Clonazepam combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ulcer Hospitalization 1/1/2002 63 Male 205 lb 1/13/2006 Physician United States
Primary
Concomitant
Dystonia Other Serious 8/14/2005 36 Female 184 lb 1/18/2006 Consumer United States
Primary
Concomitant
Breast Cancer Female Life Threatening 10/15/2005 66 Female 1/19/2006 Other Health Professional France
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 1/8/2006 Female 135 lb 1/26/2006 Canada
Primary
Concomitant
Ulcer Hospitalization 1/1/2002 63 Male 205 lb 2/3/2006 Physician United States
Primary
Concomitant
Orchitis Hospitalization 6/19/2004 Male 181 lb 2/22/2006 France
Primary
Concomitant
Polyuria Hospitalization 65 Female 3/21/2006 United States
Primary
Concomitant
Hyponatraemia Other Serious 65 Female 4/6/2006 Other Health Professional United States
Primary
Concomitant
Breast Cancer Other Serious 8/22/2005 Female 4/14/2006 Physician United States
Primary
Concomitant
Lethargy Other Serious 65 Female 4/21/2006 United States
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 5/5/2006 Consumer Canada
Primary
Concomitant
Pruritus Other Serious 1/1/2001 Female 160 lb 5/11/2006 Consumer United States
Primary
Concomitant
Orchitis Hospitalization 6/19/2004 Male 181 lb 5/18/2006 France
Primary
Concomitant
Urine Output Increased Hospitalization 65 Female 6/9/2006 Physician United States
Primary
Concomitant
Skin Cancer Other Serious 10/1/2005 Female 7/10/2006 Physician United States
Primary
Concomitant
Cholelithiasis Hospitalization 12/1/2005 Female 7/12/2006 Physician United States
Primary
Concomitant
Cholelithiasis Hospitalization 12/1/2005 Female 7/25/2006 Physician United States
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 7/26/2006 Consumer Canada
Primary
Concomitant
Synovitis Required Intervention 12/28/2005 36 Female 8/18/2006 Physician Argentina
Primary
Concomitant
Ventricular Tachycardia Other Serious 8/15/2001 Male 9/6/2006 Physician United States
Primary
Concomitant
Visual Disturbance Other Serious 8/16/2006 Female 175 lb 9/8/2006 Consumer Canada
Primary
Secondary
Concomitant
Infection Hospitalization 8/17/2006 Female 148 lb 9/25/2006 Physician Czech Republic
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2006 Female 210 lb 10/6/2006 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 9/12/2006 65 Female 114 lb 11/1/2006 Physician United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 10/12/2006 Female 117 lb 11/9/2006 Consumer Brazil
Primary
Concomitant
Speech Disorder Other Serious 6/1/2006 Female 148 lb 11/17/2006 Physician Czech Republic
Primary
Concomitant
Pulmonary Oedema Hospitalization 9/12/2006 65 Female 114 lb 12/5/2006 Physician United States
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 10/12/2006 Female 117 lb 12/6/2006 Consumer Brazil
Primary
Concomitant
Pyrexia Other Serious 10/24/2006 Female 12/8/2006 Consumer Canada
Primary
Concomitant
Nasopharyngitis 12/1/2004 Female 12/14/2006 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 8/16/2006 Female 175 lb 12/22/2006 Consumer Canada
Primary
Concomitant
Vision Blurred Other Serious 8/16/2006 Female 175 lb 12/22/2006 Consumer Canada
Primary
Concomitant
Synovitis Required Intervention 12/28/2004 35 Female 132 lb 12/22/2006 Physician Argentina
Primary
Concomitant
Muscle Spasms Other Serious Female 211 lb 12/27/2006 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 8/16/2006 Female 175 lb 1/18/2007 Consumer Canada
Primary
Concomitant
Headache Other Serious 4/13/2006 77 Female 116 lb 5/2/2006 Consumer United States
Primary
Concomitant
Death Death Female 128 lb 1/22/2007 France
Primary
Concomitant
Panic Attack Other Serious Female 211 lb 1/26/2007 Consumer United States
Primary
Concomitant
Pneumonia Other Serious 10/24/2006 Female 2/2/2007 Consumer Canada
Primary
Concomitant
Infarction Death 11/13/2006 Female 128 lb 2/16/2007 France
Primary
Concomitant
Orchitis Hospitalization 6/19/2004 Male 181 lb 2/21/2007 France
Primary
Concomitant
Speech Disorder Other Serious 6/1/2006 Female 139 lb 2/23/2007 Physician Czech Republic
Primary
Concomitant
Thrombocytopenia Other Serious 6/1/2006 Female 139 lb 2/26/2007 Physician Czech Republic
Primary
Concomitant
Road Traffic Accident Other Serious 7/1/2006 50 Female 170 lb 3/13/2007 Consumer United States
Primary
Concomitant
Sepsis Hospitalization 12/19/2006 Female 141 lb 4/5/2007 Belgium
Primary
Concomitant
Nervous System Disorder Other Serious 1/1/2007 Female 150 lb 4/13/2007 Other Health Professional United States
Primary
Concomitant
Orchitis Hospitalization 6/19/2004 Male 181 lb 4/17/2007 France
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 Female 141 lb 4/18/2007 Belgium
Primary
Concomitant
Road Traffic Accident Other Serious 7/1/2006 Female 170 lb 4/18/2007 Consumer United States
Primary
Concomitant
Visual Disturbance Other Serious 8/16/2006 Female 175 lb 4/20/2007 Consumer Canada
Primary
Concomitant
Surgery Other Serious 1/1/2007 Male 168 lb 5/30/2007 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 8/16/2006 Female 175 lb 6/19/2007 Consumer Canada
Primary
Concomitant
Weight Decreased 8/1/2006 Female 123 lb 6/25/2007 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2005 54 Female 125 lb 6/30/2007 Physician United States
Primary
Concomitant
Rash Maculo-papular Hospitalization 10/1/2006 Male 9/7/2007 Other Health Professional France
Primary
Concomitant
Skin Lesion Hospitalization 10/1/2006 Male 9/14/2007 Other Health Professional France
Primary
Concomitant
Weight Decreased 8/1/2006 50 Female 123 lb 9/26/2007 Consumer United States
Primary
Concomitant
Urticaria Other Serious 12/29/2006 Female 196 lb 10/5/2007 Other Health Professional Canada
Primary
Concomitant
Vision Blurred Other Serious 2/21/2007 Female 260 lb 10/5/2007 Canada
Primary
Concomitant
Stomatitis Hospitalization 1/25/2007 4 Male 11/16/2007 Japan
Primary
Secondary
Concomitant
Vision Blurred 9/1/2006 Female 178 lb 12/11/2007 Other Health Professional United States
Primary
Concomitant
Pain In Extremity 6/11/2007 Female 12/12/2007 Physician United States
Primary
Concomitant
Overdose Hospitalization 10/16/2007 Female 180 lb 12/14/2007 Consumer United States
Primary
Secondary
Concomitant
Underdose 1/1/2004 Male 241 lb 12/15/2007 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 Female 177 lb 12/18/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 Female 177 lb 1/4/2008 Physician United States
Primary
Concomitant
Drug Toxicity Death 52 Male 1/11/2008 Physician United States
Primary
Secondary
Chronic Obstructive Pulmonary Disease Other Serious 1/7/2007 Female 172 lb 1/18/2008 Physician Canada
Primary
Secondary
Concomitant
Prostatitis Hospitalization 6/19/2004 Male 181 lb 1/18/2008 France
Primary
Concomitant
Rectosigmoid Cancer Other Serious 4/1/2007 Female 1/18/2008 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 10/31/2007 Female 148 lb 1/25/2008 Brazil
Primary
Concomitant
Respiratory Arrest Death 52 Male 1/21/2008 United States
Primary
Secondary
Respiratory Arrest Death 52 Male 1/22/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 52 Male 1/22/2008 Physician United States
Primary
Secondary
Weight Decreased Other Serious 1/1/2004 Female 177 lb 1/29/2008 Physician United States
Primary
Concomitant
Pyelonephritis Life Threatening 6/19/2007 Female 1/31/2008 Other Health Professional France
Primary
Secondary
Concomitant
Infarction Hospitalization 11/13/2006 Female 128 lb 2/7/2008 France
Primary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 2/11/2008 Consumer United States
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 1/1/2006 52 Male 2/13/2008 Physician United States
Primary
Secondary
Urinary Tract Infection 4/7/2003 Female 135 lb 3/14/2008 United States
Primary
Concomitant
Pain 10/1/2007 Female 452 lb 3/14/2008 Other Health Professional United States
Primary
Concomitant
Injection Site Pain 11/22/2007 Female 190 lb 3/14/2008 Consumer United States
Primary
Concomitant
Somnolence 12/21/2007 Female 172 lb 3/14/2008 Consumer United States
Primary
Concomitant
Stress 1/1/2006 Female 150 lb 3/15/2008 Consumer United States
Primary
Concomitant
Smear Cervix Abnormal 3/10/2007 Female 178 lb 3/15/2008 Physician United States
Primary
Concomitant
Pain In Extremity 6/1/2007 Female 228 lb 3/15/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 1/4/2008 Female 230 lb 3/15/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 8/1/2007 210 lb 3/15/2008 Consumer United States
Primary
Concomitant
Completed Suicide Death 3/27/2008 Physician United States
Primary
Secondary
Hypertensive Crisis 3/9/2008 Female 176 lb 3/27/2008 Brazil
Primary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 4/3/2008 Consumer United States
Primary
Secondary
Concomitant
Syncope Vasovagal Hospitalization 3/26/2008 Female 4/11/2008 Physician Chile
Primary
Concomitant
Renal Failure Hospitalization 7/21/2007 Male 4/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Mucous Stools Hospitalization 11/6/2007 Female 4/16/2008 Other Health Professional France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2007 Female 113 lb 4/22/2008 Physician United States
Primary
Secondary
Concomitant
Syncope Vasovagal Hospitalization 3/26/2008 Female 146 lb 4/22/2008 Physician Chile
Primary
Concomitant
Mucous Stools Hospitalization 6/11/2007 Female 4/23/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 11/13/2006 Female 128 lb 4/25/2008 France
Primary
Concomitant
Tuberculosis Hospitalization 9/30/2007 Female 4/28/2008 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased 8/29/2007 3 Male 4/30/2008 Japan
Primary
Secondary
Concomitant
Mucosal Inflammation 11/9/2007 1 Male 4/30/2008 Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 9/30/2007 Female 5/13/2008 Physician France
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 12/20/2007 1 Male 5/15/2008 Physician Japan
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/1/2007 Female 71 lb 5/21/2008 Consumer United States
Primary
Concomitant
Rectosigmoid Cancer Other Serious 4/1/2007 Female 5/28/2008 Other Health Professional France
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/12/2007 9 Female 6/6/2008 Japan
Primary
Secondary
Concomitant
Overdose Hospitalization 10/16/2007 Female 180 lb 6/12/2008 Consumer United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal 3/1/2007 Female 275 lb 6/12/2008 Consumer United States
Primary
Concomitant
Swelling Other Serious 1/1/2007 Female 155 lb 6/12/2008 Consumer United States
Primary
Concomitant
Rhinorrhoea 4/24/2008 Female 145 lb 6/13/2008 United States
Primary
Concomitant
Pain 4/8/2008 Female 140 lb 6/13/2008 United States
Primary
Concomitant
Respiratory Arrest Other Serious 52 Male 6/19/2008 Physician United States
Primary
Secondary
Urinary Tract Infection Hospitalization 1/1/2007 Female 71 lb 6/20/2008 Consumer United States
Primary
Concomitant
Shoulder Operation Other Serious 6/19/2008 Female 138 lb 6/27/2008 Consumer United States
Primary
Concomitant
Nasopharyngitis 55 Female 205 lb 6/30/2008 Consumer United States
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Life Threatening 1/22/2008 26 Female 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Bone Marrow Transplant Rejection Life Threatening 4/15/2008 2 Male 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Pyrexia Hospitalization 2/1/2008 60 Female 7/3/2008 Consumer United States
Primary
Concomitant
Vomiting Life Threatening 5/3/2007 2 Female 6/30/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 2/29/2008 1 Female 7/2/2008 Japan
Primary
Concomitant
Rotator Cuff Syndrome Hospitalization 6/19/2008 Female 138 lb 7/11/2008 Consumer United States
Primary
Concomitant
Vasculitis Other Serious 1/1/2008 58 Female 119 lb 7/31/2008 Physician France
Primary
Concomitant
Stomatitis Life Threatening 10/12/2007 9 Female 7/25/2008 Japan
Primary
Secondary
Concomitant
Vasculitis Other Serious 1/1/2008 58 Female 119 lb 8/4/2008 Physician France
Primary
Concomitant
Oedema Peripheral Other Serious Female 150 lb 8/18/2008 Consumer United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 8/1/2008 54 Female 170 lb 8/21/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Life Threatening 5/3/2007 2 Female 8/27/2008 Japan
Primary
Secondary
Concomitant
Prostatitis Hospitalization 6/19/2004 Male 181 lb 9/10/2008 France
Primary
Concomitant
Pain Other Serious Female 150 lb 9/12/2008 Other Health Professional United States
Primary
Concomitant
Traumatic Brain Injury Other Serious 11/7/2007 Female 234 lb 9/12/2008 Physician United States
Primary
Concomitant
Haemoglobin Decreased Other Serious 5/20/2008 Female 112 lb 9/12/2008 Other Health Professional United States
Primary
Concomitant
Inappropriate Schedule Of Drug Administration 6/5/2008 Female 240 lb 9/12/2008 United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 8/1/2000 54 Female 170 lb 9/5/2008 Physician Germany
Primary
Secondary
Concomitant
Psoriatic Arthropathy Female 130 lb 9/13/2008 Consumer United States
Primary
Concomitant
Pyrexia 8/19/2008 Female 200 lb 9/13/2008 United States
Primary
Concomitant
Injection Site Urticaria 7/1/2008 Female 111 lb 9/13/2008 Consumer United States
Primary
Concomitant
Sepsis Other Serious 1/1/2006 Female 134 lb 9/19/2008 Physician United States
Primary
Concomitant
Pyrexia Other Serious 5/21/2008 Female 132 lb 9/30/2008 Canada
Primary
Concomitant
Sinusitis Other Serious 7/12/2008 Female 156 lb 10/1/2008 Canada
Primary
Concomitant
Synovitis Other Serious 2/11/2006 Female 198 lb 10/23/2008 Physician United States
Primary
Concomitant
Vomiting Death 11/30/2006 11 Male 10/17/2008 Japan
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/1/2008 Female 10/28/2008 Physician United States
Primary
Concomitant
Vomiting Life Threatening 5/3/2007 2 Female 10/23/2008 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 9/18/2008 Female 200 lb 11/3/2008 Other Health Professional United States
Primary
Concomitant
Sinusitis Other Serious 7/12/2008 Female 156 lb 11/7/2008 Canada
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 3/3/2008 Other Health Professional United States
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 9/9/2008 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 3/13/2005 Female 146 lb 11/24/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection 12/6/2006 Female 134 lb 11/26/2008 Physician United States
Primary
Concomitant

Drug Data