Cisplatin combined with Topotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ureteric Obstruction Other Serious 12/16/2005 Female 119 lb 1/4/2006 United States
Primary
Secondary
Rectal Haemorrhage Hospitalization 1/24/2006 Female 113 lb 1/25/2006 United States
Primary
Secondary
Tonsillitis Hospitalization 12/6/2005 55 Male 168 lb 1/31/2006 Physician Germany
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious 1/23/2006 Female 113 lb 1/31/2006 United States
Primary
Secondary
Vomiting Other Serious 11/29/2005 Female 156 lb 2/1/2006 United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 12/18/2005 Female 149 lb 2/1/2006 United States
Primary
Secondary
Vomiting Death Female 149 lb 2/8/2006 United States
Primary
Secondary
Thrombocytopenia Hospitalization 2/8/2006 47 Female 73 lb 2/21/2006 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 2/20/2006 67 Female 202 lb 2/21/2006 Other Health Professional United States
Primary
Secondary
Peripheral Coldness Life Threatening 4/7/2006 65 Male 4/14/2006 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 4/7/2006 65 Male 5/30/2006 Physician Germany
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious 1/7/2005 3 Female 5/24/2006 Spain
Primary
Concomitant
Pyrexia Hospitalization 5/18/2006 74 Male 187 lb 6/30/2006 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 4/7/2006 65 Male 7/10/2006 Physician Germany
Primary
Secondary
Concomitant
Neutropenia 6/14/2006 Female 157 lb 7/5/2006 United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased 6/14/2006 Female 157 lb 7/3/2006 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/8/2006 Female 114 lb 7/11/2006 United States
Primary
Secondary
Thrombocytopenia Hospitalization 7/25/2006 Female 198 lb 8/1/2006 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 Female 97 lb 8/29/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 54 Female 97 lb 9/5/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 54 Female 97 lb 9/7/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 54 Female 97 lb 9/26/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 11/10/2006 Female 99 lb 11/13/2006 United States
Primary
Secondary
Concomitant
Peripheral Arterial Occlusive Disease Hospitalization 1/7/2007 Female 173 lb 1/9/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/13/2006 74 Male 187 lb 1/16/2007 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 2/13/2007 Female 109 lb 2/21/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 2/13/2007 Female 109 lb 2/22/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/13/2007 Female 109 lb 3/7/2007 United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased 3/5/2007 Male 109 lb 3/15/2007 United States
Primary
Secondary
Epistaxis Hospitalization 3/27/2006 71 Male 165 lb 3/26/2007 Physician Germany
Primary
Secondary
Concomitant
Pneumonia 12/8/2006 Female 3/28/2007 Physician United States
Primary
Concomitant
Oral Fungal Infection Hospitalization 3/12/2007 72 3/29/2007 Physician Denmark
Primary
Secondary
Vomiting Hospitalization 2/20/2007 Female 116 lb 3/30/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 3/12/2007 72 4/11/2007 Physician Denmark
Primary
Secondary
White Blood Cell Count Decreased 3/27/2007 Female 109 lb 4/19/2007 United States
Primary
Secondary
Thrombocytopenia Hospitalization 6/1/2005 50 Female 4/30/2007 Other Health Professional Korea, Republic Of
Primary
Secondary
Oral Fungal Infection Hospitalization 3/12/2007 72 5/4/2007 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 5/8/2007 Female 132 lb 5/9/2007 United States
Primary
Secondary
Wheezing Hospitalization 4/10/2007 Female 229 lb 4/30/2007 United States
Primary
Concomitant
Tachycardia Hospitalization 4/30/2007 Female 229 lb 5/4/2007 United States
Primary
Secondary
Oral Fungal Infection Hospitalization 3/12/2007 72 5/21/2007 Physician Denmark
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 50 Female 6/4/2007 Korea, Republic Of
Primary
Secondary
Blood Glucose Increased Hospitalization 6/1/2007 Female 213 lb 6/6/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal 6/5/2007 Female 133 lb 6/6/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/6/2007 Female 229 lb 6/11/2007 United States
Primary
Secondary
Influenza Like Illness Hospitalization 5/17/2007 Female 298 lb 6/12/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 6/18/2007 Female 229 lb 6/19/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/12/2007 72 6/28/2007 Physician Denmark
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal 7/10/2007 Female 134 lb 7/12/2007 United States
Primary
Secondary
Vomiting Hospitalization 7/25/2005 62 Male 185 lb 7/26/2007 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased 8/1/2007 Female 133 lb 8/9/2007 United States
Primary
Secondary
Infection Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Infection Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Infection Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Infection Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Infection Death 9/6/2007 Other Health Professional Germany
Primary
Secondary
Infection Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Death 6/28/2007 50 Female 9/10/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Hospitalization 6/26/2007 45 9/10/2007 Other Health Professional France
Primary
Secondary
Renal Failure Other Serious 8/6/2007 70 Female 9/11/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/8/2007 70 Female 9/12/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/6/2007 50 Female 9/18/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Hospitalization 6/26/2007 45 Female 9/18/2007 Other Health Professional France
Primary
Secondary
White Blood Cell Count Abnormal 8/21/2007 Female 132 lb 9/14/2007 United States
Primary
Secondary
Hypoglycaemia Other Serious 8/6/2007 70 Female 9/19/2007 Other Health Professional Germany
Primary
Secondary
Pyrexia Hospitalization 8/22/2007 67 Female 168 lb 9/24/2007 Physician Germany
Primary
Secondary
Thrombocythaemia Other Serious 8/14/2007 41 Female 119 lb 10/2/2007 Physician Germany
Primary
Secondary
Vaginal Haemorrhage Hospitalization 7/24/2007 46 Female 10/4/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Other Serious 7/25/2007 46 Female 10/8/2007 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Hospitalization 6/12/2007 46 Female 10/10/2007 Other Health Professional Germany
Primary
Secondary
White Blood Cell Count Abnormal Hospitalization 10/1/2007 Female 133 lb 10/5/2007 United States
Primary
Secondary
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 10/31/2007 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 11/12/2007 Physician Germany
Primary
Secondary
Vaginal Haemorrhage Hospitalization 10/24/2007 Female 128 lb 11/2/2007 United States
Primary
Secondary
Nausea Hospitalization 11/6/2007 74 Male 12/5/2007 Physician Denmark
Primary
Secondary
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 12/28/2007 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 1/2/2008 Physician Germany
Primary
Secondary
Urine Output Decreased Hospitalization 12/17/2007 Female 1/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 10/16/2006 Female 122 lb 1/1/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Hospitalization 12/17/2007 Female 1/10/2008 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 1/11/2008 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 8/22/2007 67 Female 168 lb 1/17/2008 Physician Germany
Primary
Secondary
Vomiting Hospitalization 12/13/2007 Female 133 lb 1/14/2008 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 10/16/2006 Female 122 lb 2/11/2008 United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 11 Male 3/1/2008 Consumer Hong Kong
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/13/2008 Female 130 lb 3/19/2008 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 1/13/2008 Female 130 lb 3/24/2008 United States
Primary
Secondary
Vomiting Hospitalization 12/13/2007 Female 133 lb 3/24/2008 United States
Primary
Secondary
Pain 9/17/2007 32 Female 161 lb 9/18/2007 Other Health Professional United States
Primary
Concomitant
Febrile Neutropenia Hospitalization 5/7/2006 Female 243 lb 4/17/2008 Physician United States
Primary
Secondary
Pain 9/17/2007 32 Female 161 lb 9/18/2007 Other Health Professional United States
Primary
Concomitant
Therapeutic Response Delayed Other Serious 1/1/1999 Female 145 lb 7/3/2008 Consumer United States
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 7/5/2008 Male 175 lb 7/10/2008 United States
Primary
Secondary
Renal Failure Hospitalization 54 Female 7/16/2008 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 54 Female 7/31/2008 Consumer United States
Primary
Concomitant
Convulsion Hospitalization 8/6/2008 45 Female 141 lb 8/11/2008 Physician Germany
Primary
Secondary
Renal Failure Hospitalization 54 Female 8/12/2008 Physician United States
Primary
Concomitant
Therapeutic Response Delayed Other Serious 1/1/1999 Female 155 lb 9/24/2008 Physician United States
Primary
Concomitant
Gastritis Hospitalization Female 11/6/2008 Physician Germany
Primary
Secondary
Gastritis Hospitalization 10/25/2008 40 Female 320 lb 11/20/2008 Physician Germany
Primary
Secondary
Multiple Myeloma Other Serious 67 Male 1/28/2009 Other Health Professional Greece
Primary
Secondary
Multiple Myeloma Other Serious 67 Male 2/2/2009 Greece
Primary
Secondary
Multiple Myeloma Other Serious 67 Male 2/4/2009 Other Health Professional Greece
Primary
Secondary
Multiple Myeloma Other Serious 67 Male 2/5/2009 Greece
Primary
Secondary
Concomitant
Gastritis Hospitalization 10/25/2008 40 Female 320 lb 2/16/2009 Physician Germany
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 67 Male 2/24/2009 Greece
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 67 Male 4/14/2009 Other Health Professional Greece
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 67 Male 4/30/2009 Other Health Professional Greece
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 67 Male 4/28/2009 Greece
Primary
Secondary
Concomitant
Vomiting Other Serious 5/1/2008 Female 6/1/2009 Physician Romania
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 1 Female 7/24/2009 Other Health Professional Lebanon
Primary
Secondary
Venoocclusive Liver Disease Other Serious 1 Male 7/24/2009 Other Health Professional Lebanon
Primary
Secondary
Septic Shock Hospitalization 10/14/2007 Male 199 lb 9/3/2009 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 10/14/2007 Male 199 lb 9/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization 8/25/2009 Male 33 lb 9/23/2009 United States
Primary
Secondary
Weight Increased Hospitalization 8/25/2009 Male 33 lb 10/5/2009 United States
Primary
Secondary
Urinary Tract Infection Hospitalization 9/13/2009 11/3/2009 Physician Denmark
Primary
Secondary
White Blood Cell Count Increased Hospitalization 10/9/2009 Female 132 lb 11/6/2009 Physician Germany
Primary
Secondary
Concomitant
Ventricular Tachycardia Hospitalization 66 Female 11/11/2009 Germany
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 10/12/2009 Female 108 lb 11/13/2009 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 9/13/2009 11/17/2009 Physician Denmark
Primary
Secondary
Platelet Count Decreased Hospitalization 11/10/2009 Female 11/20/2009 Other Health Professional United States
Primary
Secondary
Urinary Tract Infection Hospitalization 9/13/2009 11/25/2009 Physician Denmark
Primary
Secondary
White Blood Cell Count Increased Hospitalization 10/9/2009 Female 132 lb 11/30/2009 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 9/13/2009 12/7/2009 Physician Denmark
Primary
Secondary
White Blood Cell Count Increased Hospitalization 10/9/2009 Female 132 lb 12/16/2009 Physician Germany
Primary
Secondary
Concomitant
Vaginal Haemorrhage Hospitalization 10/12/2009 Female 108 lb 12/16/2009 Physician Germany
Primary
Secondary
Concomitant
Streptococcal Sepsis Hospitalization 10/14/2007 Male 199 lb 1/8/2010 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 10/14/2007 Male 199 lb 1/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Hospitalization 1/29/2010 Female 126 lb 2/16/2010 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/2/2010 Female 160 lb 3/8/2010 United States
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Pelvic Pain 11/18/2009 Female 3/25/2010 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 3/2/2010 41 Female 160 lb 4/1/2010 United States
Primary
Secondary
Thrombocytopenia Other Serious 50 Female 4/7/2010 Physician Korea, Republic Of
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 3/2/2010 41 Female 160 lb 4/22/2010 United States
Primary
Secondary
Urinary Tract Infection Other Serious 61 Female 5/14/2010 Physician United States
Primary
Secondary
Concomitant
Wound Infection Pseudomonas Hospitalization 6/9/2010 19 Male 6/28/2010 Physician France
Primary
Secondary
Concomitant
Death Death 7/15/2010 73 Female 8/23/2010 Physician United States
Primary
Secondary
Death Death 7/15/2010 73 Female 8/26/2010 Physician United States
Primary
Secondary
Vulvovaginal Pain Hospitalization 7/31/2010 Female 8/31/2010 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 7/26/2010 52 Female 209 lb 9/1/2010 Physician Germany
Primary
Secondary
Vomiting Other Serious 7/31/2010 9/2/2010 United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 7/26/2010 52 Female 209 lb 9/3/2010 Physician Germany
Primary
Secondary
Vomiting Other Serious 7/31/2010 9/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Hospitalization 1/29/2010 51 Female 126 lb 9/15/2010 Physician Germany
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 9/6/2010 30 Female 185 lb 9/17/2010 Physician Germany
Primary
Secondary
Concomitant
Metastatic Neoplasm Hospitalization 12/4/2005 58 Female 178 lb 9/22/2010 United States
Primary
Secondary
Blood Creatinine Increased Hospitalization 9/6/2010 30 Female 185 lb 9/29/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 7/31/2010 55 Female 10/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data