primary
Secondary
Concomitant
Torticollis Hospitalization 24 Male 11/15/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/25/2007 40 Male 11/16/2007 Physician Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 11/5/2007 6 Male 11/29/2007 Physician Japan
Primary
Concomitant
Psychomotor Hyperactivity 9/4/2007 53 Female 174 lb 12/10/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 10/25/2007 40 Male 11/28/2007 Physician Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 11/5/2007 Male 33 lb 12/14/2007 Physician Japan
Primary
Concomitant
Tremor Hospitalization 11/5/2007 Male 33 lb 1/3/2008 Physician Japan
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2007 24 Male 1/16/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 11/5/2007 Male 33 lb 1/24/2008 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 24 Male 1/18/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Effect Decreased Hospitalization 8/17/2007 41 NotSpecified 172 lb 2/4/2008 Physician China
Primary
Secondary
Concomitant
Depression Hospitalization 8/17/2007 41 Male 172 lb 1/31/2008 Physician China
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 11/2/2006 0 Male 15 lb 3/11/2008 Physician Japan
Primary
Concomitant
Respiratory Failure Life Threatening 11/2/2006 0 Male 15 lb 3/18/2008 Physician Japan
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 26 lb 3/26/2008 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 11 Male 3/25/2008 Physician Japan
Primary
Secondary
Concomitant
Convulsion Hospitalization 4/27/2008 45 Female 150 lb 5/14/2008 Pharmacist United States
Primary
Concomitant
Nerve Degeneration Other Serious 5/1/2008 43 Female 154 lb 6/11/2008 Physician United States
Primary
Concomitant
Respiratory Arrest Death 31 6/19/2008 Other Health Professional United States
Primary
Secondary
Stillbirth Other Serious 8/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Premature Baby Hospitalization Female 8/14/2008 Other Health Professional United Kingdom
Primary
Secondary
Stillbirth Other Serious Female 8/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Stillbirth Other Serious 8/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Premature Baby Hospitalization 8/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Upper Respiratory Tract Inflammation Life Threatening 11/2/2006 0 Male 15 lb 11/13/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/10/2007 0 Female 12/4/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 2/10/2007 0 Female 12/9/2008 Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Life Threatening 11/2/2008 0 Male 18 lb 1/5/2009 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Life Threatening 11/2/2006 0 Male 18 lb 1/22/2009 Physician Japan
Primary
Concomitant
Sleep Disorder Hospitalization 24 Male 1/29/2009 Other Health Professional Japan
Primary
Concomitant
Sleep Disorder Hospitalization 12/1/2005 Male 3/5/2009 Physician Japan
Primary
Concomitant
Epilepsy Other Serious 6/2/2005 1 Male 22 lb 3/6/2009 Italy
Primary
Concomitant
Status Epilepticus Other Serious 30 Male 4/21/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Product Quality Issue Disability 1/1/2002 40 Male 295 lb 5/8/2009 Consumer United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 6/10/2009 Other Health Professional Japan
Primary
Concomitant
Viral Cardiomyopathy Other Serious 3/14/2006 32 Male 288 lb 6/5/2009 United States
Primary
Concomitant
Peritoneal Dialysis Hospitalization Male 152 lb 6/5/2009 Other Health Professional United States
Primary
Concomitant
Skin Striae Other Serious 5/1/2009 53 Female 274 lb 6/19/2009 Consumer United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 181 lb 6/25/2009 Other Health Professional Japan
Primary
Concomitant
Viral Cardiomyopathy Other Serious 3/14/2006 32 Male 288 lb 6/26/2009 United States
Primary
Concomitant
Traumatic Lung Injury Other Serious 3/14/2006 32 Male 288 lb 7/7/2009 United States
Primary
Concomitant
Urticaria Hospitalization 3/14/2006 32 Male 253 lb 7/20/2009 United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 1/1/2004 35 Female 8/6/2009 Consumer United States
Primary
Secondary
Concomitant
Viral Cardiomyopathy Hospitalization 3/14/2006 32 Male 253 lb 8/13/2009 United States
Primary
Concomitant
Product Substitution Issue Disability 1/1/2002 40 Male 295 lb 8/17/2009 Consumer United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 8/7/2009 35 Female 11/25/2009 Physician Japan
Primary
Concomitant
Overdose Life Threatening 18 Female 3/23/2010 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 1/1/2009 45 Female 123 lb 4/19/2010 Physician United States
Primary
Concomitant
Hyponatraemia Other Serious 2/6/2009 47 Male 192 lb 4/23/2010 Physician Japan
Primary
Concomitant
Rash Other Serious 11/1/2006 33 Male 5/5/2010 Other Health Professional Japan
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2008 42 Female 4/23/2010 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2008 42 Female 4/30/2010 Physician United States
Primary
Concomitant
Rash Other Serious 11/1/2006 33 Male 5/12/2010 Other Health Professional Japan
Primary
Concomitant
Respiratory Distress Other Serious 11/1/2006 34 Male 154 lb 5/12/2010 Japan
Primary
Concomitant
Rash Hospitalization 33 Male 5/10/2010 Physician Japan
Primary
Concomitant
Convulsion Death Female 101 lb 5/28/2010 Other Health Professional Singapore
Primary
Concomitant
Convulsion Death Female 101 lb 7/6/2010 Other Health Professional Singapore
Primary
Concomitant
Pyrexia Hospitalization 1/1/2009 45 Female 123 lb 7/7/2010 Physician United States
Primary
Concomitant
Insomnia 10/6/2007 53 Female 140 lb 7/16/2010 Consumer United States
Primary
Concomitant
Weight Decreased Death Female 93 lb 7/23/2010 Other Health Professional Singapore
Primary
Concomitant
Myoclonus Other Serious 11 Male 8/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Myoclonus Other Serious 11 Male 8/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 5 Male 9/9/2010
Primary
Secondary
Pallor 8/9/2010 5 Male 9/8/2010 United States
Primary
Concomitant
Paranoia Other Serious 22 Female 10/21/2010 Other Health Professional Japan
Primary
Concomitant
Walking Aid User Hospitalization 47 Male 11/3/2010 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Walking Aid User Hospitalization 47 Male 11/8/2010 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Paranoia Other Serious 22 Female 11/8/2010 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Lennox-gastaut Syndrome Other Serious 38 Female 11/4/2010 Italy
Primary
Concomitant
Convulsion Other Serious 12/28/2010 36 Female 1/5/2011 Consumer United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 11/1/2006 33 Male 1/28/2011 Physician Japan
Primary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 36 Female 70 lb 2/28/2011 Other Health Professional Japan
Primary
Interacting
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 5 Female 40 lb 3/15/2011 Pharmacist United States
Primary
Concomitant
Drug Resistance Other Serious 36 Female 3/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Middle Ear Effusion Hospitalization 24 Male 86 lb 3/25/2011 Japan
Primary
Concomitant
Conversion Disorder Hospitalization 8 Female 3/28/2011 Other Health Professional Japan
Primary
Concomitant
Clostridial Infection Hospitalization 1/30/2011 43 Female 3/7/2011 Consumer United States
Primary
Concomitant
Hallucination Hospitalization 9/13/2010 43 Female 3/16/2011 Physician United States
Primary
Concomitant
Clostridial Infection Hospitalization 9/13/2010 43 Female 3/16/2011 Physician United States
Primary
Concomitant
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diplopia Other Serious 37 Female 3/28/2011 United Kingdom
Primary
Secondary
Concomitant
Somnolence 8 Female 4/10/2011 Other Health Professional Japan
Primary
Concomitant
Drug Level Increased Other Serious 36 Female 70 lb 4/29/2011 Other Health Professional Japan
Primary
Interacting
Myoclonus Other Serious 2/10/2011 17 5/2/2011 Physician Japan
Primary
Concomitant
Ear Infection Fungal Hospitalization 9/13/2010 43 Female 190 lb 4/28/2011 Physician United States
Primary
Secondary
Concomitant
Drug Effect Decreased Other Serious 36 Female 71 lb 5/23/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Rash Other Serious 1/1/2007 33 Male 5/24/2011 Other Health Professional Japan
Primary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/14/2011 Physician Japan
Primary
Secondary
Concomitant
Choreoathetosis Hospitalization 11/1/2010 18 Male 6/16/2011 Physician Japan
Primary
Secondary
Concomitant
Hypotension Other Serious 1/1/1988 26 Female 6/21/2011 Other Health Professional United States
Primary
Secondary
Stevens-johnson Syndrome Other Serious 52 Male 7/18/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Drug Eruption 52 Male 7/27/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Headache Other Serious Female 8/8/2011 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 1/1/2008 67 Male 219 lb 8/16/2011 Physician United States
Primary
Secondary
Concomitant
Fall Other Serious 12 Male 8/23/2011 Other Health Professional United States
Primary
Concomitant
Renal Tubular Disorder Hospitalization 8 Female 51 lb 8/26/2011 Physician Japan
Primary
Concomitant
Headache Other Serious Female 110 lb 9/6/2011 Physician United States
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization Male 9/19/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2011 Male 9/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Foot Fracture Hospitalization 9/16/2011 Female 186 lb 9/22/2011 Physician Ukraine
Primary
Concomitant
Pyrexia Hospitalization 24 Male 86 lb 9/23/2011 Japan
Primary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 9/23/2011 Consumer United States
Primary
Secondary
Concomitant
Foot Fracture Hospitalization 9/16/2011 Female 186 lb 9/27/2011 Physician Ukraine
Primary
Concomitant
Abscess Hospitalization 9/13/2010 43 Female 205 lb 9/19/2011 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 10/3/2011 Consumer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 7/14/2011 Male 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Foot Fracture Hospitalization 9/15/2011 17 Female 186 lb 10/7/2011 Physician Ukraine
Primary
Concomitant
Drug Prescribing Error Other Serious 7/1/2011 Male 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Dyshidrosis Other Serious 7/1/2011 Male 10/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Psychomotor Retardation Other Serious Male 10/24/2011 Other Health Professional India
Primary
Secondary
Concomitant
Death Death 9/29/2011 32 Female 10/28/2011 Other Health Professional United States
Primary
Concomitant
Death Death 9/30/2011 32 Female 11/1/2011 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 7/1/2011 Male 11/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Foot Fracture Hospitalization 9/15/2011 17 Female 186 lb 11/8/2011 Physician Ukraine
Primary
Concomitant
Death Death 9/30/2011 32 Female 11/10/2011 Physician United States
Primary
Concomitant
Drug Prescribing Error Other Serious 6/27/2011 Male 11/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion Hospitalization 5/10/2010 15 Male 11/11/2011 Physician Japan
Primary
Concomitant
Nausea Female 110 lb 11/9/2011 Physician United States
Primary
Concomitant
Suicidal Ideation Hospitalization 1/14/2003 34 Male 11/21/2011 Consumer United States
Primary
Concomitant
Skin Necrosis Other Serious 9/21/2011 22 Male 12/5/2011 Physician Japan
Primary
Concomitant
Convulsion Hospitalization 11/30/2011 34 Male 12/20/2011 Consumer United States
Primary
Concomitant
Tonic Clonic Movements Hospitalization 5/10/2010 15 Male 12/22/2011 Physician Japan
Primary
Concomitant
Cardiac Valve Disease Other Serious 8/24/2011 Male 12/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cardiac Valve Disease Other Serious 8/24/2011 Male 1/3/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Dehydration Hospitalization 7/1/2011 Male 1/17/2012 Physician Japan
Primary
Secondary
Concomitant
Foot Fracture Hospitalization 9/15/2011 17 Female 186 lb 2/6/2012 Physician Ukraine
Primary
Concomitant

Drug Data