Clonazepam combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Salivary Hypersecretion Life Threatening 10/23/2005 72 Female 176 lb 1/4/2006 Physician France
Primary
Concomitant
Syncope Hospitalization 9/1/2004 26 Female 1/11/2006 Japan
Primary
Secondary
Epilepsy Other Serious 10/30/2005 37 Male 170 lb 1/25/2006 Physician France
Primary
Concomitant
Anger Hospitalization 8/18/2005 43 Male 1/20/2006 Australia
Primary
Secondary
Concomitant
Epilepsy Other Serious 1/1/2005 37 Male 170 lb 1/31/2006 Physician France
Primary
Concomitant
Overdose Life Threatening 1/25/2006 38 Female 2/7/2006 Other Health Professional Slovakia (Slovak Republic)
Primary
Secondary
Respiratory Depression Other Serious 12/17/2004 Male 8 lb 2/10/2006 Other Health Professional France
Primary
Secondary
Respiratory Depression Other Serious 12/17/2004 Male 8 lb 2/10/2006 Other Health Professional France
Primary
Secondary
Respiratory Depression Other Serious 12/17/2004 Male 8 lb 2/10/2006 Other Health Professional France
Primary
Secondary
Wrong Technique In Drug Usage Process Life Threatening 10/23/2005 72 Female 176 lb 2/13/2006 Physician France
Primary
Concomitant
Pyrexia Hospitalization 7/7/2004 56 Male 89 lb 1/31/2006 Physician Japan
Primary
Concomitant
Overdose Life Threatening 1/25/2006 38 Female 2/8/2006 Slovakia (Slovak Republic)
Primary
Secondary
Deafness Other Serious 1/17/2006 14 Male 1/30/2006 Pharmacist United Kingdom
Primary
Concomitant
Somnolence Other Serious 1/25/2006 38 Female 2/22/2006 Slovakia (Slovak Republic)
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 6 Female 3/2/2006 France
Primary
Concomitant
Neutrophil Count Decreased Other Serious 8/9/2005 54 Male 3/13/2006 United States
Primary
Secondary
Concomitant
Rash Hospitalization 9/22/2002 15 Male 3/14/2006 Japan
Primary
Concomitant
Tracheitis Other Serious 7/15/2005 Female 146 lb 3/23/2006 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/18/2005 36 Female 126 lb 12/14/2005 Physician United States
Primary
Secondary
Concomitant
Unevaluable Event Death 8/10/2005 49 Male 12/14/2005 Pharmacist United States
Primary
Concomitant
Tracheitis Other Serious 7/15/2005 Female 146 lb 4/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 1/28/2002 43 Male 4/7/2006 Physician Australia
Primary
Secondary
Concomitant
Pancreatitis Other Serious 14 Female 4/19/2006 Physician Spain
Primary
Concomitant
Completed Suicide Death 5/13/2006 45 Male 143 lb 5/30/2006 Other Health Professional Brazil
Primary
Concomitant
Death Death 4/15/2006 52 Male 6/6/2006 United States
Primary
Concomitant
Mental Disorder Required Intervention 1/26/2006 45 Female 6/14/2006 United States
Primary
Concomitant
Malaise Hospitalization 6/1/2005 17 Female 6/19/2006 Physician Japan
Primary
Concomitant
Respiratory Depression Other Serious 12/17/2004 Male 8 lb 6/29/2006 Other Health Professional France
Primary
Secondary
Injury Asphyxiation Death 5/13/2006 45 Male 143 lb 7/5/2006 Brazil
Primary
Concomitant
Therapy Non-responder Hospitalization 1/1/1997 39 Female 121 lb 6/23/2006 Physician France
Primary
Concomitant
Granulocytopenia Required Intervention 1/10/2006 49 Male 230 lb 3/27/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/28/2005 21 Male 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/12/2005 45 Female 1/30/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/1/2005 61 Male 173 lb 5/12/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/30/2005 64 Male 177 lb 2/8/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 36 Male 259 lb 1/17/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 9/19/2005 44 Female 1/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/4/2005 42 Male 5/24/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 53 Male 3/29/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 29 Male 150 lb 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/8/2005 54 Male 2/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/8/2005 59 Female 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/10/2006 31 Male 300 lb 5/17/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/25/2005 25 Male 5/31/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 46 Male 5/31/2006 United States
Primary
Concomitant
Impulsive Behaviour Required Intervention 1/1/2006 39 Male 8/4/2006 Pharmacist United Kingdom
Primary
Concomitant
Granulocytopenia Required Intervention 3/10/2006 52 Female 5/22/2006 United States
Primary
Concomitant
Hepatotoxicity Hospitalization 19 Male 9/1/2006 Australia
Primary
Concomitant
Sudden Death Death 8/24/2006 43 Female 9/8/2006 Physician Czech Republic
Primary
Concomitant
Ovarian Cyst Hospitalization 10/1/2006 Female 10/9/2006 Consumer Mexico
Primary
Concomitant
Treatment Noncompliance Death 8/1/2006 58 Male 9/28/2006 Other Health Professional Australia
Primary
Concomitant
Psychomotor Retardation Hospitalization 5/24/2005 67 Male 10/25/2006 Consumer Australia
Primary
Secondary
Concomitant
Overdose Death 9/26/2006 52 Male 190 lb 10/23/2006 United States
Primary
Concomitant
Psychotic Disorder Required Intervention 35 Male 11/7/2006 United States
Primary
Concomitant
Convulsion Other Serious 7/9/2006 72 Female 11/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 5/27/2005 3 Male 29 lb 12/14/2006 Physician Japan
Primary
Concomitant
Tachycardia Other Serious Female 1/4/2007 Consumer Ireland
Primary
Secondary
White Blood Cell Disorder Hospitalization 11/8/2006 74 Male 1/12/2007 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 2/21/2007 31 3/2/2007 Physician Peru
Primary
Concomitant
Vomiting Other Serious 2/21/2007 31 3/9/2007 Physician Peru
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 2 Female 3/2/2007 Czech Republic
Primary
Concomitant
Vomiting Other Serious 2/21/2007 31 3/18/2007 Physician Peru
Primary
Concomitant
Vomiting Other Serious 2/21/2007 31 3/23/2007 Physician Peru
Primary
Concomitant
Rhabdomyolysis Other Serious 4/3/2003 56 Male 3/29/2007 Japan
Primary
Concomitant
Tremor Hospitalization 60 Female 4/5/2007 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Tooth Injury Other Serious 1/1/1978 19 Male 4/13/2007 Australia
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 60 Female 4/19/2007
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 60 Female 4/23/2007 Taiwan, Province Of China
Primary
Concomitant
Interacting
Pneumonia Hospitalization 5/23/2006 5 Male 4/19/2007 Physician Japan
Primary
Concomitant
Serotonin Syndrome Other Serious 41 Male 5/4/2007 Switzerland
Primary
Secondary
Concomitant
Tremor Hospitalization 60 Female 5/15/2007 Physician Taiwan, Province Of China
Primary
Concomitant
Tremor Other Serious 60 Female 5/25/2007 Taiwan, Province Of China
Primary
Secondary
Concomitant
Sinusitis Other Serious 11/11/2004 Male 199 lb 6/29/2007 Consumer United States
Primary
Secondary
Concomitant
Somnolence Other Serious 12 Male 7/3/2007 Japan
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 Female 26 lb 6/29/2007 Physician Japan
Primary
Concomitant
Palpitations Hospitalization 4/22/2007 57 Male 249 lb 7/9/2007 Physician United Kingdom
Primary
Concomitant
Infarction Death 5/17/2007 64 Male 218 lb 7/16/2007 Physician Mexico
Primary
Concomitant
Somnolence Other Serious 12 Male 7/17/2007 Japan
Primary
Concomitant
Diabetes Mellitus Hospitalization 6/21/2007 Male 8/2/2007 Physician Japan
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 6/1/2007 Male 123 lb 8/3/2007 Physician Japan
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 25 Female 8/14/2007 Other Health Professional India
Primary
Secondary
Epilepsy Hospitalization 13 Male 8/15/2007 Japan
Primary
Concomitant
Myocardial Infarction Death 5/17/2007 64 Male 218 lb 8/16/2007 Physician Mexico
Primary
Concomitant
Diabetes Mellitus Hospitalization 6/21/2007 Male 8/27/2007 Physician Japan
Primary
Secondary
Concomitant
Epilepsy Hospitalization 13 Male 8/28/2007 Japan
Primary
Concomitant
Mobility Decreased Other Serious 11/1/2006 Male 8/31/2007 Physician United Kingdom
Primary
Concomitant
Interacting
Stress Hospitalization 8/11/2007 29 Female 304 lb 9/10/2007 Consumer United Kingdom
Primary
Concomitant
Somnolence Other Serious 7/1/2006 48 Male 10/5/2007 Other Health Professional France
Primary
Concomitant
Interacting
Neoplasm Malignant Other Serious 63 Male 10/19/2007 Physician France
Primary
Concomitant
Sepsis Death 3/30/2006 5 Male 33 lb 10/17/2007 Physician Japan
Primary
Concomitant
Metabolic Acidosis Other Serious 0 Male 11/1/2007 Japan
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 10/1/2007 11/5/2007 Physician China
Primary
Concomitant
Metabolic Acidosis Other Serious 0 Male 11/13/2007 Japan
Primary
Secondary
Concomitant
Hypertension Hospitalization 8/29/2007 57 Male 257 lb 11/20/2007 Consumer United Kingdom
Primary
Concomitant
Sputum Retention Hospitalization 2/15/2002 57 Female 68 lb 11/20/2007 Physician Japan
Primary
Concomitant
Tremor Hospitalization 11/5/2007 6 Male 11/29/2007 Physician Japan
Primary
Concomitant
Loss Of Consciousness Hospitalization 10/26/2007 57 Male 152 lb 11/29/2007 Physician Japan
Primary
Concomitant
Tremor Hospitalization 11/5/2007 Male 33 lb 12/14/2007 Physician Japan
Primary
Concomitant
Sputum Retention Hospitalization 11/1/2001 57 Female 68 lb 12/10/2007 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Other Serious 44 Female 12/22/2007 Japan
Primary
Secondary
Tremor Hospitalization 11/5/2007 Male 33 lb 1/3/2008 Physician Japan
Primary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 9/21/2007 19 Male 1/23/2008 Physician China
Primary
Concomitant
Tremor Hospitalization 11/5/2007 Male 33 lb 1/24/2008 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 2/1/2008 Consumer Germany
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 77 Female 1/25/2008 Physician Germany
Primary
Secondary
Interstitial Lung Disease Other Serious 1/16/2008 1 Male 2/7/2008 Physician Japan
Primary
Concomitant
Metabolic Acidosis Other Serious 0 Male 2/15/2008 Japan
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 45 Male 2/29/2008 United States
Primary
Concomitant
Rash Generalised Other Serious 20 Male 3/9/2008 Consumer
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 11/2/2006 0 Male 15 lb 3/11/2008 Physician Japan
Primary
Concomitant
Liver Injury Other Serious 3/25/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Liver Injury Other Serious 3/25/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2008 Female 160 lb 3/28/2008 Canada
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2006 8 26 lb 3/26/2008 Physician Japan
Primary
Concomitant
Tremor Disability 14 Male 4/3/2008 France
Primary
Secondary
Concomitant
Pyrexia Other Serious 11 Male 3/25/2008 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 2/13/2008 47 Female 4/4/2008 Physician Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/18/2003 Female 2/13/2008 Other Health Professional Germany
Primary
Secondary
Vertebral Injury Other Serious 9/25/2006 34 Female 4/4/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 20 Male 4/9/2008 Consumer United States
Primary
Secondary
Concomitant
Femoral Neck Fracture Hospitalization 11/10/2006 5 Male 33 lb 4/8/2008 Physician Japan
Primary
Concomitant
Petit Mal Epilepsy Other Serious Female 4/8/2008 Canada
Primary
Concomitant
Panic Attack Other Serious 22 Female 4/25/2008 Other Health Professional Iran (Islamic Republic Of)
Primary
Secondary
Concomitant
Tremor Other Serious 1/1/2007 51 Female 5/6/2008 Other Health Professional Netherlands
Primary
Concomitant
Withdrawal Syndrome Hospitalization 8/18/2002 49 Male 5/12/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 4/28/2008 27 Male 5/13/2008 Physician Brazil
Primary
Secondary
Withdrawal Syndrome Hospitalization 8/18/2002 49 Male 5/20/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Withdrawal Syndrome Hospitalization 8/18/2002 49 Male 5/28/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 16 Female 6/3/2008 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 10/17/2006 78 Male 199 lb 6/12/2008 Physician United States
Primary
Secondary
Concomitant
Ventricular Extrasystoles Hospitalization 16 Female 6/13/2008 Japan
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious Male 6/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 2/1/2008 Female 160 lb 6/19/2008 Canada
Primary
Concomitant
Withdrawal Syndrome Other Serious 45 Male 6/27/2008 United States
Primary
Concomitant
Serotonin Syndrome Other Serious 44 Male 7/9/2008 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 7/10/2008 60 Male 7/21/2008 Physician Guatemala
Primary
Concomitant
Drug Interaction Other Serious 6/29/2008 64 Male 7/29/2008 Other Health Professional France
Primary
Secondary
Concomitant
Thought Blocking Hospitalization 51 Female 7/30/2008 United States
Primary
Concomitant
Interacting
Thought Blocking Other Serious 51 Female 8/1/2008 Other Health Professional United States
Primary
Concomitant
Interacting
Thrombocytopenia Other Serious 51 Female 8/4/2008 France
Primary
Concomitant
Interacting
Rhabdomyolysis Other Serious 11/1/2007 16 Female 62 lb 8/15/2008 Physician Japan
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 6/8/2008 Female 123 lb 8/26/2008 Other Health Professional Australia
Primary
Concomitant
Pruritus Generalised 11/28/2007 Female 162 lb 8/27/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased 5/15/2008 Female 250 lb 8/29/2008 United States
Primary
Concomitant
Skin Burning Sensation 6/25/2008 Male 8/29/2008 United States
Primary
Concomitant
Wound Secretion Other Serious 8/1/2007 Male 150 lb 9/2/2008 United States
Primary
Concomitant
Epistaxis Hospitalization Female 9/11/2008 Brazil
Primary
Concomitant
Thrombocytopenia Hospitalization 6/23/2008 Male 9/16/2008 Physician France
Primary
Concomitant
Femoral Neck Fracture Hospitalization 11/10/2006 5 Male 33 lb 9/19/2008 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 8/1/2007 22 Male 9/24/2008 Consumer United States
Primary
Concomitant

Drug Data