Clonazepam combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Troponin I Increased Hospitalization 11/19/2002 49 Male 1/20/2006 Norway
Primary
Concomitant
Hemiparesis Hospitalization 3/13/2004 61 Female 128 lb 1/18/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 10/2/2004 65 Female 1/23/2006 Physician United States
Primary
Secondary
Concomitant
Speech Disorder Other Serious 25 Female 1/27/2006 Physician United States
Primary
Concomitant
Hyponatraemia Other Serious 65 Female 4/6/2006 Other Health Professional United States
Primary
Concomitant
Bladder Cancer Required Intervention 10/1/2005 42 Male 110 lb 4/4/2006 Physician Japan
Primary
Concomitant
Lethargy Other Serious 65 Female 4/21/2006 United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2003 Male 209 lb 5/8/2006 Lawyer Canada
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2002 Male 209 lb 5/10/2006 Lawyer Canada
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 12/6/2005 22 Male 155 lb 12/26/2005 Pharmacist United States
Primary
Concomitant
Insomnia 1/1/2005 59 Female 130 lb 4/3/2006 Consumer United States
Primary
Concomitant
Urine Output Increased Hospitalization 65 Female 6/9/2006 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Death 19 Female 6/23/2006 Physician Brazil
Primary
Concomitant
Weight Increased Hospitalization 9/12/2005 41 Female 6/27/2006 Physician France
Primary
Concomitant
Blood Potassium Increased Hospitalization 6/19/2006 67 Male 7/7/2006 Pharmacist United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/9/2005 29 Male 155 lb 6/20/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/7/2005 28 Female 5/31/2006 United States
Primary
Concomitant
Urinary Tract Infection Death 7/1/2006 Male 308 lb 7/24/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2000 51 Male 7/31/2006 Physician United States
Primary
Concomitant
Grand Mal Convulsion Other Serious 5/10/2006 52 Female 155 lb 8/18/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2000 51 Male 228 lb 8/16/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 6/26/2006 39 Male 8/16/2006 Physician Japan
Primary
Concomitant
Hepatotoxicity Hospitalization 19 Male 9/1/2006 Australia
Primary
Concomitant
Haemodynamic Instability Required Intervention 9 Male 8/31/2006 Physician Belgium
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2000 51 Male 228 lb 9/6/2006 Physician United States
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/25/2006 Other Health Professional Ireland
Primary
Concomitant
Parkinsonism Other Serious 2/7/2006 52 Male 10/6/2006 Physician United States
Primary
Concomitant
Swelling Hospitalization 9/1/2006 59 Male 11/30/2006 Consumer Brazil
Primary
Concomitant
Somnolence Other Serious 1/1/2006 55 Male 12/1/2006 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2005 Female 2/2/2007 Consumer United States
Primary
Concomitant
Restlessness Death 5/21/2003 69 Male 2/2/2007 Other Health Professional Japan
Primary
Concomitant
Drug Level Increased Hospitalization 10/15/2006 84 Male 2/13/2007 Pharmacist United States
Primary
Concomitant
Tooth Injury Other Serious 1/1/1978 19 Male 4/13/2007 Australia
Primary
Concomitant
Pneumonia Hospitalization 5/23/2006 5 Male 4/19/2007 Physician Japan
Primary
Concomitant
Throat Irritation Other Serious 1/1/2003 54 Female 5/25/2007 United States
Primary
Concomitant
Pneumonia Other Serious 22 Male 5/25/2007 Japan
Primary
Secondary
Concomitant
Pruritus Other Serious Female 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Throat Irritation Other Serious 1/1/2003 54 Female 8/11/2007 United States
Primary
Concomitant
Epilepsy Hospitalization 13 Male 8/15/2007 Japan
Primary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 8/10/2007 Other Health Professional Ireland
Primary
Concomitant
Pancytopenia Other Serious 9 Male 8/22/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 4/1/2005 9 Male 8/23/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Epilepsy Hospitalization 13 Male 8/28/2007 Japan
Primary
Concomitant
Pancytopenia Hospitalization 9 Male 8/25/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Urine Ketone Body Present Death 36 Female 8/23/2007 United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 9 Male 8/30/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/1/2005 9 Male 9/14/2007 France
Primary
Secondary
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/13/2007 Other Health Professional Ireland
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 9/13/2007 Physician United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 10/14/2005 32 Female 9/24/2007 Brazil
Primary
Secondary
Concomitant
Status Epilepticus Hospitalization 8/26/2006 29 Male 9/28/2007 Other Health Professional Ireland
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 10/14/2005 32 Female 10/9/2007 Brazil
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2007 36 Female 10/17/2007 Physician United States
Primary
Secondary
Sepsis Death 3/30/2006 5 Male 33 lb 10/17/2007 Physician Japan
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 10/14/2005 32 Female 11/1/2007 Brazil
Primary
Secondary
Concomitant
Rash Hospitalization 10/26/2007 40 Male 11/8/2007 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 24 Male 11/19/2007
Primary
Secondary
Concomitant
Torticollis Hospitalization 1/28/2007 24 Male 11/16/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/25/2007 40 Male 11/16/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/25/2007 40 Male 11/28/2007 Physician Japan
Primary
Secondary
Concomitant
Petit Mal Epilepsy Other Serious 53 Male 1/10/2008 Other Health Professional France
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 22 Male 1/7/2008 Consumer United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 36 Female 135 lb 1/10/2008 Other Health Professional United States
Primary
Concomitant
Fracture Other Serious 1/1/2007 55 Female 1/28/2008 Physician Japan
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 22 Male 1/24/2008 Physician United Kingdom
Primary
Concomitant
Intentional Self-injury Other Serious 33 Female 2/29/2008 United States
Primary
Secondary
Concomitant
Somnolence 12/21/2007 Female 172 lb 3/14/2008 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 11 Male 3/25/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 5/31/2008 17 Male 121 lb 6/5/2008 Physician United States
Primary
Concomitant
Death Death 37 6/19/2008 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 9/1/2007 Female 6/24/2008 Physician United Kingdom
Primary
Concomitant
Ventricular Septal Defect Congenital Anomaly Female 7 lb 7/9/2008 Physician Mexico
Primary
Secondary
Concomitant
Ventricular Septal Defect Congenital Anomaly Female 7 lb 7/28/2008 Physician Mexico
Primary
Secondary
Concomitant
Stress Hospitalization 37 Female 7/24/2008 Switzerland
Primary
Concomitant
Vomiting Other Serious 9/1/2007 25 Female 8/5/2008 Physician United Kingdom
Primary
Concomitant
Drug Interaction Death 12 Female 126 lb 8/6/2008 Other Health Professional Spain
Primary
Concomitant
Interacting
Somnambulism Other Serious 54 Female 8/11/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pruritus Other Serious 2/10/2008 28 Female 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 75 Female 9/19/2008 Other Health Professional United States
Primary
Concomitant
Interacting
Pruritus Other Serious 2/10/2008 28 Female 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 37 Female 10/21/2008 Other Health Professional Switzerland
Primary
Secondary
Sopor Other Serious 10/17/2008 29 Female 10/24/2008 Physician Brazil
Primary
Secondary
Treatment Noncompliance Life Threatening 10/14/2008 43 Female 12/3/2008 Other Health Professional United States
Primary
Concomitant
Drug Toxicity Death 37 12/18/2008 Physician United States
Primary
Secondary
Sepsis Hospitalization 3/8/1988 Male 165 lb 12/18/2008 Physician Canada
Primary
Secondary
Concomitant
Accidental Exposure Other Serious 53 Female 132 lb 2/25/2009 Other Health Professional Germany
Primary
Secondary
Sepsis Hospitalization Female 3/10/2009 Physician United Kingdom
Primary
Concomitant
Suicide Attempt Life Threatening 11/20/2008 46 Male 3/31/2009 Spain
Primary
Secondary
Weight Decreased Other Serious Female 4/17/2009 France
Primary
Concomitant
Interacting
Vision Blurred Other Serious 3 Male 4/28/2009 Other Health Professional Germany
Primary
Secondary
Wheezing Other Serious 8/6/2001 25 Male 256 lb 5/21/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization Female 5/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 6/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization Male 7 lb 6/5/2009 Physician Australia
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 6/10/2009 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Increased Death 2/21/2009 Male 101 lb 6/19/2009 Physician Japan
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 181 lb 6/25/2009 Other Health Professional Japan
Primary
Concomitant
Visual Impairment Required Intervention 4/23/2009 41 Female 100 lb 5/5/2009 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization Female 6/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Micturition Urgency Other Serious Male 7/10/2009 Physician Australia
Primary
Concomitant
Neuropathy Peripheral Other Serious 8/9/2006 45 Male 222 lb 7/16/2009 United States
Primary
Concomitant
Sinus Arrhythmia Other Serious 46 Male 176 lb 7/30/2009
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1998 Female 190 lb 7/31/2009 Consumer United States
Primary
Secondary
Concomitant
Temporomandibular Joint Syndrome Other Serious 56 Female 8/14/2009 Canada
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 1/1/2009 Female 8/26/2009 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious Female 9/14/2009 France
Primary
Concomitant
Interacting
Hypertransaminasaemia Other Serious 4/6/2009 37 Male 10/6/2009 Consumer Spain
Primary
Secondary
Viral Upper Respiratory Tract Infection Required Intervention 21 Female 128 lb 10/6/2009 Switzerland
Primary
Concomitant
Vasoconstriction Death 73 Male 143 lb 10/6/2009 Other Health Professional Switzerland
Primary
Concomitant
Tooth Disorder Other Serious 12/1/2005 Female 10/22/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization Female 10/21/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hypertransaminasaemia Other Serious 4/6/2009 37 Male 10/29/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 11 Female 11/5/2009 Physician Spain
Primary
Concomitant
Vomiting Hospitalization Female 12/4/2009 Japan
Primary
Concomitant
Peritonitis Hospitalization 7/17/2009 58 Male 11/3/2009 United States
Primary
Concomitant
Vomiting Other Serious Female 12/16/2009 Japan
Primary
Secondary
Vomiting Other Serious Female 12/29/2009 Japan
Primary
Secondary
Hypotension Required Intervention 0 Female 12/22/2009 Physician India
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 Female 190 lb 1/27/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1998 Female 153 lb 2/3/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious Female 3/5/2010 Japan
Primary
Secondary
Tooth Malformation Other Serious 3/14/1987 23 Male 66 lb 3/16/2010 Physician Brazil
Primary
Concomitant
Weight Increased Other Serious 1/1/1998 32 Female 153 lb 4/8/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/15/2010 Netherlands
Primary
Secondary
Concomitant
Hepatitis Toxic Hospitalization 10/21/2009 35 Female 132 lb 4/28/2010 Physician France
Primary
Concomitant
Hyponatraemia Other Serious 2/6/2009 47 Male 192 lb 4/23/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/1/2009 72 Female 4/27/2010 Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/16/2009 53 Female 5/5/2010 Physician United Kingdom
Primary
Concomitant
Respiratory Distress Hospitalization Male 7 lb 5/10/2010 Physician Sweden
Primary
Concomitant
Respiratory Distress Other Serious 11/1/2006 34 Male 154 lb 5/12/2010 Japan
Primary
Concomitant
Rash Hospitalization 33 Male 5/10/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/26/2010 44 Male 5/19/2010 Physician United Kingdom
Primary
Concomitant
Death Death 4/11/2010 10 Female 6/10/2010 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/11/2010 82 Female 7/19/2010 India
Primary
Secondary
Concomitant
Completed Suicide Death 6/26/2007 45 Female 175 lb 7/22/2010 Physician United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 7/14/2010 26 Female 176 lb 7/26/2010 Physician Portugal
Primary
Concomitant
Overdose Other Serious 70 Female 7/29/2010 Other Health Professional United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 7/7/2010 26 Female 176 lb 8/2/2010 Physician Portugal
Primary
Secondary
Concomitant
Tooth Malformation Other Serious 3/14/1987 23 Male 66 lb 8/3/2010 Physician Brazil
Primary
Concomitant
Myoclonus Other Serious 11 Male 8/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased 1/1/2005 45 Female 149 lb 8/9/2010 Consumer United States
Primary
Concomitant
Hepatitis Toxic Hospitalization 10/21/2009 35 Female 132 lb 8/10/2010 Physician France
Primary
Concomitant
Myoclonus Other Serious 11 Male 8/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 8/23/2010 24 Female 174 lb 8/31/2010 Pharmacist United States
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 9/10/2010 Physician Sweden
Primary
Concomitant
Interacting
Vertigo Other Serious 59 Female 110 lb 9/29/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 10/13/2010 Physician Sweden
Primary
Concomitant
Interacting

Drug Data