Chlorambucil combined with Cyclophosphamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Subacute Endocarditis Other Serious 9/1/2004 82 Male 157 lb 1/18/2006 Other Health Professional Germany
Primary
Concomitant
T-cell Lymphoma Death 66 Male 5/12/2006 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Death 6/15/2006 Austria
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 62 Female 10/13/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Viral Infection Life Threatening 4/1/2006 62 Female 10/13/2006 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/1/1999 54 Male 10/13/2006
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Death 62 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/1/2005 66 Male 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Crossmatch Incompatible Other Serious 8/1/2006 76 Male 10/12/2006 Physician Germany
Primary
Concomitant
Haemolysis Other Serious 8/1/2006 76 Male 11/22/2006 Physician Germany
Primary
Concomitant
Viral Infection Life Threatening 62 Female 3/5/2007
Primary
Secondary
Concomitant
Neutropenia Other Serious Female 3/6/2007 United Kingdom
Primary
Secondary
Stem Cell Transplant Other Serious 49 Female 3/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Stem Cell Transplant Other Serious 49 Female 4/30/2007 United Kingdom
Primary
Secondary
T-cell Lymphoma Other Serious 7/1/2005 66 Male 5/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Infection Other Serious 62 Female 5/21/2007
Primary
Secondary
Concomitant
Respiratory Failure Death Female 8/14/2007
Primary
Secondary
White Blood Cell Count Increased Hospitalization 69 Female 8/16/2007
Primary
Secondary
Viral Infection Life Threatening 4/1/2005 62 Female 10/18/2007 United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 4/1/2005 62 Female 10/23/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 7/1/2003 Female 128 lb 10/26/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 10/26/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Viral Infection Life Threatening 4/1/2005 62 Female 10/30/2007 United Kingdom
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 70 Female 11/1/2007
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 62 Female 10/31/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Infection Life Threatening 4/1/2005 62 Female 11/12/2007 United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 11/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Viral Infection Life Threatening 4/1/2005 62 Female 12/21/2007 United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 4/1/2005 62 Female 12/26/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Viral Infection Life Threatening 4/1/2005 62 Female 12/28/2007 United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 62 Female 12/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Life Threatening 62 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Viral Infection Death 62 Female 1/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 62 Female 1/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious 60 Male 2/4/2008 Physician Germany
Primary
Concomitant
Status Epilepticus Other Serious 70 Female 2/8/2008 Physician United Kingdom
Primary
Concomitant
Status Epilepticus Other Serious 70 Female 2/14/2008 Physician United Kingdom
Primary
Concomitant
Status Epilepticus Other Serious 70 Female 4/1/2008 Physician United Kingdom
Primary
Concomitant
Respiratory Moniliasis Death 55 Female 4/25/2008 Physician United Kingdom
Primary
Secondary
Stem Cell Transplant Other Serious 49 Female 4/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Autoimmune Neutropenia Other Serious 49 Female 5/7/2008 United Kingdom
Primary
Secondary
Autoimmune Neutropenia Other Serious 49 Female 5/13/2008 Consumer United States
Primary
Secondary
Autoimmune Neutropenia Other Serious 49 Female 5/14/2008 United Kingdom
Primary
Secondary
Neutropenia Other Serious 49 Female 5/16/2008 United Kingdom
Primary
Secondary
Autoimmune Neutropenia Other Serious 49 Female 5/29/2008 United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Life Threatening 2/2/2008 65 Female 6/11/2008 Physician United Kingdom
Primary
Secondary
Wheezing Other Serious 1/1/2001 58 Male 6/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 44 Male 8/21/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2003 62 Female 134 lb 9/12/2008 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Other Serious 1/1/2003 62 Female 134 lb 9/15/2008 Other Health Professional Germany
Primary
Secondary
Myelodysplastic Syndrome Disability 5/2/2007 67 Female 10/9/2008 Physician Canada
Primary
Secondary
Neoplasm Malignant Death 4/9/2008 Male 10/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Other Serious 1/1/2008 74 Female 10/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/28/2008 74 Female 10/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/15/2008 United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 10/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Neoplasm Malignant Death 4/9/2008 Male 10/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 10/31/2008 Consumer United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Death 4/9/2008 Male 11/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Other Serious 74 Female 11/7/2008 United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 4/9/2008 Male 11/7/2008 United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Death 4/9/2008 Male 10/31/2008 United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Death 4/9/2008 Male 11/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 8/28/2008 74 Female 11/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/18/2008 Consumer United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Death 4/9/2008 Male 11/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Neoplasm Malignant Death 4/9/2008 Male 11/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 74 Female 11/18/2008 United Kingdom
Primary
Secondary
Concomitant
Neoplasm Malignant Death 4/9/2008 Male 11/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Acute Myelomonocytic Leukaemia Death 4/9/2008 Male 11/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Disease Progression Death 67 Male 12/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Death 63 Male 2/27/2009 Other Health Professional Italy
Primary
Secondary
Pancytopenia Other Serious 1/1/2008 74 Female 4/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pericarditis Hospitalization 73 Female 4/28/2009 Physician France
Primary
Concomitant
Septic Shock Other Serious 6/1/2005 69 Male 6/15/2009 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Septic Shock Other Serious 69 Male 6/23/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 1/1/2006 69 Male 6/26/2009 Other Health Professional Czech Republic
Primary
Secondary
Leukoencephalopathy Hospitalization 69 Male 6/26/2009 Czech Republic
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 1/1/2006 69 Male 6/30/2009 Other Health Professional Czech Republic
Primary
Secondary
Leukoencephalopathy Hospitalization 69 Male 7/9/2009 Czech Republic
Primary
Secondary
Concomitant
Septic Shock Other Serious 6/1/2005 69 Male 7/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/1/2006 69 Male 7/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Other Serious 3/1/2004 57 Male 7/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Streptococcal Infection Other Serious 1/1/2003 57 Male 7/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Streptococcal Infection Death 3/1/2004 57 Male 7/23/2009 Consumer United Kingdom
Primary
Secondary
Pneumonia Other Serious 52 Male 8/13/2009 Consumer Poland
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 11/2/2004 63 Male 200 lb 9/4/2009 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 11/4/2004 63 Male 200 lb 10/5/2009 United States
Primary
Concomitant
Septic Shock Other Serious 6/1/2005 Male 10/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 12/1/2006 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nocardiosis Death 69 Female 11/24/2009 Korea, Republic Of
Primary
Secondary
Myelodysplastic Syndrome Death 8/20/2009 Male 196 lb 12/17/2009 Physician United Kingdom
Primary
Secondary
Streptococcal Infection Other Serious 3/1/2004 57 Male 12/28/2009 United Kingdom
Primary
Secondary
Streptococcal Infection Death 3/1/2004 57 Male 1/6/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Streptococcal Infection Death 3/1/2004 57 Male 1/7/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 34 Male 1/21/2010 Other Health Professional France
Primary
Concomitant
Jaundice Cholestatic Other Serious 82 Male 2/12/2010 Consumer United Kingdom
Primary
Concomitant
Autoimmune Neutropenia Other Serious 49 Female 2/22/2010 United Kingdom
Primary
Secondary
Lymphocytosis Other Serious 54 Male 3/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Tonsillar Hypertrophy Disability 60 Female 4/22/2010 Consumer France
Primary
Concomitant
Leukoencephalopathy Death 2/1/2009 71 Female 110 lb 5/13/2010 Physician Netherlands
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 2/1/2006 48 Female 5/27/2010 Physician United States
Primary
Secondary
Pleural Effusion Other Serious 1/29/2010 82 Male 154 lb 7/7/2010 Consumer United Kingdom
Primary
Concomitant
Subdural Haematoma Death 6/16/2009 7/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 2/2/2009 65 Male 8/20/2010 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 65 Female 134 lb 10/28/2010 Physician Germany
Primary
Secondary
Concomitant
Muscle Spasms Disability 58 Female 10/29/2010 Consumer United Kingdom
Primary
Concomitant
Lung Infection Other Serious 3/1/2007 53 Male 11/11/2010 Consumer Germany
Primary
Concomitant
Chronic Lymphocytic Leukaemia Transformation Death 74 Female 12/22/2010 Consumer United Kingdom
Primary
Secondary
Chronic Lymphocytic Leukaemia Transformation Other Serious 67 Male 12/22/2010 Consumer United Kingdom
Primary
Secondary
Asthenia Hospitalization 2/20/2009 76 Female 97 lb 1/28/2011 Other Health Professional France
Primary
Concomitant
Acute Myeloid Leukaemia Death 60 Female 2/7/2011 Other Health Professional Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 46 Male 2/28/2011 Physician Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 51 Female 2/28/2011 Physician Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 51 Female 2/28/2011 Physician Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 69 Male 2/28/2011 Other Health Professional Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 61 Female 2/28/2011 Physician Australia
Primary
Secondary
Myelodysplastic Syndrome Other Serious 53 Male 2/28/2011 Other Health Professional Australia
Primary
Secondary
Lung Infection Other Serious 3/1/2007 53 Male 4/5/2011 Consumer Germany
Primary
Concomitant
Humoral Immune Defect Death 78 Male 6/20/2011 Other Health Professional Italy
Primary
Secondary
Hyperosmolar State Other Serious 78 Male 6/29/2011 Other Health Professional Italy
Primary
Secondary
Cell-mediated Immune Deficiency Hospitalization 78 Male 6/29/2011 Other Health Professional Italy
Primary
Secondary
Humoral Immune Defect Death 1/1/2010 78 Male 7/5/2011 Physician Italy
Primary
Secondary
Thrombocytopenia Hospitalization 5/16/2011 68 Male 9/6/2011 Physician Netherlands
Primary
Concomitant
Gaze Palsy Death 60 Male 9/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Disease Progression Life Threatening 5/16/2011 68 Male 9/12/2011 Physician Netherlands
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 8/16/2011 64 Male 10/14/2011 Physician Denmark
Primary
Secondary
Concomitant
Laryngeal Cancer Other Serious 6/16/2011 71 Male 165 lb 10/19/2011 Physician Netherlands
Primary
Concomitant
Laryngeal Cancer Other Serious 6/16/2011 71 Male 165 lb 11/8/2011 Physician Netherlands
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious Female 11/11/2011 Physician Finland
Primary
Secondary
Cerebral Ischaemia Disability 9/21/2011 65 Male 227 lb 11/23/2011 Physician France
Primary
Secondary
Concomitant
Foetal Exposure During Pregnancy Other Serious 12/9/2011 Physician United States
Primary
Secondary
Paraesthesia Death 8/16/2011 64 Male 12/9/2011 Physician Denmark
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 8/16/2011 64 Male 12/16/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Sepsis Other Serious 1/12/2012 Other Health Professional Italy
Primary
Secondary
Guillain-barre Syndrome Other Serious 1/12/2012 Other Health Professional Italy
Primary
Secondary
Neutropenia Death 1/19/2012 Physician United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 59 Male 1/31/2012 Other Health Professional Latvia
Primary
Secondary
Hemianopia Death 2/2/2009 65 Male 181 lb 2/3/2012 Germany
Primary
Secondary
Concomitant

Drug Data