Clonazepam combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Overdose Other Serious 8/4/2001 48 Female 1/27/2006 Consumer Canada
Primary
Concomitant
Hemivertebra Congenital Anomaly 31 Female 138 lb 2/10/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Rib Fracture Other Serious Male 2/24/2006 Canada
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 1/14/2006 41 Female 150 lb 3/22/2006 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Shoulder Pain Other Serious Male 4/10/2006 Canada
Primary
Concomitant
Documented Hypersensitivity To Administered Drug Other Serious 4/4/2006 31 Female 193 lb 4/12/2006 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2003 Male 209 lb 5/8/2006 Lawyer Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2002 Male 209 lb 5/10/2006 Lawyer Canada
Primary
Concomitant
Urine Ketone Body Present Required Intervention 5/20/2003 28 Female 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Shoulder Pain Other Serious Male 5/30/2006 Canada
Primary
Concomitant
Status Epilepticus Other Serious 5/5/2006 Female 49 lb 5/5/2006 Pharmacist United States
Primary
Concomitant
Vomiting Required Intervention 5/20/2003 28 Female 6/13/2006 Physician United States
Primary
Secondary
Concomitant
Drug Withdrawal Syndrome Hospitalization 9/14/2005 36 Male 247 lb 5/9/2006 Physician United States
Primary
Secondary
Concomitant
Haemodynamic Instability Required Intervention 9 Male 8/31/2006 Physician Belgium
Primary
Concomitant
Mental Impairment Other Serious 10/11/2004 17 Female 107 lb 10/3/2006 France
Primary
Concomitant
Thrombocytopenia Hospitalization 10/15/2005 35 Male 8/18/2006 France
Primary
Secondary
Wrong Technique In Drug Usage Process Required Intervention 9/19/2006 57 Male 195 lb 11/3/2006 United States
Primary
Concomitant
Neutropenia Hospitalization 1/11/2007 47 Female 1/16/2007 Pharmacist United States
Primary
Concomitant
Death Death 39 Female 4/6/2007
Primary
Secondary
Death Death 39 Female 4/18/2007
Primary
Secondary
Joint Sprain Other Serious 10/11/2004 17 Female 107 lb 5/2/2007 Physician France
Primary
Concomitant
Raynaud's Phenomenon Other Serious 43 Female 5/11/2007
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 7 Female 35 lb 5/11/2007 Israel
Primary
Concomitant
Poisoning Death 39 Female 6/21/2007 Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 9 Male 7/17/2007 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Angle Closure Glaucoma Hospitalization 6/1/2007 36 Female 128 lb 8/13/2007 Physician Chile
Primary
Secondary
Concomitant
Pancytopenia Other Serious 9 Male 8/22/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 4/1/2005 9 Male 8/23/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 9 Male 8/25/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 11/1/2006 Male 8/31/2007 Physician United Kingdom
Primary
Concomitant
Interacting
Pancytopenia Hospitalization 9 Male 8/30/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/1/2005 9 Male 9/14/2007 France
Primary
Secondary
Vomiting Hospitalization 1/1/2007 51 Male 167 lb 9/13/2007 Consumer United States
Primary
Concomitant
Raynaud's Phenomenon Other Serious 2/2/2003 43 Female 9/20/2007 Other Health Professional Denmark
Primary
Concomitant
Transaminases Increased Hospitalization 1 Female 9/22/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 2 Female 9/22/2007 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Urticaria Other Serious 12/29/2006 Female 196 lb 10/5/2007 Other Health Professional Canada
Primary
Concomitant
Somnolence Other Serious 7/1/2006 48 Male 10/5/2007 Other Health Professional France
Primary
Concomitant
Interacting
Raynaud's Phenomenon Other Serious 2/2/2003 43 Female 10/2/2007 Denmark
Primary
Concomitant
Convulsion Other Serious 11/1/2006 6 Male 42 lb 10/1/2007 United States
Primary
Concomitant
Radiculopathy Other Serious 10/11/2004 17 Female 107 lb 11/14/2007 Physician France
Primary
Concomitant
Thrombocytopenia Other Serious 3/28/2007 52 Female 12/3/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pancreatitis Chronic Other Serious 3/1/2006 33 Female 121 lb 12/10/2007 Physician United States
Primary
Concomitant
Weight Increased Life Threatening 6/4/2007 24 Female 12/14/2007 Physician United States
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 1 Male 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 1 Female 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 2 Female 1/8/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Drug Toxicity Death 36 Female 1/10/2008 Physician United States
Primary
Secondary
Lethargy 7/4/2007 Male 43 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Multiple Drug Overdose Intentional Death 36 Female 2/1/2008 Denmark
Primary
Secondary
Poisoning Death 36 Female 2/5/2008 Physician United States
Primary
Secondary
Sudden Death Death 1/1/2007 57 Female 115 lb 2/18/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Sinusitis 2/1/2007 Female 175 lb 3/14/2008 United States
Primary
Concomitant
Liver Injury Other Serious 3/25/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Liver Injury Other Serious 3/25/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Epilepsy Other Serious 12/15/2007 29 Male 3/28/2008 Other Health Professional France
Primary
Concomitant
Interacting
Tonic Clonic Movements Other Serious 8/2/2007 Male 4/25/2008 Other Health Professional France
Primary
Secondary
Inhibitory Drug Interaction Other Serious 1/1/2008 2 Female 5/12/2008 Netherlands
Primary
Secondary
Concomitant
Inhibitory Drug Interaction Other Serious 1/1/2008 1 Female 5/12/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Fatigue Death 37 Male 198 lb 5/19/2008 Physician France
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 1 Female 5/30/2008 Netherlands
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 2 Female 6/2/2008 Other Health Professional Netherlands
Primary
Concomitant
Drug Eruption Hospitalization 12/1/2007 36 Male 187 lb 6/3/2008 Physician Switzerland
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 6/12/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 5/1/2004 Female 6/12/2008 Physician United Kingdom
Primary
Concomitant
Skin Atrophy 1/1/2007 Female 165 lb 6/13/2008 Consumer United States
Primary
Concomitant
Pain 4/8/2008 Female 140 lb 6/13/2008 United States
Primary
Concomitant
Paresis Hospitalization 6/1/2008 51 Female 6/25/2008 Physician South Africa
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 7/9/2008 Other Health Professional Netherlands
Primary
Secondary
Drug Exposure During Pregnancy Other Serious Female 7/10/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 5/1/2004 Female 7/17/2008 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 5/1/2004 Female 7/25/2008 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/20/2008 Male 7/28/2008 Physician France
Primary
Secondary
Pancytopenia Hospitalization 9 Male 8/8/2008 Korea, Republic Of
Primary
Secondary
Concomitant
Simple Partial Seizures Other Serious 7/25/2008 26 Female 8/22/2008 Other Health Professional South Africa
Primary
Concomitant
Pancreatitis Acute Hospitalization 4/30/2008 Male 8/27/2008 Other Health Professional France
Primary
Concomitant
Joint Sprain 5/31/2008 Male 258 lb 9/2/2008 Physician United States
Primary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Injury Hospitalization 1 Female 9/3/2008 Physician Netherlands
Primary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wound Drainage Other Serious 10/9/2008 Male 154 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Pregnancy With Implant Contraceptive 1/1/2007 36 Female 11/5/2008 Australia
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Required Intervention 9/19/2006 57 Male 11/12/2008 United States
Primary
Secondary
Concomitant
Paranoia Other Serious 35 Female 12/1/2008 United States
Primary
Concomitant
Pyrexia Hospitalization 11/1/2008 Female 130 lb 12/11/2008 United States
Primary
Concomitant
Petit Mal Epilepsy Other Serious Female 1/12/2009 Consumer Canada
Primary
Concomitant
Rash Disability 6/1/2008 73 Female 1/13/2009 Physician United States
Primary
Concomitant
Petit Mal Epilepsy Other Serious 23 Female 1/26/2009 Consumer Canada
Primary
Concomitant
Drug Toxicity Death Female 150 lb 2/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/1/2008 51 Female 169 lb 2/17/2009 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 3/1/2008 35 Female 2/18/2009 United States
Primary
Secondary
Epilepsy Other Serious 6/2/2005 1 Male 22 lb 3/6/2009 Italy
Primary
Concomitant
Weight Decreased Hospitalization 53 Female 3/11/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 1/1/2003 36 Female 4/6/2009 United States
Primary
Concomitant
Bipolar Disorder Hospitalization 3/2/2009 34 Female 190 lb 4/20/2009 Other Health Professional United States
Primary
Concomitant
Bipolar Disorder Hospitalization 3/2/2009 34 Female 190 lb 5/11/2009 Other Health Professional United States
Primary
Concomitant
Product Substitution Issue Other Serious 5/1/2009 29 Female 165 lb 5/20/2009 United States
Primary
Concomitant
Visual Impairment Hospitalization 4/14/2008 53 Female 5/22/2009 Canada
Primary
Secondary
Concomitant
Visual Impairment Other Serious 5/18/2009 66 Female 185 lb 5/29/2009 Consumer United States
Primary
Concomitant
Lethargy 7/4/2007 4 Male 43 lb 6/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myoclonus Hospitalization 4/1/2007 49 Male 6/5/2009 Consumer Italy
Primary
Concomitant
Ventricular Hypokinesia Other Serious 4/17/2009 1 Male 12 lb 6/22/2009 Physician Brazil
Primary
Concomitant
Pneumonia Other Serious 19 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 1 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Pneumonia Other Serious 2 Female 7/16/2009 Netherlands
Primary
Secondary
Concomitant
Premature Baby Hospitalization 8/8/2008 Male 7 lb 7/22/2009 Physician Australia
Primary
Concomitant
Premature Baby Hospitalization 8/8/2008 Male 7 lb 7/24/2009 Physician Australia
Primary
Concomitant
Vertigo Other Serious 38 Male 8/12/2009
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 8/1/2009 45 Female 8/21/2009 Pharmacist United States
Primary
Concomitant
Interacting
Suicide Attempt Required Intervention 6/1/2008 46 Female 8/13/2009 Consumer United States
Primary
Concomitant
Skin Warm 168 lb 8/29/2009 United States
Primary
Concomitant
Pancreatitis Chronic Other Serious 10/10/2005 32 Female 134 lb 9/11/2009 United States
Primary
Concomitant
Sinusitis 2/1/2007 Female 175 lb 9/11/2009 United States
Primary
Concomitant
Pain 4/8/2008 Female 140 lb 9/12/2009 United States
Primary
Concomitant
Pancreatitis Other Serious 3/30/2001 48 Male 265 lb 9/23/2009 United States
Primary
Concomitant
Pharyngitis 11/30/2003 58 Female 159 lb 9/23/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/20/2004 46 Male 234 lb 10/5/2009 United States
Primary
Concomitant
Vasculitis Hospitalization 9/21/2009 46 Female 161 lb 10/1/2009 Pharmacist United States
Primary
Concomitant
Craniofacial Dysostosis Other Serious Female 10/2/2009 France
Primary
Concomitant
Rib Fracture Other Serious Male 10/7/2009 Physician Canada
Primary
Concomitant
Retrognathia Congenital Anomaly Female 10/8/2009 Other Health Professional France
Primary
Secondary
Concomitant
Teratogenicity Other Serious 25 Female 10/13/2009
Primary
Secondary
Viral Upper Respiratory Tract Infection Required Intervention 21 Female 128 lb 10/6/2009 Switzerland
Primary
Concomitant
Teratogenicity Other Serious Female 10/13/2009
Primary
Secondary
Rib Fracture Other Serious Male 10/14/2009 Physician Canada
Primary
Concomitant
Nausea Other Serious 10/1/2008 Female 168 lb 10/19/2009 Consumer United States
Primary
Secondary
Concomitant
Multiple Congenital Abnormalities Congenital Anomaly Female 10/20/2009 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/22/2008 57 Male 10/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Retrognathia Other Serious Female 10/22/2009 France
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 1/1/2009 Female 10/13/2009 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/1/2006 Female 11/4/2009 Physician Canada
Primary
Concomitant
Craniofacial Dysostosis Other Serious Female 11/13/2009 France
Primary
Concomitant
Retrognathia Congenital Anomaly Female 8 lb 11/16/2009 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Other Serious 16 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Epilepsy Other Serious 60 Female 11/18/2009 France
Primary
Concomitant
Potentiating Drug Interaction Other Serious 31 Female 287 lb 11/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 8/7/2009 35 Female 11/25/2009 Physician Japan
Primary
Concomitant
Nystagmus Other Serious 5 Female 11/27/2009 Physician Israel
Primary
Secondary
Concomitant
Weight Increased Hospitalization 16 Male 12/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Weight Increased Other Serious 16 Male 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 1/1/2005 45 Female 143 lb 12/1/2009 United States
Primary
Concomitant
Overdose Death 49 Female 1/21/2010 Physician United States
Primary
Secondary
Gingival Pain Other Serious 1/6/2010 59 Female 172 lb 1/22/2010 Consumer United States
Primary
Concomitant
Overdose Death 49 Female 1/26/2010 Physician United States
Primary
Secondary
Drug Toxicity Other Serious 49 Female 1/25/2010 Physician United States
Primary
Secondary
Poisoning Death 49 Female 1/16/2010 Physician United States
Primary
Secondary
Completed Suicide Death 49 Female 1/21/2010 Other Health Professional United States
Primary
Secondary
Poisoning Death 1/1/2008 49 Female 1/29/2010 Physician United States
Primary
Secondary

Drug Data