Clonazepam combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Arrest Death 37 Male 2/7/2006 Pharmacist United States
Primary
Secondary
Neutrophilia Other Serious 11/23/2001 42 Female 2/13/2006 Canada
Primary
Concomitant
Neutropenia Other Serious 29 Male 194 lb 5/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash 1/18/2006 Male 173 lb 5/18/2006 Pharmacist United States
Primary
Concomitant
Lethargy Other Serious 26 Female 5/25/2006 Consumer Canada
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 27 Female 6/20/2006 India
Primary
Concomitant
Weight Increased Life Threatening Female 331 lb 6/23/2006 Physician United States
Primary
Concomitant
Nocturia Disability 4/11/2006 Male 256 lb 7/10/2006 Pharmacist United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 36 Male 259 lb 1/17/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 10/24/2005 51 Male 1/31/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/1/2005 35 Male 190 lb 1/6/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 31 Female 7/28/2006 Physician Japan
Primary
Secondary
Concomitant
Haemodynamic Instability Required Intervention 9 Male 8/31/2006 Physician Belgium
Primary
Concomitant
Loss Of Consciousness Hospitalization 26 Female 9/15/2006 Physician United States
Primary
Secondary
Concomitant
Intentional Overdose Death 7/25/2006 23 Female 150 lb 10/26/2006 Physician Russian Federation
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/8/2006 Lawyer United States
Primary
Concomitant
Completed Suicide Death 40 11/9/2006 United States
Primary
Secondary
Thrombocytopenia Hospitalization 10/15/2005 35 Male 8/18/2006 France
Primary
Secondary
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/13/2006 Lawyer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/2000 50 Male 333 lb 11/16/2006 Physician United States
Primary
Concomitant
Poisoning Death 40 11/16/2006 Physician United States
Primary
Secondary
Psychotic Disorder Other Serious 10/24/2006 42 Male 11/28/2006 Physician Ecuador
Primary
Concomitant
Vomiting Death 7/13/2006 Male 88 lb 12/22/2006 Pharmacist United States
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 12/7/2006 Male 12/28/2006 Pharmacist United States
Primary
Concomitant
Protein Total Decreased Other Serious 5/1/2004 41 Male 1/12/2007 Physician Canada
Primary
Concomitant
Interacting
Mental Status Changes Required Intervention 1/8/2007 57 Male 153 lb 1/8/2007 Pharmacist United States
Primary
Concomitant
Polycystic Ovaries Hospitalization 3/1/2006 27 Female 2/8/2007 Physician Philippines
Primary
Concomitant
Unevaluable Event Other Serious 11/5/2006 Male 156 lb 2/12/2007 Physician France
Primary
Concomitant
Death Death 1/1/2005 40 Unknown 2/7/2007 Physician United States
Primary
Secondary
Weight Increased Other Serious 1/1/2001 41 Female 245 lb 3/5/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization Male 3/17/2007 Consumer Canada
Primary
Concomitant
Weight Increased Other Serious 1/1/2001 41 Female 245 lb 3/21/2007 Consumer United States
Primary
Concomitant
Death Death 1/1/2004 65 3/21/2007 Pharmacist United States
Primary
Secondary
Cardio-respiratory Arrest Death 1/1/2004 45 Unknown 3/22/2007 Pharmacist United States
Primary
Secondary
Somnolence Other Serious 2/2/2007 46 Female 4/11/2007 Physician Canada
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/23/2006 72 Female 4/25/2007 Other Health Professional France
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Life Threatening 1/15/2007 44 Male 4/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Arrhythmia Other Serious Male 4/30/2007 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Stupor Hospitalization 38 Male 5/11/2007 Other Health Professional United States
Primary
Concomitant
Stupor Hospitalization 38 Male 5/11/2007 Other Health Professional United States
Primary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 7 Female 35 lb 5/11/2007 Israel
Primary
Concomitant
White Blood Cell Disorder Other Serious 1/27/2003 28 Male 225 lb 6/7/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Visual Acuity Reduced Disability 3/7/2007 50 Female 7/2/2007 Other Health Professional France
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 63 Female 7/11/2007
Primary
Secondary
Vomiting Other Serious 9 Male 7/17/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Respiration Abnormal Life Threatening 25 Female 7/17/2007 Physician India
Primary
Secondary
Visual Acuity Reduced Other Serious 50 Female 8/17/2007 Physician France
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 25 Female 7/27/2007 India
Primary
Secondary
Pancytopenia Other Serious 9 Male 8/22/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 4/1/2005 9 Male 8/23/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 9 Male 8/25/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Vitamin B12 Increased Death 1/1/2007 36 Female 135 lb 8/30/2007 Physician United States
Primary
Secondary
Urine Ketone Body Present Death 36 Female 8/23/2007 United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 9 Male 8/30/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/1/2005 9 Male 9/14/2007 France
Primary
Secondary
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 9/13/2007 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 1 Female 9/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 2 Female 9/22/2007 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2007 36 Female 10/17/2007 Physician United States
Primary
Secondary
Completed Suicide Death 40 10/29/2007 Physician United States
Primary
Secondary
Gastroenteritis Other Serious Male 165 lb 11/7/2007 Physician France
Primary
Concomitant
Hepatotoxicity Hospitalization 1 Male 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 1 Female 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 2 Female 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 1/10/2008 Other Health Professional United States
Primary
Concomitant
Tremor Hospitalization 60 Female 1/18/2008 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 1/25/2008 50 Male 2/6/2008 Physician Brazil
Primary
Secondary
Weight Increased Other Serious 1/1/2001 Female 245 lb 2/5/2008 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 2/15/2008 72 Female 2/28/2008 Physician United States
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 54 Female 3/6/2008 Physician United States
Primary
Concomitant
Nervous System Disorder Hospitalization 3/11/2008 Female 85 lb 3/13/2008 Pharmacist United States
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 3/19/2008 Germany
Primary
Secondary
Red Blood Cell Count Decreased Other Serious 16 Male 129 lb 3/20/2008 United States
Primary
Concomitant
Tinnitus Hospitalization 5/1/2007 47 Male 4/26/2008 Pharmacist United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 36 Male 5/1/2008 Brazil
Primary
Secondary
Concomitant
Depression Hospitalization 3/24/2008 Male 163 lb 5/8/2008 Physician Argentina
Primary
Secondary
Concomitant
Inhibitory Drug Interaction Other Serious 1/1/2008 2 Female 5/12/2008 Netherlands
Primary
Secondary
Concomitant
Inhibitory Drug Interaction Other Serious 1/1/2008 1 Female 5/12/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Drug Toxicity Hospitalization 36 Male 5/22/2008 Consumer Brazil
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 1 Female 5/30/2008 Netherlands
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 2 Female 6/2/2008 Other Health Professional Netherlands
Primary
Concomitant
Drug Toxicity Death 35 6/9/2008 Other Health Professional United States
Primary
Secondary
Convulsion Neonatal Death 6/11/2008 Other Health Professional Israel
Primary
Secondary
Respiratory Arrest Other Serious 45 6/19/2008 Physician United States
Primary
Secondary
Completed Suicide Death 65 6/19/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 31 6/19/2008 Other Health Professional United States
Primary
Secondary
Sleep Apnoea Syndrome Other Serious 1/1/2004 37 Male 370 lb 7/10/2008 United States
Primary
Concomitant
Septic Shock Death 12 Female 148 lb 7/30/2008 Pharmacist Spain
Primary
Concomitant
Interacting
Drug Level Decreased Other Serious 4 Male 44 lb 8/5/2008 Pharmacist Spain
Primary
Concomitant
Interacting
Drug Interaction Death 12 Female 126 lb 8/6/2008 Other Health Professional Spain
Primary
Concomitant
Interacting
Drug Interaction Other Serious 4 Male 44 lb 8/8/2008 Pharmacist Spain
Primary
Concomitant
Interacting
Pancytopenia Hospitalization 9 Male 8/8/2008 Korea, Republic Of
Primary
Secondary
Concomitant
Liver Injury Hospitalization 1 Female 9/3/2008 Physician Netherlands
Primary
Concomitant
Depression Disability 6/27/2007 54 Male 9/11/2008 Physician Canada
Primary
Concomitant
Vomiting Other Serious 10/2/2008 Female 10/21/2008 Consumer Colombia
Primary
Concomitant
Death Death 8/16/2008 Female 287 lb 11/14/2008 Physician United States
Primary
Concomitant
Tremor Other Serious 23 Male 11/20/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 11/24/2008 Physician United States
Primary
Concomitant
Psychiatric Symptom Disability 67 Male 11/24/2008 Physician Argentina
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 12/22/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2007 43 Female 12/19/2008 Physician Canada
Primary
Concomitant
Liver Disorder Other Serious 58 Male 12/26/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Drug Interaction Other Serious 54 Male 12/31/2008 Other Health Professional Canada
Primary
Secondary
Interacting
Drug Interaction Other Serious 6/20/2007 54 Male 1/12/2009 Physician Canada
Primary
Secondary
Concomitant
Interacting
Hepatic Function Abnormal Other Serious 58 Male 1/12/2009 Physician Netherlands
Primary
Secondary
Concomitant
Pleurothotonus Other Serious 67 Male 1/19/2009 Argentina
Primary
Concomitant
Visual Field Defect Other Serious 1/23/2009 Other Health Professional France
Primary
Concomitant
Infection Hospitalization 58 Male 1/23/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Sleep Disorder Hospitalization 24 Male 1/29/2009 Other Health Professional Japan
Primary
Concomitant
Drug Level Increased Hospitalization 58 Male 1/28/2009 Consumer Netherlands
Primary
Secondary
Concomitant
Urinary Tract Infection Required Intervention 58 Male 2/11/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 20 Female 2/16/2009 Consumer Argentina
Primary
Concomitant
Pleurothotonus Disability 67 Male 2/5/2009 Physician Argentina
Primary
Secondary
Concomitant
Pleurothotonus Other Serious 67 Male 2/20/2009 Argentina
Primary
Concomitant
Renal Disorder Other Serious 7/1/2008 2/23/2009 Other Health Professional France
Primary
Secondary
Sleep Disorder Hospitalization 12/1/2005 Male 3/5/2009 Physician Japan
Primary
Concomitant
Unresponsive To Stimuli Death 10/4/2008 44 Female 225 lb 2/9/2009 Pharmacist United States
Primary
Concomitant
Thinking Abnormal Hospitalization 36 Male 3/5/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Epilepsy Other Serious 6/2/2005 1 Male 22 lb 3/6/2009 Italy
Primary
Concomitant
Sepsis Hospitalization Female 3/10/2009 Physician United Kingdom
Primary
Concomitant
Rouleaux Formation Other Serious 34 Male 3/17/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Motor Neurone Disease Other Serious 3/16/2009 Physician United Kingdom
Primary
Concomitant
Urticaria Other Serious 8 Male 3/12/2009 Canada
Primary
Concomitant
Therapy Regimen Changed Other Serious 36 Male 3/16/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Reticulocyte Count Decreased Hospitalization 37 Male 3/20/2009 Spain
Primary
Concomitant
Thinking Abnormal Other Serious 36 Male 3/20/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Liver Disorder Other Serious 58 Male 3/27/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 37 Male 4/6/2009 Spain
Primary
Concomitant
Aplasia Pure Red Cell Hospitalization 37 Male 4/8/2009 Spain
Primary
Concomitant
Posture Abnormal Other Serious 67 Male 4/7/2009 Physician Argentina
Primary
Concomitant
Aggression 48 Male 179 lb 4/1/2009 Physician United States
Primary
Concomitant
Status Epilepticus Other Serious 30 Male 4/21/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vision Blurred Other Serious 3 Male 4/28/2009 Other Health Professional Germany
Primary
Secondary
Motor Neurone Disease Other Serious 5/15/2009 Physician United Kingdom
Primary
Concomitant
Interacting
Substance Abuse Hospitalization 1/22/2002 48 Male 179 lb 5/18/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization Female 5/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urticaria Other Serious 8 Male 6/8/2009 Canada
Primary
Concomitant
Ventricular Hypokinesia Other Serious 4/17/2009 1 Male 12 lb 6/22/2009 Physician Brazil
Primary
Concomitant
Drug Interaction Hospitalization 58 Male 6/23/2009 Netherlands
Primary
Concomitant
Neurotoxicity Other Serious 7/6/2009 Physician United Kingdom
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 7/13/2009 Physician United States
Primary
Concomitant
Splenomegaly Hospitalization 8/23/2006 4 Female 7/7/2009 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Apnoea Other Serious Male 7/15/2009 Other Health Professional Mexico
Primary
Concomitant
Aggression 48 Male 179 lb 7/9/2009 Physician United States
Primary
Concomitant
Pneumonia Other Serious 19 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 1 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Pneumonia Other Serious 2 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Insomnia 10/16/2008 Female 8/22/2009 Consumer United States
Primary
Concomitant

Drug Data